1、国家自然科学基金面上项目。

2、北京市自然科学基金面上项目。

3、高层次公共卫生技术人才建设项目培养计划。

一、近五年重要学术论文

1.          Zhao,L., Yang, W., Ji, W., Pan, Q., Yang, J., and Cao, X. (2024) Untargeted metabolomics uncoversmetabolic dysregulation and tissue sensitivity in ACE2 knockout mice. Heliyon 10, e27472

2.           Yang,W. L., Zhang, C. Y., Ji, W. Y., Zhao, L. L., Yang, F. Y., Zhang, L., and Cao, X. (2024) BerberineMetabolites Stimulate GLP-1 Secretion by Alleviating Oxidative Stress andMitochondrial Dysfunction. Am J ChineseMed 52, 253-274

3.           Shi,T. T., Liu, H. Y., Zhu, X. R., Xin, Z., Hua, L., Xie, R. R., Sun, R., Cao, X., and Yang, J. K. (2023)Integrated Proteomics and Metabolomics Analyses of Serum in Chinese Patientswith Severe and Active Graves' Orbitopathy: A Cross-sectional Study. Endocrine, metabolic & immune disordersdrug targets 23, 1151-1161

4.           Zuo,Q., Yang, W., Liu, B., Yan, D., Wang, Z., Wang, H., Deng, W., Cao, X. #, and Yang, J. #(2022) A novel FGF23 mutation in hyperphosphatemic familial tumoral calcinosisand its deleterious effect on protein O-glycosylation. Frontiers in endocrinology 13,1008800

5.           Yang,W. L., Li, Q., Sun, J., Huat Tan, S., Tang, Y. H., Zhao, M. M., Li, Y. Y., Cao, X., Zhao, J. C., and Yang, J. K.(2022) Potential Drug Discovery for COVID-19 Treatment Targeting Cathepsin LUsing a Deep Learning-Based Strategy. Computationaland structural biotechnology journal

6.           Song,L. *, Cao, X*., Ji, W., Zhao,L., Yang, W., Lu, M., and Yang, J. (2022) Inhibition of STAT3 enhances UCP1expression and mitochondrial function in brown adipocytes. European journal of pharmacology 926, 175040

7.           Cao, X. *, Shi, T. T. *,Zhang, C. H*., Jin, W. Z., Song, L. N., Zhang, Y. C., Liu, J. Y., Yang, F. Y.,Rotimi, C. N., Xu, A., and Yang, J. K. (2022) ACE2 pathway regulatesthermogenesis and energy metabolism. eLife11

8.           Cao, X. *, Lu, M. *, Xie, R. R.,Song, L. N., Yang, W. L., Xin, Z., Yang, G. R., and Yang, J. K. (2022) A HighTSH Level is Associated with Diabetic Macular Edema: A Cross-Sectional Study ofPatients with Type 2 Diabetes Mellitus. Endocrineconnections

9.           Zhao,M. M., Lu, J., Li, S., Wang, H., Cao, X.,Li, Q., Shi, T. T., Matsunaga, K., Chen, C., Huang, H., Izumi, T., and Yang, J.K. (2021) Berberine is an insulin secretagogue targeting the KCNH6 potassiumchannel. Nature communications 12, 5616

10.        Liu,J. Y., Zhang, Y. C., Xie, R. R., Song, L. N., Yang, W. L., Xin, Z., Cao, X. #, and Yang, J.K. # (2021) Nifuroxazide improvesinsulin secretion and attenuates high glucose-induced inflammation andapoptosis in INS-1 cells. Europeanjournal of pharmacology 899,174042

11.         Cao, X. *, Song, L. N. *, and Yang, J. K. (2021) ACE2 andenergy metabolism: the connection between COVID-19 and chronic metabolicdisorders. Clinical science 135, 535-554

12.         Zuo,Q. Y. *, Cao, X. *, Liu, B. Y., Yan, D., Xin, Z., Niu, X. H., Li, C.,Deng, W., Dong, Z. Y., and Yang, J. K. (2020) Clinical and genetic analysis ofidiopathic normophosphatemic tumoral calcinosis in 19 patients. Journal of endocrinological investigation43, 173-183

13.         Tan,S. Y., Lei, X., Little, H. C., Rodriguez, S., Sarver, D. C., Cao, X., and Wong, G. W. (2020) CTRP12ablation differentially affects energy expenditure, body weight, and insulinsensitivity in male and female mice. Americanjournal of physiology. Endocrinology and metabolism 319, E146-E162

14.         Song,L. N., Liu, J. Y., Shi, T. T., Zhang, Y. C., Xin, Z., Cao, X., # and Yang, J. K.# (2020) Angiotensin-(1-7), the product of ACE2 ameliorates NAFLD by actingthrough its receptor Mas to regulate hepatic mitochondrial function andglycolipid metabolism. FASEB journal :official publication of the Federation of American Societies for ExperimentalBiology 34, 16291-16306

15.         Rodriguez,S., Stewart, A. N., Lei, X., Cao, X.,Little, H. C., Fong, V., Sarver, D. C., and Wong, G. W. (2019) PRADC1: a novelmetabolic-responsive secretory protein that modulates physical activity andadiposity. FASEB journal : officialpublication of the Federation of American Societies for Experimental Biology33, 14748-14759

16.         Liu,J.-Y., Zhang, Y.-C., Song, L.-N., Zhang, L., Yang, F.-Y., Zhu, X.-R., Cheng,Z.-Q., Cao, X., # and Yang,J.-K. (2019) Nifuroxazide ameliorates lipid and glucose metabolism inpalmitate-induced HepG2 cells. RSCAdvances 9, 39394-39404

17.         Cao, X.*, Song, L. N.*, Zhang,Y. C., Li, Q., Shi, T. T., Yang, F. Y., Yuan, M. X., Xin, Z., and Yang, J. K.(2019) Angiotensin-converting enzyme 2 inhibits endoplasmic reticulumstress-associated pathway to preserve nonalcoholic fatty liver disease. Diabetes/metabolism research and reviews35, e3123

18.         Cao, X.*, Lu, X. M.*, Tuo, X.,Liu, J. Y., Zhang, Y. C., Song, L. N., Cheng, Z. Q., Yang, J. K., and Xin, Z.(2019) Angiotensin-converting enzyme 2 regulates endoplasmic reticulum stressand mitochondrial function to preserve skeletal muscle lipid metabolism. Lipids in health and disease 18, 207

二、奖项

（1）糖尿病分子靶标的研发与应用，高等学校科学研究优秀成果奖科技进步二等奖, 中华人民共和国教育部, 科技进步, 2023(4/12)。

（2）冠状病毒受体ACE2与糖尿病诊疗新靶点的研究与应用，华夏医学科技奖二等奖，中国医疗保健国际交流促进会, 科技进步, 2020(2/10) 。

（3）糖尿病发病机制和诊疗关键技术的研究与应用，中华医学科技奖医学科学技术奖二等奖，中华医学会, 2020(3/10) 。