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本人于2008年至2016年就读于北京大学医学部免疫学系（基础医学八年制），博士研究生期间主要从事新细胞因子的免疫学功能研究以及肿瘤生物学、肿瘤免疫相关研究。后就职于首都医科大学附属北京儿童医院，北京市儿科研究所肿瘤与免疫研究室，担任研究室副主任，副教授/副研究员，硕导，主要从事儿童恶性实体瘤中T细胞、中性粒细胞等免疫细胞的功能调节相关研究，同时涉及儿童神经退行性疾病、免疫性脑炎等疾病的免疫学机制相关研究。承担国家自然科学基金青年项目、北京市优秀人才培养资助项目、首都医科大学科研培育基金等项目，在Cancer Research、Journal of Immunology、OncoImmunology、Clinical Immunology、Genes & Diseases等期刊发表论文23篇。任Frontiers in Physiology客座编辑。
1.国家自然科学基金青年科学基金项目，82002637，活化性受体DNAM-1表达下调介导的γδT细胞对神经母细胞瘤杀伤功能障碍的调控机制研究，2021.1-2023.12，在研，主持
2.北京市优秀人才培养资助项目（青年骨干个人），中共北京市委组织部，2018000021469G272，Mcl-1介导的γδ T细胞凋亡调控对神经母细胞瘤的杀伤作用研究，2020.6-2022.6，结题，主持
3.首都医科大学科研培育基金，首都医科大学，1200020147，激活性受体DNAM-1在γδT细胞对神经母细胞瘤杀伤中的作用及机制研究，2020.1-2020.12，结题，主持
1. Xiaolin Wang, Hui Wang, Zhengjing Lu, Xiangjun Liu, Wenjia Chai, Wei Wang, Jun Feng, Shen Yang, Wei Yang, Haiyan Cheng, Chenghao Chen, Shihan Zhang, Nian Sun, Qiaoyin Liu, Qiliang Li, Wenqi Song, Fang Jin, Qi Zeng, Shengcai Wang, Yan Su, Huanmin Wang, Xin Ni*, Jingang Gui*. Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor-Ligand Interactions That Instructs Intratumoral γδT-cell Activity. Cancer Res. 2025 Jan 15;85(2):277-298.
2. Zhengjing Lu#, Xiaolin Wang#, Jun Feng#, Wenjia Chai, Wei Wang, Qixin Wang, Shen Yang, Wei Yang, Yan Su, Wenjun Mou, Yun Peng, Huanmin Wang*, Jingang Gui*.Intratumoral CXCR4hi neutrophils display ferroptotic and immunosuppressive signatures in hepatoblastoma. Front Immunol. 2024 Feb 29:15:1363454.
3. Zhengjing Lu, Wenjun, Mou, Jianxin He, Xuedong Ge, Xiaolin Wang*, Jingang Gui*. Spontaneous NETosis and type I IFN signaling activation in resting neutrophils of chronic granulomatous disease patients with CYBB mutations. Genes Dis. 2023 Sep 20;11(6):101118.
4. Xiangjun Liu, Jingang Gui, Xiaolin Wang*. Circulating fibroblasts present neutrophil-like features in severe COVID-19 cases revealed by single-cell landscape analyses. Genes Dis. 2023, 10(6):2233-6.
5. Xiangjun Liu#, Mengmiao Pei#, Xiaolin Wang*, Jingang Gui*. Reduction of LPAR1 Expression in Neuroblastoma Promotes Tumor Cell Migration. Cancers (Basel). 2022, 14(14):3346.
6. Ying Li#, Xiaolin Wang#, Hanxue Yang, Yanlin Li, jingang Gui* and Yonghua Cui*. Profiles of proinflammatory cytokines and T cells in patients with Tourette syndrome: A meta-analysis. Front Immunol. 2022, 13:843247.
7. Xiaolin Wang, Jingang Gui*. Cell-mediated immunity to SARS-CoV-2. Pediatr Investig. 2020, 4(4):281-291.
8. Hui Zhang, Wenjia Chai, Wei Yang, Wei Han, Wenjun Mou, Yue Xi, Xi Chen, Hui Wang, Wei Wang, Hong Qin, Huanmin Wang, Xiaoli Ma, Xiaolin Wang*, Jingang Gui*. The increased IL-17-producing γδT cells promote tumor cell proliferation and migration in neuroblastoma, Clin Immunol, 2020, 211: 108343.
9. Xiaolin Wang, Wenjun Mou, Wei Han, Yue Xi, Xi Chen, Hui Zhang, Hong Qin, Huanmin Wang, Xiaoli Ma, Jingang Gui*. Diminished cytolytic activity of γδ T cells with reduced DNAM-1 expression in neuroblastoma patients. Clin Immunol. 2019, 203:63-71.
10. Xiaolin Wang, Ting Li, Yingying Cheng, Pingzhang Wang, Wanqiong Yuan, Qiyao Liu, Fan Yang, Qiang Liu, Dalong Ma, Shigang Ding*, Jun Wang*, Wenling Han*, CYTL1 inhibits tumor metastasis with decreasing STAT3 phosphorylation, OncoImmunology, 2019, 18;8(5):e1577126.
11. Xiaolin Wang#, Wenjun Mou#, Zhan Qi, Xi Chen, Hui Zhang, Hong Jiao, Xiaojiao Wang, Yajuan Wang*, Jingang Gui*, Neonates are armed with deviated immune cell proportion and cytokine reduction but higher T cell proliferation potentiality, Acta Biochim Biophys Sin, 2018, 50(9): 934-937.
12. Xiaolin Wang, Ting Li, Wenyan Wang, Wanqiong Yuan, Huihui Liu, Yingying Cheng, Pingzhang Wang, Yu Zhang, Wenling Han*, Cytokine like-1 chemoattracts monocytes/macrophages via CCR2, J Immunol, 2016, 196(10): 4090-4099.
13. Xiaolin Wang, Huihui Liu, Wanqiong Yuan, Yingying Cheng, Wenling Han*. Efficient production of CYTL1 protein using mouse IgGκ signal peptide in the CHO cell expression system. Acta Biochim Biophys Sin. 2016 Apr;48(4):391-4.
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