附属北京地坛医院-王玺导师介绍
王玺
教授
硕，博士生导师
男
附属北京地坛医院
免疫学
肿瘤免疫和免疫系统的表观遗传调控
xiwang@ccmu.edu.cn
1. 1989/09-1994/07，北京医科大学（北京大学医学部），医学学士。
2. 1994/09-1997/07，北京医科大学，理学硕士。
3. 1997/08-2003/12，美国宾夕法尼亚州立大学，博士。
4. 2004/01-2010/12，美国哈佛大学医学院，博士后。
5. 2011/01-2012/09，美国哈佛大学医学院，儿科，讲师。
6. 2012/09-2017/08，天津医科大学基础医学院副院长、细胞生物学系创系主任、教授、博士生导师。
7. 2017.09-2021.09， 首都医科大学，免疫学教授、系主任、博士生导师；北京市肿瘤侵袭和转移重点实验室主任；肿瘤学系（院）副主任; 首都医科大学儿童血液肿瘤诊疗与研究中心副主任。
8. 2021.10-至今，国家传染病医学中心，北京市感染性疾病研究中心，首都医科大学附属地坛医院研究所。所长、教授、博士生导师。兼任北京市新发突发传染病重点实验室副主任；首都医科大学肿瘤学系（院）副主任; 首都医科大学儿童血液肿瘤诊疗与研究中心副主任。
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科研项目
1. 中国人体健康科技促进会泌尿男科生殖系肿瘤专业委员会常委。
2. 欧美同学会-留学归国人员联谊会北美分会理事兼副秘书长兼留美医学委员会常务副会长。
3. 欧美同学会医师协会青年委员会，副主任委员。
4. 中国生物物理学会理事兼体育医学分会副会长。
5. 中国细胞生物学会染色质分会委员会，委员。
6. 中华医学会医学细胞生物委员会，常务委员。
7. 北京市免疫学会，理事。
8. 《Cancer Biology & Medicine》编委
9. 《科学通报》编委
10. 《中国医学前沿杂志》编委
11.北京慢性病防治与健康教育研究会感染性疾病专业委员会，主任委员
12.中国免疫学会基础免疫分会，常务委员
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研究成果
1.Junnan Li#, Wenjuan Peng#, Yuting Zhang, Shunai Liu, Ming Han, Rui Song, Yuanyuan Zhang, Ronghua Jin*, Xi Wang*. A Comparative Study of Clinical Characteristics and COVID-19 Vaccine Effectiveness Against SARS-CoV-2 Variants Wild-Type, Alpha, Delta, and Omicron in Beijing, China. Infection and Drug Resistance. 2024,17:5147-5161. doi: 10.2147/IDR.S483098.
2.Jun Liu, Gary Wong, Hui Li, Yan Yang, Yuxi Cao, Yongfeng Li, Yan Wu, Zijie Zhang, Cong Jin, Xi Wang, Yongwen Chen, Bin Su, Zhongfang Wang, Qihui Wang, Yunlong Cao, Guobing Chen, Zhaohui Qian, Jincun Zhao, Guizhen Wu. Biosafety and immunology: An interdisciplinary field for health priority. Biosafety and Health. 2024 July 11, doi: https://doi.org/10.1016/j.bsheal.2024.07.005.
3.Minghang Yu#, Yang Xiong#, Pu Liang#, Danying Chen, Yuting Zhang, Huan Liu, Yuanyuan Zhang*, Xuesen Zhao*, Ronghua Jin*, and Xi Wang*. Validation of 12 Rapid Antigen Tests for the Detection of SARS-CoV-2. Journal of Biological Methods. 2024 Jan 12:11:e99010009. doi: 10.14440/jbm.2024.409. eCollection 2024. (*Co-responding author).
4.Xin Wang#, Jie Zhang#, Maoshun Liu, Yuanyuan Guo, Peipei Guo, Xiaonan Yang, Bingli Shang, Min Li, Jinmin Tian, Ting Zhang, Xi Wang, Ronghua Jin, Jikun Zhou, and George Gao, Jun Liu. Nonconserved epitopes dominate reverse preexisting T cell immunity in COVID-19 convalescents. Signal Transduction and Targeted Therapy. 2024 Jun 12;9(1):160. doi: 10.1038/s41392-024-01876-3. (*Co-responding author).
5.Bing Han#, Xu-ming Li #, Ran Li#, Wu Ning#, Yuan-yuan Zhang#, Yan-fen Tang, Ye Zhang, Long Hu, Jian dong Li, Gang Liu, Dan Zhang, Han Xia, Xi Wang*, and Rongmeng Jiang*. Epidemiological Surveillance of Acute Respiratory Infections Based on Targeted Metagenomic Next Generation Sequencing in Beijing. Journal of Infection. 2024 May 22;89(1):106188. doi: 10.1016/j.jinf.2024.106188. (*Co-responding author).
6.Yanlong Zhang#, Xuefeng Huang#, Minghang Yu#, Menghan Zhang, Li Zhao, Yong Yan*, Liyun Zhang*, Xi Wang*. The integrate profiling of single-cell and spatial transcriptome RNA-seq reveals tumor heterogeneity, therapeutic targets, and prognostic subtypes in ccRCC. Cancer Gene Therapy. 2024 Jun;31(6):917-932. doi: 10.1038/s41417-024-00755-x. Epub 2024 Mar 13.(*Co-responding author).
7.Xuefeng Huang#, Minghang Yu#, Bingbing Wang#, Yanlong Zhang, Junjing Xue, Yu Fu*, Xi Wang*. Prevention, Diagnosis and Eradication of Mycoplasma Contamination in Cell Culture. Journal of Biological Methods. 2023 Nov 1:10:e99010005. doi: 10.14440/jbm.2023.407. eCollection 2023. (*Co-responding author).
8.Danying Chen#, Xinglin Li#, Xiaohua Hao#, Yaruo Qiu#, Yanjun Song, Hui Sun, Yongmei Liu,| Juan Du, Yuanyuan Zhang, Fan Xiao, Chuan Song, Yonghong Yan, Rui Song, Xi Wang*, Xuesen Zhao*, Ronghu Jin*. Reduced neutralization and fc effector function to Omicron subvariants in sera from SARS-CoV-1 survivors after two doses of Corona Vac plus one dose subunit vaccine.Journal of Medical Virology. 2023 Oct;95(10):e29136 doi: 10.1002/jmv.29136. (*Co-responding author).
9.Miaoran Xia#, Bingbing Wang#, Wujianan Sun#, Dengyu Ji, Hang Zhou, Xuefeng Huang, Minghang Yu, Ziyang Su, Ping Chen* , Kun Qu*, Xi Wang*，Lsd1 safeguards T-cell development via suppressing endogenous retroelements and interferon responses. Life Science Alliance(2023) 2023 Jul 10;6(10):e202302042.
doi: 10.26508/lsa.202302042 (*Co-responding author).
10.Huishan Sun#, Junyu Long, Bangyou Zuo, Yiran Li, Yu Song, Minghang Yu, Ziyu Xun, Yanyu Wang, Xi Wang*, Xinting Sang*，Haitao Zhao*，Development and validation of a selenium metabolism regulators associated prognostic model for hepatocellular carcinoma. BMC Cancer (2023) 23:451-468. doi.org/10.1186/s12885-023-10944-w. (*Co-responding author).
11.Zhou, Yu-Jie#; Li, Guoli#; Wang, Jiyin; Liu, Mengyuan; Wang, Zihan; Song, Yu; Zhang, Xulong*; Wang, Xi,*. PD-L1: expression regulation. Blood Science. January 13, 2023.(*Co-responding author).
12.Yanlong Zhang#, Xin Zhang#, Xuefeng Huang#, Xiaomeng Tang, Menghan Zhang, Ziyi Li, Xiaopeng Hu, Min Zhang*, Xi Wang* and Yong Yan*. Tumor stemness score to estimate epithelial-to-mesenchymal transition (EMT) and cancer stem cells (CSCs) characterization and to predict the prognosis and immunotherapy response in bladder urothelial carcinoma. Stem Cell Research & Therapy 14, 15 (2023). (*Co-responding author). 影响因子：8.079. 迄今被引用：7次。
13.Minghang Yu#，Danying Chen#, Xiaomeng Tang#, Yuanyuan Zhang#, Pu Liang, Yang Xiong, Rui Li, Rui Song，Xiaoyou Chen，Xuesen Zhao*, Xi Wang*, Ronghua Jin*, Evaluation of a high-sensitivity SARS-CoV-2 antigen test on the fully automated light-initiated chemiluminescent immunoassay platform. Clinical Chemistry and Laboratory Medicine. 2023 Jan 19;61(6):1123-1130.doi: 10.1515/cclm-2022-1039. (*Co-responding author).
14.Xin Zhang#, Yanlong Zhang#, Li Zhao#, Jiayu Wang, Jiaxing Li, Xi Wang*, Min Zhang*, Xiaopeng Hu*, Exploitation of tumor antigens and construction of immune subtype classifier for mRNA vaccine development in bladder cancer. Frontiers in Immunology. 2022, 13:1014638. Doi: 10.3389/fimmu.2022.1014638 (*Co-responding author).
15.Yan-Fen Tang #, Jun-Yan Han # , Ai-Min Ren, Li Chen, Tian-Jiao Xue, Yong-Hong Yan, Xi Wang, Yu Wang*, and Rong-Hua Jin*, Assessment of Long-Term Effects on Pulmonary Functions Between Severe and Non-Severe Convalescent COVID-19 Patients: A Single-Center Study in China.
Journal of Inflammation Research. 2022 Aug 19;15:4751-4761. doi: 10.2147/JIR.S371283.
16.Guangxu Xuan#, Xin Zhang#, Min Zhang#, Minghang Yu, Yujie Zhou, Xiaosong He, Xiaopeng Hu*, Xi Wang*，Liangfa Liu*，NTF2 Upregulation in HNSCC: a Predictive Marker and Potential Therapeutic Target Associated With Immune Infiltration. Frontiers in Oncology. 2022 Jun 17;12:783919. doi: 10.3389/fonc.2022.783919. eCollection 2022. (*Co-responding author).
17. XixiTao#, Rui Zhang#, Ronglu Du#, Tingting Yu#,Hui Yang, Jiwen Li, Yuhong Wang, Qian Liu, Shengkai Zuo, Xi Wang, Michael Lazarus, Lu Zhou,Bangmao Wang, Ying Yu*, and Yujun Shen*, Targeting E-prostanoid 3 receptorameliorates liver fibrosis through enhancing adhesion and cytotoxicity of NKcells toward HSCs. Journal of Experimental Medicine. 2022 May 2;219(5):e20212414. doi: 10.1084/jem.20212414..
18. Jianmei W Leavenworth*, LewisZhichang Shi*, Xi Wang*, Haiming Wei*, Editorial: Immune Cell LineageReprogramming in Cancer. Frontiers in Immunology. 2022 Jan 19; 12: 838464.
19. Yunlong Cao#,*, XiaohuaHao#, Xi Wang#, QianhuiWu#, Rui Song, Dong Zhao, Weiliang Song, Yao Wang, AyijiangYisimayi, Wei Wang, Wen Zhang, Juan Du, Hongjie Yu*, Xiaoliang Sunney Xie*,Ronghua Jin*，Humoral immunogenicity and reactogenicity ofCoronaVac or ZF2001 booster after two doses of inactivated vaccine. CellResearch. 2022 Jan;32(1):107-109.
20. Minghang Yu, Ziyang Su, Xuefeng Huang, Yujie Zhou, Xulong Zhang, Bingbing Wang, Zihan Wang, Yi Liu, Nianzeng Xing*, Miaoran Xia*, Xi Wang*, Histone methyltransferase Ezh2 negatively regulates NK cellterminal maturation and function. Journal of Leukocyte Biology. 2021 Aug 23. 110(6):1033-1045.
21. MinZhang#, Xin Zhang#, Minghang Yu#, Wei Zhang, Di Zhang, Song Zeng, Xi Wang*and Xiaopeng Hu*, A Novel Ferroptosis-Related Gene Model for Overall SurvivalPredictions of Bladder Urothelial Carcinoma Patients. Frontiers in oncology.2021 Jul 27;11:698856.
22. Minghang Yu #, Ziyang Su#, XuefengHuang and Xi Wang*, Single-cell sequencingreveals the novel role of Ezh2 in NK cell maturation and function. Frontiersin Immunology. 2021 Oct 26;12:724276.
23. Miaoran Xia, Bingbing Wang, ZihanWang, Xulong Zhang*, XiWang*, Epigeneticregulation of NK cell-mediated antitumor immunity. Frontiers in Immunology.2021 May 4;12:672328.
24. Xu Yang#, Ying Hu#, Keyan Yang#,Dongxu Wang#, Jianzhen Lin, Junyu Long, Fucun Xie, Jinzhu Mao, Jin Bian, MeiGuan, Jie Pan, Li Huo, Ke Hu, Xiaobo Yang, Yilei Mao, Xinting Sang, Jiao Zhang,Xi Wang*, Henghui Zhang*, Haitao Zhao*, Cell-free DNA copy number variations predict efficacy ofimmune checkpoint inhibitor-based therapy in hepatobiliary cancers. Journalfor ImmunoTherapy of Cancer. 2021 Feb, 9:e001942.
25.Yang Li#, Minghang Yu#, Jie Yin,Han Yan，and Xi Wang*, Enhanced calcium signalinduces NK cell degranulation but inhibits its cytotoxic activity. Journalof Immunology. 2022 Jan 15;208(2):347-357.
26.Shan Huang#, Zexing Li#, Zewen Wu#, Chang Liu#,Minghang Yu, Mingjie Wen, Liyun Zhang*, and Xi Wang*, DDAH2 suppressesRLR-MAVS-mediated innate antiviral immunity by stimulating nitricoxide-activated, Drp1-induced mitochondrial fission. Science Signaling.2021, April 13, 14(678):eabc7931.
27. Junyu Long#, Shan Huang#, Yi Bai#, Jinzhu Mao#,Anqiang Wang, Yu Lin, Xu Yang, Dongxu Wang, Jianzhen Lin, Jin Bian, XiaoboYang, Xinting Sang*, Xi Wang* and Haitao Zhao*，Transcriptional landscape ofcholangiocarcinoma revealed by weighted gene co-expression network analysis. Briefingsin Bioinformatics. 2020 Oct 14; bbaa224.
28. Yi Bai#, Chunlian Wei#, Yuxin Zhong#, Yamin Zhang,Junyu Long, Shan Huang, Fucun Xie, Yantao Tian, XiWang*, and Haitao Zhao*, Developmentand Validation of a Prognostic Nomogram for Gastric Cancer Based on DNAMethylation-Driven Differentially Expressed Genes. International Journal ofBiological Sciences. 2020 Feb 10; 16(7): 1153-1165.
29. Chang Liu#, Shan Huang#, Xuelin Wang, Mingjie Wen,Jiarui Zheng, Wenjuan Wang, Yanbin Fu, Shunli Tian, Long Li, Zexing Li*, Xi Wang*, Theotubain YOD1 suppresses 1 aggregation and activation of the signaling adaptorMAVS through Lys63-linked deubiquitination. Journal of Immunology. 2019Apr; 202(10):2957-2970.
30. Yang Li#, Jin Wang#, Minghang Yu, Yang Wang, HuilaiZhang, Jie Yin, Zexing Li, Ting Li, Han Yan, Fajin Li and Xi Wang*，SNF5 deficiency induces apoptosisresistance by repressing SATB1 expression in Sezary syndrome. Leukemia &Lymphoma. 2018 Jan: 59:10, 2405-2413.
31. Jie Yin#, Jianmei W. Leavenworth#*, Yang Li, Qi Luo,Huafeng Xie, Xinhua Liu, Shan Huang, Han Yan, Zheng Fu, Liyun Y. Zhang, LitaoZhang, Junwei Hao, Xudong Wu, Xianming Deng, Charles W. M. Roberts, Stuart H.Orkin, Harvey Cantor*, Xi Wang*, Ezh2 regulates differentiation and function ofnatural killer cells through its histone methyltransferase activity. Proceedingsof the National Academy of Sciences of the United States of America. 2015：112(52): 15988-15993.
32. Wencui Shen, Yating Han, Bingqing Huang, Yan Qi,Linqi Xu, Ruru Guo, Xi Wang*, Jiantao Wang*, MicroRNA-483-3p InhibitsExtracellular Matrix Production by Targeting Smad4 in Human Trabecular MeshworkCells. Investigative Ophthalmology & Visual Science. 2015: 56(13),8419-8427.
33. Yang Li#, Jie Yin#, Ting Li, Shan Huang, Han Yan,Jianmei W. Leavenworth, Xi Wang*, Natural Killer cell based cancer immunotherapy:from basic biology to clinical application. SCIENCE CHINA Life Sciences.2015: 58(12): 1233-1245.
34. Xianhuo Wang, Xiujuan Zhao, Luhua Qiu, Huaqing Wang,Xi Wang*, Epigenetics in tumorigenesis: advances and clinicalimplications. Journal of Peking University (Health Sciences). 2012:44(5): 701-707.
35. Xi Wang, Charles W. M. Roberts, Cancer-Fighting Smurf. NatureMedicine. 2012, 18 (2): 204-205.
36. Xi Wang#, Miriam B.F. Werneck#, Boris G.Wilson, Hye-Jung Kim, Michael J. Kluk, Christopher S. Thom, Jonathan W.Wischhusen, Julia A. Evans, Jonathan L. Jesneck, Phuong Nguyen, Courtney G.Sansam, Harvey Cantor, and Charles W.M. Roberts*, T cell receptor dependenttransformation of mature memory phenotype T cells in mice. Journal ofClinical Investigation. 2011:121 (10): 3834-3845.
37. Boris G. Wilson#, Xi Wang#, Xiaohua Shen, Elizabeth S. McKenna, Madeleine E. Lemieux, Yoon-JaeCho, Edward C. Koellhoffer, Scott L. Pomeroy, Stuart H. Orkin, and Charles W.M.Roberts, Epigenetic antagonism between Polycomb and SWI/SNF complexes duringoncogenic transformation. Cancer Cell. 2010:18 (4): 316-328.
38. Xi Wang, Courtney G. Sansam, Christopher S. Thom, DanielMetzger, Julia A. Evans, Phuong T.L. Nguyen, and Charles W.M. Roberts, Oncogenesis caused by loss of the SNF5 tumor suppressor isdependent upon activity of BRG1, the ATPase of the SWI/SNF complex. CancerResearch. 2009:69 (20): 8094-8101.
39. Xi Wang, Robert T. Simpson, Chromatin structure mapping in Saccharomyces cerevisiaeinvivo with DNase I. Nucleic Acids Research.2001: 29:1943-1950.
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学校介绍
首都医科大学建校于1960年，是北京市重点高等院校，著名泌尿外科专家、中国科学院院士、中国工程院院士、原全国人大常委会副委员长吴阶平教授为首任院长。学校由校本部和附属医院(即临床医学院)组成。校本部设有基础医学院、生物医学工程学院、公共卫生与家庭医学学院、高等职业教育学院、中医药学院、顺义校区、继续教育学院、护理学院、卫生事业管理与发展学院及首都医科大学国际教学部；附属医院包括宣武医院(第一临床医学院)、附属北京友谊医院(第二临床医学院)、附属北京朝阳医院(第三临床医学院)、附属北京同仁医院(第四临床医学院)、附属北京天坛医院(第五临床医学院)、附属北京安贞医院(第六临床医学院)、附属北京口腔医院(口腔医学院)、附属北京儿童医院(儿科医学院)、附属北京妇产医院(妇产医学院)、附属北京安定医院(精神卫生学院)、附属复兴医院(第八临床医学院)、附属北京中医医院(中医药临床医学院)和康复医学院。
学校和附属医院现有教职员工和医护人员22575人。有院士4人，正高职称700余人，副高职称1800余人。学校学科专业齐全，学科力量雄厚，在基础和临床各专业拥有一大批具有很高造诣的专家学者，现有3个国家级重点学科，有38个博士学位授予权学科，58个硕士学位授予权学科和2个博士后科研流动站。
校本部和附属医院总占地面积97.3万平方米，总建筑面积134万平方米 ，固定资产总值近46.5亿元，图书馆藏书108.3万册 ，住院病床10039张。学校开办的七年制专业中设有临床医学和口腔医学；五年制专业中设有临床医学、口腔医学、预防医学、护理学、中医学等；四年制专业中设有生物医学工程、中药学和康复治疗学。在临床医学专业中设有儿科医学、康复医学、医学影像、精神卫生与精神病学和医学检验5个专业方向；在生物医学工程专业中设有医学影像设备与技术和听力学专业方向。高等职业教育设有护理、医学检验、药学、医学影像技术、康复技术、口腔修复工艺、眼科验光、实验动物技术、中医学、中药制剂、医学信息、临床医学、预防医学、中药经营贸易和中医学美容专业方向15个专业。首都医科大学现已成为以培养高层次本科生与研究生为核心、以临床应用型人才为主和培养预防、康复、生物医学工程和医学基础各学科、各层次人才，位于全国先进医学院校行列的高等学府。
学校具有较强的学术发展与科研实力，在校本部和附属医院建有一批国家级和市级重点学科和重点实验室，建有高水平的国家级或市级研究和培训机构，如卫生部全科医学培训中心、临床医学研究所、基础医学研究所、神经科学研究所、眼科研究所、老年病医疗研究中心、泌尿外科研究所、心肺血管医疗研究中心、生命科学院、卫生毒理检测中心、生物工程技术研究中心、祖国医学研究所、临床疾病研究中心、中医肝病临床研究中心、生殖医学研究所、心血管疾病临床试验及社区干预中心和北京市卫生政策与卫生经济研究中心等。神经生物学、细胞生物学、电生理学、基础免疫学、实验寄生虫学、医学图像处理、生物医学、信息检测与处理、神经内科、神经外科、心脏内外科、肾移植、呼吸和消化内科、口腔颌面外科、眼科、耳鼻咽喉科、小儿血液病等领域在国内外享有较高声誉，很多学科的研究和医疗水平已经达到或接近国际先进水平。
学校十分重视对外交流与合作，改革开放以来，先后与世界20多个国家和地区签定了友好交流协议， 近十年中,先后接待美国、加拿大、英国、澳大利亚、法国、瑞典、日本、荷兰、意大利、德国、丹麦及台湾、香港和澳门等50多个国家和地区的专家学者8000余人次来校进行学术交流和参观访问。同时，学校积极选送教师、科研人员和管理干部出国进修、参加学术会议和考察访问。
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