

首都医科大学附属北京积水潭医院教授/研究员,硕/博士生导师,北京市创伤骨科研究所生物材料与骨组织工程研究室主任。长期从事骨关节/软组织修复生物材料与机体交互作用、骨再生机理及运动系统类器官构建研究。先后主持及参加国家自然科学基金面上/重点项目、北京市自然科学基金面上/重点项目、国家“十三五/十四五”重点研发计划等 26项科研课题,目前在研主持国家级项目2项。在 Science Advances、 Adv. Funct Mater、Biomaterials、Bioact Mater、ACS Nano 等期刊发表SCI论文160篇(IF>10的58篇),他引 9329次,H指数53,授权专利 14 件。现为国家药品监督管理局(NMPA)创新医疗器械评审委员会委员、NMPA 骨科用医疗器械专家咨询委员会委员,中国生物材料学会医用金属材料分会第三届委员会常务委员、中国生物材料学会生物材料表界面工程分会第二届常务委员、中国医疗保健国际交流促进会骨科分会骨科生物材料学部常务委员、中国医疗器械行业协会再生医学技术产业第二届专业委员会委员、近三年连续入选斯坦福大学Elsevier“全球2%顶尖科学家”、生物材料国际权威杂志Bioactive Materials编委。
1. 基于复合微凝胶的骨痂类器官构建及其调控脉管系统促骨再生机制研究,国家自然科学基金面上项目,2024.01-2027.12,项目负责人(第一),项目总经费52万元,本人可支配52万,在研。
2. 国家自然科学基金重点项目:智能化人工关节表面场响应基元构建及其感知/应答的作用机制 (第二作者,参加单位负责人,项目编号:52533013 ,起止时间:2026.01-2030.12 ,资助经费:230万元,本单位可支配经费92万元)
3. 北京自然科学基金-交叉融合重点项目:时空序贯可降解骨植入物构建及其对感染性骨缺损治疗作用研究(骨干参加,项目编号: Z250013,起止时间: 2025.09-2029.08,资助经费:300万)
4. 动态自适应和主动组织修复生物材料及关键技术:课题五 生物适配性硬/软组织修复材料的临床,中华人民共和国科学技术部十四五国家重点研发计划,2022.11-2025.10,课题负责人(第一),课题总经费247万元,本人可支配169万,在研。
5. 骨肿瘤响应性多功能阳离子CircRNA载体构建及其作用机理研究,国家自然科学基金面上项目,2020.01-2023.12,项目负责人(第一),项目总经费58万元,本人可支配58万,结题。
6. 骨修复植入体表面力-电响应微环境的构建及其骨整合机制研究,国家自然科学基金重点项目,2020.01-2024.12,项目合作单位负责人(第二),项目总经费305万元,本人可支配122万,结题。
7. 基于动态力学的类器官骨修复材料构建及其平台建设,北京市卫健委改革与发展试点项目(四批),2021.01-2024.09,项目骨干(第三),项目总经费800万元,本人可支配200万,结题。
8. 再生修复大节段骨缺损的组织工程骨研究,北京市卫健委科技发展项目,2020.01-2022.12,项目负责人(第一),总经费408万元,本人可支配408万,结题。
9. 骨科再生材料与技术的应用研究,北京市卫计委科技发展项目,2017.01-2019.12,项目负责人(第一),总经费692万元,本人可支配231万,结题。
10. 磷酸钙抗菌表面构建及其骨质疏松骨折治疗作用研究,北京市自然科学基金重点项目,2016.01-2019.12,项目负责人(第一),总经费65万元,本人可支配65万,结题。
11. 骨修复材料移植早期的细胞应激与稳态维持对骨形成的作用机理,国家自然科学基金重点项目,2015.01-2019.12,项目合作单位负责人(第二),总经费310万元,本人可支配124万,结题。
12. 钙磷基纳米粒子的分布降解及其成骨系细胞响应机制研究,国家自然科学基金面上项目,2012.01-2015.12,项目负责人(第一),总经费60万元,本人可支配60万,结题。
近年发表论文:
1. Nanocomposite hydrogel orchestrating multiple modulation of degenerative microenvironment for potential application in intervertebral disc regeneration.Journal of Materials Science & Technology 229(2025)14-29. Huitong Luo, Zhipeng Sun, Zetao Wang, Wanqing Lun, Qi Feng, Dafu Chen∗, Xiaodong Cao∗(IF=14.3,JCR1区,中科院1区,TOP)
2. Impact of scandium on the microstructure, mechanical properties, corrosion behaviors and in-vitro biocompatibility of a Zn-0.1Li alloy. Journal of Materials Science & Technology 229(2025)235-251. He Huang, Gencheng Gong, Hui Yu, Zhipei Tong, Qinggong Jia, Liudang Fang, Shaokang Guan, Jing-Jun Nie, DaFu Chen∗, Jing Bai∗, Dong Bian∗, Yufeng Zheng∗(IF=14.3,JCR1区,中科院1区,TOP)
3. Biodegradable Zn-Li-Mn alloy to achieve optimal strength and ductility for bone implants. Acta Biomaterialia 199(2025)483-499. Danni Shen, Yahong Li, Jiahui Shi, Ting Zhang, Jing-Jun Nie, Dafu Chen∗, Dandan Xia∗, Yufeng Zheng∗. (IF=9.6,JCR1区,中科院1区,TOP)
4. Eco-friendly multifunctional CeO₂/ZnMn₂O₄ heterojunction with robust photocatalysis for rapid bacteria-killing and highly effective eradication of formaldehyde simultaneously. Journal of Environmental Chemical Engineering 13(3)(2025)116945. Wee Lai, Yufeng Zheng, Hanpeng Liu, Zhaoyang Li, Shengli Zhu, Hui Jiang, Zhenduo Cui, Xiangmei Liu∗. 4.(IF=7.2,JCR1区,中科院2区)
5. Interfering with proton and electron transfer enables antibacterial starvation therapy. Science Advances 11(12)(2025)eadt3159. Ji Tan, Haifeng Zhang, Yisi Liu, Zhenhao Hou, Donghui Wang, Junjie Zhou, Yuanming Cao, Shi Qian, Bowen Zheng, JingJun Nie, Yuanyuan Cui, Yun Du, Kai Huang, Shengbing Yang, Dafu Chen∗, Xuanyong Liu∗. (IF=12.5,JCR1区,中科院1区,TOP)
6. The Lattice Defects of Nanofilm Introduced by N Doping Promotes Radical Oxygen Species Production for Rapid Photocatalytic Elimination of Contact Infection. Advanced Functional Materials (2025) 2500256. Renyuan Deng, Xiangmei Liu∗, Jin Huang, Yi Wang, Dafu Chen∗, Chaofeng Wang, Khin Wee Lai, Congyang Mao∗, Guangrong Qian, Yufeng Zheng, Shuilin Wu∗. (IF=19.0,JCR1区,中科院1区,TOP)
7. Hydrogel Enhanced Organoid Multidirectional Differentiation via Yap/Tead4 Mechanotransduction for Accelerated Tissue Regeneration. ACS Appl. Mater. Interfaces, Doi.org/10.1021/acsami.5c06161. Peng Luo,# Yuning Cheng,# Yuwen Luo,# Nan Zhang, Jingjing Cao, Honggang Wang, Xieyuan Jiang,* Qian Wang, Xinbao Wu, Yajun Liu, Jianping Mao, Xinhua Zhou, Jing-Jun Nie,* and Dafu Chen*. (IF=8.2, JCR1区,中科院2区)
8. Enhanced antibacterial activity, corrosion resistance and endothelialization potential of Ti-5Cu alloy by oxygen and nitrogen plasma-based surface modification. Journal of Materials Science & Technology 168(2024)250-264. Xiaotong Zhao, Jiali Hu, Jingjun Nie, Dafu Chen*, Gaowu Qin, Erlin Zhang*(IF=11.2,JCR1区,中科院1区,TOP)
9. Microgel-based carriers enhance skeletal stem cell reprogramming towards immunomodulatory phenotype in osteoarthritic therapy. Bioactive Materials 34 (2024) 204–220. Pei-Lin Li #, Da-Fu Chen# , Xiao-Tong Li# , Rui-Cong Hao #, Zhi-Dong Zhao , Zhi-Ling Li , Bo-Feng Yin , Jie Tang , Yu-Wen Luo , Chu-Tse Wu**, Jing-Jun Nie***, Heng Zhu*(IF=18,JCR1区,中科院1区,TOP)
10. Two-Dimensional Biodegradable Black Phosphorus Nanosheets Promote Large Full-Thickness Wound Healing through In Situ Regeneration Therapy. ACS Nano 2024, 18, 3553−3574. Xueshan Bai,# Renxian Wang,# Xiaohua Hu, Qiang Dai, Jianxun Guo, Tongyu Cao, Weili Du,Yuning Cheng, Songxia Xia, Dingding Wang, Liya Yang,* Li Teng,* Dafu Chen,* and Yajun Liu*(IF=15.8,JCR1区,中科院1区,TOP)
11. Composited silk fibroins ensured adhesion stability and magnetic controllability of Fe3O4-nanoparticle coating on implant for biofilm treatment. Materials Horizons, 2024, DOI: 10.1039/d4mh00097h. Kecheng Quan, Zhinan Mao, Yupu Lu, Yu Qin, Shuren Wang, Chunhao Yu, Xuewei Bi, Hao Tang, Xiaoxiang Ren, Dafu Chen*, Yan Cheng, Yong Wang,* Yufeng Zheng* and Dandan Xia*(IF=12.1,JCR1区,中科院1区,TOP)
12. Enhanced pyroptosis induction with pore-forming gene delivery for osteosarcoma microenvironment reshaping. Bioactive Materials 38 (2024) 455–471. Jing-Jun Nie# , Bowen Zhang# , Peng Luo# , Maoguo Luo , Yuwen Luo , Jingjing Cao , Honggang Wang , Jianping Mao , Yonggang Xing , Weifeng Liu , Yuning Cheng , Renxian Wang , Yajun Liu**, Xinbao Wu , Xieyuan Jiang , Xiaoguang Cheng***, Chi Zhang , Da-Fu Chen*(IF=18,JCR1区,中科院1区,TOP)
13. Reduction-responsive nucleic acid nanocarrier-mediated miR-22 inhibition of PI3K/AKT pathway for the treatment of patient-derived tumor xenograft osteosarcoma. Bioactive Materials. 2023,28:376–385. Dafu Chen#, Chengyue Lei#, Weifeng Liu#, MeiyuShao, Meizhou Sun, Jianxun Guo, Jingjing Cao, Jing-Jun Nie, Peng Luo, YuwenLuo, Bingran Yu, Renxian Wang*, Shun Duan**, Fu-Jian Xu*** (IF=18,JCR1区,中科院1区,TOP)
14. Function-oriented design: A novel strategy for advanced biomedical materials. Journal of Materials Science & Technology.2023,145:197-209. Zhiyu Zhou#, Wentao Wang#, Jianmin Wang#, Hongshui Wang, YiXia, Wei Zhang, Yuxiao Lai, Xiao Lin, Yongcan Huang, Xuenong Zou, Martin J.Stoddart, Zhen Li, Wei Tian, Shaoyu Liu, Xinbao Wu, Manman Gao*, Junhong Li*, Lei Yang*, Dafu Chen* (IF=11.2, JCR1区,中科院1区, TOP)
15. Systematic in vitro and in vivo study on biodegradable binary Zn-0.2 at% Rare Earth alloys (Zn-RE: Sc, Y, La–Nd, Sm–Lu). Bioactive Materials. 24 (2023) 507-523. Shaokang Du , Yunong Shen , Yufeng Zheng , YanCheng , Xiaoxue Xu*, Dafu Chen**, Dandan Xia*** (IF=18,JCR1区,中科院1区,TOP)
16. Carboxypeptidase E is a prognostic biomarker co-expressed with osteoblastic genes in osteosarcoma. PeerJ.2023,11:e15814. Dafu Chen#, Ben Wan#, Yuning Cheng,YuwenLuo,XueshanBai,Jianxun Guo,Guangping Li,Tao Jin,Jingjun Nie,Weifeng Liu and Renxian Wang*(IF=2.3,JCR2区,中科院3区)
17. Zinc oxide nanoparticles inhibit osteosarcoma metastasis by downregulating β-catenin via HIF-1α/BNIP3/LC3B-mediated mitophagy pathway. Bioactive Materials. 2023,19: 690–702. Guanping He#, Jing-Jun Nie#, Xiao Liu, Zihao Ding, Peng Luo, Yu Liu, Bo-Wen Zhang, Renxian Wang, Xiaoguang Liu***, Yong Hai**, Da-Fu Chen* (IF=18, JCR1区,中科院1区, TOP)
18. Immunomodulatory effect of Ti-Cu alloy by surface nanostructure synergistic with Cu2+ release. Colloids and Surfaces B: Biointerfaces. 2023,231: 113586. Xiaotong Zhao, Jiali Hu, Jingjun Nie, Dafu Chen*, Gaowu Qin, Erlin Zhang** (IF= 5.4, JCR1区, 中科院2区)
19. The combination of S-doped ZIF-8 with graphene oxide for enhanced near-infrared light photocatalytic and photothermal sterilization. Chemical Engineering Journal. 2023,455:140857. Ziling Zhou, Huiping Zhu, Shuilin Wu*, Yuelin Lv, Yufeng Zheng, Dafu Chen*, Shengli Zhu, Zhaoyang Li, Zhenduo Cui, Xiangmei Liu*(IF=13.3, JCR1区,中科院1区, TOP)
20. Reduction-responsive nucleic acid nanocarriers-mediated miR-22 inhibition of PI3K/AKT pathway for the treatment of patient-derived tumor xenograft osteosarcoma. Bioactive Materials. 2023,28:376–385.Hao Hu#, Xiao Liu#, Jun Chen#, Shangbin Cui, Hualin Yi, Gang Wang, RenxianWang, Tiansheng Zheng, Ben Wan, Zhiyu Zhou, Yong Wan, Manman Gao*, Dafu Chen*, Xuenong Zou*(IF=18, JCR1区,中科院1区, TOP)
21. Regulation of hypoxic stress and oxidative stress in bone grafting: Current trends and future perspectives. Journal of Materials Science & Technology. 2023,157:144–153. Hao Hu#, Xiao Liu#, JunChen#, Shangbin Cui, Hualin Yi, Gang Wang, Renxian Wang, Tiansheng Zheng, BenWan, Zhiyu Zhou, Yong Wan, Manman Gao*, Dafu Chen*, Xuenong Zou*(IF=11.2, JCR1区,中科院1区, TOP)
22. Deciphering postnatal limb development at single-cell resolution. iScience. 2023,26(1):105808. ManmanGao, Xizhe Liu, Peng Guo, Jianmin Wang, Junhong Li, Wentao Wang, Martin J.Stoddart, Sibylle Grad, Zhen Li, Huachuan Wu, Baoliang Li, Zhongyuan He, Guangqian Zhou, Shaoyu Liu, Weimin Zhu*, Dafu Chen*, Xuenong Zou*, Zhiyu Zhou* (IF=4.6, JCR1区,中科院2区)
23. Kinome-wide CRISPR-Cas9 knockout screens revealed PLK1 as a therapeutic target for osteosarcoma. CellDeath Discovery. 2023,9:231. Renxian Wang, Dingding Wang, Xueshan Bai, JianxunGuo, Songxia Xia, Yuning Cheng, Yani Gu, Qian Wang, Jingjun Nie, Dafu Chen*, Weifeng Liuand Junbo Liang(IF=6.1, JCR2区,中科院2区)
24. Fatigue behavior of biodegradable Zn-Libinary alloys in air and simulated body fluid with pure Zn as control. ActaBiomaterialia. 2023,168:637–649. Guannan Li, Dafu Chen*, Yoji Mine, Kazuki Takashima, Yufeng Zheng*(IF=9.4, JCR1区,中科院1区, TOP)
25. Mechanical Stimulation on Mesenchymal StemCells and Surrounding Microenvironments in Bone Regeneration: Regulations and Applications. Frontiers in Cell and Developmental Biology. 2022,10:808303. YuyangSun#, Ben Wan#, Renxian Wang, Bowen Zhang, Peng Luo, Diaodiao Wang, Jing-JunNie*, DafuChen* and Xinbao Wu (IF=4.6,JCR1区,中科院2区)
26. A single-cell transcriptome of mesenchymal stromal cells to fabricate bioactive hydroxyapatite materials for bone regeneration.Bioactive Materials. 2022,9:281-298. Peng Guo #, XizheLiu#, Penghui Zhang#, Zhongyuan He, Zhen Li, Mauro Alini, R. Geoff Richards, Sibylle Grad, Martin J. Stoddart, Guangqian Zhou, Xuenong Zou, Danny Chan, WeiTian, Dafu Chen***, Manman Gao**, Zhiyu Zhou*, Shaoyu Liu,(IF=18, JCR1区,中科院1区, TOP)
27. Improvement in antibacterial ability and cell cytotoxicity of Ti–Cu alloy by anodic oxidation. RARE METALS. 2022,41(2):594–609. Shuang Cao, Zi-Ming Zhang, Jia-Qi Zhang, Ren-Xian Wang, Xiao-YanWang, Lei Yang, Da-Fu Chen*, Gao-Wu Qin, Er-Lin Zhang*(IF=9.6, JCR1区,中科院1区, TOP)
28. Recent progress of photo-excited antibacterial materials via chemical vapor deposition. Chemical Engineering Journal. 2022,437:135401. Zexin Liu, Xieyuan Jiang*, Zhaoyang Li, Yufeng Zheng, Jing-Jun Nie , Zhenduo Cui , Yanqin Liang , Shengli Zhu , Dafu Chen*, Shuilin Wu*(IF=13.3,JCR1区,中科院1区,TOP)
29. Preparation of polycation with hydroxyls for enhanced delivery of miRNA in osteosarcoma therapy. Biomaterials Science. 2022,10:2844-2856.Da-FuChen#, Bo-Wen Zhang#, Jingjing Cao, Honggang Wang, PengLuo,Weifeng Liu*, Xiaohui Niu, Renxian Wang and Jing-Jun Nie*(IF=5.8, JCR1区,中科院2区)
30. ALD-induced TiO2/Ag nanofilm for rapid surface photodynamic ion sterilization. Rare Metals. 2022,41:4138–4148. Peng-FeiCai, Jun Li, Xin-Bao Wu*, Zhao-Yang Li, Jie Shen*,Jing-Jun Nie, Zhen-Duo Cui, Da-Fu Chen*, Yan-Qin Liang,Sheng-Li Zhu, Shui-Lin Wu*( IF=9.6, JCR1区,中科院1区,TOP)
31. Sea urchin-like Bi2S3/curcumin heterojunction rapidly kills bacteria and promotes wound healing under near-infrared light. Biomaterials Science. 2022,10:6377-6387. Danya Wan,Xiangmei Liu,* Wenchan Sun, Yuqian Qiao, Da-fu Chen*, Yufeng Zheng andShuilin Wu*(IF=5.8, JCR1区,中科院2区)
32. IL-11Rα-targeted nanostrategy empowers chemotherapy of relapsed and patient-derived osteosarcoma. Journal of Controlled Release. 2022,350:460–470. Jingjing Jiang#, Renxian Wang#, LiangYang, Yongjie Sha, Songsong Zhao, Jianxun Guo, Dafu Chen*, Zhiyuan Zhong**,Fenghua Meng**(IF=10.5,JCR1区,中科院1区,TOP)
33. The Influence of Copper Content on theElastic Modulus and Antibacterial Properties of Ti-13Nb-13Zr-xCu Alloy. Metals.2022,12:1132. Xinru Mao, Anqi Shi, Renxian Wang, Jingjun Nie, Gaowu Qin, Dafu Chen*, Erlin Zhang* (IF=2.6,JCR2区,中科院3区)
34. Local delivery of naringin in beta-cyclodextrin modified mesoporous bioactive glass promotes bone regeneration: from anti-inflammatory to synergistic osteogenesis and osteoclastogenesis. Biomaterials science. 2022, 10(7):1697-1712. Yunfei Mo,Fujian Zhao*, Zefeng Lin, Xiaodong Cao, Dafu Chen*, Xiaofeng Chen*(IF=5.8, JCR1区,中科院2区)
35. Psoralen alleviates radiation-induced bone injury by rescuing skeletal stem cell stemness through AKT mediated up-regulation of GSK-3β and NRF2. Stem Cell Research & Therapy. 2022, 13(1):241. Bo-Feng Yin #, Zhi-Ling Li #, Zi-Qiao Yan #, Zheng Guo #, Jia-Wu Liang #, Qian Wang, Zhi-DongZhao, Pei-Lin Li, Rui-Cong Hao, Meng-Yue Han, Xiao-Tong Li Ning Mao, Li Ding*, Da-Fu Chen*, Yue Gao*, HengZhu*(IF=7.1, JCR 1区,中科院2区 )
36. Charge-reversal nanocomolexes-based CRISPR/Cas9 delivery system for loss-of-function oncogene editing in hepatocellular carcinoma. Journal of Controlled Release. 2021,333: 362–37. Jing-Jun Nie#, Yanli Liu#, Yu Qi, Nasha Zhang, Bingran Yu, Da-Fu Chen*, Ming Yang*, Fu-Jian Xu*(IF=10.5, JCR1区,中科院1区, TOP)
37. 0D/1D Heterojunction Implant with Electro-Mechanobiological Coupling Cues Promotes Osteogenesis. AdvancedFunctional Materials. 2021, 31:2106249. Xiao Huang#, Jun Xing#, Zhengao Wang, Jin Han, Renxian Wang, ChanghaoLi, Cairong Xiao, Fang Lu, Jinxia Zhai, Zhengnan Zhou, Yangfan Li, Lei Zhou, Zhiguo Song, Dafu Chen*, Peng Yu,* Chengyun Ning,* and XieyuanJiang(IF=18.5, JCR1区,中科院1区, TOP)
38. Exploring the biodegradation of pure Znunder simulated inflammatory condition. Corrosion Science.2021,189:109606. Xiao Liu, Wei Yuan, Danni Shen, Yan Cheng, Dafu Chen**, Yufeng Zheng*(IF=8.3,JCR1区,中科院1区,TOP)
39. 3D printed silk-gelatin hydrogel scaffold with different porous structure and cell seeding strategy for cartilage regeneration. Bioactive Materials. 2021,6:3396–3410. Qingtao Li #, Sheng Xu#, Qi Feng, Qiyuan Dai, Longtao Yao, Yichen Zhang, Huichang Gao, HuaDong, Dafu Chen**, Xiaodong Cao*(IF=18, JCR1区,中科院1区, TOP)
40. Effect of cyclic mechanical loading on immunoinflammatory microenvironment in biofabricating hydroxyapatite scaffold for bone regeneration. Bioactive Materials. 2021,6:3097–3108. Penghui Zhang#, Xizhe Liu#, Peng Guo#, Xianlong Li, Zhongyuan He, Zhen Li, Martin J. Stoddart, Sibylle Grad, Wei Tian, Dafu Chen***, Xuenong Zou**, Zhiyu Zhou*, Shaoyu Liu (IF=18, JCR1区,中科院1区, TOP)
41. Regulation of Ce (III) / Ce (Ⅳ) ratio of cerium oxide for antibacterial application. iScience. 2021,24(3):102226, HaifengZhang, Jiajun Qiu, Bangcheng Yan, Lidan Liu, Dafu Chen*,and Xuanyong Liu*(IF=4.6,JCR1区,中科院2区)
42. 3D printing of Cu-doped bioactive glass composite scaffolds promotes bone regeneration through activating the HIF-1αandTNF-α pathway of hUVECs. Biomaterials Science. 2021,9:5519–5532. Qiyuan Dai#, Qingtao Li#, Huichang Gao, Longtao Yao, Zefeng Lin, Dingguo Li, Shuangli Zhu, Cong Liu, Zhen Yang, Gang Wang, Dafu Chen*, Xiaofeng Chen and Xiaodong Cao*(IF=5.8, JCR1区,中科院2区)
43. Degradable photothermal bioactive glass composite hydrogel for the sequential treatment of tumor-related bone defects: From anti-tumor to repairing bone defects. Chemical Engineering Journal.2021,419:129520. Zhen Yang, Fujian Zhao*, Wen Zhang, Zhengyu Yang, Man Luo, LuLiu, Xiaodong Cao, Dafu Chen*, Xiaofeng Chen*(IF=13.3, JCR1区,中科院1区, TOP)
44. Building Osteogenic Microenvironments With Strontium-Substituted Calcium Phosphate Ceramics. Frontiers in Bioengineering and Biotechnology. 2020,8:591467. Ben Wan, RenxianWang*, Yuyang Sun, Jingjing Cao, Honggang Wang, Jianxun Guo and Dafu Chen*( IF=4.3,JCR1区,中科院2区)
45. Therapeutic Potential of Circular RNAs inOsteosarcoma. Frontiers in Oncology. 2018, 10:4871-4880. BenWan†, Hao Hu†, Renxian Wang, Weifeng Liu and Dafu Chen* ( IF=3.5,JCR2区,中科院3区)
46. Anti-osteosarcoma effect of hydroxyapatite nanoparticles both in vitro and in vivo by downregulating the FAK/PI3K/Akt signaling pathway. Biomaterials Science. 2020,8(16):4426-4437, RenxianWang#, WeiFeng Liu#, Qian Wang, Guangping Li, BenWan, Yuyang Sun, Xiaohui Niu*, Dafu Chen* and Wei Tian.(IF=5.8,JCR1区,中科院2区)
47. Effect of ultrasonic micro-arc oxidation on the antibacterial properties and cell biocompatibility of Ti-Cu alloy for biomedical application. Materials Science & Engineering C.2020,115:110921. Jiali Hu#, Haixia Li#, Xiaoyan Wang, Lei Yang, Mian Chen, Renxian Wang, Gaowu Qin, Da-Fu Chen*, Erlin Zhang*(IF= 5.880, JCR1区,中科院2区)
48. Strontium modulates osteogenic activity of bone cement composed of bioactive borosilicate glass particles by activatingWnt/β-catenin signaling pathway. Bioactive Materials. 2020,5:334-347. Xu Cui#, Yadong Zhang#, Jianyun Wang#, Chengcheng Huang,Yudong Wang, Hongsheng Yang, Wenlong Liu, Ting Wang, Deping Wang, GuochengWang,Changshun Ruan, Dafu Chen**, William W. Lu, Wenhai Huang, Mohamed N.Rahaman***,Haobo Pan* (IF=18,JCR1区,中科院1区)
49. What controls the antibacterial activity of Ti-Ag alloy, Ag ion or Ti2Ag particles? MaterialsScience & Engineering C. 2020,109:110548. Anqi Shi#, Chenshun Zhu#, Shan Fu, Renxian Wang, Gaowu Qin, Dafu Chen*, Erlin Zhang*(IF= 5.880, JCR1区,中科院2区)
50. Effect of fluorination/oxidation level of nano-structured titanium on the behaviors of bacteria and osteoblasts.Applied Surface Science. 2020,502:144077. Mian Chen, Yuan Zhang, Shan Fu, Lei Yang, Xiaoyan Wang, Qiang Wang, Gaowu Qin, Dafu Chen*, Erlin Zhang*(IF= 6.182, JCR1区,中科院2区)
51. Engineered macroporous hydrogel scaffolds: Via pickering emulsions stabilized by MgO nanoparticles promote bone regeneration. Journal of Materials Chemistry B. 2020,8 (28): 6100- 6114. Pan H#, Gao H#, Li Q, Lin Z, Feng Q, Yu C, Zhang X, Dong H, ChenD*, Cao X*( IF= 6.1, JCR1区,中科院2区)
52. Novel CoCrWNi alloys with Cu addition: Microstructure, mechanical properties, corrosion properties and biocompatibility. Journal of Alloys and Compounds. 2020,824:153924.Wang R, Wang R, Chen D*, Qin G, Zhang E*(IF= 5.8,JCR1区,中科院2区)
53. Rapid and highly effective bacteria-killing by polydopamine/IR780@MnO2–Ti using near-infrared light. Progress in Natural Science: Materials International. 2020,30:677-685. Teng X, Liu X*, Cui Z, Zheng Y, Chen D F*, Li Z, Liang Y,Zhu S, Wu S*(IF= 4.8,JCR1区,中科院2区)
54. Local delivery of FTY720 in mesoporous bioactive glass improves bone regeneration by synergistically immunomodulating osteogenesis and osteoclastogenesis. Journal of materials chemistry B. 2020,8(28):6148-6158. Lu Liu#, Fujian Zhao#, Xiaoyu Chen, Man Luo, Zhen Yang,Xiaodong Cao, Guohou Miao, Dafu Chen*, Xiaofeng Chen*(IF=6.1,JCR1区,中科院2区)
55. Self-Adaptive Antibacterial Porous Implants with Sustainable Responses for Infected Bone Defect Therapy.Advanced Functional Materials. 2019, 29: 1807915. Xin Jin, Yan-HuaXiong, Xin-Yang Zhang, Renxian Wang, Yonggang Xing, Shun Duan*, Dafu Chen*, Wei Tian, and Fu-Jian Xu*(IF=18.5, JCR1区,中科院1区, TOP)
56. 3D Printing of Mechanically StableCalcium-Free Alginate-Based Scaffolds with Tunable Surface Charge to EnableCell Adhesion and Facile Biofunctionalization. Advanced Functional Materials. 2019,29(9):1808439. Z. Lin, M. Wu, H. He, Q. Liang, C. Hu, Z. Zeng, D. Cheng, G.Wang, D.Chen*, H. Pan*, C. Ruan*(IF= 18.5,JCR1区,中科院1区,TOP)
57. Antimicrobial Peptide Functionalized Conductive Nanowire Array Electrode as a Promising Candidate for Bacterial Environment Application. Advanced Functional Materials. 2019,29(13):1806353. J.Xing, S. Qi, Z. Wang, X. Yi, Z. Zhou, J. Chen, S. Huang, G. Tan, D. Chen*, Peng Yu*, C.Ning*(IF= 18.5,JCR1区,中科院1区,TOP)
58. Vancomycin- and Strontium-LoadedMicrospheres with Multifunctional Activities against Bacteria, in Angiogenesis, and in Osteogenesis for Enhancing Infected Bone Regeneration. ACS applied materials & interfaces. 2019, 11(34):30596–30609.Pengfei Wei, Wei Jing, Zuoying Yuan, Yiqian Huang, Binbin Guan, Wenxin Zhang, Xu Zhang, Jianping Mao, Qing Cai*, Dafu Chen*, and XiaopingYang(IF= 8.3, JCR1区,中科院1区, TOP)
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首都医科大学建校于1960年,是北京市重点高等院校,著名泌尿外科专家、中国科学院院士、中国工程院院士、原全国人大常委会副委员长吴阶平教授为首任院长。学校由校本部和附属医院(即临床医学院)组成。校本部设有基础医学院、生物医学工程学院、公共卫生与家庭医学学院、高等职业教育学院、中医药学院、顺义校区、继续教育学院、护理学院、卫生事业管理与发展学院及首都医科大学国际教学部;附属医院包括宣武医院(第一临床医学院)、附属北京友谊医院(第二临床医学院)、附属北京朝阳医院(第三临床医学院)、附属北京同仁医院(第四临床医学院)、附属北京天坛医院(第五临床医学院)、附属北京安贞医院(第六临床医学院)、附属北京口腔医院(口腔医学院)、附属北京儿童医院(儿科医学院)、附属北京妇产医院(妇产医学院)、附属北京安定医院(精神卫生学院)、附属复兴医院(第八临床医学院)、附属北京中医医院(中医药临床医学院)和康复医学院。
学校和附属医院现有教职员工和医护人员22575人。有院士4人,正高职称700余人,副高职称1800余人。学校学科专业齐全,学科力量雄厚,在基础和临床各专业拥有一大批具有很高造诣的专家学者,现有3个国家级重点学科,有38个博士学位授予权学科,58个硕士学位授予权学科和2个博士后科研流动站。
校本部和附属医院总占地面积97.3万平方米,总建筑面积134万平方米 ,固定资产总值近46.5亿元,图书馆藏书108.3万册 ,住院病床10039张。学校开办的七年制专业中设有临床医学和口腔医学;五年制专业中设有临床医学、口腔医学、预防医学、护理学、中医学等;四年制专业中设有生物医学工程、中药学和康复治疗学。在临床医学专业中设有儿科医学、康复医学、医学影像、精神卫生与精神病学和医学检验5个专业方向;在生物医学工程专业中设有医学影像设备与技术和听力学专业方向。高等职业教育设有护理、医学检验、药学、医学影像技术、康复技术、口腔修复工艺、眼科验光、实验动物技术、中医学、中药制剂、医学信息、临床医学、预防医学、中药经营贸易和中医学美容专业方向15个专业。首都医科大学现已成为以培养高层次本科生与研究生为核心、以临床应用型人才为主和培养预防、康复、生物医学工程和医学基础各学科、各层次人才,位于全国先进医学院校行列的高等学府。
学校具有较强的学术发展与科研实力,在校本部和附属医院建有一批国家级和市级重点学科和重点实验室,建有高水平的国家级或市级研究和培训机构,如卫生部全科医学培训中心、临床医学研究所、基础医学研究所、神经科学研究所、眼科研究所、老年病医疗研究中心、泌尿外科研究所、心肺血管医疗研究中心、生命科学院、卫生毒理检测中心、生物工程技术研究中心、祖国医学研究所、临床疾病研究中心、中医肝病临床研究中心、生殖医学研究所、心血管疾病临床试验及社区干预中心和北京市卫生政策与卫生经济研究中心等。神经生物学、细胞生物学、电生理学、基础免疫学、实验寄生虫学、医学图像处理、生物医学、信息检测与处理、神经内科、神经外科、心脏内外科、肾移植、呼吸和消化内科、口腔颌面外科、眼科、耳鼻咽喉科、小儿血液病等领域在国内外享有较高声誉,很多学科的研究和医疗水平已经达到或接近国际先进水平。
学校十分重视对外交流与合作,改革开放以来,先后与世界20多个国家和地区签定了友好交流协议, 近十年中,先后接待美国、加拿大、英国、澳大利亚、法国、瑞典、日本、荷兰、意大利、德国、丹麦及台湾、香港和澳门等50多个国家和地区的专家学者8000余人次来校进行学术交流和参观访问。同时,学校积极选送教师、科研人员和管理干部出国进修、参加学术会议和考察访问。