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2021-10 – 至今，首都医科大学基础医学院，副教授
● 研究 LSD、DMT、裸盖菇素等致幻剂诱导啮齿类动物认知改变的神经机制，以及其在自闭症动物模型中促进社会行为的潜在作用机理。
● 探究小鼠垂体分泌激素对自闭症及抑郁症相关行为障碍改善的分子及神经环路调控机制。
2016/08 - 2021/06，Case Western Reserve University，博士及博士后
● 阐明 CUL3 通过促进 Cap 依赖的蛋白翻译破坏皮层兴奋-抑制平衡，从而诱发社交缺陷和焦虑样行为的新功能。该研究已被 Neuron 杂志作为封面文章发表（Neuron, 105: 475-490, 2020），并被 Chen & Maher（Neuron, 105: 398-399, 2020） 评论。
● 探索脊髓背侧一类 ErbB4 阳性神经元的新作用，发现它们对热痛觉至关重要，可以通过激活 ErbB4 配体 NRG1 或通过抑制剂抑制 ErbB4 操纵热痛觉。该研究已被 Neuron 杂志发表（Neuron, 110: 2315-2333, 2022）并被 Yu 等（Neuron, 110: 2206-2208, 2022）评论。
● 发现雄性小鼠体内垂体分泌的某激素的新功能，以及在自闭症模型中该激素是如何促进社会行为的，并在雄性小鼠体内证明其亲社会行为作用（投稿中）。
近5年在 Neuron、Molecular Psychiatry、Journal of Clinical Investigation、PNAS、Current Biology、eLife、Journal of Neuroscience等期刊发表SCI学术论文14篇，累计影响因子>150。 以第一作者（含并列）发表Neuron论文2篇。入选北京市海聚工程青年人才项目。
1. Wang H#, Chen W#, Dong Z#, Xing G, Cui W, Yao L, Zou W, Robinson H, Bian Y, Liu Z, Zhao K, Luo B, Yu Z, Meixiong J, Xiong WC, Mei L (2022) A novel spinal neuron connection for heat sensation. Neuron 110, 2315-2333 e6. (# equally contributed)
2. Wang, H., Cui, W., Chen, W., Liu, F., Dong, Z., Xing, G., Luo, B., Gao, N., Zou, W.J., and Zhao, K., et al. (2021). The laterodorsal tegmentum-ventral tegmental area circuit controls depression-like behaviors by activating ErbB4 in DA neurons. Mol Psychiatry. doi:10.1038/s41380-021-01137-7.
3. Cui W, Gao N, Dong Z, Shen C, Zhang H, Luo B, Chen P, Comoletti D, Jing H, Wang H, Robinson H, Xiong WC, Mei L (2021) In trans neuregulin3-Caspr3 interaction controls DA axonal bassoon cluster development. Curr Biol. 31(15):3330-3342.
4. Chen W, Luo B, Gao B, Li H, Wang H, Li L, Cui W, Zhang L, Sun D, Liu F, Dong Z, Ren X, Zhang H, Su H, Xiong WC, Mei L (2021) Neddylation stabilizes Nav1.1 to maintain interneuron excitability and prevent seizures in murine epilepsy models. J Clin Invest. 131(8): e136956.
5. Dong Z#, Chen W#, Chen C, Wang H, Cui W, Tan Z, Robinson H, Gao N, Luo B, Zhang L, Zhao K, Xiong WC, Mei L (2020) CUL3 deficiency causes social deficits and anxiety-like behaviors by impairing excitation-inhibition balance through the promotion of Cap-dependent translation. Neuron 105, 475-490 e476. (Cover article). (# equally contributed)
6. Zhang H, Chen W, Tan Z, Zhang L, Dong Z, Cui W, Zhao K, Wang H, Jing H, Cao R, Kim C, Safar J, Xiong WC, Mei L (2020) A role of low-density lipoprotein receptor-related protein 4 (LRP4) in astrocytic Aβ clearance. J Neurosci 40 (28) 5347-5361.
7. Zhang L, Jing H, Li H, Chen W, Luo B, Zhang H, Dong Z, Li L, Su H, Xiong WC, Mei L (2020) Neddylation is critical to cortical development by directly regulating Wnt/β-catenin signaling. PNAS 117 (42), 26448-26459.
8. Yu H, Peng Y, Zhao Y, Lan Y, Wang B, Zhao L, Sun D, Pan J, Dong Z, Mei L, Ding Y, Zhu X, Xiong WC (2020) Myosin X interaction with KIF13B, a crucial pathway for Netrin-1-induced axonal development. J Neurosci 40 (48), 9169-9185.
9. Zhang H, Sathyamurthy A, Liu F, Li L, Zhang L, Dong Z, Cui W, Sun X, Zhao K, Wang H, Ho HH, Xiong WC, Mei L (2019) Agrin-Lrp4-Ror2 signaling regulates adult hippocampal neurogenesis in mice. Elife 8.
10. Xing G, Jing H, Zhang L, Cao Y, Li L, Zhao K, Dong Z, Chen W, Wang H, Cao R, Xiong WC, Mei L (2019) A mechanism in agrin signaling revealed by a prevalent Rapsyn mutation in congenital myasthenic syndrome. Elife 8.
11. Wang Y, Figueiredo D, Sun X, Dong Z, Chen W, Cui W, Liu F, Wang H, Li H, Robinson H, Fei E, Pan B, Li B, Xiong WC, Mei L (2018) Controlling of glutamate release by neuregulin3 via inhibiting the assembly of the SNARE complex. PNAS 115:2508-2513.
12. Wang H, Liu F, Chen W, Sun X, Cui W, Dong Z, Zhao K, Zhang H, Li H, Xing G, Fei E, Pan BX, Li BM, Xiong WC, Mei L (2018) Genetic recovery of ErbB4 in adulthood partially restores brain functions in null mice. PNAS 115:13105-13110.
13. Sun X, Chen W, Sun D, Huang J, Li Y, Pan J, Wang Y, Zhao K, Dong Z, Wang H, Xiong L, Xuan A, Zhao S, Pillai A, Xiong WC, Mei L (2018) Neogenin in amygdala for neuronal activity and information processing. J Neurosci. 38 (44):9600-9613.
14. Zhao K, Shen C, Li L, Wu H, Xing G, Dong Z, Jing H, Chen W, Zhang H, Tan Z, Pan J, Wang H, Cui W, Sun X, Li S, Huang X, Xiong WC, Mei L (2018) Sarcoglycan Alpha Mitigates Neuromuscular Junction Decline in Aged Mice by Stabilizing LRP4. J Neurosci. 38 (41), 8860-8873.
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