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王珊珊,副教授,硕士生导师;北京市第十二届青年联合会委员;中华医学会肝病学分会委员;从事肝脏疾病相关的基础与临床研究。主要研究方向是终末期肝病的机制研究。获国家自然科学基金,北京市自然科学基金和中德科学中心等多项基金支持。研究成果发表在 J HEPATOL, HEPATOLOGY及CELL DEATH DIS等国际期刊上;
1. 北京市医院管理中心,青苗人才项目,QML20211701,肝脏中CSE/H2S轴促进肝癌细胞凋亡及潜在治疗靶点的研究,6万,在研,主持
2. 中德科学中心(中国国家自然科学基金委员会(NSFC)和德国科学基金会(DFG)),中德合作交流项目,M-0200, 肝脏微环境调控原发性肝脏肿瘤的机制研究,150万元,在研,主持。
3. 北京市自然科学基金委员会,面上项目,7212052,肝脏免疫微环境通过上调肝始祖细胞中HNF4a从而参与调控肝脏再生的分子机制,20万元,在研,主持。
4. 国家自然科学基金委员会,面上项目,81870424,肝星状细胞通过分泌维甲酸促进肝始祖细胞增殖的分子机制,结题,主持。
5. 国家自然科学基金委员会,青年项目,81401970,在肝癌中甲胎蛋白参与调控细胞自噬的分子机制及其意义,结题,主持。
1. WangY*, Che Y*, Wang S*, et al. ASPP2reduction attenuates HBV induced chronic liver damage: A hybrid mouse modelstudy. Biochem Biophys Res Commun. 2022;610:61-69.doi:10.1016/j.bbrc.2022.03.109
2. MaY*, Wang S*, Wu Y, et al. Hepaticstellate cell mediates transcription of TNFSF14 in hepatocellular carcinomacells via H2S/CSE-JNK/JunB signaling pathway. Cell Death Dis. 2022;13(3):238.Published 2022 Mar 15. doi:10.1038/s41419-022-04678-z
3. LinT*, Wang S*, Munker S*, et al.Follistatin-controlled activin-HNF4α-coagulation factor axis in liverprogenitor cells determines outcome of acute liver failure. Hepatology.2022;75(2):322-337. doi:10.1002/hep.32119
4. Wang S*, Sun Y*, WangY*, et al. ASPP2 inhibits hepatitis B virus replication by preventing nucleustranslocation of HSF1 and attenuating the transactivation of ATG7. J Cell MolMed. 2021;25(14):6899-6908. doi:10.1111/jcmm.16699
5. Wang S, Kou B,Chai M, et al. Knockout of ASPP2 promotes DEN-induced hepatocarcinogenesis viathe NF-κB pathway in mice. Cancer Gene Ther. 2022;29(2):202-214.doi:10.1038/s41417-021-00300-0
6. Wang S , Feng R ,Shi Y , et al. Intracellular alpha-fetoprotein interferes with all-transretinoic acid induced ATG7 expression and autophagy in hepatocellular carcinomacells. Sci Rep. 2021;11(1):2146. Published 2021 Jan 25.doi:10.1038/s41598-021-81678-7
7. Wang S, Zhu M,Wang Q, et al. Alpha-fetoprotein inhibits autophagy to promote malignantbehaviour in hepatocellular carcinoma cells by activating PI3K/AKT/mTORsignaling. Cell Death Dis. 2018 Oct 9;9(10):1027. doi:10.1038/s41419-018-1036-5.
8. Wang S, Cui S,Zhao W, et al. Screening and bioinformatics analysis of circular RNA expressionprofiles in hepatitis B-related hepatocellular carcinoma. Cancer Biomark. 2018Jun 8, online. doi: 10.3233/CBM-170910.
9. Wang S , Chen Y H,Ning C, et al. Hydrogen sulfide promotes autophagy of hepatocellular carcinomacells through the PI3K/Akt/mTOR signaling pathway[J]. Cell Death & Disease,2017, 8(3):e2688.
10. Wang S, JiangW, Chen X, et al. Alpha-fetoprotein acts as a novel signal molecule andmediates transcription of Fn14 in human hepatocellular carcinoma. J Hepatol.2012;57(2):322-329. doi:10.1016/j.jhep.2012.03.029.
11. LiP*, Wang SS*, Liu H, et al. Elevated serum alpha fetoproteinlevels promote pathological progression of hepatocellular carcinoma. World JGastroenterol. 2011;17(41):4563-4571. doi:10.3748/wjg.v17.i41.4563.
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