在读硕士学生

贺奕捷，男，2023级博士研究生

胡舒缘，女，2023级博士研究生

张舒羽，女，2023级硕士研究生

高    姗，女，2022级博士研究生

朱    苹，女，2022级博士研究生

李    璇，女，2021级硕士研究生

吴诗杨，女，2022级硕士研究生

欢迎具有计算机科学与技术、生物信息学、基因组学、计算生物学等专业的本科、硕士研究生加入我们团队！

1、主持北京市自然科学基金杰出青年科学基金一项

项目编号：JQ21022，100万

项目名称：非编码区遗传变异增加中国人群阿尔茨海默病风险的机制研究

起止时间：2021年11月1日-2024年12月31日

主持，负责新一代高通量基因组和转录组数据处理与分析，在研中

2、主持国家自然科学基金面上项目一项

项目编号：82071212，55万

项目名称：APOC1基因非编码变异rs73052335增加阿尔茨海默病遗传风险的机制研究

起止时间: 2021年1月1日-2023年12月31日

主持，负责新一代高通量基因组和转录组数据处理与分析，在研中

3、主持国家自然科学基金青年科学基金项目一项

项目编号：81300945，23万

项目名称：整合基因组范围内的关联研究和新一代RNA-Seq数据识别阿尔茨海默疾病相关通路

起止时间: 2014年1月1日-2016年12月31日

主持，负责新一代高通量基因组和转录组数据处理与分析，已结题

4、主持北京市百千万人才工程A创新研发类项目一项

项目编号：2020A15，6.1万

项目名称：阿尔茨海默病遗传变异的调控机制研究

起止时间: 2020年12月-2022年12月

主持，负责新一代高通量基因组和转录组数据处理与分析，在研

论文列表 (*通讯作者，#第一作者)

2023年

1.       Yan Zhang, Haijie Liu, Haihua Zhang, Zhifa Han, Tao Wang,Longcai Wang, Guiyou Liu*. Causalassociation of genetically determined circulating vitamin D metabolites andcalcium with multiple sclerosis in participants of European descent. Eur JClin Nutr. 2023 Apr;77(4):481-489.（IF: 4.825）

2.       Shizheng Qiu, Keyang Zheng, Yang Hu*, Guiyou Liu*. Geneticcorrelation, causal relationship, and shared loci between vitamin D andCOVID-19: a genome-wide cross-trait analysis. J Med Virol. 2023;95:e28780.（IF: 20.693）

2022年

3.       Yang Hu, Yan Zhang, Haihua Zhang, Shan Gao, Longcai Wang, TaoWang, Zhifa Han, Bao-liang Sun, GuiyouLiu*. Cognitive performance protects against Alzheimer’s diseaseindependently of educational attainment and intelligence. Molecular Psychiatry. 2022Oct;27(10):4297-4306.（IF: 15.992）

4.       Haijie Liu, Yang Hu, Yan Zhang, Haihua Zhang, Shan Gao,Longcai Wang, Tao Wang, Zhifa Han, Bao-liang Sun, Guiyou Liu*. Mendelian randomization highlights significantdifference and genetic heterogeneity in clinically diagnosed Alzheimer’sdisease GWAS and self-report proxy phenotype GWAX. AlzheimersRes Ther.2022 Jan28;14(1):17.（IF: 9.037）

5.       Yang Hu, Yan Zhang, Haihua Zhang, Shan Gao, Longcai Wang, TaoWang, Zhifa Han, International Genomics of Alzheimer’s Project (IGAP), Guiyou Liu*. Mendelian randomizationhighlights causal association between genetically increased C-reactive proteinlevels and reduced Alzheimer’s disease risk. Alzheimers Dement. 2022Oct;18(10):2003-2006.（IF: 21.566）

6.       Feng Xue#, Luyan Gao#, TingTing Chen, Hongyuan Chen, HaihuaZhang, Tao Wang, Zhifa Han, Shan Gao, Longcai Wang, Yang Hu, Jiangwei Tang, LeiHuang, Guiyou Liu*, Yan Zhang*.Parkinson’s disease rs117896735 variant regulates INPP5F expression in brain tissues and increases risk ofAlzheimer’s disease. J AlzheimersDis. 2022;89(1):67-77.（IF: 4.472）

7.       Sijie Li, Bian Liu, Qing-Hao Li, Yan Zhang , Haihua Zhang, Shan Gao, Longcai Wang, Tao Wang, Zhifa Han, Guiyou Liu*, Kun Wang*. Evaluating theBidirectional Causal Association Between Daytime Napping and Alzheimer'sDisease Using Mendelian Randomization. J Alzheimers Dis. 2022;89(4):1315-1322.（IF: 4.472）

8.       Shizheng Qiu, YangHu*, Quan Zou*, Guiyou Liu*.Genetic variant rs9848497 up-regulates MST1R expression, thereby influencingleadership phenotypes. Proc Natl Acad Sci U S A. 2022 Jul19;119(29):e2207847119.（IF: 10.249）

9.       Wenbo Zhao, Fang Jiang, Sijie Li, Guiyou Liu, Chuanjie Wu, Yuang Wang, Changhong Ren, Jing Zhang, FeiGu, Quanzhong Zhang, Xinjing Gao, Zongen Gao, Haiqing Song , Qingfeng Ma,Yuchuan Ding, Xunming Ji*, RICH-1 Investigators. Safety and efficacy of remoteischemic conditioning for the treatment of intracerebral hemorrhage: Aproof-of-concept randomized controlled trial. Int J Stroke. 2022Apr;17(4):425-433.（IF: 5.266）

10.   Sijie Li, Wenbo Zhao, Guiyou Liu, Changhong Ren, Ran Meng, YuanWang, Haiqing Song, Qingfeng Ma, Yuchuan Ding, Xunming Ji*.Chronic remote ischemic conditioning for symptomatic internal carotid or middlecerebral artery occlusion: A prospective cohort study. CNS Neurosci Ther. 2022Sep;28(9):1365-1371.（IF: 7.035）

11.   Jiali Xu, Gary B Rajah, Houdi Zhang, CongHan, Xuxuan Shen, Bin Li, Zhengxing Zou, WenboZhao, Changhong Ren, GuiyouLiu, Yuchuan Ding, Qi Yang, Sijie Li*, Xunming Ji*. Imagingfeatures of adult moyamoya disease patients with anterior intracerebralhemorrhage based on high-resolution magnetic resonance imaging. JCereb Blood Flow Metab. 2022 Nov;42(11):2123-2133.（IF: 7.430）

12.   Peng Ren#, Wencai Ding#, SiyangLi, Guiyou Liu, Meng Luo, Wenyang Zhou, RuiCheng, Yiqun Li, Pingping Wang, Zhipeng Li, LifenYao, Qinghua Jiang*, Xia Liang*; Alzheimer's DiseaseNeuroimaging Initiative. Regional transcriptional vulnerability to basalforebrain functional dysconnectivity in mild cognitive impairment patients. NeurobiolDis. 2022 Dec 28;105983. （IF: 7.046）

2021年

13.   Yang Hu, Jing-yi Sun, Yan Zhang, Haihua Zhang, Shan Gao, TaoWang, Zhifa Han, Longcai Wang, Bao-liang Sun, Guiyou Liu*. rs1990622 variant associates with Alzheimer’s diseaseand regulates TMEM106B expression in human brain tissues. BMC Med. 2021 Jan19;19(1):11.（IF: 10.249）

14.   Jing-yi Sun, Haihua Zhang, Yan Zhang, Longcai Wang, Bao-liangSun, Feng Gao*, Guiyou Liu*. Impactof serum calcium levels on total body bone mineral density: A Mendelianrandomization study in five age strata. Clin Nutr. 2021 Mar25;40(5):2726-2733.（IF: 7.643）

15.   Haijie Liu, Yan Zhang, Yang Hu, Haihua Zhang, Tao Wang, ZhifaHan, Shan Gao, Longcai Wang, Guiyou Liu*.Mendelian randomization to evaluate the effect of plasma vitamin C levels onthe risk of Alzheimer’s disease. Genes & Nutrition. 2021 Oct29;16(1):19.（IF: 5.523）

16.   Haijie Liu, Yan Zhang, Haihua Zhang, Longcai Wang, Tao Wang,Zhifa Han, Liyong Wu*, Guiyou Liu*.Effect of plasma vitamin C levels on Parkinson’s disease and age at onset: aMendelian randomization study. J Transl Med. 2021 May 24;19(1):221.（IF: 8.440）

17.   Fan Chen, Yan Zhang, Longcai Wang, Tao Wang, Zhifa Han, HaihuaZhang, Shan Gao, Yang Hu*, Guiyou Liu*.PLCG2 rs72824905 variant reduces therisk of Alzheimer’s disease and multiple sclerosis. J Alzheimers Dis. 2021;80(1): 71-77.（IF: 4.472）

18.   Wenbo Zhao*, Jiali Xu, Sijie Li, Guiyou Liu, Longfei Wu, Chuanhui Li, Chuanjie Wu, Changhong Ren,Jian Chen, Jiangang Duan, Ruixian Wang, Haiqing Song , Qingfeng Ma, XunmingJi*. Low-dose tirofiban is associated with reduced in-hospital mortality incardioembolic stroke patients treated with endovascular thrombectomy. JNeurol Sci. 2021 Aug 15;427:117539.（IF: 4.553）

19.   Siyu Wei#, Junxian Tao#, Jing Xu#, XingyuChen, Zhaoyang Wang, Nan Zhang, Lijiao Zuo, ZheJia, Haiyan Chen, Hongmei Sun, Yubo Yan, MingmingZhang, Hongchao Lv, Fanwu Kong, Lian Duan, YeMa, Mingzhi Liao, Liangde Xu, Rennan Feng, Guiyou Liu, The EwasProject, Yongshuai Jiang*. Ten Years of EWAS. Adv Sci (Weinh). 2021Oct;8(20):e2100727.（IF: 17.521）

2020年

20.   Guiyou Liu*, Wenbo Zhao, HaihuaZhang, Tao Wang, Zhifa Han, Xunming Ji*. rs1769793 variant reduces EGLN1expression in skeletal muscle and hippocampus and contributes to high aerobiccapacity in hypoxia. Proc Natl Acad Sci U S A. 2020 Nov24;117(47):29283-29285.（IF: 12.291）

21.   Guiyou Liu*, Haihua Zhang, Bian Liu, Tao Wang, Zhifa Han, Xunming Ji*. rs4147929variant minor allele increases ABCA7 gene expression and ABCA7 shows increasedgene expression in Alzheimer’s disease patients compared with controls. Acta Neuropathol. 2020 May;139(5):937-940.（IF: 20.906）

22.   Yang Hu, Haihua Zhang, Bian Liu, Shan Gao, Tao Wang, ZhifaHan, International Genomics of Alzheimer's Project (IGAP), Xunming Ji, Guiyou Liu*. rs34331204 regulatesTSPAN13 expression and contributes to Alzheimer’s disease with sex differences.Brain.2020 Dec 5;143(11):e95.1-e95.6.（IF: 14.25）

23.   Longcai Wang#, Yanchun Qiao#, Haihua Zhang, Yan Zhang, JiaoHua, Shuilin Jin, Guiyou Liu*.Circulating vitamin D levels and Alzheimer’s disease: a Mendelian randomizationstudy in IGAP and UK Biobank. J AlzheimersDis.2020;73(2):609-618.（IF: 4.472）

24.   Haihua Zhang, Tao Wang, Zhifa Han, Longcai Wang, Yan Zhang,Lijun Wang*, Guiyou Liu*. Impact ofvitamin D binding protein levels on Alzheimer’s disease: a Mendelianrandomization study. J AlzheimersDis. 2020;74(3):991-998.（IF: 4.472）

25.   Haihua Zhang, Tao Wang, Zhifa Han, Guiyou Liu*. Mendelian randomization study to evaluate the effectsof interleukin-6 signaling on four neurodegenerative diseases. NeurolSci. 2020 Oct;41(10):2875-2882.（IF: 2.227）

26.   Yating He, Haihua Zhang, Tao Wang, Zhifa Han, Qing-bin Ni,Kun Wang, Longcai Wang, Yan Zhang, Yang Hu, Shuilin Jin, Bao-liang Sun, Guiyou Liu*. Impact of serum calciumlevels on Alzheimer’s disease: a Mendelian randomization study. J Alzheimers Dis. 2020;76(2):713-724.（IF: 4.472）

27.   SERPINA1 gene expression in whole blood links the rs6647variant G allele to an increased risk of large artery atherosclerotic stroke.Qingrong Liu, Pan Cui, Kai Zheng, Junjie Wang, WeiJiang, Guiyou Liu, JunweiHao*, Haijie Liu*. FASEB J. 2020 Aug;34(8):10107-10116.（IF: 5.834）

2019年

28.   Guiyou Liu*, Haihua Zhang, Bian Liu,Xunming Ji*. Rs2293871 regulates HTRA1 expression and affects cerebral smallvessel stroke and Alzheimer’s disease. Brain. 2019 Nov 1;142(11):e61.1-e61.5.（IF: 14.25）

29.   Guiyou Liu, Yang Hu, Qinghua Jiang. Population difference and diseasestatus affect the association between genetic variants and gene expression. Gastroenterology.2019 Sep;157(3):894-896.（IF: 33.883）

30.   Guiyou Liu, Shuilin Jin, QinghuaJiang. Interleukin 6 receptor and inflammatory boweldisease: a Mendelian randomization study. Gastroenterology. 2019Feb;156(3):823-824.（IF: 33.883）

31.   Guiyou Liu, Yi Zhao, Jing-yiSun, Bao-liang Sun*. Parkinson’s disease risk variant rs1109303 regulates theexpression of INPP5K and CRK in human brain tissues. Neurosci Bull. 2019Apr;35(2):365-368.（IF: 5.203）

32.   Guiyou Liu, Yang Hu, Zhifa Han,Shuilin Jin, Qinghua Jiang*. Genetic variant rs17185536 regulates SIM1 geneexpression in human brain hypothalamus. Proc Natl Acad Sci U S A. 2019 Feb26;116(9):3347-3348.（IF: 12.291）

33.   Chang-JuanWei#, Pan Cui#,He Li,Wen-Jing Lang,Gui-You Liu*,Xiao-Feng Ma*.Shared genes between Alzheimer’s disease and ischemic stroke. CNSNeurosci Ther. 2019 Aug;25(8):855-864.（IF: 7.035）

34.   Liang Cheng#, Pingping Wang#, Rui Tian#, Song Wang, QinghuaGuo, Meng Luo, Wenyang Zhou, Guiyou Liu,Huijie Jiang*, Qinghua Jiang*. LncRNA2Target v2.0: a comprehensive database fortarget genes of lncRNAs in human and mouse. Nucleic Acids Research.2019 Jan 8;47(D1):D140-D144.（IF: 19.160）

2018年

35.   Guiyou Liu, Shuilin Jin, Yang Hu,Qinghua Jiang*. Disease status affects the association between rs4813620 andthe expression of Alzheimer’s disease susceptibility gene TRIB3. ProcNatl Acad Sci U S A. 2018 Nov 6;115(45):E10519-E10520.（IF: 12.291）

36.   Guiyou Liu*, Tao Wang, Rui Tian,Meng Luo, Yang Hu, Zhifa Han, Pingping Wang, Wenyang Zhou, Peng Ren, Jian Zong,Shuilin Jin*, Qinghua Jiang*. Alzheimer’s disease risk variant rs2373115regulates GAB2 and NARS2 expressionin human brain tissues. J Mol Neurosci. 2018Sep;66(1):37-43.（IF: 2.454）

37.   Guiyou Liu, Shuilin Jin, Yang Hu,Tao Wang, Rui Tian, Zhifa Han, Dandan Xu, Qinghua Jiang*. Circulating vitamin Elevels and Alzheimer’sdisease: aMendelian randomization study. Neurobiol Aging. 2018Dec;72:189.e1-189.e9.（IF: 5.117）

38.   Guiyou Liu, Yan Zhang, Longcai Wang,Jianyong Xu, Xiaoyun Chen, Yunjuan Bao, Yang Hu, Shuilin Jin, Rui Tian,Weiyang Bai, Wenyang Zhou, Tao Wang, Zhifa Han, Jian Zong, Qinghua Jiang*.Alzheimer's Disease rs11767557 Variant Regulates EPHA1 Gene ExpressionSpecifically in Human Whole Blood. J AlzheimersDis.2018;61(3):1077-1088.（IF: 4.472）

39.   Yan Zhang#, Longcai Wang#, Haiyang Jia, Mingzhi Liao, XiaoyunChen, Jianyong Xu, Yunjuan Bao, GuiyouLiu*. Genetic variants regulate NR1H3 expressionand contribute to multiple sclerosis risk. J Neurol Sci. 2018 Jul 15;390:162-165.（IF: 3.181）

40.   Linna Zhao#, Di Liu#, Zhaoyang Wang, Jingxu, Yang chen, Guiyou Liu*, Yongshuai Jiang*. Theframework for population epigenetic study. Brief Bioinform. 2018 Jan 1;19(1):89-100.（IF: 11.622）

41.   Fang Zhang, Guiyou Liu,Daojing Li, Changjuan Wei and Junwei Hao*. DDIT4 and Associated lncDDIT4Modulate Th17 Differentiation through the DDIT4/TSC/mTOR Pathway. JImmunol. 2018 Mar 1;200(5):1618-1626.（IF: 5.422）

42.   Jing Xu#, Linna Zhao#, Di Liu#, Simeng Hu#, Xiuling Song, JinLi, Hongchao Lv, Lian Duan, Mingming Zhang, Qinghua Jiang, Guiyou Liu, Shuilin Jin, Mingzhi Liao, Meng Zhang, Rennan Feng,Fanwu Kong*, Liangde Xu*, Yongshuai Jiang*. EWAS: epigenome-wide associationstudy software 2.0. Bioinformatics. 2018 Aug 1;34(15):2657-2658.（IF: 7.307）

43.   Wenjing Wang#, Peng Zhang#, Leijie Li, Zhaobin Chen, WeiyangBai, Guiyou Liu, Liangcai Zhang,Haiyang Jia, Li Li*, Yingcui Yu*, Mingzhi Liao*. ATD: a comprehensivebioinformatics resource for deciphering the association of autophagy anddiseases. Database (Oxford).2018 Jan 1;2018.（IF: 3.978）

2017年

44.   Guiyou Liu#, Yang Hu#,Shuilin Jin, Qinghua Jiang*. Genetic variant rs763361 regulates multiplesclerosis CD226 gene expression. Proc Natl Acad Sci U S A. 2017 Feb7;114(6):E906-E907.（IF: 12.291）

45.   Yang Hu, Shuilin Jin, Liang Cheng, Guiyou Liu*, Qinghua Jiang*. Autoimmune disease variants regulateGSDMB gene expression in human immune cells and whole blood. ProcNatl Acad Sci U S A. 2017 Sep 19;114(38):E7860-E7862.（IF: 12.291）

46.   Guiyou Liu, Jing-yi Sun, Meiling Xu,Xiao-yi Yang*, Bao-liang Sun*. SORL1 variants show different association withearly‑onset and late onset Alzheimer’s disease risk. J Alzheimers Dis. 2017;58(4):1121-1128.（IF: 4.472）

47.   Guiyou Liu#, Fang Zhang#, Yang Hu,Yongshuai Jiang, Zhongying, Gong, Shoufeng Liu, Xiuju Chen, Qinghua Jiang*,Junwei Hao*. Multiple sclerosis risk pathways differ in Caucasian and Chinesepopulations. J Neuroimmunol. 2017 Jun 15;307:63-68.（IF: 2.720）

48.   Guiyou Liu#, Fang Zhang#, YongshuaiJiang, Yang Hu, Zhongying Gong, Shoufeng Liu, Xiuju Chen, Qinghua Jiang*,Junwei Hao*. Integrating genome-wide association studies and gene expressiondata highlights disregulated multiple sclerosis risk pathways. MultScler. 2017 Feb;23(2):205-212.（IF: 5.280）

49.   Guiyou Liu#, Yining Xu#,Yongshuai Jiang, Liangcai Zhang, Rennan Feng, Qinghua Jiang*. PICALM rs3851179variant confers susceptibility to Alzheimer’s disease in Chinese population. MolNeurobiol. 2017Jul;54(5):3131-3136.（IF: 6.190）

50.   Guiyou Liu#, Fang Zhang#, Yang Hu,Yongshuai Jiang, Zhongying Gong, Shoufeng Liu, Xiuju Chen, Qinghua Jiang*,Junwei Hao*. Genetic Variants and Multiple Sclerosis Risk Gene SLC9A9 Expression in Distinct Human BrainRegions. Mol Neurobiol. 2017 Nov;54(9):6820-6826.（IF: 6.190）

51.   Zhuo Wang#, Shuilin Jin#, Guiyou Liu#, Xiurui Zhang, Nan Wang,Deliang Wu, Yang Hu, Chiping Zhang*, Qinghua Jiang*,Li Xu, Yadong Wang. DTWscore: differential expression and cell clusteringanalysis for time-series single-cell RNA-seq data. BMC Bioinformatics. 2017May 23;18(1):270.（IF: 2.448）

52.   Yang Hu#, Likun Zheng#, Liang Cheng, Ying Zhang, WeiyangBai, Wenyang Zhou, Tao Wang, Zhifa Han, Jian Zong, Shuilin Jin, Jun Zhang*, Guiyou Liu*, Qinghua Jiang*. GAB2 rs2373115 variant contributes toAlzheimer's disease risk specifically in European population. JNeurol Sci. 2017 Apr 15;375:18-22.（IF: 3.181）

53.   Yang Hu, Liang Cheng, Ying Zhang, Weiyang Bai, WenyangZhou, Tao Wang, Zhifa Han, Jian Zong, Shuilin Jin, Jun Zhang, QinghuaJiang, Guiyou Liu*. Rs4878104contributes to Alzheimer’s disease risk and regulates DAPK1 gene expression. NeurolSci. 2017 Jul;38(7):1255-1262.（IF: 1.749）

54.   Qinghua Jiang#, Shuilin Jin#, Yongshuai Jiang, MingzhiLiao, Rennan Feng, Liangcai Zhang, GuiyouLiu*, Junwei Hao*. Alzheimer’s disease variants with the genome-widesignificance are significantly enriched in immune pathways and active in immunecells. Mol Neurobiol. 2017 Jan;54(1):594-600.（IF: 6.190）

55.   Fang Zhang, Guiyou Liu,Changjuan Wei, Chao Gao, Junwei Hao*. Linc-MAF-4 regulates Th1/Th2differentiation and is associated with the pathogenesis of multiple sclerosisby targeting MAF. FASEB J. 2017 Feb;31(2):519-525.（IF: 5.834）

56.   Dongxue Che, Yang Wang, Weiyang Bai, Leijie Li, Guiyou Liu, Liangcai Zhang, YongchunZuo, Shiheng Tao, Jinlian Hua, Mingzhi Liao*. Dynamic and modular generegulatory networks drive the development of gametogenesis. BriefBioinform. 2017 Jul 1;18(4):712-721.（IF: 11.622）