宣武医院-唐毅导师介绍

更新于 2023-10-17 导师主页
唐毅 主任医师 硕,博士生导师
宣武医院
神经病学
阿尔茨海默病和血管性认知障碍的早期诊断与早期干预
tangyi@xwhosp.org

唐毅,主任医师、教授、博士研究生导师、教育部长江学者,毕业于中国协和医科大学医学博士(M.D.)、理学博士(Ph.D.)双学位;美国康奈尔大学医学院/纽约长老会医院神经病学与神经科学系博士后,现任首都医科大学宣武医院纪委书记兼神经内科党总支书记、国家神经疾病医学中心常务副主任、神经变性病教育部重点实验室副主任,担任国家卫健委认知障碍疾病专科能力建设项目专家组组长、中华医学会神经病学分会青年学组副组长、中华医学会神经病学分会痴呆与认知障碍学组委员、中国医师协会神经内科医师分会青年副主任委员、中国医师协会神经内科医师分会脑与脊髓学组副组长、北京医学会痴呆与认知障碍学组组长等学术任职。主要从事阿尔茨海默病及相关认知障碍疾病的发病机制和诊治研究。已在Alzheimer’s & Dementia, Annals of Internal Medicine, Molecular Psychiatry等杂志发表SCI收录文章90余篇,参编参译教材和学术专著4部。主持国家重点研发计划、国自然重点国际合作等国家级项目/课题6项,省部级课题和人才项目9项。先后入选北京市科技新星(2010)、北京市优秀人才青年拔尖个人(2014)、北京市百千万人才工程(2016)、北京市高层次创新创业人才领军人才(2017)、北京市杰出青年科学基金(2019)、教育部长江学者(2021)、北京市“登峰”人才计划(2022)、青年北京学者(2022)、北京市属高校高水平科研创新团队(2023),北京市先进科技工作者(2023)。

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科研项目

研究成果

一、SCI文章90篇

1.       Qin Q, Qu J, Yin Y, Liang Y, Wang Y, Xie B, Liu Q, Wang X, Xia X, Wang M, Zhang X, Jia J, Xing Y*, Li C*, Tang Y*. Unsupervised machine learning model to predict cognitive impairment in subcortical ischemic vascular disease. Alzheimers Dement. 2023 Feb 14. doi: 10.1002/alz.12971.

2.       Qin Q, Wang M, Li H*, Xu ZD*, Tang Y*. Editorial: The role of microglia in the pathogenesis of neurodegenerative diseases. Front Aging Neurosci. 2023 Jan 6;14:1105896. doi: 10.3389/fnagi.2022.1105896. 

3.       Liu PP, Dai SK, Mi TW, Tang GB, Wang Z, Wang H, Du HZ, Tang Y*, Teng Z*, Liu CM*.. Acetate supplementation restores cognitive deficits caused by ARID1A haploinsufficiency in excitatory neurons. EMBO Mol Med. 2022;e15795. doi:10.15252/emmm.202215795.

4.       Yu CJ, Wang M, Li RY, Wei T, Yang HC, Yin YS, Mi YX, Qin Q, Tang Y*. TREM2 and Microglia Contribute to the Synaptic Plasticity: from Physiology to Pathology. Mol Neurobiol. 2023 Feb;60(2):512-523. doi: 10.1007/s12035-022-03100-1.

5.       Xia X, Qin Q, Peng Y, Wang M, Yin Y, Tang Y*. Retinal Examinations Provides Early Warning of Alzheimer's Disease. J Alzheimers Dis. 2022;10.3233/JAD-220596. doi: 10.3233/JAD-220596.

6.       Shi X, Wei T, Hu Y, Wang M, Tang Y*. The associations between plasma soluble Trem1 and neurological diseases: a Mendelian randomization study. J Neuroinflammation. 2022 Sep 6;19(1):218. doi: 10.1186/s12974-022-02582-z.

7.       Lutz MW, Khachaturian AS, Zetterberg H, Blennow K, Willette AA, Mielke MM, Hayden KM, Dodge HH, Tang Y, Greenberg BD, Kukull WA, Khachaturian ZS. Biomarkers of Alzheimer syndrome and related dementias: A&D author's guide. Alzheimers Dement. 2022 Sep;18(9):1595-1601. doi: 10.1002/alz.12772.

8.       Zhang SF, Dai SK, Du HZ, Wang H, Li XG, Tang Y*, Liu CM*. The epigenetic state of EED-Gli3-Gli1 regulatory axis controls embryonic cortical neurogenesis. Stem Cell Reports. 2022 Sep 13;17(9):2064-2080. doi: 10.1016/j.stemcr.2022.07.004.

9.       Yu Y, Lu Y, Wang F, Lu Y, Xie B, Meng X, Tang Y*. Acanthocytes Identified in Huntington's Disease. Front Neurosci. 2022 Jun 6; 16:913401. doi: 10.3389/fnins.2022.913401.

10.    Qin Q, Wang M, Yin Y, Tang Y*. The Specific Mechanism of TREM2 Regulation of Synaptic Clearance in Alzheimer's Disease. Front Immunol. 2022 May 19; 13:845897. doi: 10.3389/fimmu.2022.845897.

11.    Wang YY, Deng YS, Dai SK, Mi TW, Li RY, Liu PP, Liu C, HeBD, He XC, Du HZ, Yang HC, Tang Y*, Liu CM*, Teng ZQ*. Loss of microglial EED impairs synapse density, learning and memory. Mol Psychiatry. 2022 Jul; 27(7):2999-3009. doi: 10.1038/s41380-022-01576-w.

12.    Li RY, Qin Q, Yang HC, Wang YY, Mi YX, Yin YS, Wang M, Yu CJ, Tang Y*. TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target. Mol Neurodegener. 2022 Jun 3;17(1):40. doi: 10.1186/s13024-022-00542-y.

13.    Wei T, Guo Z, Wang Z, Li C, Zhu W, Zheng Y, Yin Y, Mi Y, Xia X, Hou H, Tang Y*. Five Major Psychiatric Disorders and Alzheimer's Disease: A Bidirectional Mendelian Randomization Study. J Alzheimers Dis. 2022 Mar 31. doi: 10.3233/JAD-220010.

14.    Mi Y, Qin Q, Xing Y, Tang Y*. Capgras Syndrome as the Core Manifestation of Early-Onset Alzheimer's Disease. J Alzheimers Dis. 2022 Mar 2. doi: 10.3233/JAD-215565.

15.    Temp AGM, Ly A, van Doorn J, Wagenmakers EJ, Tang Y, Lutz MW, Teipel S. A Bayesian perspective on Biogen's aducanumab trial. Alzheimers Dement. 2022 Mar 2. doi: 10.1002/alz.12615.

16.    Shenoy SA, Zheng S, Liu W, Dai Y, Liu Y, Hou Z, Mori S, Tang Y, Cheng J, Duan W, Li C. A novel and accurate full-length HTT mouse model for Huntington's disease. Elife. 2022 Jan 13;11:e70217. doi: 10.7554/eLife.70217.

17.    Teipel S, Gustafson D, Ossenkoppele R, Hansson O, Babiloni C, Wagner M, Riedel-Heller S, Kilimann I, Tang Y. Alzheimer's disease - standard of diagnosis, treatment, care, and prevention. J Nucl Med. 2022 Feb 10:jnumed.121.262239. doi: 10.2967/jnumed.121.262239.

18.    Qin Q, Yin Y, Xing Y, Wang X, Wang Y, Wang F, Tang Y*. Lipid Metabolism in the Development and Progression of Vascular Cognitive Impairment: A Systematic Review. Front Neurol. 2021 Nov 19;12:709134. doi: 10.3389/fneur.2021.709134.

19.    Xing Y, Yang J, Zhou A, Wang F, Tang Y*, Jia J*. Altered brain activity mediates the relationship between white matter hyperintensity severity and cognition in older adults. Brain Imaging Behav. 2022 Apr;16(2):899-908.

20.    Wang C#, Wang Z#, Xie B, Shi X, Yang P, Liu L, Qu T, Qin Q, Xing Y, Zhu W, Teipel SJ, Jia J, Zhao G*, Li L*, Tang Y*. Binaural processing deficit and cognitive impairment in Alzheimer’s disease. Alzheimers Dement. 2021, DOI: 10.1002/alz.12464.

21.    Wang Z, Zhu W, Xing Y, Jia J, Tang Y*. B vitamins and prevention of cognitive decline and incident dementia: a systematic review and meta-analysis. Nutr Rev. 2022 Mar 10;80(4):931-949.

22.    Temp AGM, Lutz MW, Trepel D, Tang Y, Wagenmakers EJ, Khachaturian AS, Teipel S. How Bayesian statistics may help answer some of the controversial questions in clinical research on Alzheimer's disease. Alzheimers Dement. 2021 Jun;17(6):917-919.

23.    Xing Y, Yang J, Zhou A, Wang F, Wei C, Tang Y*, Jia J*. White Matter Fractional Anisotropy Is a Superior Predictor for Cognitive Impairment Than Brain Volumes in Older Adults With Confluent White Matter Hyperintensities. Front Psychiatry. 2021, 5;12:633811. doi: 10.3389/fpsyt.2021.633811. eCollection 2021.

24.    Wang F, Ma X, Shi Y, Jia L, Zuo X, Yu Y, Jin H, Tang Y, Guo D, Jia J. Cognitive profiles in adult-onset neuronal intranuclear inclusion disease: a case series from the memory clinic. Neurol Sci. 2020; doi: 10.1007/s10072-020-04864-x.

25.    Wang Z, Yang J, Zhu W, Tang Y*, Jia J. The synaptic marker neurogranin as a disease state biomarker in Alzheimer's disease: a systematic review and meta-analysis. Int J Neurosci. 2021; 10:1-9. doi: 10.1080/00207454.2021.1881087.

26.    Qin Q, Teng Z, Liu C, Li Q, Yin Y, Tang Y*. TREM2, microglia, and Alzheimer's disease. Mech Ageing Dev. 2021;195:111438.

27.    Jia L, Du Y, Chu L, Zhang Z, Li F, Lyu D, Li Y, Li Y, Zhu M, Jiao H, Song Y, Shi Y, Zhang H, Gong M, Wei C, Tang Y, Fang B, Guo D, Wang F, Zhou A, Chu C, Zuo X, Yu Y, Yuan Q, Wang W, Li F, Shi S, Yang H, Zhou C, Liao Z, Lv Y, Li Y, Kan M, Zhao H, Wang S, Yang S, Li H, Liu Z, Wang Q, Qin W, Jia J; COAST Group. Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: a cross-sectional study. Lancet Public Health. 2020;5(12):e661-e671.

28.    Jia L, Li F, Wei C, Zhu M, Qu Q, Qin W, Tang Y, Shen L, Wang Y, Shen L, Li H, Peng D, Tan L, Luo B, Guo Q, Tang M, Du Y, Zhang J, Zhang J, Lyu J, Li Y, Zhou A, Wang F, Chu C, Song H, Wu L, Zuo X, Han Y, Liang J, Wang Q, Jin H, Wang W, Lü Y, Li F, Zhou Y, Zhang W, Liao Z, Qiu Q, Li Y, Kong C, Li Y, Jiao H, Lu J, Jia J. Prediction of Alzheimer's disease using multi-variants from a Chinese genome-wide association study. Brain. 2020. doi: 10.1093/brain/awaa364.

29.    Sikkes SAM, Tang Y, Jutten RJ, Wesselman LMP, Turkstra LS, Brodaty H, Clare L, Cassidy-Eagle E, Cox KL, Chételat G, Dautricourt S, Dhana K, Dodge H, Dröes RM, Hampstead BM, Holland T, Lampit A, Laver K, Lutz A, Lautenschlager NT, McCurry SM, Meiland FJM, Morris MC, Mueller KD, Peters R, Ridel G, Spector A, van der Steen JT, Tamplin J, Thompson Z; ISTAART Non-pharmacological Interventions Professional Interest Area, Bahar-Fuchs A. Toward a theory-based specification of non-pharmacological treatments in aging and dementia: Focused reviews and methodological recommendations. Alzheimers Dement. 2021;17(2):255-270.

30.    Jia L, Xu H, Chen S, Wang X, Yang J, Gong M, Wei C, Tang Y, Qu Q, Chu L, Shen L, Zhou C, Wang Q, Zhao T, Zhou A, Li Y, Li F, Li Y, Jin H, Qin Q, Jiao H, Li Y, Zhang H, Lyu D, Shi Y, Song Y, Jia J*. The APOE ε4 exerts differential effects on familial and other subtypes of Alzheimer's disease. Alzheimers Dement. 2020. doi: 10.1002/alz.12153.

31.    Tang Y*, Xing Y, Cui L, Wu C, Wen X, Song H, Wu L, Chang H, Song J, Wang Y*, Zhao G*. Neurology practice during the COVID-19 outbreak and post-pandemic era: experiences and challenges. Eur J Neurol. 2020 Jul 17:10.1111/ene.14445. doi: 10.1111/ene.14445.

32.    Jia L, Zhu M, Kong C, Pang Y, Zhang H, Qiu Q, Wei C, Tang Y, Wang Q, Li Y, Li T, Li F, Wang Q, Li Y, Wei Y, Jia J. Blood neuro-exosomal synaptic proteins predict Alzheimer's disease at the asymptomatic stage. Alzheimers Dement. 2021;17(1):49-60.

33.    Qin Q, Yin Y, Wang Y, Lu Y, Tang Y*, Jia J*. Gene mutations associated with early onset familial Alzheimer's disease in China: An overview and current status. Mol Genet Genomic Med. 2020 Aug 6:e1443. doi: 10.1002/mgg3.1443.

34.    Xing Y, Zhu Z, Du Y, Zhang J, Qu Q, Sun L, Li Y, Guo Y, Peng G, Liu Y, Yu Y, Qiao Y, Xie B, Shi X, Lu J, Jia J, Tang Y*. The Efficacy of COGnitive tRaining in patiEnts with Amnestic mild coGnitive impairmENT (COG-REAGENT): Protocol for a Multi-Center Randomized Controlled Trial. J Alzheimers Dis. 2020;75(3):779-787.

35.    Xing Y, Wei P, Wang C, Shan Y, Yu Y, Qiao Y, Xie B, Shi X, Zhu Z, Lu J, Zhao G, Jia J, Tang Y*. TRanscranial AlterNating current Stimulation FOR patients with Mild Alzheimer's Disease (TRANSFORM-AD study): Protocol for a randomized controlled clinical trial. Alzheimers Dement (N Y). 2020;6(1):e12005.

36.    Xie B, Shi X, Xing Y, Tang Y*. Association between atherosclerosis and Alzheimer's disease: A systematic review and meta-analysis. Brain Behav. 2020;10(4):e01601.

37.    Qin Q, Tang Y*, Dou X, Qu Y, Xing Y, Yang J, Chu T, Liu Y, Jia J. Default mode network integrity changes contribute to cognitive deficits in subcortical vascular cognitive impairment, no dementia. Brain Imaging Behav. 2021;15(1):255-265.

38.    Jia J*, Wei C, Chen W, Jia L, Zhou A, Wang F, Tang Y, Xu L. Safety and Efficacy of Donepezil 10 mg/day in Patients with Mild to Moderate Alzheimer's Disease. J Alzheimers Dis. 2020. doi: 10.3233/JAD-190940.

39.    Jia L, Fu Y, Shen L, Zhang H, Zhu M, Qiu Q, Wang Q, Yan X, Kong C, Hao J, Wei C, Tang Y, Qin W, Li Y, Wang F, Guo D, Zhou A, Zuo X, Yu Y, Li D, Zhao L, Jin H, Jia J*. PSEN1, PSEN2, and APP mutations in 404 Chinese pedigrees with familial Alzheimer's disease. Alzheimers Dement. 2020;16(1):178-191.

40.    Tang Y*, Liu Y, Li D, Guo D, Xing Y*. A novel mutation in the CYP27A1 gene in a family with cerebrotendinous xanthomatosis. Int J Neurosci. 2020; 1-4.

41.    Quan M, Zhao T, Tang Y, Luo P, Wang W, Qin Q, Li T, Wang Q, Fang J, Jia J*. Effects of gene mutation and disease progression on representative neural circuits in familial Alzheimer's disease. Alzheimers Res Ther. 2020;12(1):14.

42.    Wang H, Fan Z, Shi C, Xiong L, Zhang H, Li T, Sun Y, Guo Q, Tian Y, Qu Q, Zhang N, Cheng Z, Wu L, Wu D, Han Z, Tian J, Xie H, Tan S, Gao J, Luo B, Pan X, Peng G, Qin B, Tang Y, Wang K, Wang T, Zhang J, Zhao Q, Gauthier S, Yu X*. Consensus statement on the neurocognitive outcomes for early detection of mild cognitive impairment and Alzheimer dementia from the Chinese Neuropsychological Normative (CN-NORM) Project. Journal of global health. 2019; 9(2): 020320

43.    Shi X, Xie B, Xing Y, Tang Y*. Plasma Clusterin as a Potential Biomarker for Alzheimer's Disease-A Systematic Review and Meta-analysis. Curr Alzheimer Res. 2019;16(11):1018-1027.

44.    Jia L, Quan M, Fu Y, Zhao T, Li Y, Wei C, Tang Y, Qin Q, Wang F, Qiao Y, Shi S, Wang YJ, Du Y, Zhang J, Zhang J, Luo B, Qu Q, Zhou C, Gauthier S, Jia J*; Group for the Project of Dementia Situation in China. Dementia in China: epidemiology, clinical management, and research advances. Lancet Neurol. 2020 Jan;19(1):81-92.

45.    Shen L, Qin W, Wu L, Zhou A, Tang Y, Wang Q, Jia L, Jia J*. Two novel presenilin-1 mutations (I249L and P433S) in early onset Chinese Alzheimer's pedigrees and their functional characterization. Biochem Biophys Res Commun. 2019;516(1):264-269.

46.    Tang Y#*, Xing Y#, Zhu Z#, He Y, Li F, Yang J, Liu Q, Li F, Teipel SJ, Zhao G*, Jia J*. The effects of 7-week cognitive training in patients with vascular cognitive impairment, no dementia (the Cog-VACCINE study): A randomized controlled trial. Alzheimers Dement. 2019;15(5):605-614.

47.    Liu Z*, Jiao L, Qiu Z, Da Y, Tang Y, Lin Y, Li D, Huang J, Kang X, Dong H*. Clinical characteristics of patients with paraneoplastic myelopathy.  J Neuroimmunol. 2019 ;330:136-142.

48.    Tang Y*, Qin Q*, Xing Y, Guo D, Di L, Jia J. AARS2 leukoencephalopathy: a new variant of mitochondrial encephalomyopathy. Mol Genet Genomic Med. 2019; 7(4):e00582.

49.    Babulal GM, Quiroz YT, Albensi BC, Arenaza-Urquijo E, Astell AJ, Babiloni C, Bahar-Fuchs A, Bell J, Bowman GL, Brickman AM, Chételat G, Ciro C, Cohen AD, Dilworth-Anderson P, Dodge HH, Dreux S, Edland S, Esbensen A, Evered L, Ewers M, Fargo KN, Fortea J, Gonzalez H, Gustafson DR, Head E, Hendrix JA, Hofer SM, Johnson LA, Jutten R, Kilborn K, Lanctôt KL, Manly JJ, Martins RN, Mielke MM, Morris MC, Murray ME, Oh ES, Parra MA, Rissman RA, Roe CM, Santos OA, Scarmeas N, Schneider LS, Schupf N, Sikkes S, Snyder HM, Sohrabi HR, Stern Y, Strydom A, Tang Y, Terrera GM, Teunissen C, Melo van Lent D, Weinborn M, Wesselman L, Wilcock DM, Zetterberg H, O'Bryant SE*; International Society to Advance Alzheimer's Research and Treatment, Alzheimer's Association. Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need. Alzheimers Dement. 2019;15(2):292-312.

50.    Du X#, Ji Y#, Chen T*, Tang Y, Han B. Can working memory capacity be expanded by boosting working memory updating efficiency in older adults? Psychology and Aging. 2018;33(8):1134-1151. (IF 2.608)

51.    Jia J*, Wei C, Chen S, Li F, Tang Y, Qin W, Shi L, Gong M, Xu H, Li F, He J, Song H, Yang S, Zhou A, Wang F, Zuo X, Chu C, Liang J, Jia L, Gauthier S. Efficacy and safety of the compound Chinese medicine SaiLuoTong in vascular dementia: A randomized clinical trial. Alzheimers Dement (N Y): TRCI. 2018; 4:108-117.

52.    Tang Y*, Lutz MW, Xing Y. A systems-based model of Alzheimer's disease. Alzheimers Dement. 2019;15(1):168-171.

53.    Hayden KM*, Inouye SK, Cunningham C, Jones RN, Avidan MS, Davis D, Kuchel GA, Tang Y, Khachaturian AS. Reduce the burden of dementia now. Alzheimers Dement. 2018;14(7):845-847.

54.    Khachaturian AS*, Hayden KM, Mielke MM, Tang Y, Lutz MW, Gold M, Kukull WA, Mohs R, Gauthier S, Molinuevo JL, Zetterberg H, Khachaturian ZS. New thinking about thinking, part two. Theoretical articles for Alzheimer's & Dementia. Alzheimers Dement. 2018;14(6):703-706.

55.    Li J, Wu L, Tang Y, Zhou A, Wang F, Xing Y, Jia J*. Differentiation of neuropsychological features between posterior cortical atrophy and early onset Alzheimer's disease. BMC Neurol. 2018;18(1):65.

56.    Khachaturian AS#*, Hayden KM, Mielke MM, Tang Y, Lutz MW, Gustafson DR, Kukull WA, Mohs R, Khachaturian ZS. Future prospects and challenges for Alzheimer's disease drug development in the era of the NIA-AA Research Framework. Alzheimers Dement. 2018;14(4):532-534.

57.    Wang Z, Qin W, Wei CB, Tang Y, Zhao LN, Jin HM, Li Y, Wang Q, Luan XQ, He JC, Jia J*. The microRNA-1908 up-regulation in the peripheral blood cells impairs amyloid clearance by targeting ApoE. Int J Geriatr Psychiatry. 2018;33(7):980-986.

58.    Jia J#*, Wei C*, Chen S, Li F, Tang Y, Qin W, Zhao L, Jin H, Xu H, Wang F, Zhou A, Zuo X, Wu L, Han Y, Han Y, Huang L, Wang Q, Li D, Chu C, Shi L, Gong M, Du Y, Zhang J, Zhang J, Zhou C, Lv J, Lv Y, Xie H, Ji Y, Li F, Yu E, Luo B, Wang Y, Yang S, Qu Q, Guo Q, Liang F, Zhang J, Tan L, Shen L, Zhang K, Zhang J, Peng D, Tang M, Lv P, Fang B, Chu L, Jia L, Gauthier S. The cost of Alzheimer's disease in China and re-estimation of costs worldwide. Alzheimers Dement. 2018;14(4):483-491

59.    Zhang Y, Guo D, Tang Y*. Autonomic dysfunction in a patient with X-linked adrenoleukodystrophy. Int J Neurosci.  2017; 28:1-2

60.    Liu Q#, Zhu Z#, Teipel SJ, Yang J, Xing Y, Tang Y*, Jia J* White Matter Damage in the Cholinergic System Contributes to Cognitive Impairment in Subcortical Vascular Cognitive Impairment, No Dementia. Front. Aging Neurosci. 2017; 9: 47.

61.    Jia J#*, Gauthier S, Pallotta S, Ji Y, Wei W, Xiao S, Peng D, Guo Q, Wu L, Chen S, Kuang W, Zhang J, Wei C, Tang Y. Consensus-based recommendations for the management of rapid cognitive decline due to Alzheimer's disease. Alzheimers Dement. 2017;13(5):592-597.

62.    Dong J, Qin W, Wei C, Tang Y, Wang Q, Jia J*. A Novel PSEN1 K311R Mutation Discovered in Chinese Families with Late-Onset Alzheimer's Disease Affects Amyloid-β Production and Tau Phosphorylation.  J Alzheimers Dis. 2017;57(2):613-623.

63.    Jia J#*, Wei C#, Jia L, Tang Y, Liang J, Zhou A, Li F, Shi L, Doody RS. Efficacy and Safety of Donepezil in Chinese Patients with Severe Alzheimer's Disease: A Randomized Controlled Trial. J Alzheimers Dis. 2017;56(4):1495-1504.

64.    Xing Y#, Tang Y#, Zhao L, Wang Q, Qin W, Ji X, Zhang J, Jia J*. Associations between plasma ceramides and cognitive and neuropsychiatric manifestations in Parkinson's disease dementia. J Neurol Sci. 2016;370:82-87.

65.    Tang Y#*, Zhu Z#, Liu Q, Li F, Yang J, Li F, Xing Y, Jia J*. The efficacy of Cognitive training in patients with VAsCular Cognitive Impairment, No dEmentia (the Cog-VACCINE study): study protocol for a randomized controlled trial. Trials. 2016;17(1):392.

66.    Xing Y#, Tang Y#, Zhao L, Wang Q, Qin W, Zhang J, Jia J*. Plasma ceramides and neuropsychiatric symptoms of Alzheimer’s disease. J Alzheimers Dis. 2016; 52(3):1029-35.

67.    Jia J*, Zuo X, Jia XF, Chu C, Wu L, Zhou A, Wei C, Tang Y, Li D, Qin W, Song H, Ma Q, Li J, Sun Y, Min B, Xue S, Xu E, Yuan Q, Wang M, Huang X, Fan C, Liu J, Ren Y, Jia Q, Wang Q, Jiao L, Xing Y, Wu X; China Cognition and Aging Study (COAST) Group. Diagnosis and treatment of dementia in neurology outpatient departments of general hospitals in China. Alzheimers Dement. 2016; 12(4):446-53.

68.    Xing Y, Tang Y, Jia J*. Sex Differences in Neuropsychiatric Symptoms of Alzheimer's Disease: The Modifying Effect of Apolipoprotein E ε4 Status. Behav Neurol. 2015;2015:275256. doi: 10.1155/2015/275256.

69.    Tang Y*#, Wang X#, Jia J#. Mercury poisoning presenting as sporadic creutzfeldt-jakob disease: a case report. Ann Intern Med. 2015;162(6):462-3.

70.    Lu H, Wang XB, Tang Y*. Subdural hematoma associated with high altitude. Chin Med J (Engl). 2015;128(3):407-8.

71.    Qin W, Jia X, Wang F, Zuo X, Wu L, Zhou A, Li D, Min B, Wei C, Tang Y, Xing Y, Dong X, Wang Q, Gao Y, Li Y, Jia J*. Elevated plasma angiogenesis factors in Alzheimer's disease. J Alzheimers Dis. 2015;45(1):245-52.

72.    Liang J, Li F, Wei C, Song H, Wu L, Tang Y, Jia J*. Rationale and Design of a Multicenter, Phase 2 Clinical Trial to Investigate the Efficacy of Traditional Chinese Medicine SaiLuoTong in Vascular Dementia. J Stroke Cerebrovasc Dis. 2014; 23(10):2626-34.

73.    Jia J*, Zhou A, Wei C, Jia X, Wang F, Li F, Wu X, Mok V, Gauthier S, Tang M, Chu L, Zhou Y, Zhou C, Cui Y, Wang Q, Wang W, Yin P, Hu N, Zuo X, Song H, Qin W, Wu L, Li D, Jia L, Song J, Han Y, Xing Y, Yang P, Li Y, Qiao Y, Tang Y, Lv J, Dong X. The prevalence of mild cognitive impairment and its etiological subtypes in elderly Chinese. Alzheimers Dement. 2014;10(4):439-47.

74.    Jia J*, Wang F, Wei C, Zhou A, Jia X, Li F, Tang M, Chu L, Zhou Y, Zhou C, Cui Y, Wang Q, Wang W, Yin P, Hu N, Zuo X, Song H, Qin W, Wu L, Li D, Jia L, Song J, Han Y, Xing Y, Yang P, Li Y, Qiao Y, Tang Y, Lv J, Dong X. The prevalence of dementia in urban and rural areas of China. Alzheimers Dement. 2014;10(1):1-9

75.    Jia J*, Wang F, Yuan Q, Qin W, Tang Y, Zuo XM, Han Y. Progresses on Genetics of Predementia Phase of Alzheimer's Disease. Prog Biochem Biophys. 2012;39(8), 698-702.

76.    Xing Y, Wei C, Chu C, Zhou A, Li F, Wu L, Song H, Zuo X, Wang F, Qin W, Li D, Tang Y, Jia XF, Jia J*. Stage-specific gender differences in cognitive and neuropsychiatric manifestations of vascular dementia. Am J Alzheimers Dis Other Demen. 2012;27(6):433-8.

77.    Tang Y#, Xing Y#, Lin MT, Zhang J, Jia J*. Hashimoto's encephalopathy cases: Chinese experience. BMC Neurol. 2012; 24;12:60.

78.    Dong HQ#, Liu Z#, Tang Y, Lu Y, Wang Q, Jia J*. Recurrent Fisher-Bickerstaff syndrome: report of a Chinese case. Chin Med J (Engl). 2011;124(17):2786-8.

79.    Tang Y#, Chu C#, Lin MT, Wei G, Zhang X, Da Y, Huang H, Jia J*. Hashimoto's encephalopathy mimicking spinocerebellar ataxia. J Neurol. 2011;258(9):1705-7.

80.    Huang H#*, Chen J, Lin T, Wang T, Tang Y, Dong Y, Wang J. Epoxyeicosatrienoic acids--novel mechanism and pharmacological therapy of chronic renocardiac syndrome. Med Hypotheses. 2011;76(4):550-2.

81.    Tang Y, Ding Y, Li CJ, Wang XB*, Jia J. longitudinal lesion of the spinal cord in a patient with Vogt-Koyanagi-Harada disease. J Neurol Neurosurg Psychiatry 2010;81:941-942

82.    Xu EH#, Tang Y, Li D, Jia J*. Polymorphism of HD and UCHL-1 genes in Huntington's disease. J Clin Neurosci. 2009, 16(11):1473-7.

83.    Li Y#, Liu W#, Oo TF, Wang L, Tang Y, Jackson-Lewis V, Zhou C, Geghman K, Bogdanov M, Przedborski S, Beal MF, Burke RE, Li C*. Mutant hR1441G LRRK2 BAC Transgenic Mice Recapitulate Cardinal Features of Parkinson’s Disease. Nature Neuroscience 2009, 12(7):826-8.

84.    Tang Y#, Huang Y#, Shen W, Liu DP*, Liu G, Wang Z, Tang XB, Liang CC. Cluster specific regulation pattern of upstream regulatory elements in human α- and β-globin gene clusters. Exp. Cell Res. 2008, 314(1):115-22

85.    Wei YJ#*, Tang Y#, Cui CJ#, Zhang H, Liu XN, Zhang H, Hu SS*. Expression pattern of dog stromal cell derived factor-1 (SDF-1) and implications in ischemic myocardium. Cytokine 2007, 40(1):52-9

86.    Tang Y, Wang Z, Huang Y, Liu G, Shen W, Tang XB, Feng DX, Liu DP*, Liang CC, Gene Order in Human alpha-globin Locus is Required for Their Temporal Specific Expressions. Genes Cells. 2006,11(2):123-31.

87.    Tang Y, Liu DP*, Liang CC. Further understanding of the beta-globin locus regulation at the molecular level: looping or linking models? Genes Cells. 2002, 7(9): 889-900.

88.    Tang XB, Feng DX, Di LJ, Huang Y, Fu XH, Liu G, Tang Y, Liu DP*, Liang CC. HS-48 alone has no enhancement role on the expression of human alpha-globin gene cluster. Blood Cells Mol Dis. 2007, 38(1):32-6

89.    Shen W, Huang Y, Tang Y, Liu DP*, Liang CC. A General Method to Modify BACs to Generate Large Recombinant DNA Fragments Mol. Biotechnology.2005, 31: 181-186

90.    Huang Y, Liu DP*, Feng DX, Wu M, Shen W, Tang Y, Tang XB, Liang CC. No existence of translocus balancer to coordinate the expression and regulation of human hemoglobin genes in transgenic mice study. Int J Biochem Cell Biol. 2004, 36(7): 1261-5.


二、第一/通讯作者中文文章23篇

1.  中华医学会神经病学分会痴呆与认知障碍学组, 认知数字疗法中国专家共识写作组,通讯作者,认知数字疗法中国专家共识(2023). 中华医学杂志, 2023,103(9) : 640-647.

2.   秦琪,夏心怡,唐毅.神经病学临床案例库的建立与应用研究[J].中国医刊,2023,58(02):229-232.

3.   认知训练中国指南写作组,中国医师协会神经内科医师分会,通讯作者:唐毅.认知训练中国指南(2022年版)[J].中华医学杂志,2022,102(37):2918-2925.

4.   秦琪,唐毅,曲怡达,周爱红,丁建平,尹筠思,刘勇,贾建平.利用弥散张量成像技术观察小血管病所致非痴呆型血管性认知障碍患者白质结构损害与认知下降的关系[J].首都医科大学学报,2021,42(03):373-384.

5.   邢怡,唐毅. 认知训练早期干预痴呆的研究进展[J]. 中国神经免疫学和神经病学杂志,2020,27(6):358-359.

6.   石新蕊,王治斌,唐毅.听觉信息整合障碍与阿尔茨海默病[J].中国医学前沿杂志(电子版),2020,12(10):8-12.

7.   认知训练中国专家共识写作组, 中国医师协会神经内科医师分会认知障碍疾病专业委员会,唐毅朱祖德执笔. 认知训练中国专家共识[J].中华医学杂志,2019,99( 1 ): 4-8.

8.   中国痴呆与认知障碍诊治指南写作组,中国医师协会神经内科医师分会认知障碍疾病专业委员会,贾建平,唐毅执笔.2018中国痴呆与认知障碍诊治指南(六):阿尔茨海默病痴呆前阶段[J].中华医学杂志,2018,98(19):1457-1460.

9.   中国痴呆与认知障碍诊治指南写作组,中国医师协会神经内科医师分会认知障碍疾病专业委员会,唐毅,吕佩源执笔.2018中国痴呆与认知障碍诊治指南(七):阿尔茨海默病的危险因素及其干预[J].中华医学杂志,2018,98(19):1461-1466.

10.    楚长彪,唐毅. 医学专业英语运用能力培养的探索[J]. 中国医刊,2018,53(07):824-826.

11.    唐毅,杨坚炜,郭冬梅,邱琼琼,楚长彪. 免疫介导性帕金森综合征四例报告并文献复习[J]. 中国医刊,2018,53(06):665-668.

12.    唐毅. 阿尔茨海默病诊断标准:从临床诊断到病理生理诊断[J].    山东大学学报,2017,55(10):14-20.

13.    唐毅,杨坚炜,郭冬梅,李丹,赵丽娜,李洁颖,贾建平*. 皮质基底节综合征四例临床分析[J]. 中华医学杂志,2017,97(17):1343-1345.

14.    唐毅,杨坚炜,郭冬梅,楚长彪. 舞蹈病-棘红细胞增多症4例临床分析及文献复习[J]. 中国医刊,2017,52(05):81-83.

15.    唐毅,邢怡,秦伟,贾建平. 阿尔茨海默病患者性腺轴激素水平与认知功能的相关性及载脂蛋白E基因的调节作用[J]. 中华老年心脑血管病杂志,2017,19(04):340-344.

16.    唐毅,邢怡,张津等.桥本脑病患者的临床特征和预后随访观察[J].中华医学杂志,2014,94(9):670-673.

17.    唐毅,陆慧,王向波等.以周围神经损害为主要表现的汞中毒患者9例分析[J].疑难病杂志,2014,13(2):139-142.

18.    唐毅,楚长彪.医学英语教学的特点分析和策略探讨[J].中国医药导报,2014,11(4):122-124.

19.    唐毅,王向波.小柳原田病合并脊髓损害的临床研究并文献复习[J].中国医刊,2014,49(1):44-46.

20.    唐毅,纪笑娟,邢怡,左秀美, 周爱红, 贾建平*.帕金森病痴呆与阿尔茨海默病的认知和精神行为症状比较[J].中华医学杂志,2013,93(31):2459-2462.

21.    唐毅,贾建平. tau蛋白和自噬在PS-1基因突变发病机制中的作用[J]. 中国现代神经疾病杂志,2010,02:261-264.

22.    唐毅,贾建平. 肌张力障碍的治疗进展[J].中风与神经疾病杂志,2007,05:629-632.

23.    唐毅,魏英杰,胡盛寿等.SDF-1-CXCR4轴与缺血性心脏病的干细胞治疗[J].基础医学与临床,2006,26(8):915-921.


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学校介绍


  首都医科大学建校于1960年,是北京市重点高等院校,著名泌尿外科专家、中国科学院院士、中国工程院院士、原全国人大常委会副委员长吴阶平教授为首任院长。学校由校本部和附属医院(即临床医学院)组成。校本部设有基础医学院、生物医学工程学院、公共卫生与家庭医学学院、高等职业教育学院、中医药学院、顺义校区、继续教育学院、护理学院、卫生事业管理与发展学院及首都医科大学国际教学部;附属医院包括宣武医院(第一临床医学院)、附属北京友谊医院(第二临床医学院)、附属北京朝阳医院(第三临床医学院)、附属北京同仁医院(第四临床医学院)、附属北京天坛医院(第五临床医学院)、附属北京安贞医院(第六临床医学院)、附属北京口腔医院(口腔医学院)、附属北京儿童医院(儿科医学院)、附属北京妇产医院(妇产医学院)、附属北京安定医院(精神卫生学院)、附属复兴医院(第八临床医学院)、附属北京中医医院(中医药临床医学院)和康复医学院。

  学校和附属医院现有教职员工和医护人员22575人。有院士4人,正高职称700余人,副高职称1800余人。学校学科专业齐全,学科力量雄厚,在基础和临床各专业拥有一大批具有很高造诣的专家学者,现有3个国家级重点学科,有38个博士学位授予权学科,58个硕士学位授予权学科和2个博士后科研流动站。

  校本部和附属医院总占地面积97.3万平方米,总建筑面积134万平方米 ,固定资产总值近46.5亿元,图书馆藏书108.3万册 ,住院病床10039张。学校开办的七年制专业中设有临床医学和口腔医学;五年制专业中设有临床医学、口腔医学、预防医学、护理学、中医学等;四年制专业中设有生物医学工程、中药学和康复治疗学。在临床医学专业中设有儿科医学、康复医学、医学影像、精神卫生与精神病学和医学检验5个专业方向;在生物医学工程专业中设有医学影像设备与技术和听力学专业方向。高等职业教育设有护理、医学检验、药学、医学影像技术、康复技术、口腔修复工艺、眼科验光、实验动物技术、中医学、中药制剂、医学信息、临床医学、预防医学、中药经营贸易和中医学美容专业方向15个专业。首都医科大学现已成为以培养高层次本科生与研究生为核心、以临床应用型人才为主和培养预防、康复、生物医学工程和医学基础各学科、各层次人才,位于全国先进医学院校行列的高等学府。

  学校具有较强的学术发展与科研实力,在校本部和附属医院建有一批国家级和市级重点学科和重点实验室,建有高水平的国家级或市级研究和培训机构,如卫生部全科医学培训中心、临床医学研究所、基础医学研究所、神经科学研究所、眼科研究所、老年病医疗研究中心、泌尿外科研究所、心肺血管医疗研究中心、生命科学院、卫生毒理检测中心、生物工程技术研究中心、祖国医学研究所、临床疾病研究中心、中医肝病临床研究中心、生殖医学研究所、心血管疾病临床试验及社区干预中心和北京市卫生政策与卫生经济研究中心等。神经生物学、细胞生物学、电生理学、基础免疫学、实验寄生虫学、医学图像处理、生物医学、信息检测与处理、神经内科、神经外科、心脏内外科、肾移植、呼吸和消化内科、口腔颌面外科、眼科、耳鼻咽喉科、小儿血液病等领域在国内外享有较高声誉,很多学科的研究和医疗水平已经达到或接近国际先进水平。

  学校十分重视对外交流与合作,改革开放以来,先后与世界20多个国家和地区签定了友好交流协议, 近十年中,先后接待美国、加拿大、英国、澳大利亚、法国、瑞典、日本、荷兰、意大利、德国、丹麦及台湾、香港和澳门等50多个国家和地区的专家学者8000余人次来校进行学术交流和参观访问。同时,学校积极选送教师、科研人员和管理干部出国进修、参加学术会议和考察访问。

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