首都医科大学附属北京积水潭医院北京市创伤骨科研究所生物材料及骨组织工程研究室成立于2003年（前身为骨移植研究室，1978），研究室现下设组织细胞培养、生物材料、材料-生物交互、运动系统类器官构建、组织形态计量、电镜等六个实验室；目前团队成员15名，其中研究人员4名、技术人员4名及在读研究生7名（骨外科学）。主要从事骨关节/软组织生物材料与机体相互作用、骨再生机理、组织工程、运动系统类器官构建等基础及应用基础性研究。团队成员曾主持或作为骨干成员参加国家级/省部级/北京市局级项目33项，目前团队成员在研主持国家级项目4项、省部级1项、局级1项，作为骨干成员参加在研的国家级项目4项、局级1项。团队成员在包括Advanced Materials、Science Advances、Advanced Functional Materials、Biomaterials、 Bioactive Materials、ACS Nano等国内外专业期刊发表科技论文200余篇，其中SCI收录论文160余篇（IF>10的60余篇）。授权国家发明专利6件、实用新型专利7件，研发并获取产品注册证1项，作为骨干成功转化1项骨科植入器件。团队主要成员兼职国家药品监督管理局医疗器械技术审评专家咨询委员会委员1人次、二级学会常委2人次、三级学会常委1人次及委员2人、担任Bioactive Materials编委1人、Advanced Orthopedics编委1人。

1. 基于复合微凝胶的骨痂类器官构建及其调控脉管系统促骨再生机制研究，国家自然科学基金面上项目，2024.01-2027.12，项目负责人（第一），项目总经费52万元，本人可支配52万，在研。

2. 国家自然科学基金重点项目：智能化人工关节表面场响应基元构建及其感知/应答的作用机制 （第二作者，参加单位负责人，项目编号:52533013 ，起止时间：2026.01-2030.12 ，资助经费：230万元，本单位可支配经费92万元）

3. 北京自然科学基金-交叉融合重点项目：时空序贯可降解骨植入物构建及其对感染性骨缺损治疗作用研究（骨干参加，项目编号： Z250013，起止时间： 2025.09-2029.08，资助经费：300万）

4. 动态自适应和主动组织修复生物材料及关键技术：课题五 生物适配性硬/软组织修复材料的临床，中华人民共和国科学技术部十四五国家重点研发计划，2022.11-2025.10，课题负责人（第一），课题总经费247万元，本人可支配169万，在研。

5. 骨肿瘤响应性多功能阳离子CircRNA载体构建及其作用机理研究，国家自然科学基金面上项目，2020.01-2023.12，项目负责人（第一），项目总经费58万元，本人可支配58万，结题。

6. 骨修复植入体表面力-电响应微环境的构建及其骨整合机制研究，国家自然科学基金重点项目，2020.01-2024.12，项目合作单位负责人（第二），项目总经费305万元，本人可支配122万，结题。

7. 基于动态力学的类器官骨修复材料构建及其平台建设，北京市卫健委改革与发展试点项目（四批），2021.01-2024.09，项目骨干（第三），项目总经费800万元，本人可支配200万，结题。

8. 再生修复大节段骨缺损的组织工程骨研究，北京市卫健委科技发展项目，2020.01-2022.12，项目负责人（第一），总经费408万元，本人可支配408万，结题。

9. 骨科再生材料与技术的应用研究，北京市卫计委科技发展项目，2017.01-2019.12，项目负责人（第一），总经费692万元，本人可支配231万，结题。

10. 磷酸钙抗菌表面构建及其骨质疏松骨折治疗作用研究，北京市自然科学基金重点项目，2016.01-2019.12，项目负责人（第一），总经费65万元，本人可支配65万，结题。

11. 骨修复材料移植早期的细胞应激与稳态维持对骨形成的作用机理，国家自然科学基金重点项目，2015.01-2019.12，项目合作单位负责人（第二），总经费310万元，本人可支配124万，结题。

12. 钙磷基纳米粒子的分布降解及其成骨系细胞响应机制研究，国家自然科学基金面上项目，2012.01-2015.12，项目负责人（第一），总经费60万元，本人可支配60万，结题。

近年发表论文：

1.  Nanocomposite hydrogel orchestrating multiple modulation of degenerative microenvironment for potential application in intervertebral disc regeneration.Journal of Materials Science & Technology 229（2025）14-29. Huitong Luo, Zhipeng Sun, Zetao Wang, Wanqing Lun, Qi Feng, Dafu Chen∗, Xiaodong Cao∗（IF=14.3，JCR1区，中科院1区，TOP）

2. Impact of scandium on the microstructure, mechanical properties, corrosion behaviors and in-vitro biocompatibility of a Zn-0.1Li alloy. Journal of Materials Science & Technology 229（2025）235-251. He Huang, Gencheng Gong, Hui Yu, Zhipei Tong, Qinggong Jia, Liudang Fang, Shaokang Guan, Jing-Jun Nie, DaFu Chen∗, Jing Bai∗, Dong Bian∗, Yufeng Zheng∗（IF=14.3，JCR1区，中科院1区，TOP）

3. Biodegradable Zn-Li-Mn alloy to achieve optimal strength and ductility for bone implants. Acta Biomaterialia 199（2025）483-499. Danni Shen, Yahong Li, Jiahui Shi, Ting Zhang, Jing-Jun Nie, Dafu Chen∗, Dandan Xia∗, Yufeng Zheng∗. （IF=9.6，JCR1区，中科院1区，TOP）

4. Eco-friendly multifunctional CeO₂/ZnMn₂O₄ heterojunction with robust photocatalysis for rapid bacteria-killing and highly effective eradication of formaldehyde simultaneously. Journal of Environmental Chemical Engineering 13(3)（2025）116945. Wee Lai, Yufeng Zheng, Hanpeng Liu, Zhaoyang Li, Shengli Zhu, Hui Jiang, Zhenduo Cui, Xiangmei Liu∗. 4.（IF=7.2，JCR1区，中科院2区）

5. Interfering with proton and electron transfer enables antibacterial starvation therapy. Science Advances 11(12)（2025）eadt3159. Ji Tan, Haifeng Zhang, Yisi Liu, Zhenhao Hou, Donghui Wang, Junjie Zhou, Yuanming Cao, Shi Qian, Bowen Zheng, JingJun Nie, Yuanyuan Cui, Yun Du, Kai Huang, Shengbing Yang, Dafu Chen∗, Xuanyong Liu∗. （IF=12.5，JCR1区，中科院1区，TOP）

6. The Lattice Defects of Nanofilm Introduced by N Doping Promotes Radical Oxygen Species Production for Rapid Photocatalytic Elimination of Contact Infection. Advanced Functional Materials (2025) 2500256. Renyuan Deng, Xiangmei Liu∗, Jin Huang, Yi Wang, Dafu Chen∗, Chaofeng Wang, Khin Wee Lai, Congyang Mao∗, Guangrong Qian, Yufeng Zheng, Shuilin Wu∗. （IF=19.0，JCR1区，中科院1区，TOP）

7. Hydrogel Enhanced Organoid Multidirectional Differentiation via Yap/Tead4 Mechanotransduction for Accelerated Tissue Regeneration. ACS Appl. Mater. Interfaces, Doi.org/10.1021/acsami.5c06161. Peng Luo,# Yuning Cheng,# Yuwen Luo,# Nan Zhang, Jingjing Cao, Honggang Wang, Xieyuan Jiang,* Qian Wang, Xinbao Wu, Yajun Liu, Jianping Mao, Xinhua Zhou, Jing-Jun Nie,* and Dafu Chen*. (IF=8.2, JCR1区，中科院2区)

8. Enhanced antibacterial activity, corrosion resistance and endothelialization potential of Ti-5Cu alloy by oxygen and nitrogen plasma-based surface modification. Journal of Materials Science & Technology 168（2024）250-264. Xiaotong Zhao, Jiali Hu, Jingjun Nie, Dafu Chen*, Gaowu Qin, Erlin Zhang*（IF=11.2，JCR1区，中科院1区，TOP）

9. Microgel-based carriers enhance skeletal stem cell reprogramming towards immunomodulatory phenotype in osteoarthritic therapy. Bioactive Materials 34 (2024) 204–220. Pei-Lin Li #, Da-Fu Chen# , Xiao-Tong Li# , Rui-Cong Hao #, Zhi-Dong Zhao , Zhi-Ling Li , Bo-Feng Yin , Jie Tang , Yu-Wen Luo , Chu-Tse Wu**, Jing-Jun Nie***, Heng Zhu*（IF=18，JCR1区，中科院1区，TOP）

10. Two-Dimensional Biodegradable Black Phosphorus Nanosheets Promote Large Full-Thickness Wound Healing through In Situ Regeneration Therapy. ACS Nano 2024, 18, 3553−3574. Xueshan Bai,# Renxian Wang,# Xiaohua Hu, Qiang Dai, Jianxun Guo, Tongyu Cao, Weili Du,Yuning Cheng, Songxia Xia, Dingding Wang, Liya Yang,* Li Teng,* Dafu Chen,* and Yajun Liu*（IF=15.8，JCR1区，中科院1区，TOP）

11. Composited silk fibroins ensured adhesion stability and magnetic controllability of Fe3O4-nanoparticle coating on implant for biofilm treatment. Materials Horizons, 2024, DOI: 10.1039/d4mh00097h. Kecheng Quan, Zhinan Mao, Yupu Lu, Yu Qin, Shuren Wang, Chunhao Yu, Xuewei Bi, Hao Tang, Xiaoxiang Ren, Dafu Chen*, Yan Cheng, Yong Wang,* Yufeng Zheng* and Dandan Xia*（IF=12.1，JCR1区，中科院1区,TOP）

12. Enhanced pyroptosis induction with pore-forming gene delivery for osteosarcoma microenvironment reshaping. Bioactive Materials 38 (2024) 455–471. Jing-Jun Nie# , Bowen Zhang# , Peng Luo# , Maoguo Luo , Yuwen Luo , Jingjing Cao , Honggang Wang , Jianping Mao , Yonggang Xing , Weifeng Liu , Yuning Cheng , Renxian Wang , Yajun Liu**, Xinbao Wu , Xieyuan Jiang , Xiaoguang Cheng***, Chi Zhang , Da-Fu Chen*（IF=18，JCR1区，中科院1区，TOP）

13. Reduction-responsive nucleic acid nanocarrier-mediated miR-22 inhibition of PI3K/AKT pathway for the treatment of patient-derived tumor xenograft osteosarcoma. Bioactive Materials. 2023,28:376–385. Dafu Chen#, Chengyue Lei#, Weifeng Liu#, MeiyuShao, Meizhou Sun, Jianxun Guo, Jingjing Cao, Jing-Jun Nie, Peng Luo, YuwenLuo, Bingran Yu, Renxian Wang*, Shun Duan**, Fu-Jian Xu*** (IF=18，JCR1区，中科院1区，TOP)

14. Function-oriented design: A novel strategy for advanced biomedical materials. Journal of Materials Science & Technology.2023,145:197-209. Zhiyu Zhou#, Wentao Wang#, Jianmin Wang#, Hongshui Wang, YiXia, Wei Zhang, Yuxiao Lai, Xiao Lin, Yongcan Huang, Xuenong Zou, Martin J.Stoddart, Zhen Li, Wei Tian, Shaoyu Liu, Xinbao Wu, Manman Gao*, Junhong Li*, Lei Yang*, Dafu Chen* (IF=11.2， JCR1区，中科院1区， TOP)

15. Systematic in vitro and in vivo study on biodegradable binary Zn-0.2 at% Rare Earth alloys (Zn-RE: Sc, Y, La–Nd, Sm–Lu). Bioactive Materials. 24 (2023) 507-523. Shaokang Du , Yunong Shen , Yufeng Zheng , YanCheng , Xiaoxue Xu*, Dafu Chen**, Dandan Xia*** (IF=18，JCR1区，中科院1区，TOP)

16. Carboxypeptidase E is a prognostic biomarker co-expressed with osteoblastic genes in osteosarcoma. PeerJ.2023,11:e15814. Dafu Chen#, Ben Wan#, Yuning Cheng,YuwenLuo,XueshanBai,Jianxun Guo,Guangping Li,Tao Jin,Jingjun Nie,Weifeng Liu and Renxian Wang*(IF=2.3，JCR2区，中科院3区)

17. Zinc oxide nanoparticles inhibit osteosarcoma metastasis by downregulating β-catenin via HIF-1α/BNIP3/LC3B-mediated mitophagy pathway. Bioactive Materials. 2023,19: 690–702. Guanping He#, Jing-Jun Nie#, Xiao Liu, Zihao Ding, Peng Luo, Yu Liu, Bo-Wen Zhang, Renxian Wang, Xiaoguang Liu***, Yong Hai**, Da-Fu Chen* (IF=18， JCR1区，中科院1区， TOP)

18. Immunomodulatory effect of Ti-Cu alloy by surface nanostructure synergistic with Cu2+ release. Colloids and Surfaces B: Biointerfaces. 2023,231: 113586. Xiaotong Zhao, Jiali Hu, Jingjun Nie, Dafu Chen*, Gaowu Qin, Erlin Zhang** (IF= 5.4, JCR1区, 中科院2区)

19. The combination of S-doped ZIF-8 with graphene oxide for enhanced near-infrared light photocatalytic and photothermal sterilization. Chemical Engineering Journal. 2023,455:140857. Ziling Zhou, Huiping Zhu, Shuilin Wu*, Yuelin Lv, Yufeng Zheng, Dafu Chen*, Shengli Zhu, Zhaoyang Li, Zhenduo Cui, Xiangmei Liu*(IF=13.3， JCR1区，中科院1区， TOP)

20. Reduction-responsive nucleic acid nanocarriers-mediated miR-22 inhibition of PI3K/AKT pathway for the treatment of patient-derived tumor xenograft osteosarcoma. Bioactive Materials. 2023,28:376–385.Hao Hu#, Xiao Liu#, Jun Chen#, Shangbin Cui, Hualin Yi, Gang Wang, RenxianWang, Tiansheng Zheng, Ben Wan, Zhiyu Zhou, Yong Wan, Manman Gao*, Dafu Chen*, Xuenong Zou*(IF=18， JCR1区，中科院1区， TOP)

21. Regulation of hypoxic stress and oxidative stress in bone grafting: Current trends and future perspectives. Journal of Materials Science & Technology. 2023,157:144–153. Hao Hu#, Xiao Liu#, JunChen#, Shangbin Cui, Hualin Yi, Gang Wang, Renxian Wang, Tiansheng Zheng, BenWan, Zhiyu Zhou, Yong Wan, Manman Gao*, Dafu Chen*, Xuenong Zou*(IF=11.2， JCR1区，中科院1区， TOP)

22. Deciphering postnatal limb development at single-cell resolution. iScience. 2023,26(1):105808. ManmanGao, Xizhe Liu, Peng Guo, Jianmin Wang, Junhong Li, Wentao Wang, Martin J.Stoddart, Sibylle Grad, Zhen Li, Huachuan Wu, Baoliang Li, Zhongyuan He, Guangqian Zhou, Shaoyu Liu, Weimin Zhu*, Dafu Chen*, Xuenong Zou*, Zhiyu Zhou* (IF=4.6， JCR1区，中科院2区)

23. Kinome-wide CRISPR-Cas9 knockout screens revealed PLK1 as a therapeutic target for osteosarcoma. CellDeath Discovery. 2023,9:231. Renxian Wang, Dingding Wang, Xueshan Bai, JianxunGuo, Songxia Xia, Yuning Cheng, Yani Gu, Qian Wang, Jingjun Nie, Dafu Chen*, Weifeng Liuand Junbo Liang(IF=6.1, JCR2区,中科院2区)

24. Fatigue behavior of biodegradable Zn-Libinary alloys in air and simulated body fluid with pure Zn as control. ActaBiomaterialia. 2023,168:637–649. Guannan Li, Dafu Chen*, Yoji Mine, Kazuki Takashima, Yufeng Zheng*(IF=9.4, JCR1区，中科院1区， TOP)

25. Mechanical Stimulation on Mesenchymal StemCells and Surrounding Microenvironments in Bone Regeneration: Regulations and Applications. Frontiers in Cell and Developmental Biology. 2022,10:808303. YuyangSun#, Ben Wan#, Renxian Wang, Bowen Zhang, Peng Luo, Diaodiao Wang, Jing-JunNie*, DafuChen* and Xinbao Wu (IF=4.6，JCR1区，中科院2区）

26. A single-cell transcriptome of mesenchymal stromal cells to fabricate bioactive hydroxyapatite materials for bone regeneration.Bioactive Materials. 2022,9:281-298. Peng Guo #, XizheLiu#, Penghui Zhang#, Zhongyuan He, Zhen Li, Mauro Alini, R. Geoff Richards, Sibylle Grad, Martin J. Stoddart, Guangqian Zhou, Xuenong Zou, Danny Chan, WeiTian, Dafu Chen***, Manman Gao**, Zhiyu Zhou*, Shaoyu Liu，(IF=18， JCR1区，中科院1区， TOP)

27. Improvement in antibacterial ability and cell cytotoxicity of Ti–Cu alloy by anodic oxidation. RARE METALS. 2022,41(2):594–609. Shuang Cao, Zi-Ming Zhang, Jia-Qi Zhang, Ren-Xian Wang, Xiao-YanWang, Lei Yang, Da-Fu Chen*, Gao-Wu Qin, Er-Lin Zhang*(IF=9.6, JCR1区，中科院1区， TOP）

28. Recent progress of photo-excited antibacterial materials via chemical vapor deposition. Chemical Engineering Journal. 2022,437:135401. Zexin Liu, Xieyuan Jiang*, Zhaoyang Li, Yufeng Zheng, Jing-Jun Nie , Zhenduo Cui , Yanqin Liang , Shengli Zhu , Dafu Chen*, Shuilin Wu*(IF=13.3，JCR1区，中科院1区，TOP)

29. Preparation of polycation with hydroxyls for enhanced delivery of miRNA in osteosarcoma therapy. Biomaterials Science. 2022,10:2844-2856.Da-FuChen#, Bo-Wen Zhang#, Jingjing Cao, Honggang Wang, PengLuo,Weifeng Liu*, Xiaohui Niu, Renxian Wang and Jing-Jun Nie*（IF=5.8, JCR1区，中科院2区）

30. ALD-induced TiO2/Ag nanofilm for rapid surface photodynamic ion sterilization. Rare Metals. 2022,41:4138–4148. Peng-FeiCai, Jun Li, Xin-Bao Wu*, Zhao-Yang Li, Jie Shen*,Jing-Jun Nie, Zhen-Duo Cui, Da-Fu Chen*, Yan-Qin Liang,Sheng-Li Zhu, Shui-Lin Wu*( IF=9.6, JCR1区，中科院1区，TOP）

31. Sea urchin-like Bi2S3/curcumin heterojunction rapidly kills bacteria and promotes wound healing under near-infrared light. Biomaterials Science. 2022,10:6377-6387. Danya Wan,Xiangmei Liu,* Wenchan Sun, Yuqian Qiao, Da-fu Chen*, Yufeng Zheng andShuilin Wu*（IF=5.8， JCR1区，中科院2区）

32. IL-11Rα-targeted nanostrategy empowers chemotherapy of relapsed and patient-derived osteosarcoma. Journal of Controlled Release. 2022,350:460–470. Jingjing Jiang#, Renxian Wang#, LiangYang, Yongjie Sha, Songsong Zhao, Jianxun Guo, Dafu Chen*, Zhiyuan Zhong**,Fenghua Meng**(IF=10.5，JCR1区，中科院1区，TOP)

33. The Influence of Copper Content on theElastic Modulus and Antibacterial Properties of Ti-13Nb-13Zr-xCu Alloy. Metals.2022,12:1132. Xinru Mao, Anqi Shi, Renxian Wang, Jingjun Nie, Gaowu Qin, Dafu Chen*, Erlin Zhang* (IF=2.6,JCR2区，中科院3区)

34. Local delivery of naringin in beta-cyclodextrin modified mesoporous bioactive glass promotes bone regeneration: from anti-inflammatory to synergistic osteogenesis and osteoclastogenesis. Biomaterials science. 2022, 10(7):1697-1712. Yunfei Mo,Fujian Zhao*, Zefeng Lin, Xiaodong Cao, Dafu Chen*, Xiaofeng Chen*(IF=5.8， JCR1区，中科院2区）

35. Psoralen alleviates radiation-induced bone injury by rescuing skeletal stem cell stemness through AKT mediated up-regulation of GSK-3β and NRF2. Stem Cell Research & Therapy. 2022, 13(1):241. Bo-Feng Yin #, Zhi-Ling Li #, Zi-Qiao Yan #, Zheng Guo #, Jia-Wu Liang #, Qian Wang, Zhi-DongZhao, Pei-Lin Li, Rui-Cong Hao, Meng-Yue Han, Xiao-Tong Li Ning Mao, Li Ding*, Da-Fu Chen*, Yue Gao*, HengZhu*（IF=7.1， JCR 1区，中科院2区 ）

36. Charge-reversal nanocomolexes-based CRISPR/Cas9 delivery system for loss-of-function oncogene editing in hepatocellular carcinoma. Journal of Controlled Release. 2021,333: 362–37. Jing-Jun Nie#, Yanli Liu#, Yu Qi, Nasha Zhang, Bingran Yu, Da-Fu Chen*, Ming Yang*, Fu-Jian Xu*(IF=10.5， JCR1区，中科院1区， TOP)

37. 0D/1D Heterojunction Implant with Electro-Mechanobiological Coupling Cues Promotes Osteogenesis. AdvancedFunctional Materials. 2021, 31:2106249. Xiao Huang#, Jun Xing#,  Zhengao Wang, Jin Han, Renxian Wang, ChanghaoLi, Cairong Xiao, Fang Lu, Jinxia Zhai, Zhengnan Zhou, Yangfan Li, Lei Zhou, Zhiguo Song, Dafu Chen*, Peng Yu,* Chengyun Ning,* and XieyuanJiang(IF=18.5， JCR1区，中科院1区， TOP)

38. Exploring the biodegradation of pure Znunder simulated inflammatory condition. Corrosion Science.2021,189:109606. Xiao Liu, Wei Yuan, Danni Shen, Yan Cheng, Dafu Chen**, Yufeng Zheng*(IF=8.3，JCR1区，中科院1区，TOP)

39. 3D printed silk-gelatin hydrogel scaffold with different porous structure and cell seeding strategy for cartilage regeneration. Bioactive Materials. 2021,6:3396–3410. Qingtao Li #, Sheng Xu#, Qi Feng, Qiyuan Dai, Longtao Yao, Yichen Zhang, Huichang Gao, HuaDong, Dafu Chen**, Xiaodong Cao*(IF=18， JCR1区，中科院1区， TOP)

40. Effect of cyclic mechanical loading on immunoinflammatory microenvironment in biofabricating hydroxyapatite scaffold for bone regeneration. Bioactive Materials. 2021,6:3097–3108. Penghui Zhang#, Xizhe Liu#, Peng Guo#, Xianlong Li, Zhongyuan He, Zhen Li, Martin J. Stoddart, Sibylle Grad, Wei Tian, Dafu Chen***, Xuenong Zou**, Zhiyu Zhou*, Shaoyu Liu (IF=18， JCR1区，中科院1区， TOP)

41. Regulation of Ce (III) / Ce (Ⅳ) ratio of cerium oxide for antibacterial application. iScience. 2021,24(3):102226, HaifengZhang, Jiajun Qiu, Bangcheng Yan, Lidan Liu, Dafu Chen*,and Xuanyong Liu*(IF=4.6，JCR1区，中科院2区)

42. 3D printing of Cu-doped bioactive glass composite scaffolds promotes bone regeneration through activating the HIF-1αandTNF-α pathway of hUVECs. Biomaterials Science. 2021,9:5519–5532. Qiyuan Dai#, Qingtao Li#, Huichang Gao, Longtao Yao, Zefeng Lin, Dingguo Li, Shuangli Zhu, Cong Liu, Zhen Yang, Gang Wang, Dafu Chen*, Xiaofeng Chen and Xiaodong Cao*（IF=5.8, JCR1区，中科院2区）

43. Degradable photothermal bioactive glass composite hydrogel for the sequential treatment of tumor-related bone defects: From anti-tumor to repairing bone defects. Chemical Engineering Journal.2021,419:129520. Zhen Yang, Fujian Zhao*, Wen Zhang, Zhengyu Yang, Man Luo, LuLiu, Xiaodong Cao, Dafu Chen*, Xiaofeng Chen*(IF＝13.3， JCR1区，中科院1区， TOP）

44. Building Osteogenic Microenvironments With Strontium-Substituted Calcium Phosphate Ceramics. Frontiers in Bioengineering and Biotechnology. 2020,8:591467. Ben Wan, RenxianWang*, Yuyang Sun, Jingjing Cao, Honggang Wang, Jianxun Guo and Dafu Chen*( IF=4.3，JCR1区，中科院2区)

45. Therapeutic Potential of Circular RNAs inOsteosarcoma. Frontiers in Oncology. 2018, 10:4871-4880. BenWan†, Hao Hu†, Renxian Wang, Weifeng Liu and Dafu Chen* ( IF=3.5，JCR2区，中科院3区)

46. Anti-osteosarcoma effect of hydroxyapatite nanoparticles both in vitro and in vivo by downregulating the FAK/PI3K/Akt signaling pathway. Biomaterials Science. 2020,8(16):4426-4437, RenxianWang#, WeiFeng Liu#, Qian Wang, Guangping Li, BenWan, Yuyang Sun, Xiaohui Niu*, Dafu Chen* and Wei Tian.（IF=5.8，JCR1区，中科院2区）

47. Effect of ultrasonic micro-arc oxidation on the antibacterial properties and cell biocompatibility of Ti-Cu alloy for biomedical application. Materials Science & Engineering C.2020,115:110921. Jiali Hu#, Haixia Li#, Xiaoyan Wang, Lei Yang, Mian Chen, Renxian Wang, Gaowu Qin, Da-Fu Chen*, Erlin Zhang*（IF= 5.880， JCR1区，中科院2区）

48. Strontium modulates osteogenic activity of bone cement composed of bioactive borosilicate glass particles by activatingWnt/β-catenin signaling pathway. Bioactive Materials. 2020,5:334-347. Xu Cui#, Yadong Zhang#, Jianyun Wang#, Chengcheng Huang,Yudong Wang, Hongsheng Yang, Wenlong Liu, Ting Wang, Deping Wang, GuochengWang,Changshun Ruan, Dafu Chen**, William W. Lu, Wenhai Huang, Mohamed N.Rahaman***,Haobo Pan* (IF=18，JCR1区，中科院1区)

49. What controls the antibacterial activity of Ti-Ag alloy, Ag ion or Ti2Ag particles? MaterialsScience & Engineering C. 2020,109:110548. Anqi Shi#, Chenshun Zhu#, Shan Fu, Renxian Wang, Gaowu Qin, Dafu Chen*, Erlin Zhang*（IF= 5.880， JCR1区，中科院2区）

50. Effect of fluorination/oxidation level of nano-structured titanium on the behaviors of bacteria and osteoblasts.Applied Surface Science. 2020,502:144077. Mian Chen, Yuan Zhang, Shan Fu, Lei Yang, Xiaoyan Wang, Qiang Wang, Gaowu Qin, Dafu Chen*, Erlin Zhang*（IF= 6.182， JCR1区，中科院2区)

51. Engineered macroporous hydrogel scaffolds: Via pickering emulsions stabilized by MgO nanoparticles promote bone regeneration. Journal of Materials Chemistry B. 2020,8 (28): 6100- 6114. Pan H#, Gao H#, Li Q, Lin Z, Feng Q, Yu C, Zhang X, Dong H, ChenD*, Cao X*( IF= 6.1， JCR1区，中科院2区)

52. Novel CoCrWNi alloys with Cu addition: Microstructure, mechanical properties, corrosion properties and biocompatibility. Journal of Alloys and Compounds. 2020,824:153924.Wang R, Wang R, Chen D*, Qin G, Zhang E*（IF= 5.8，JCR1区，中科院2区）

53. Rapid and highly effective bacteria-killing by polydopamine/IR780@MnO2–Ti using near-infrared light. Progress in Natural Science: Materials International. 2020,30:677-685.   Teng X, Liu X*, Cui Z, Zheng Y, Chen D F*, Li Z, Liang Y,Zhu S, Wu S*（IF= 4.8，JCR1区，中科院2区）

54. Local delivery of FTY720 in mesoporous bioactive glass improves bone regeneration by synergistically immunomodulating osteogenesis and osteoclastogenesis. Journal of materials chemistry B. 2020,8(28):6148-6158. Lu Liu#, Fujian Zhao#, Xiaoyu Chen, Man Luo, Zhen Yang,Xiaodong Cao, Guohou Miao, Dafu Chen*, Xiaofeng Chen*（IF＝6.1，JCR1区，中科院2区）

55. Self-Adaptive Antibacterial Porous Implants with Sustainable Responses for Infected Bone Defect Therapy.Advanced Functional Materials. 2019, 29: 1807915. Xin Jin, Yan-HuaXiong, Xin-Yang Zhang, Renxian Wang, Yonggang Xing, Shun Duan*, Dafu Chen*, Wei Tian, and Fu-Jian Xu*（IF=18.5， JCR1区，中科院1区， TOP）

56. 3D Printing of Mechanically StableCalcium-Free Alginate-Based Scaffolds with Tunable Surface Charge to EnableCell Adhesion and Facile Biofunctionalization. Advanced Functional Materials. 2019,29(9):1808439. Z. Lin, M. Wu, H. He, Q. Liang, C. Hu, Z. Zeng, D. Cheng, G.Wang, D.Chen*, H. Pan*, C. Ruan*（IF= 18.5，JCR1区，中科院1区，TOP）

57. Antimicrobial Peptide Functionalized Conductive Nanowire Array Electrode as a Promising Candidate for Bacterial Environment Application. Advanced Functional Materials. 2019,29(13):1806353. J.Xing, S. Qi, Z. Wang, X. Yi, Z. Zhou, J. Chen, S. Huang, G. Tan, D. Chen*, Peng Yu*, C.Ning*（IF= 18.5，JCR1区，中科院1区，TOP）

58. Vancomycin- and Strontium-LoadedMicrospheres with Multifunctional Activities against Bacteria, in Angiogenesis, and in Osteogenesis for Enhancing Infected Bone Regeneration. ACS applied materials & interfaces. 2019, 11(34):30596–30609.Pengfei Wei, Wei Jing, Zuoying Yuan, Yiqian Huang, Binbin Guan, Wenxin Zhang, Xu Zhang, Jianping Mao, Qing Cai*, Dafu Chen*, and XiaopingYang（IF= 8.3， JCR1区，中科院1区， TOP）

59. A pH-sensitive self-healing coating for biodegradable magnesium implants. Acta Biomaterialia. 2019,98(11):160-173. PanXiong, JiangLong Yan, Pei Wang, ZhaoJun Jia, Wenhao Zhou, Wei Yuan, Yangyang Li, Yang Liu, Yan Cheng*, Dafu Chen*, Yufeng Zheng*（IF= 9.4， JCR1区，中科院1区， TOP）

60. Comparative, real-time in situ monitoring of galvanic corrosion in Mg-Mg2Ca and Mg-MgZn2 couples in Hank’s solution. Corrosion Science. 2019,161:108185. Yang Liu, Xiao Liu, Zechuan Zhang, Nicholas Farrell, Dafu Chen*, Yufeng Zheng* ( IF=8.3， JCR1区，中科院1区， TOP)

61. Minocycline hydrochloride loaded graphene oxide enables enhanced osteogenic activity in the presence of Gram-positive bacteria, Staphylococcus aureus. Journal of MaterialsChemistry B. 2019,7:3590-3598. Jiajun Qiu#, Wenhao Qian#, Jinkai Zhang, Dafu Chen*, Kelvin W. K.Yeung* and Xuanyong Liu* (IF= 5.8，JCR1区，中科院2区）

62. In vivo antibacterial property of Ti-Cusintered alloy implant. Materials Science & Engineering C. 2019,100:38-47.Xiaoyan Wang, Hui Dong, Jie Liu, Gaowu Qin, Dafu Chen*, Erlin Zhang*（IF= 5.880， JCR1区，中科院1区， TOP）

63. Nano-Hydroxyapatite Modulates OsteoblastDifferentiation Through Autophagy Induction via mTOR Signaling Pathway.Journal of Biomedical Nanotechnology. 2019,15(2):405-415. R. Wang, H. Hu, J. Guo, Q. Wang, J. Cao, H. Wang, G. Li, J. Mao, X. Zou, D. Chen*, W. Tian*（IF= 4.483，JCR1区，中科院2区）

64. Role of Cu element in biomedical metal alloy design. Rare Metals. 2019,38(6):476–494. Er-Lin Zhang*, Shan Fu, Ruo-Xian Wang, Hai-Xia Li, Ying Liu, Zhi-Qiang Ma, Guang-Kun Liu, Chen-Shun Zhu, Gao-Wu Qin, Da-Fu Chen*(IF=9.6， JCR1区，中科院1区， TOP）

65. Biocorrosion properties of Ti–3Cu alloy in F ion-containing solution and acidic solution and biocompatibility. Rare Metals.2019,38(6): 503–511. Dian-Geng Cai, Mian-Mian Bao, Xiao-Yan Wang, Lei Yang,Gao-Wu Qin, Ren-Xian Wang, Da-Fu Chen* , Er-Lin Zhang* (IF= 9.6，JCR1区，中科院1区，TOP）

66. A spatially varying charge model for regulating site-selective protein adsorption and cell behaviors. Biomaterials Science. 2019, 7 (3): 876-888. Zhang K, Xing J, Chen J, Wang Z, Zhai J, Yao T, Tan G, Qi S, Chen D*, Yu P*, Ning C*（IF= 6.183， JCR1区，中科院2区）