个人信息
Personal Information
联系方式
Contact Information
个人简介
Personal Profile
副教授、硕士生导师。
博士，毕业于北京大学医学部基础医学（八年制）专业。长期从事主动脉瘤、主动脉夹层等血管重塑性疾病发病机制的基础和临床研究工作。先后主持国家自然科学基金青年项目、国家自然科学基金面上项目、北京市自然科学基金面上项目等。已在心血管领域发表SCI论文20余篇，其中以第一或通讯作者身份在Cell Death&Disease、JAHA、Aging&Disease、iScience等期刊发表论文。获批国家发明专利三项，实用新型专利一项。指导团队获得第八届“全国大学生基础医学创新研究暨实验设计论坛”总决赛（基础临床赛道）优秀成果奖（国家级），第十四届“挑战杯”秦创原中国大学生创业计划竞赛国赛铜奖。
团队依托心血管疾病精准医学北京实验室，拥有首都医科大学基础医学院生理学与病理生理学系和附属北京安贞医院临床样本库等资源，主要从事主动脉疾病、心肌病等重大心血管疾病的基础和临床研究工作。
北京市自然科学基金面上项目，主持，2023.1-2025.12
国家自然科学基金面上项目，主持，2023.1-2026.12
国家自然科学基金青年项目，主持，2020.1-2022.12
北京市自然科学基金面上项目，主持，2023.1-2025.12
国家自然科学基金面上项目，主持，2023.1-2026.12
国家自然科学基金青年项目，主持，2020.1-2022.12
1. Jinzhang Li#, Meili Wang#, Maozhou Wang, He Sang, Wei Wang, Ming Gong*, Hongjia Zhang*. Bradykinin induces acute kidney injury after hypothermic circulatory arrest through the repression of the Nrf2-xCT pathway. iScience. 2024 May 22;27(6):110075.
2. Xin F#, Cheng Y#, Wen X#, Zhang J, Shi X, Liu P, Ren J, Lu W, Liu F, Li Z, Yan X, Wang W, Wang M*, Huang H*. BK Channel Depletion Promotes Adipocyte Differentiation by Activating the MAPK/ERK Pathway. Stem Cells. 2024 Feb 8;42(2):146-157.
3. Xi Zhang, Bingjie Li, Yingshuo Yan, Fei Sun, Suli Zhang, Meili Wang*, Huirong Liu*. AT1R autoantibody promotes phenotypic transition of smooth muscle cells by activating AT1R-OAS2. Biochem Pharmacol. 2024 Jan:219:115977.
4. Xiaohui He#, Jing Wang#, Yuan Xue#, Shipan Wang, Yanjun Dong*, Hongjia Zhang*, Meili Wang*. Mammalian sterile 20-like kinase 1 acts as a candidate biomarker of mortality ofemergency surgical repair for acute type a aortic dissection. BMC Cardiovasc Disord. 2023 Apr 10;23(1):188.
5. Haiyan Zhao#, Ping Liu#, Xu Zha, Sitao Zhang, Jiaqi Cao, Hua Wei, Meili Wang, Haixia Huang*, Wei Wang. Integrin ligands block mechanical-signal transduction in baroreceptors. Life Science Alliance. 2022 Dec 20;6(3):e202201785.
6. Meili Wang#, Shuanglei Li#, Hongshan Liu, Mingyuan Liu, Jin Zhang, Yang Wu, Cangsong Xiao*, Haixia Huang*. Large-conductance Ca2+-activated K+ channel β1-subunit maintains the contractile phenotype of vascular smooth muscle cells. Front Cardiovasc Med. 2022 Dec 9;9:1062695.
7. Meili Wang, Xiaochen Yin, Shuanglei Li, Xi Zhang, Ming Yi, Chunyu He, Xiaoyue Li, Wei Wang, Suli Zhang*, Huirong Liu*. Large-Conductance Calcium-Activated Potassium Channel Opener, NS1619, Protects Against Mesenteric Artery Remodeling Induced by Agonistic Autoantibodies Against the Angiotensin II Type 1 Receptor. J Am Heart Assoc. 2022 Feb 15;11(4):e024046.
8. Jie Ren#, Yuan Cheng#, Xinxin Wen, Ping Liu, Feng Zhao, Fang Xin, Meili Wang, Haixia Huang*, Wei Wang*. BKCa channel participates in insulin-induced lipid deposition in adipocytesby increasing intracellular calcium. J Cell Physiol. 2021 Aug;236(8):5818-5831.
9. Yi Fu#, Yaqian Huang#, Zhao Yang#, Yufei Chen, Jingang Zheng, Chenfeng Mao, Zhiqing Li, Zhixin Liu, Bing Yu, Tuoyi Li, Meili Wang, Chanjuan Xu, Yiwei Zhou, Guizhen Zhao, Yiting Jia, Wei Guo, Xin Jia, Tao Zhang, Li Li, Ziyi Liu, Shengchao Guo, Mingliang Ma, Heng Zhang, Bo Liu, Junbao Du, Wengong Wang, Chaoshu Tang, Pei Gao, Qingbo Xu, Xian Wang, Jianfeng Liu, Jinpeng Sun*, Wei Kong*. Cartilage oligomeric matrix protein is an endogenousβ-arrestin-2-selective allosteric modulator of AT1 receptor counteractingvascular injury. Cell Res. 2021 Jul;31(7):773-790.
10. Meili Wang, Xiaochen Yin, Suli Zhang, Chenfeng Mao, Ning Cao, Xiaochun Yang, Jingwei Bian, Weiwei Hao, Qian Fan, Huirong Liu*. Autoantibodies against AT1 Receptor Contribute to Vascular Aging and Endothelial Cell Senescence. Aging Dis. 2019 Oct 1;10(5):1012-1025.
11. Yiting Jia#, Meili Wang#, Chenfeng Mao, Fang Yu, Yingbao Wang, Rui Xiao, Changtao Jiang, Lemin Zheng, Qingbo Xu, Ming Zheng, Yi Fu, Qinghua Hu, Wei Kong*. COMP-prohibitin2 interaction maintains mitochondrial homeostasis and controls smooth musclecell identity. Cell Death Dis. 2018 Jun 4;9(6):676.
文件上传中...
