本课题组主要围绕抑郁症的生物标记物，尤其是肠道微生物，开展转化研究。基于临床队列样本，采用包括基因、转录、蛋白、代谢等多组学手段，发现跟疾病发生以及治疗相关的靶点，在此基础上，利用动物和细胞模型对相关靶点的进行验证及机制探索，以期挖掘出潜在的新药靶点。本课题组近几年来围绕抑郁症的“微生物-肠-脑”轴方面开展了一系列的基础和临床转化研究，已获批多项专利，开发的创新诊疗技术已进入临床验证阶段。

（1）首都临床特色诊疗技术研究及转化应用专项，Z221100007422049，菌群移植技术附加治疗抑郁症的随机双盲安慰剂对照研究，2022/11—2025/11，35万，主持；

（2）国家自然科学基金面上项目，82171526，解析调控Th17细胞分化的关键菌株及其导致抑郁的“肠-脑”轴机制，2022/01—2025/12，55万元，主持；

（3）北京市人才工作局北京市百千万人才工程培养资助，抑郁症的肠道微生物诊断试剂盒研发，2020A38，2021/01—2022/12，5.8万，主持；

（4）北京市优秀人才培养资助青年拔尖个人，2018000021223ZK36，2018/08—2021/08，50万元，主持；

（5）北京市医院管理中心“青苗”计划，QML20181901，东莨菪碱快速抗抑郁的作用机制研究，2019/01—2020/12，12万元，主持；

（6）国家自然科学基金青年项目，81601185，M2受体在东莨菪碱抗抑郁效应中的作用及机制研究，2017/01—2019/12，17万元，主持

1、基于量化评估的抑郁症治疗技术创新及推广应用，华夏医学科学技术奖一等奖，排名9/10，2022

2、抑郁症量化诊疗全病程技术体系的创建与应用。北京市科学技术进步奖二等奖，排名2/10，2024

1. Zuoli Sun#, Bowen Zhang#,Jingjing Zhou#, Yanting Luo, Xuequan Zhu, Yaping Wang, Yi He, Peng Zheng, LingZhang, Jian Yang*, Gang Wang*. Integrated Single-Cell RNA-seq andATAC-seq Reveals Heterogeneous Differentiation of CD4+ Naive T Cell Subsets isAssociated with Response to Antidepressant Treatment in Major DepressiveDisorder. Advanced Science, 2024, 11(30): e2308393.

2. YapingWang#, Jingjing Zhou#, Junbin Ye, Zuoli Sun, Yi He, Yingxin Zhao, Siyu Ren,Guofu Zhang, Min Liu, Peng Zheng, Gang Wang*, Jian Yang*. Multi-omicsreveal microbial determinants impacting the treatment outcome ofantidepressants in major depressive disorder. Microbiome, 2023, 11:195.

3. Haixia Wang#, Yi He#, Zuoli Sun, Siyu Ren, Mingxia Liu, Gang Wang*, Jian Yang*. Microglia in depression: an overview of microglia in thepathogenesis and treatment of depression. Journal of Neuroinflammation, 2022, 19:132.

4. Jingjing Zhou#, Jia Zhou#, Zuoli Sun, Lei Feng, Yuan Feng, Le Xiao,Xu Chen, Jian Yang*. The association of C-reactive protein withresponses to escitalopram antidepressant treatment in patients with majordepressive disorder. Journal of Affective Disorders, 2022, 306: 32-38.

5. Peng Zheng#, Jian Yang#, Yifan Li, Jing Wu, Weiwei Liang,Bangmin Yin, Xunmin Tan, Yu Huang, Tingjia Chai, Hanping Zhang, Jiajia Duan,Jingjing Zhou, Zuoli Sun, Xu Chen, Subhi Marwari, Jianbo Lai, Tingting Huang,Yanli Du, Peifen Zhang, Seth W. Perry, Ma‐Li Wong, Julio Licinio, Shaohua Hu*, PengXie*, Gang Wang*. Gut microbial signatures can discriminate unipolar from bipolardepression. Advanced Science, 2020, 7(7): p. 1902862. 

6. Jian Yang#, Peng Zheng#, Yifan Li, Jing Wu, Xunmin Tan, Jingjing Zhou, ZuoliSun, Xu Chen, Guofu Zhang, Hanping Zhang, Yu Huang, Tingjia Chai, Jiajia Duan,Weiwei Liang, Bangmin Yin, Jianbo Lai, Tingting Huang, Yanli Du, Peifen Zhang,Jiajun Jiang, Caixi Xi, Lingling Wu, Jing Lu, Tingting Mou, Yi Xu, Seth W.Perry, Ma-Li Wong, Julio Licinio, Shaohua Hu*, Gang Wang*, Peng Xie*. Landscapesof bacterial and metabolic signatures and their interaction in major depressivedisorders. Science Advances, 2020, 6 (49): eaba8555.  

7. Jian Yang#, Jingjing Zhou#, Jia Zhou, Haixia Wang, Zuoli Sun, Xuequan Zhu,Yi He, Albert H C Wong, Fang Liu*, Gang Wang*. Serum amyloid P component levelis associated with clinical response to escitalopram treatment in patients withmajor depressive disorder. Journal of Psychiatric Research, 2022, 146: 172-178.

8. JiaZhou#, Jingjing Zhou#, Lei Feng, Yuan Feng, Le Xiao, Xu Chen, Jian Yang*,Gang Wang*. The associations between depressive symptoms, functionalimpairment, and quality of life, in patients with major depression: undirectedand Bayesian network analyses. Psychological Medicine, 2022, 1-13.

9. Junfeng Wang#, Rui Lu#, Jian Yang#, Hongyu Li, Zhuohao He,Naihe Jing, Xiaomin Wang*, Yizheng Wang*. TRPC6 specifically interacts with APPto inhibit its cleavage by γ-secretase and reduce Aβ production. NatureCommunications, 2015, 6: 8876.