基础医学院-金新春导师介绍
金新春
教授
硕，博士生导师
男
基础医学院
人体解剖与组织胚胎学
脑血管病与认知
xcjin@ccmu.edu.cn
金新春，教授，首都医科大学博士生导师。中国神经科学学会脑血管功能与疾病委员会委员，中国神经科学会神经胶质细胞分会委员 中国药理学会生化与分子药理学专业委员会及心血管药理专业委员会委员。2007年毕业于复旦大学获神经生物学博士学位，2007年至2013年在加州大学等大学进行博士后研究。2013年3月被苏州大学人才引进。2019年调入首都医科大学。研究方向为脑血管病与认知。主持获得国家自然科学基金面上项目、江苏省自然科学基金面上项目，并作为骨干参与国家重点研发计划。作为第一发明人获国家发明专利授权1项；担任Neuroscience bulletin和Acta Pharmaceutica Sinica B 青年编委及Angiogenesis及stroke等20个国际期刊的审稿人。以第一或通讯作者发表论文在Acta Pharmaceutica Sinica B，Acta Pharmacologica Sinica，Journal of Neuroscience, Neuropsychopharmacology, Aging Cell等国际著名期刊40余篇。论文被Annual Review of Neuroscience, Pharmaceutical Review以及教科书引用1500余次，单篇论文被引400余次。2017年获教育部科技进步二等奖和江苏省科学技术一等奖。
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科研项目
1. 急性脑梗后如何减少tPA溶栓后的脑出血？
吸烟病人溶栓后出血率比正常人低，从这个现象出发提出尼古丁可减轻脑缺血及tPA引起的血脑屏障损伤
2. 如何促发脑梗后的神经功能恢复？
从白质和血脑屏障完整性出发，刺激内源性干细胞的增值和分化来促进中风后的神经功能恢复
3. 如何减轻精神分裂症引起的认知损害？
精神分裂症病人的吸烟率高，从这个现象提出尼古丁减轻精神分裂症引起的认知损伤
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研究成果
发表论文：
1. Du W, Geng P, Lian Z, Sun Y, Zhou Y, Guo C, Jin X. DPSCs-Exos promote OPCs differentiation and white matter repair via Myl9-mediated PRMT5 nucleation after ischemic stroke. J Cereb Blood Flow Metab. 2025 Nov 21:271678X251399014. doi: 10.1177/0271678X251399014. Epub ahead of print.
2. Du W, Liu W, Sun Y, Guo C, Geng P, Jin X. Targeting angiogenesis and white matter repair for enhanced functional recovery after acute ischemic stroke: A focus on the roles of glial cells. J Cereb Blood Flow Metab. 2025 Nov 3:271678X251389346. doi: 10.1177/0271678X251389346. Epub ahead of print.
3. Guo H, Liu W, Sun Y, Jin X, Geng P. Neuroglia and immune cells play different roles in neuroinflammation and neuroimmune response in post-stroke neural injury and repair. Acta Pharmacol Sin. 2025 Aug 12. doi: 10.1038/s41401-025-01640-5. Epub ahead of print.
4. Du W, He Y, Li L, Jin X, Geng P. The effects and mechanisms of stem cells and exosomes on neurological function protection and recovery after ischemic stroke. Neuroprotection. 2025; 3: 266-279.
5. Zhang X#, Du W#, Qian S#, Lu X#, Yu X, Fang H, Dong J, Song M, Sun Y, Wu X, Shen Y, Hao Y, Shen M, Zhou B, Wang Y*, Xu C*, Jin X*. Glial growth factor 2 treatment alleviates ischemia and reperfusion-compromised integrity of the blood-brain barrier through decreasing Mfsd2a/caveolin-1-mediated transcellular and YAP/TAZ-mediated paracellular permeability. Acta Pharmacologica Sinica 2024 Q1 IF 7.6
6. Hu X#, Dong J#, Geng P#, Sun Y#, Du W, Zhao X, Wang Q, Liu C, Wang X, Liu Y, Liu W, Cheng H*, Wang W*, Jin X*. Nicotine treatment alleviates acute ischemia stroke-compromised integrity of blood-brain barrier through regulating Pdlim5. Translational Stroke Research. 2024 15,672–687 JCR Q1 IF 5.1
7. Wang X#, Wang Q#, Song M#, Wang Y#, Shen X, Sun Y, Guo C, Geng P*, Ma C*, Jin X*. Chronic but not acute nicotine treatment ameliorates acute inflammation-induced working memory impairment by increasing CRTC1 and HCN2 in adult male mice. CNS Neurosci Ther. 2024 Feb;30(2): e14627 JCR Q1 IF 5.9
8. Gao F, Du W, Guo C, Geng P, Liu W, Jin X*. α7nACh receptor, a promising target to reduce BBB damage by regulating inflammation and autophagy after ischemic stroke. Biomed Pharmacother.2024 Oct;179:117337. Q1 IF6.8
9. Wang Y#, Liu W#, Zhang J#, Geng P, Jin X**. The role of crosstalk between cerebral immune cells and peripheral immune cells in the damage and protection of blood–brain barrier after intracerebral hemorrhage. Brain Hemorrhages, 2024,5(3):117-130
10. Wang Q#, Wang M#, Sun Y#, Hu X, Geng P, Shu H, Wang X, Wang H, Zhang J, Cheng H, Wang W*, Jin X*. Nicotine pretreatment alleviates MK-801-induced behavioral and cognitive deficits in mice by regulating Pdlim5/CRTC1 in the PFC. Acta Pharmacologica Sinica 2023 44(4):780-790 JCR Q1 IF 7.6
11. Wang Y#, Du W#, Hu X, Yu X, Jin X*, Wang W*. Targeting blood-brain barrier to delay aging-induced neurological diseases by modulating gut microbe, circadian rhythms and their interplays. Acta Pharmaceutica Sinica B 2023 13 (12), 4667-4687 JCR Q1 IF 14.1
12. Wang Y#, Du W#, Sun Y#, Zhang J*, Ma C*, Jin X*. CRTC1 is a potential target to delay aging-induced cognitive deficit by protecting the integrity of the blood-brain barrier via inhibiting inflammation. Journal of Cerebral Blood Flow and Metabolism 2023;43(7):1042-1059 JCR Q1 IF6.1
13. Hu X#, Geng P#, Zhao X#, Wang Q, Liu C, Guo C, Dong W*, Jin X*. The NG2-glia is a potential target to maintain the integrity of neurovascular unit after acute ischemic stroke. Neurobiology of Disease. 2023 180:106076. JCR Q1 IF 5.6
14. Wang Y#, Liu W#, Geng P#, Du W, Guo C, Wang Q, Zheng GQ*, Jin X*. Role of crosstalk between glial cells and Immune Cells in Blood-Brain Barrier Damage and Protection after Acute Ischemic Stroke. Aging and Disease, 2023. JCR Q1 IF 7.1
15. Wang Q, Du W, Wang H, et al. Nicotine's effect on cognition, a friend or foe?. Prog Neuropsychopharmacol Biol Psychiatry. 2023;124:110723. Q1 IF 5.2
16. Chen S#, Sun Y#, Li F#, Zhang X, Hu X, Zhao X, Li Y, Li H, Zhang J, Liu W, Zheng GQ*, Jin X*. Modulation of α7nAchR by melatonin alleviates ischemia and reperfusion-compromised integrity of blood brain barrier through inhibiting HMGB1-mediated microglia activation and CRTC1-mediated neuronal loss. Cellular and Molecular Neurobiology, 2022, 42(7):2407-2422. JCR Q2 IF 4.2
17. Yan Wang#, Xiaona Wang#, Xinyu Zhang#, Shuang Chen#,Yanyun Sun, Wenlan Liu, Xinchun JinCA , Guo-qing ZhengCA. D1 receptor-mediated endogenous tPA upregulation contributes to blood brain barrier damage after acute ischemic stroke. Journal of Cellular and Molecular Medicine, 2020, 24(16):9255-66. IF 5.3（5 Year Impact Factor:5.533）
18. Li F, Liu WC, Wang Q, Sun Y, Wang H, Jin X. NG2-glia cell proliferation and differentiation by glial growth factor 2 (GGF2), a strategy to promote functional recovery after ischemic stroke. Biochem Pharmacol. 2020;171:113720. Q1 IF 6.8
19. Shu H#, Wang M#, Song M#, Sun Y#, Shen X, Zhang J*, Jin X*. Acute nicotine treatment alleviates LPS-induced impairment of fear memory reconsolidation through AMPK activation and CRTC1 upregulation in hippocampus. International Journal of Neuropsychopharmacology. 2020, 23(10):687-699. JCR Q1 IF 4.7
20. Wang Y#, Wang X#, Zhang X#, Chen S#, Sun Y, Liu W, Jin X*, Zheng G*. D1 receptor-mediated endogenous tPA upregulation contributes to blood brain barrier damage after acute ischemic stroke. Journal of Cellular and Molecular Medicine, 2020, 24(16):9255-66. 4.486 JCR Q2 IF 5
21. Xinyu Zhang#, Xianzhi Shen#, Jiali Dong#, Wen-Cao Liu#, Yanyun Sun, Hui Shu, Wenlan LiuCA, Chun-feng LiuCA, Xinchun JinCA Inhibition of reactive astrocytes with fluorocitrate alleviates ischemic stroke-induced memory impairment through upregulating CRTC1 and synaptophysin in rat. Cellular and Molecular Neurobiology 2019, 39:1151–1163. IF 3.89（5 Year Impact Factor:4.780）
22. Xianzhi Shen, Yanyun Sun, Mengwei Wang, Hui Shu, Junfang ZhangCA, Xinchun JinCA. Chronic N-acetylcysteine treatment alleviates lipopolysaccharide-induced working memory deficit through upregulating caveolin-1 and synaptophysin in mice. Psychopharmacology 2018, 235(1):179-191 IF 3.54 引用7次（5 Year Impact Factor:4.077）
23. Yufei Shen, Jingxia Gu, Ziyun Liu, Congying Xu, Shuxia Qian, Xiaoling Zhang, Beiqun Zhou, Qiaobing Guan, Yanping WangCA, Xinchun JinCA. Inhibition of HIF-1α reduced blood brain barrier damage by regulating MMP-2 and VEGF during acute cerebral ischemia. Frontiers in Cellular Neuroscience 2018 12:200 IF 4.3引用7 次2017 年中国脑卒中防治百篇优秀论文“思南奖”（5 Year Impact Factor:5.574）
24. Svetlana Semenova#, Xinchun Jin#, Tristan McClure-Begley, Matthew Tadman, Michael Marks and Athina Markou. Differential effects of intermittent and continuous nicotine exposure on affective and somatic aspects of nicotine withdrawal and expression of α4β2* nAChRs in rats. Pharmacology Biochemistry Behavior (共同第一作者) 2018,171, 54-65 IF 2.9引用2次
25. Yanyun Sun, Xi Chen, Xinyu Zhang, Xianzhi Shen, Mengwei Wang, Xiaona Wang, Wen-Cao Liu, Chun-Feng Liu, Jie Liu,Wenlan Liu, Xinchun JinCA. ß2-adrenergic receptor mediated HIF-1a upregulation during acute cerebral ischemia. Frontiers in Molecular Neuroscience 2017, 10:257 IF 5.07 引用16次 获得苏州市自然科学学术论文优秀奖（5 Year Impact Factor:5.760）
26. Xiaona Wang, Gai-Xiu Xue, Wen-Cao Liu, Hui Shu, Mengwei Wang, Yanyun Sun, Xiaojing Li, Yi Sun, Chun-Feng Liu, Jie LiuCA, Wenlan LiuCA, Xinchun JinCA. Melatonin alleviates lipopolysaccharide-compromised integrity of blood brain barrier by activation of AMP-activated protein kinase (AMPK) in old mice. Aging cell 2017, 16(2):414-421 IF 7.6 引用20次（5 Year Impact Factor:9.951）
27. Yushan Liu, Wencao Liu, Yanyun Sun, Xianzhi Shen, Xiaona Wang, Rong Pan, Hui Shu, Chun-Feng Liu, Wenlan Liu, Ke jian Liu, Xinchun JinCA. Normobaric hyperoxia extends neuro- and vaso-protection of N-Acetylcysteine in transient focal ischemia. Molecular Neurobiology 2017, 54:3418–3427 IF 6.1 引用14 次 2017 年中国脑卒中防治百篇优秀论文“北斗奖” （5 Year Impact Factor:5.512）
28. Yuan Zhang, Ke Yang, Ting Wang, Weiping Li, Xinchun JinCA,Wenlan LiuCA. Nrdp1 increases ischemia induced primary rat cerebral cortical neurons and pheochromocytoma cells apoptosis via downregulation of HIF-1α protein. Frontiers in Cellular Neuroscience 2017, 11:293 IF 4.55引用3次（5 Year Impact Factor:5.574）
29. Wen-Cao Liu, Xiaona Wang, Xinyu Zhang, Xi Chen, Xinchun JinCA. Melatonin supplementation, a strategy to prevent neurological diseases through maintaining integrity of blood brain barrier in old people. Frontiers in Aging Neuroscience 2017, 9:165 IF 4.5 引用8次 （5 Year Impact Factor:5.913）
30. Jie Liu, John Weaver, Xinchun Jin, Yuan Zhang, Ji Xu, Ke J Liu, Weiping Li, Wenlan Liu. The interactions between nitric oxide, caveolin-1 and autophagosome contribute to oxygen-glucose deprivation-induced of claudin-5 degradation in endothelial cells. Molecular Neurobiology 53(9):5935-5947, 2016 IF 6.1引用32 次（5 Year Impact Factor:5.512）
31. Xiaona Wang, Yushan Liu, Yanyun Sun,Wenlan Liu, Xinchun JinCA. Blood brain barrier breakdown was found in non-infarcted area after 2-h MCAO. Journal of Neurological Sciences 2016, 363:63-68. IF 2.44 引用5 次（5 Year Impact Factor:2.661）
32. Wen-Cao Liu, Xinchun JinCA. Oxygen or cooling, to make a decision after acute ischemia stroke Medical Gas Research 2016, 6(4):206-211. 引用7 次
33. Lijun Liang, Jinming Yang, Xinchun JinCA. Cocktail treatment, a promising strategy to treat acute cerebral ischemic stroke? Medical Gas Research 2016,6(1), 33-38. 引用13 次
34. Hui Shu, Guo-qing Zheng, Xiaona Wang, Yanyun Sun, Yushan Liu, John Weaver, Xianzhi Shen, Wenlan LiuCA, Xinchun JinCA. Activation of matrix metalloproteinase in dorsal hippocampus drives improvement in spatial working memory after intra-VTA nicotine infusion in rats. Journal of Neurochemistry 2015, 135(2):357-367. IF 4.28引用6 次（5 Year Impact Factor:5.690）
35. Xinchun JinCA, Yanyun Sun, Ji Xu, Wenlan Liu. Caveolin-1 mediates tissue plasminogen activator-induced MMP-9 upregulation in cultured brain microvascular endothelial cells. Journal of Neurochemistry. 2015,132(6):724-730. IF 4.28 引用21 次（5 Year Impact Factor:5.690）
36. Xinchun Jin, Jie Liu and Wenlan Liu. Early ischemic blood brain barrier damage: a potential indicator for hemorrhagic transformation following tissue plasminogen activator (tPA) thrombolysis? Current Neurovascular Research 2014,11(3):254-262. IF 2.804 引用32 次（5 Year Impact Factor:2.481）
37. Xinchun Jin, Jie Liu, Ke J Liu, Gary Rosenberg, Yi Yang, Wenlan Liu. Normobaric hyperoxia combined with minocycline provides greater neuroprotection than either alone in transient focal cerebral ischemia. Experimental Neurology 2013, 240C:9-16. IF 4.645引40次（5 Year Impact Factor:5.340）
38. Jie Liu*, Xinchun Jin*, Ke J Liu, Wenlan Liu. Matrix metalloproteinase-2-mediated occludin degradation and caveolin-1-mediated claudin-5 redistribution contribute to blood-brain barrier damage in early ischemic stroke stage. Journal of Neuroscience 2012, 32(9):3044-57. (共同第一作者) IF 6.908 引用288次（5 Year Impact Factor:2.661）
39. Xinchun Jin, Jie Liu, Ke J Liu, Yi Yang, Wenlan Liu. Spatiotemporal evolution of BBB damage and tissue infarction within the first 3 hours after ischemia onset. Neurobiology of Disease 2012, 48(3):309-316. IF 5.624引用 41次（5 Year Impact Factor:6.170）
40. Xinchun Jin, Svetlana Semenova, Li Yang, Robert Ardecky, and Athina Markou. The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats. Neuropsychopharmacology 2010, 35, 2021–2036. (亮点介绍. Neuropsychopharmacology 35, 2007–2008). IF 8.678 引用58次（5 Year Impact Factor:8.210）
41. Xinchun Jin, Yufei Lu, Xiaofei Yang, Lan Ma, Baoming Li. Glucocorticoid receptor in the basolateral nucleus of amygdala is required for post-reactivation reconsolidation of auditory fear memory. European Journal of Neuroscience 2007, 25, 3702–3712. IF 3.879 引用74次（5 Year Impact Factor:3.374）
42. Xinchun Jin, Xuelian Qi, Xiaofei Yang, Baoming Li. Protein synthesis inhibition in the basolateral nucleus of amygdala facilitates extinction of auditory fear memory. Chinese Science Bulletin, 52, 2532-2542, 2007. IF 1.6（5 Year Impact Factor:1.738）
43. Xinchun Jin, Chaolin Ma and Baoming Li. The alpha (2A)-adrenoceptor agonist guanfacine improves spatial learning but not fear conditioning in rats. Acta Physiologica Sinica, 59(6):739-744, 2007. 引用11次
专利：
药物组合物及其应用 2016.5.9-2036.5.8
授权号 ZL201610301881.X
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学校介绍
首都医科大学建校于1960年，是北京市重点高等院校，著名泌尿外科专家、中国科学院院士、中国工程院院士、原全国人大常委会副委员长吴阶平教授为首任院长。学校由校本部和附属医院(即临床医学院)组成。校本部设有基础医学院、生物医学工程学院、公共卫生与家庭医学学院、高等职业教育学院、中医药学院、顺义校区、继续教育学院、护理学院、卫生事业管理与发展学院及首都医科大学国际教学部；附属医院包括宣武医院(第一临床医学院)、附属北京友谊医院(第二临床医学院)、附属北京朝阳医院(第三临床医学院)、附属北京同仁医院(第四临床医学院)、附属北京天坛医院(第五临床医学院)、附属北京安贞医院(第六临床医学院)、附属北京口腔医院(口腔医学院)、附属北京儿童医院(儿科医学院)、附属北京妇产医院(妇产医学院)、附属北京安定医院(精神卫生学院)、附属复兴医院(第八临床医学院)、附属北京中医医院(中医药临床医学院)和康复医学院。
学校和附属医院现有教职员工和医护人员22575人。有院士4人，正高职称700余人，副高职称1800余人。学校学科专业齐全，学科力量雄厚，在基础和临床各专业拥有一大批具有很高造诣的专家学者，现有3个国家级重点学科，有38个博士学位授予权学科，58个硕士学位授予权学科和2个博士后科研流动站。
校本部和附属医院总占地面积97.3万平方米，总建筑面积134万平方米 ，固定资产总值近46.5亿元，图书馆藏书108.3万册 ，住院病床10039张。学校开办的七年制专业中设有临床医学和口腔医学；五年制专业中设有临床医学、口腔医学、预防医学、护理学、中医学等；四年制专业中设有生物医学工程、中药学和康复治疗学。在临床医学专业中设有儿科医学、康复医学、医学影像、精神卫生与精神病学和医学检验5个专业方向；在生物医学工程专业中设有医学影像设备与技术和听力学专业方向。高等职业教育设有护理、医学检验、药学、医学影像技术、康复技术、口腔修复工艺、眼科验光、实验动物技术、中医学、中药制剂、医学信息、临床医学、预防医学、中药经营贸易和中医学美容专业方向15个专业。首都医科大学现已成为以培养高层次本科生与研究生为核心、以临床应用型人才为主和培养预防、康复、生物医学工程和医学基础各学科、各层次人才，位于全国先进医学院校行列的高等学府。
学校具有较强的学术发展与科研实力，在校本部和附属医院建有一批国家级和市级重点学科和重点实验室，建有高水平的国家级或市级研究和培训机构，如卫生部全科医学培训中心、临床医学研究所、基础医学研究所、神经科学研究所、眼科研究所、老年病医疗研究中心、泌尿外科研究所、心肺血管医疗研究中心、生命科学院、卫生毒理检测中心、生物工程技术研究中心、祖国医学研究所、临床疾病研究中心、中医肝病临床研究中心、生殖医学研究所、心血管疾病临床试验及社区干预中心和北京市卫生政策与卫生经济研究中心等。神经生物学、细胞生物学、电生理学、基础免疫学、实验寄生虫学、医学图像处理、生物医学、信息检测与处理、神经内科、神经外科、心脏内外科、肾移植、呼吸和消化内科、口腔颌面外科、眼科、耳鼻咽喉科、小儿血液病等领域在国内外享有较高声誉，很多学科的研究和医疗水平已经达到或接近国际先进水平。
学校十分重视对外交流与合作，改革开放以来，先后与世界20多个国家和地区签定了友好交流协议， 近十年中,先后接待美国、加拿大、英国、澳大利亚、法国、瑞典、日本、荷兰、意大利、德国、丹麦及台湾、香港和澳门等50多个国家和地区的专家学者8000余人次来校进行学术交流和参观访问。同时，学校积极选送教师、科研人员和管理干部出国进修、参加学术会议和考察访问。
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