2019年调入首都医科大学附属北京同仁医院，每年已经招收1名博士，1名统招硕士和1名5+3长学制硕士，目前是首医博士后导师、阶平班导师和留学生导师。每位在校博士至少已经发表SCI论文2篇（IF＞10分），每位硕士发表1篇SCI论文（IF＞2分）和1篇中华系列文章。

团队学术氛围浓厚，互相团结帮助，老师亲自指导课题研究与论文撰写修改。

Our team focuses on the basic and clinical research of bone and cartilage, especially on cartilage tissue engineering and the diagnosis and treatment of foot and ankle related diseases.

本团队研究方向包括软骨损伤与关节炎，足踝外科基础与临床，数字化骨科，干细胞成骨和软骨分化，骨代谢

· 主持国家自然科学基金4项，在研2项

· 省部级课题7项，包括北京市自然基金重点项目.北京市自然基金面上项目，北京市教委课题

· 入选省部级人才计划5项，包括北京市高层次人才建设项目培养计划, 北京市百千万人才工程，登峰人才计划，上海市优秀学术带头人计划，上海市医学人才杰青项目

1. 足踝矫形外科：并发症的处理，人民卫生出版社，主译

2. 足踝外科翻修手术：策略与技术，北京大学医学出版社，主译

3. 俞光荣 主编，跟骨骨折的基础与临床，参编

4. 赵定麟 主编，骨科手术学，参编

5. 王正义 主编，足踝外科学，参编

6. 王正义 主编，足踝外科手术学，参编

7. 唐康来主译，曼氏足踝外科学，担任主译助理

8.足踝外科精要，科学出版社，主译

团队研究网页地址，欢迎访问： https://www.researchgate.net/profile/Mingzhu-Zhang-6

1.       YaoY, Ying T, Zong C, Ding T, Li Q, Han Z, Wang F, Cui W, Zhang M*. Closed-loopiron chelate recycling via molecularly imprinted hydrogels suppressesferroptosis. Nat Commun. 2026 Jun 12;17(1):7486. doi:10.1038/s41467-026-74330-3. (IF 18.1)

2.       SunY, Ding SL, Zhao X, Sun D, Yang Y, Chen M, Zhu C, Jiang B, Gu Q, Liu H, ZhangM*. Self-reinforced MOF-based nanogel alleviates osteoarthritis bylong-acting drug release.Advanced Materials. 2024 Apr 29:e2401094. doi:10.1002/adma.202401094（IF 27.4）

3.       DingSL, Zhao XY, Xiong W, Ji L, Jia M, Liu Y, Guo H, Qu F, Cui WG, Gu Q, ZhangMZ*. Cartilage Lacuna-inspired Microcarriers Drive Hyaline NeocartilageRegeneration. Advanced Materials. 2023 Mar 6;e2212114, doi.org/10.1002/adma.202212114（IF27.4）

4.       HanZ, Wang F, Xiong W, Meng C, Yao Y, Cui W, Zhang M*. Precise Cell TypeElectrical Stimulation Therapy Via Force-electric Hydrogel Microspheres forCartilage Healing. Adv Mater. 2025 Feb;37(7):e2414555. doi:10.1002/adma.202414555. (IF 27.4）

5.       CuiY , Shan Yizhu , Jiaxuan Li, Meng Kiao, Yuan Ki, Jianving Ji, Engui Wang,BaokumnZhang, Lingling Xu , Mingzhu Zhang*, Li Zhou and Zhang Yingzi.Bifunctional Piezo-enhanced PLLAZA Coating Prevents Aseptic Looseningof Bone lmplants. Advanced Functional Materials, 2024, adfm.202403759. (IF18.9)

6.       XiongW, Han Z, Ding SL, Wang H, Du Y, Cui W, Zhang MZ*. In Situ Remodeling ofEfferocytosis via Lesion-Localized Microspheres to Reverse CartilageSenescence. Advanced Science. 2024 Mar 11(19):e2400345. doi:10.1002/advs.202400345.（IF 14.3）

7.       YaoY, Cui X, Ding S, Wang K, Zhang M*. Advances in Electrical Materials forBone and Cartilage Regeneration: Developments, Challenges, and Perspectives.Adv Sci (Weinh). 2025 Feb 14:e2411209. doi: 10.1002/advs.202411209. (IF 14.3)

8.       HanZ, Wang K, Ding S, Zhang M*. Cross-talk of inflammation and cellularsenescence: a new insight into the occurrence and progression ofosteoarthritis. Bone Res. 2024 Dec 3;12(1):69. doi: 10.1038/s41413-024-00375-z.（IF14.3）

9.       HanZY; Bai L, Zhou J, Qian YH; Tang Y,Han Q, Zhang X, Zhang MZ*. Yang X,Cui WG, Hao Y. Nanofat functionalized injectable super-lubricating microfluidicmicrospheres for treatment of osteoarthritis. Biomaterials. 2022, 285:121545.doi.org/10.1016/j.biomaterials.2022.121545.（IF15.304）

10.   DingSL,Liu X, Zhao XY, Wang KT, Xiong Wei, Gao Zi-Li, Sun Cheng-Yi, Jia MXLi C, GuQ, Zhang MZ*. Microcarriers in application for cartilage tissueengineering: Recent progress and challenges. Bioactive Materials, 2022, 17(11):81-108.(IF 18)

11.   WangK, Li Ji, Wang Y, Wang Y, Qin Y, Yang F, Zhang MZ*, Zhu H*, Li Z* Orchestratedcellular, biochemical, and biomechanical optimizations endow platelet-richplasma-based engineered cartilage with structural and biomechanical recovery. BioactiveMaterials, 2021, 6(11): 3824-3838. (IF 18)

12.   ZhaoZY, Ruan H，Chen A, Xiong W, Zhang MZ*, Cai M,Cui W. Genetic engineered ultrasound-triggered injectable hydrogels forpromoting bone reconstruction.Research. 17 Aug 2023, doi.org/10.34133/research.0221(IF 11.0)

13.   NieZ, Ding S, Zhu C, Liu J, Zhang L, Wang W, Zhang M*. Preoperativepatient-reported depression and anxiety may affect short-term surgical outcomesin women with hallux valgus. J Orthop Surg Res. 2026 May 24;21(1):438. doi:10.1186/s13018-026-06968-0. (IF 3.8)

14.   YuQW, Wang JC, Xu C, Li JT, Bai XD, Huang X, Tang JJ, Wei FY, Tang PF, ZhangMZ*, Chen H. Optimizing the correlation between first metatarsal headposition and osteotomy plane angle in modified scarf osteotomy: athree-dimensional digital analysis. BMC Musculoskelet Disord. 2026 Mar27;27(1):395. doi: 10.1186/s12891-025-09412-2. (IF 2.8)

15.   SunC, Ding S, Zhang Y, Ji L, Zhang J, Zhang M*. Three-dimensional featuresof the tarsal sinus and canal complex in normal feet and flexible flatfeet ofchildren. BMC Musculoskelet Disord. 2026 Jul 4;27(1):804. doi:10.1186/s12891-026-10147-x. (IF 2.8)

16.   ShenJ, Liu J, Liang F, Liu X, Zhang M*. Prevalence of flatfoot and analysisof plantar pressure distribution in adolescents based on body mass index: aregional study. J Orthop Surg Res. 2024 Dec 23;19(1):864. doi:10.1186/s13018-024-05365-9. (IF 2.8)

17.   QuF, Ji L, Sun C, Zhu M, Myerson MS, Li S, Zhang M*. Arthroscopic AnteriorTalofibular Ligament Repair Combined With All-Inside Suture Tape Augmentationfor Treatment of Chronic Lateral Ankle Instability With Generalized JointLaxity. Foot Ankle Int. 2024 Oct;45(10):1102-1110. doi: 10.1177/10711007241271247.(IF 2.4)

18.   ZhaoZY, Li R Ruan H, Cai Z, Zhuang Y, Han Z, Zhang MZ*, Cui W, Cai M.Biological Signal Integrated Microfluidic Hydrogel Microspheres for PromotingBone Regeneration. Chemical Engineering Journal,2022,436,135176,doi.org/10.1016/j.cej.2022.135176.（IF16.744）

19.   HuangWH, Ding SL, Zhao XY, Li K, Guo HT, Zhang MZ*, Gu Q. Collagen for neuraltissue engineering: Materials, strategies, and challenges.Mater Today Bio. 2023May 2;20:100639 (IF 8)

20.   ZhouJ, Li Q, Tian Z, Yao Q, Zhang M*. Recent advances in 3D bioprintedcartilage-mimicking constructs for applications in tissue engineering..MaterToday Bio. 2023 Nov 17;23:100870. doi: 10.1016/j.mtbio.2023.100870 (IF 8)

21.   GaoZ, Ding S, Fan T, Huang W, Zhao X, Liu X, Liu W, Zhang M*, Gu Q.Protocolfor embedded 3D printing of heart tissues using thiol-norbornene collagen.STARProtoc. 2024 Apr 2;5(2):102994. doi: 10.1016/j.xpro.2024.102994 （IF1.3）

22.   ZhangMZ, Ferrigno O, Wang Z, Ohnishi M, Prunier C, Levy L,Razzaque M, Horne WC, Romero D, Tzivion G, Colland F, Baron R, Atfi A.TGIFGoverns a Feed-Forward Network that Empowers Wnt Signaling to Drive MammaryTumorigenesis, Cancer Cell，2015 Apr13;27(4):547-560.（IF 48.8）

23.   SongL, Li H, Liu Y, Zhang X, Wen Y, Zhang K, Zhang MZ*. Postnatal deletion of β-catenin inpreosteoblasts regulates global energy metabolism through increasing boneresorption and adipose tissue fibrosis. Bone. 2022 Mar;156:116320. doi:10.1016/j.bone.2021.116320 ( IF 4.626)

24.   DingSL, Ji LF, Zhang MZ*, Xiong W, Sun CY, Han ZY, Wang C.Safety andefficacy of intra-articular injection of platelet-rich plasma for the treatmentof ankle osteoarthritis: a systematic review and meta-analysis.Int Orthop. 2023Aug;47(8):1963-1974. doi: 10.1007/s00264-023-05773-2.（IF2.0）

25.   JiL, Ding S, Zhang M*, Colon Reyes K, Zhu M, Sun C.The Role of FirstTarsometatarsal Joint Morphology and Instability in the Etiology of HalluxValgus: A Case-Control Study.Foot Ankle Int. 2023 Aug;44(8):778-787. doi:10.1177/10711007231175846.（IF 2.4）

26.   ZhangS, Sun C, Zhang J, Wang Z, Zhao H, Zhang M*. Changes in thesubtalar joint alignment after supramalleolar osteotomy for varus anklearthritis.Foot Ankle Surg. 2023 Aug;29(6):475-480.（IF1.9）

27.   ZhangS, Sun C, Zhang J, Wang Z, Li S, Zhang M*. Subchondral bone cystsremodel after correction of varus deformity in ankle arthritis. Foot AnkleSurg. 2023 Jul;29(5):419-423.（IF 1.9）

28.   PrunierC#, Zhang MZ#, Kumar S, Levy L, Ferrigno O,Tzivion G, Atfi A. Disruption of the PHRF1 Tumor SuppressorNetwork by PML-RARα Drives Acute Promyelocytic Leukemia Pathogenesis. CellReports, 2015 February 17,10( 6): 883–890 ( IF  9.993)

29.   ZhangS, Aiyer A, Sun C, Wang Z, Lin D, Qu F, Wei F, Wang X, Zhang F, Li S, Chen Y,Zhang J, Lintz F, Zhang M*, Operative Treatment for Ganglion Cyst ofFlexor Hallucis Longus Sheath. Foot Ankle International. 2020 Aug;41(8):978-983. ( IF 3.569)

30.   YuQ, Li Z, Li J, Yu Q, Zhang L, Liu D, Zhang M*, Tang P.J.Calcanealfracture maps and their determinants. Journal of Orthopaedic Surgery andResearch. 2022 Jan 21;17(1):39. doi: 10.1186/s13018-022-02930-y ( IF2.677)

31.   JiL, Wang K, Ding S, Sun C, Sun S, Zhang M*. Minimally Invasive vs.Open Surgery for Hallux Valgus: A Meta-Analysis. Frontiers in Surgery.2022March.volume 9,843410-843421. doi: 10.3389/fsurg.2022.843410 (IF 2.568)

32.   SunC, Miao X, Zhang M*, Yang Y, Zhao H, Tang X, Yu G.Lisfranc injurieswith dislocation the frst tarsometatarsal joint: primary arthrodesisor internal fxation (a randomized controlled trial).InternationalOrthopaedics. 2022 Jun 20. doi: 10.1007/s00264-022-05478-y（IF3.479）

33.   YuG, Zhang M*, Aiyer A,Tang X, Xie M, Zeng Li, Zhao Y, Zhou J, LiB,Yang Y Repair of the acute deltoid ligament complex rupture associatedwith ankle fractures: a multicenter clinical study. Journal of Foot andAnkle Surgery，2015，Mar-Apr;54(2):198-202.(IF1.286)

34.   EttaharA, Ferrigno O, Zhang MZ, Ohnishi M, Ferrand N, Prunier C, Levy L,Bourgeade MF, Bieche I, Romero DG, Colland F, Atfi A. Identificationof PHRF1 as a Tumor Suppressor that Promotes the TGF-β Cytostatic Programthrough Selective Release of TGIF-Driven PML Inactivation. Cell Reports.2013,4(3) 530-541（IF 9.99）

35.   YuGR, Zhang MZ, Yang YF, Corrective Osteotomies for Malunited Tongue-TypeCalcaneal Fractures, Foot Ankle Clin. 2016 Mar;21(1):123-134.(IF 1.653)

36.   YuG, Zhao Y, Zhou J, Zhang M. Surgical fusion of talonavicular jointand naviculocuneiform joint for Müller-Weiss disease. Journal ofFoot and Ankle Surgery, 2012,51(4) :415-419 (IF 1.286)

37.   ZhangM,Zhao Q, Tang X, Yu G, Inhibitory effect of siRNAs on glial fibrillary acidicexpression in astrocytes, Neural Regen Res,2008, 3(9): 950-953. (IF 6.058)

38.   李鹏飞,王智,曲峰,等. 急性跟腱断裂愈合后腱体延长的评估及影响因素研究进展[J]. 中华创伤杂志,2023,39(10):940-946.

39.   王超，丁声龙，张明珠. 医源性内翻发病原因及治疗的研究进展. 中华解剖与临床杂志，2023，28(02):136-140. 

40.   曲峰，孙成宜，张明珠,张琳,王智,孙超,王显军,张建中. 关节镜下改良Broström术联合腓骨肌腱清理治疗慢性踝关节外侧不稳伴腓骨肌腱炎. 中华创伤杂志，2023，39(08):680-687. 

41.   李琪，张明珠. 抗衰老药物治疗骨关节炎的研究进展. 中华实验外科杂志，2023，40(07):1439-1445. 

42.   王昊，曲峰，丁声龙,孙颂民,张明珠. 细胞移植技术治疗距骨骨软骨损伤的研究进展. 中华创伤杂志，2023，39(07):665-672. 

43.   王超，王智，孙超,张建中,王显军,丁声龙,张明珠. 改良卡槽单钉Scarf截骨术与传统Scarf截骨术治疗足拇外翻畸形效果的比较. 中华解剖与临床杂志，2023，28(07):423-430. 

44.   王智，孙成宜，张建中,张明珠. 副舟骨植骨与髂骨植骨Cotton截骨术对儿童柔韧性平足症的疗效对比研究. 中华医学杂志，2023，103(37):2926-2932. 

45.   张建中，曲峰，张明珠. 进行性塌陷足畸形专家共识解读. 中华医学杂志，2023，103(37):2907-2911.

46.   纪霖锋，丁声龙，张明珠. 第一跖楔关节矢状不稳与拇外翻合并转移性跖骨痛的相关性. 中华医学杂志，2023，103(01):25-31. 

47.   张树，张建中，王智，孙超，张明珠. 胫前肌腱外移联合踝上截骨治疗3b期内翻性踝关节炎的临床疗效. 中华医学杂志，2023，103(39):3136-3139. 

48.   张明珠,杨云峰,苗旭东,徐海林,黄建华,张洪涛,张晖,王志坚,杨茂伟,栾波,阿发武,俞光荣.切开复位内固定与Ⅰ期融合治疗伴第一跖跗关节脱位Lisfranc损伤的疗效比较. 中华创伤杂志2018,34:(7) 585-590

49.   张明珠,和文宝,李润民,赵有光,李兵,于涛,杨云峰,尤春芳,姚英,俞光荣,踝关节骨折伴三角韧带完全断裂的手术治疗.中华解剖与临床杂志,2019,24:(2) 118-122

50.   张明珠,王智,曲峰,魏芳远,张树,孙超,王显军,张建中,俞光荣.闭合复位经皮内固定治疗低能量Lisfranc损伤的临床疗效,中华骨与关节外科杂志，2020，13:(9) 757-760

51.   张明珠,王智,曲峰,魏芳远,张树,孙超,王显军,张建中.女性拇外翻引起籽骨嵴磨损的影响因素分析，中华解剖与临床杂志，2020,25:(5) 478-483

52.   张明珠,纪霖锋,张英琪.3D打印导板辅助微创复位内固定治疗SandersⅡ型跟骨骨折的疗效分析,中华创伤骨科杂志,2022,24(04):310-315.3

53.   张明珠,纪霖锋.微创Chevron联合Akin截骨治疗足拇外翻的研究进展,中华解剖与临床杂志,2022,27(05):364-367.

1. American Society for Bone and Mineral Research (ASBMR，美国骨矿研究学会年会) 31st Annual Meeting September 11-15, 2009, Colorado Convention Center, Denver, Colorado, USA

2. 37th European Symposium on Calcified Tissues(ECTS，欧洲骨矿研究学会年会), 26-30 June 2010, Glasgow, Scotland, UK

3. TGIF Is Required for Canonical Wnt Signaling-induced Bone Formation. American Society for Bone and Mineral Research (ASBMR，美国骨矿研究学会年会)  Annual Meeting September 12-15,Houston, Taxas, USA，2014, September 12

4. Biomechanical Analysis of Calcaneocuboid Joint Pressure after Sequential Lengthening of the Lateral Column. The American Orthopaedic Foot & Ankle Society (AOFAS，美国足踝外科年会)，September 19-22,2014, Chicago, USA

5. TGIF promotes Wnt Signaling and Bone Formation.European Symposium on Calcified Tissues(ECTS，欧洲骨矿研究学会年会)和 International Bone and Mineral Society (IBMS，国际骨矿研究学会年会)联合会议，25 - 28 April 2015，Rotterdam, Netherlands

6. SICOT(国际骨科大会)，16-19 September,2015, Guangzhou, China

7. Repair of the deltoid ligament associated with ankle fractures. SICOT(国际骨科大会)，8-11 September, 2016, Rome, Italy

8. Primary arthrodesis vs ORIF for Lisfranc injuries with the first TMT dislocation. A multicenter study. IFFAS(国际足踝外科大会)，27-29 September，2017，Lisbon, Portugal.

9. Primary arthrodesis for Lisfranc injuries with the first TMT dislocation. A multicenter study. The American Orthopaedic Foot & Ankle Society (AOFAS，美国足踝外科年会)，July 11-14,2018, Boston, USA

10. Treatment of Lisfranc injuries. SICOT(国际骨科大会)，9-14 October,2018, Montreal, Canada

11. Primary arthrodesis compared with open reduction and internal fixation for Lisfranc injuries。美国足踝外科学会（AOFAS）年会 美国足踝外科学会（ AOFAS）2019-9 美国芝加哥

12. Minimally invasive treatment of calcaneal fractures via the sinus tarsi approach based on a 3D printing technique.亚洲足踝外科学 会（AFFAS）年会 亚洲足踝外科学会 （ AFFA S） 2019-10 泰国曼谷

13. Close reduction and percutaneous internal fixation for low energic Lisfranc injuries. SICOT(国际骨科大会)， 布达佩斯，网络会议 September,2021

14.The Role of First Tarsometatarsal Joint Morphology and Instability in the Etiology of Hallux Valgus: A Case-Control Study. 美国足踝外科学会（AOFAS）年会 美国足踝外科学会（ AOFAS） 2024-9 加拿大温哥华