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王香明，男，首都医科大学基础医学院副教授。本科毕业于烟台大学，博士毕业于北京大学（导师朱作言院士），博士期间在加州大学圣克鲁斯分校金亦石院士实验室进行访问研究，随后在中国中医科学院开展博士后研究（合作导师李连达院士）。2010年至2022年任职于中国科学院生物物理所，2022年10月入职首医。长期从事神经发育和退行性疾病机制研究，以第一或通讯作者在Dev. Cell、Nat. Commun.(两篇）、PNAS（两篇）、ACS ami、Nano Research、Cell reports、PLoS genet.、Eur J Med Chem、JCS等发表SCI 论文10多篇，授权发明专利两项，入选中科院青年创新促进会会员。获得国家自然科学基金、北京市自然基金，中科院先导项目，首都医科大学优秀青年人才项目A类（首都医学青年创新学者）等资助。Innovation (影响因子32.1）杂志青年编委，Innovation life杂志联合创始人，Review Editor of Frontiers in Cell and Developmental Biology。
神经退行性疾病是神经元功能和结构的逐渐丧失导致认知障碍（如痴呆）、运动异常等。随着老龄化的加剧,神经退行性疾病患病人数逐年上升。目前神经退行性疾病的发病机制尚未明晰,治疗药物很少,且仅能缓解症状，无法逆转或阻止神经元的丧失。神经退行性疾病是全球主要致残原因之一，也是仅次于心血管疾病的第二大致死原因，给患者、家庭及社会带来了极大的痛苦和沉重的负担。因此开展神经退行性疾病研究,探索疾病发生发展机制,寻找有效的早期诊断、预防和治疗具有重要现实意义。本课题组利用模式生物线虫、小鼠等构建了阿尔兹海默症（AD），帕金森症（PD），肌萎缩侧索硬化症（ALS）等模型，开展基因、药物、益生菌等筛选，并探究机制，最终进行转化。
首医优秀青年人才项目A类
Innovation (影响因子32.1）杂志青年编委
Innovationlife 联合创始人
Feiyan Zhu, Jiuyang He,Lingfei Kong, Zhanjun Guo, Pengpeng Liang, Jianlin Zhang*, Xiangming Wang*,and Minmin Liang*，H-ferritin: A new cytoprotective antioxidant strategy via detoxificationof hydrogen peroxide to oxygen, 2025. Nano Research.
Wenqian Wang#, Mingqin Qu#,Tong Zhang#, Yang Wang#, Ceping Zheng#, Fuping Lu, Xiangming Wang*Fufeng Liu*, 2025. A microbiome war in our gut. The Innovation Life3:100111.
Zhengdi Wang, Hailong Wen,Ceping Zheng, Xiangming Wang*, Sijie Yin*, Ningning Song*, Minmin Liang*,Synergistic Co-Cu Dual-Atom Nanozyme with Promoted Catalase-like Activity forParkinson's Disease Treatment. ACS Appl Mater Interfaces. 2024Dec 17.
Xiangming Wang*. and Kang Shen*. 2024. Newscissor for lysosome. The Innovation Life. 2(2).
Z. Cui#, F.Y. Guo#, L. Li, F. Lu,C.H. Jin*, X. Wang*, F. Liu*, Brazilin-7-acetate, a novel potential drug ofParkinson's disease, hinders the formation of alpha-synuclein fibril, mitigatescytotoxicity, and decreases oxidative stress, Eur J Med Chem 264 (2024) 115965.
Xie J, Zou W, Tugizova M, Shen K*, Wang X*, MBL-1 and EEL-1 affect the splicing and protein levels of MEC-3 to control dendrite complexity. 2023, PLoS Genet19(9): e1010941.
Qin Q, Shen K*, Wang X*,Targeting and surveillance mechanisms for tail-anchored proteins. 2023, The Innovation Life 1 (1), 100013-1-100013-6.
Deng H#, Qiao X#, Xie T, Fu W, Li H, Zhao Y, Guo M, Feng Y, Chen L, Zhao Y, Miao L, Chen C*, Shen K*, and Wang X*, SLC-30A9 is required for Zn2+ homeostasis, Zn2+ mobilization, and mitochondrial health, 2021, Aug 31, Proc Natl Acad Sci USA, 118(35): e2023909118.
Zhao Y,Song E,Wang W, Hsieh C, Wang X, Feng W*, Wang X*,Shen K*, Metaxins are core components of mitochondria transport adaptor complexes, 2021, Nat Commun.12(1): 83.
Qin Q, Zhao T, Zou W, Shen K*, Wang X*, An endoplasmic reticulum (ER) ATPase safeguards ER identity by removing ectopically localized mitochondrial proteins. 2020, Cell Rep. VOLUME 33, ISSUE 6, 108363.
Liu X, Guo X, Niu L,Li X, Sun F, Hu J, Wang X*,Shen K*, Atlastin-1 regulates morphology and function of endoplasmic reticulum in dendrites. 2019, Nat Commun.4;10(1):568.
Ting Zhu#, Xing Liang#, Xiangming Wang*, Kang Shen*.Dynein and EFF-1 control dendrite morphology by regulating the localization pattern of SAX-7 in epidermal cells.J Cell Sci..2017.130(23).4063-4071.
Xing Liang, Xintong Dong, Moerman, D. G., Kang Shen*, and Xiangming Wang*.Sarcomeres Pattern Proprioceptive Sensory Dendritic Endings through UNC-52/Perlecan in C. elegans.Dev. cell.2015.33(4).388-400.
Xiangming Wang, Fanli Zhou, Sijing Lv, Peishan Yi, Zhiwen Zhu, Yihong Yang, Guoxin Feng, Wei Li, and Guangshuo Ou*.Transmembrane protein MIG-13 links the Wnt signaling and Hox genes to the cell polarity in neuronal migration.Proc Natl Acad Sci U S A..2013.110(27).11175-11180.
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