首都医科大学宣武医院衰老与再生研究中心成立于2017年，依托于首都医科大学宣武医院国家老年疾病临床医学研究中心，是一支基础研究与临床应用紧密结合、优势互补的研究队伍。王思研究员任中心执行主任，目前中心人员共13人，其中正高级职称2人、副高级职称2人、中级职称2人、初级职称7人；现有博士生导师1名，硕士生导师1名，在读博士生8名，在读硕士生8名。

      中心基于人类干细胞及模式动物（包括灵长类）衰老研究体系，联合基因编辑、单细胞及多层次组学分析等技术，开展器官及干细胞衰老的机制与干预研究，为衰老及相关疾病的干预提供了潜在的新型分子标志物以及干预靶标。在此基础上，团队探索并发展了一系列针对衰老及相关疾病的基因干预、细胞及衍生物干预、小分子干预、主动健康等新型干预手段，为衰老相关疾病的临床治疗提供新思路新路径，以期推动衰老及其相关疾病的基础研究向临床治疗的转化应用。

学术论文

1.    Lei J, Xin Z, Liu N, Ning T, Jing Y,Qiao Y, He Z, Jiang M, Yang Y, Zhang Z, Zhao L, Li J, Lv D, Yan Y, Zhang H,Xiao L, Zhang B, Huang H, Sun S, Zheng F, Jiang X, Lu H, Dong X, Yue S, Ma C,Shuai J, Ji Z, Liu F, Ye Y, Yan K, Hu Q, Xu G, Zhao Q, Wu R, Cai Y, Fan Y, JingY, Wang Q, Reddy P, Lu X, Zheng Z, Liu B, Haghani A, Ma S, Suzuki K, RodriguezEsteban C, Yang J, Song M, Horvath S, Zhang W, Li W, Xiang AP, Zhu L, Fu X,Zhao G, Belmonte JCI, Qu J*, Wang S*, Liu GH*. Senescence-resistanthuman mesenchymal progenitor cells counter aging in primates. Cell. 2025. 188(18):5039-5061.e35.

2.    Zhao Q, Jing Y, Jiang X, Zhang X,Liu F, Huang H, Zhang Z, Wang H, Sun S, Ma S, Zhang W, Yu Y, Fu X, Zhao G, Qu J*,Wang S*, Liu GH*. SIRT5 safeguards against primate skeletal muscleageing via desuccinylation of TBK1. Nature Metabolism. 2025. 7(3):556-573.

3.    Jing Y, Lu H, Li J, He Z, Zhao L,Zhang C, Huang Z, Liu L, Sun S, Ma S, Rodriguez Esteban C, Fu X, Zhao G,Izpisua Belmonte JC, Zhang W*, Qu J*, Wang S*, Liu GH*. Vitamin C conveysgeroprotection on primate ovaries. Cell Stem Cell. 2025. 32(11):1723-1740.e9.

4.    Sun G, He Z, Lv D, Wang Q, Xu G, LiuF, Wang P, Luo B, Zheng Y, Hu J, Sun S, Ma S, Esteban CR, Yang J, Fu X,Belmonte JCI, Zhang W*, Qu J*, Wang S*, Liu GH*. Reprogramming the GRHL2-CDK19axis by gene therapy alleviates prostate aging. Nature Aging. 2025. doi:10.1038/s43587-025-01020-y.

5.    Sun G, Fu X, Zheng Y, Hong G, Liu Z,Luo B, Lei J, Lv D, Chang M, Xiao Y, Guo S, Ma S, Lu L, Zhang W, Belmonte JCI,Qu J*, Wang S*, Chai R*, Liu GH*. Single-cell profiling identifies haircell SLC35F1 deficiency as a signature of primate cochlear aging. Nature Aging. 2025. 5(9):1862-1879.

6.    Sun G, Li K, Ping J, Zhao L, Cui C,Wu J, Xie L, Yao X, Xu G, Ma S, Fan Y, Wang Q, Yang D, Luo B, Liu H, Yang J,Zhang W, Song W, Zhao G, Fu X, Bian XW, Qu J*, Wang S*, Chen H*, Liu GH*.A single-cell transcriptomic atlas reveals senescence and inflammation in thepost-tuberculosis human lung. Nature Microbiology. 2025. 10(8):2073-2091.

7.    Zheng F, Lei J, He Z, Ning T, Sun S,Cai Y, Zhao Q, Ma S, Zhang W, Qu J*, Liu GH*, Wang S*. FOXO3-engineeredhuman mesenchymal stem cells efficiently enhance post-ischemic strokefunctional rehabilitation. Protein Cell. 2025. 16(5):365-373.

8.   Wang S*, Ren J, Jing Y, Qu J*, Liu GH*. Perspectives on biomarkersof reproductive aging for fertility and beyond. Nature Aging. 2024. 4(12):1697-1710.

9.    Lu H, Jing Y, Zhang C, Ma S, Zhang W,Huang D, Zhang B, Zuo Y, Qin Y, Liu GH*, Yu Y*, Qu J*, Wang S*. Aginghallmarks of the primate ovary revealed by spatiotemporal transcriptomics. Protein Cell. 2024. 15(5):364-384.

10.  Huang D, Zhao Q, Yang K, Lei J, JingY, Li H, Zhang C, Ma S, Sun S, Cai Y, Wang G, Qu J, Zhang W*, Wang S*, Liu GH*. CRL2APPBP2-mediated TSPYL2 degradation counteracts human mesenchymal stemcell senescence. SCIENCE CHINA Life Sciences. 2024. 67(3):460-474.

11.  Jing Y, Zuo Y, Sun L, Yu ZR, Ma S,Hu H, Zhao Q, Huang D, Zhang W, Belmonte JCI, Yu Y*, Qu J*, Liu GH*, Wang S*. SESN1 is a FOXO3 effector that counteracts human skeletal muscle ageing. Cell Proliferation. 2023. 56(5):e13455.

12.  Huang D, Zuo Y, Zhang C, Sun G, JingY, Lei J, Ma S, Sun S, Lu H, Zhang X, Cai Y, Zhang W, Gao F, Xiang A, BelmonteJCI, Liu GH*, Qu J*, Wang S*. A single-nucleus transcriptomic atlas ofprimate testicular aging reveals exhaustion of the spermatogonial stem cellreservoir and loss of Sertoli cell homeostasis. Protein Cell. 2023. 14(12):888-907.

13.  Wang S, Zheng Y, Li J, Yu Y, Zhang W, SongM, Liu Z, Min Z, Hu H, Jing Y, He X, Sun L, Ma L, Esteban CR, Chan P, Qiao J,Zhou Q, Izpisua Belmonte JC*, Qu J*, Tang F*, Liu GH*. Single-celltranscriptomic atlas of primate ovarian aging. Cell. 2020.180(3):585-600.

荣誉和奖项

1.    干细胞卓越青年研究员 2025

2.    北京市科学技术奖自然科学奖二等奖 2024

3.    中华医学科学技术奖二等奖 2022