目前主持国家自然科学基金面上项目1项，北京市自然科学基金1项。

作为课题负责人先后主持国家自然科学基金3项，北京市自然科学基金1项，北京市医管局科研培育计划1项和院级课题1项。作为课题骨干参加国家重点研发计划1项，国家自然科学基金重点项目1项、国际自然科学基金重点国际合作项目1项和国家自然科学基金2项。

近五年内发表的主要论文： 

1: High bicarbonate concentration increases glucose-induced insulin secretion in pancreatic b-cells. Biochemicaland Biophysical Research Communications. 2022,589:165-172. YingChao Zhang#, FengRan Xiong#, YingYingWang, Han Shen , RuXuan Zhao , Sen Li , Jing Lu*, JinKui Yang* SCI(IF=3.32)

2: Single-cell heterogeneity analysis and CRISPR screens in MIN6 cell line reveal transcriptional regulators ofinsulin. Cell cycle. 2022,19:2053-2065. Ruxuan Zhao#, Jing Lu#, Qi Li, Fengran Xiong, Yingchao Zhang, JuanjuanZhu, Gongxin Peng, Jinkui Yang* SCI(IF=5.17)

3: Cisapride induced hypoglycemia via the KCNH6 potassium channel. Frontiers in Endocrinology. 2022,13:1-12.Jing Lu#,TingTing Shi#, ShaSha Yuan,RongRong Xie,RuXuan Zhao,JuanJuan Zhu,JinKui Yang* SCI(IF=5.05)

4: A Higher Serum Anion Gap Is Associated with the Risk of Progressing to Impaired Fasting Glucose andDiabetes. International Journal of Endocrinology . 2021,1:1-6. Yingchao Zhang, Fengran Xiong , Ruxuan Zhao ,Tingting Shi , Jing Lu*, Jinkui Yang* SCI(IF=3.29)

5: The dual role of RFX6 in directing β cell development and insulin production. Journal of MolecularEndocrinology. 2021,66(2):129-140. Jing Lu, Cheng Cheng,ZhenChao Cheng,Qian Wu, Han Shen, Mingxia Yuan,Bo Zhang, JinKui Yang* SCI(IF=5.09)

6: KCNH6基因肝脏特异性敲除小鼠的构建及其初步应用. 首都医科大学学报. 2020,41(1):8-13. 卢晶，李奇，朱晓蓉，谢荣荣，杨金奎* 核心期刊

7: Effect of KCNH6 on Hepatic Endoplasmic Reticulum Stress and Glucose Metabolism. Hormone and MetabolicResearch. 2020,52(9):669-675. Jing Lu, Han Shen, Qi Li,FengRan Xiong, MingXia Yuan, JinKui Yang*SCI(IF=2.94)

8: KCNH6 protects pancreatic β cells from endoplasmic reticulum stress and apoptosis. Faseb journal.2020,34(34):15015-15028. Jing Lu#, Han Shen#, Qi Li, Fengran Xiong, Rongrong Xie, Mingxia Yuan, Jinkui Yang*SCI(IF=5.39)

9: From Hyper- to Hypoinsulinemia and Diabetes: Effect of KCNH6 on Insulin Secretion. Cell Reports.2018,25:3800–3810. JinKui Yang#*, Jing Lu#, ShaSha Yuan#, Asan#,Qian Li, CuiPing Liu,Qian Wu,YuHui Wang,HaiXia Huang, Abudurexiti Kayoumu,JianPing Feng, RongRong Xie, XiaoRong Zhu,Chang Liu, GuangRan Yang,MingRong Zhang,ChunLan Xie,Chen Chen,Bo Zhang, George Liu, XiuQing Zhang, and Aimin Xu SCI(IF=8.03) 

10. Zhang C, Zhang X, Zhang Q, Zhao R, Xiong F, Wei G, Ke X, Lu J*. Dihydroberberine normalizes insulin secretion by regulating glucokinase. Diabetes Obes Metab. 2026 Jan;28(1):151-165. doi: 10.1111/dom.70171. Epub 2025 Oct 13. PMID: 41077968.(IF=5.7)

11.Xiong FR, Zhu JJ, Zhu XR, Lu J*, Yang JK*. Low-dose quinine targets KCNH6 to potentiate glucose-induced insulin secretion. J Mol Cell Biol. 2025 May 22;16(11):mjae051. doi: 10.1093/jmcb/mjae051. PMID: 39848918; PMCID: PMC12120441.(IF=5.9)

12.Lu J#, Xiong F#, Zhang Q, Zhao R, Zhang C, Wei G, Yang J. The contrasting effects of two antimalarial drugs on insulin secretion. Cell Mol Life Sci. 2025 Nov 25;82(1):419. doi: 10.1007/s00018-025-05933-0. PMID: 41288707; PMCID: PMC12647422.(IF=8.2)

13. Wang W#, Zhang Q#, Lu J*, Zhou L*. Transcriptome Sequencing Identifies PCK1 and IRS4 as Key Regulators of Gestational Diabetes Mellitus in Placenta: A Pilot Study. Diabetes Metab Syndr Obes. 2025 Oct 27;18:3985-3997. doi: 10.2147/DMSO.S542175. PMID: 41179578; PMCID: PMC12577461.(IF=2.9)

14.Lu J#, Zhao RX#, Xiong FR, Zhu JJ, Shi TT, Zhang YC, Peng GX, Yang JK. All-potassium channel CRISPR screening reveals a lysine-specific pathway of insulin secretion. Mol Metab. 2024 Feb;80:101885. doi: 10.1016/j.molmet.2024.101885. Epub 2024 Jan 19. PMID: 38246588; PMCID: PMC10847698.(IF=7)

15.Xiong FR#, Lu J#, Zhu JJ, Zhao RX, Zhang YC, Yang JK. KCNH6 is essential for insulin secretion by regulating intracellular ER Ca²⁺ store. FASEB J. 2024 Feb 29;38(4):e23490. doi: 10.1096/fj.202302194RR. PMID: 38363581.(IF=4.5)