1. 首都医科大学优秀青年人才项目（B类），中药对天然免疫的双向调节作用，2024.01-2026.12，100万元，在研，主持。

2. 首都医科大学院级引进人才项目，基于天然免疫的中药“毒效”转化研究，2022.05-2027.05，50万元，在研，主持。

3. 首都卫生发展科研专项青年优才项目，基于天然免疫通路NLRP3炎症小体的甘草“和诸药、解百毒”的生物学机制研究，2022.01-2024.12，25万元，在研，主持。

4. 中国博士后科学基金面上项目，基于NLRP3炎症小体研究苍耳亭对NASH的防治作用及机制，2020.08-2022.08，8万元，结题，主持。

5. 国家自然科学基金青年科学基金项目，甘草中刺甘草查尔酮靶向NLRP3炎症小体的作用及其机制研究，2020.01-2022.12，21万元，结题，主持。

6. 解放军总医院首届军事医学青年专项，中药小分子鼠尾草酚靶向炎症小体的作用机制及意义研究，2019.11-2021.11，10万元，结题，主持。

重要学术论文：

(1) Guang Xu#; Ting Li#; Jiayi Chen;Changyan Li; Haixin Zhao; Chengcheng Yao; Hua Dong; Kaiqing Wen; Kai Wang; JieZhao; Qing Xia; Tao Zhou; Huafeng Zhang; Ping Gao; Ailing Li*; Xin Pan*.Autosomal dominant retinitis pigmentosa-associated gene PRPF8 is essential forhypoxia-induced mitophagy through regulating ULK1 mRNA splicing, Autophagy,2018; 14(10): 1818~1830.

(2) Yuanyuan Chen#; Ruisheng Li#; Zhilei Wang; Xiaorong Hou;Chunyu Wang; Yongqiang Ai; Wei Shi; Xiaoyan Zhan; Jia-bo Wang; Xiaohe Xiao;Zhaofang Bai; Hongsheng Sun*; Guang Xu*. Dehydrocostus lactone inhibits NLRP3inflammasome activation by blocking ASC oligomerization and preventsLPS-mediated inflammation in vivo, Cellular Immunology, 2020, 349:104046.

(3) Guang Xu#; Shubin Fu#; Xiaoyan Zhan#;Zhilei Wang#; Ping Zhang; Wei Shi; Nan Qin; Yuanyuan Chen; Chunyu Wang; MingNiu; Yuming Guo; Jiabo Wang; Zhaofang Bai*; Xiaohe Xiao*. Echinatin effectivelyprotects against NLRP3 inflammasome-driven diseases by targeting HSP90, JCIInsight, 2021, 6(2):134601.

(4) Lutong Ren#, Qiang Li#, Hui Li#,Xiaoyan Zhan, Ruichuang Yang , Zhiyong Li, Zhie Fang, Tingting Liu , Ziying Wei, Jia Zhao, Li Lin, Wenqing Mou, Wenzhang Dai, Zhaofang Bai*, Guang Xu*,Junling Cao*. Polysaccharide extract from Isatidis Radix inhibits multipleinflammasomes activation and alleviate gouty arthritis. Phytotherapy Research,2022 Jun 6. doi: 10.1002/ptr.7514.

(5) Wenqing Mu#, Guang Xu#*, Ziying Wei#, Zhilei Wang, Qin Qin,Li Lin, Lutong Ren, Tingting Liu, Zhie Fang, Yan Yang, Jing Zhao, Junnan Wang,Xiaoyan Zhan, Xiaohe Xiao*, Zhaofang Bai*. The role of NLRP3 inflammasome inpsychotropic drug-induced hepatotoxicity. Cell Death Discovery, 2022; 8:313.doi:10.1038/s41420-022-01109-y.

(6) Hongbin Liu#, Xiaoyan Zhan#*, GuangXu#, Zhilei Wang, Ruisheng Li, Yan Wang, Qin Qin, Wei Shi, Xiaorong Hou,Ruichuang Yang, Jian Wang*, Xiaohe Xiao*, Zhaofang Bai*. Cryptotanshinonespecifically suppresses NLRP3 inflammasome activation and protects againstinflammasome-mediated diseases[J]. Pharmacological Research, 2021; 164:105384.

(7) Yuan Gao#; Guang Xu#; Li Ma#; Wei Shi#; Zhilei Wang; XiaoyanZhan; Nan Qin; Tingting He; Yuming Guo; Ming Niu; Jiabo Wang; Zhaofang Bai*;Xiaohe Xiao*. Icariside I specifically facilitates ATP or nigericin-inducedNLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity, CellCommunication and Signaling, 2021, 19(1): 13.

(8) Nan Qin#, Guang Xu#, Yan Wang#,Xiaoyan Zhan, Yuan Gao, Zhilei Wang, Shubin Fu, Wei Shi, Xiaorong Hou, ChunyuWang, Ruisheng Li, Yan Liu, Jiabo Wang, Haiping Zhao*, Xiaohe Xiao*, ZhaofangBai*. Bavachin enhances NLRP3 inflammasome activation induced by ATP ornigericin and causes idiosyncratic hepatotoxicity, Frontiers of Medicine, 2021;15(4):594-607.

(9) Zhilei Wang#; Guang Xu#; Hongbo Wang#; Xiaoyan Zhan; YuanGao; Nian Chen; Ruisheng Li; Xueai Song; Yuming Guo; Ruichuang Yang; Ming Niu;Jiabo Wang; Youping Liu*; Xiaohe Xiao*; Zhaofang Bai*. Icariside II, a maincompound in Epimedii Folium, induces idiosyncratic hepatotoxicity by enhancingNLRP3 inflammasome activation. Acta Pharmaceutica Sinica B, 2020;10(9):1619-1633.

(10) Wei Shi#; Guang Xu#; Xiaoyan Zhan#; Yuan Gao#; Zhilei Wang;Shubin Fu; Nan Qin; Xiaorong Hou; Yongqiang Ai; Chunyu Wang; Tingting He;Hongbin Liu; Yuanyuan Chen; Yan Liu; Jiabo Wang; Ming Niu; Yuming Guo; XiaoheXiao*; Zhaofang Bai*. Carnosol inhibits inflammasome activation by directlytargeting HSP90 to treat inflammasome-mediated diseases, Cell Death andDisease, 2020; 11(4):252.

(11) Zhilei Wang#; Guang Xu#; Yuan Gao#; Xiaoyan Zhan; Nan Qin;Shubin Fu; Ruisheng Li; Ming Niu; Jiabo Wang; Youping Liu*; Xiaohe Xiao*;Zhaofang Bai*. Cardamonin from a medicinal herb protects against LPS-inducedseptic shock by suppressing NLRP3 inflammasome, Acta Pharmaceutica Sinica B,2019; 9(4):734–744.

(12) Zhilei Wang#; Guang Xu#; Xiaoyan Zhan#; Youping Liu#; YuanGao; Nian Chen; Yuming Guo; Ruisheng Li; Tingting He; Xueai Song; Ming Niu;Jiabo Wang; Zhaofang Bai*; Xiaohe Xiao*. Carbamazepine promotes specificstimuli-induced NLRP3 inflammasome activation andcauses idiosyncratic liver injury in mice, Archives of Toxicology, 2019;93(12):3585-3599.