【课题组简介】：https://www.taohonglab.org/

脑出血是全球共同面对的重大疾病，中枢神经系统血管畸形是其中一类难治性的出血性脑血管病，明确发病机制继而研发有效治疗药物是血管畸形领域亟待解决的关键问题，并有助于促进其他脑出血疾病的研究。近些年，血管畸形核心遗传机制的发现推动该疾病成为脑血管病研究的热点领域。

本课题组目前聚焦血管畸形的发病机制研究和创新疗法，建立了领先的小鼠疾病模型、多组学研究方法和类器官平台，解析体细胞突变诱导形成血管畸形的机制，解析血管畸形出血的分子和免疫机制，为开发血管畸形新疗法提供靶点。

洪韬课题组依托国家神经疾病医学中心的优势平台，拥有一支优秀的科研团队、独立的实验空间和充裕的科研经费，形成了临床医生和科学家交融的良好氛围，多位成员在Science、Cell等顶尖期刊发表论文。欢迎有意向的青年才俊加入。

【1】       Jian Ren#, Yazi Huang#,Yeqing Ren#, Tianqi Tu, Baoshan Qiu, Daosheng Ai, Zhanying Bi, Xue Bai, FengzhiLi, Jun-Liszt Li, Xing-jun Chen, Ziyan Feng, Zongpei Guo, Jianfeng Lei, AnTian, Ziwei Cui, Jakob Körbelin, Volkhard Lindner, Ralf H. Adams, Yibo Wang, YilongWang, Fei Zhao, Wenzhi Sun, Hongqi Zhang, Tao Hong*, Woo-ping Ge*. Somatic variants of MAP3K3 aresufficient to cause cerebral and spinal cord cavernous malformations. Brain. 2023 Sep 1;146(9):3634-3647. 【IF15.255】

【2】       Jian Ren#, XiaoXiao#, Ruofei Li#, Cheng Lv, Yu Zhang, Leiming Wang, Tao Hong*, Hongqi Zhang*, YiboWang*. Single-cell sequencing reveals that endothelial cells, EndMT cells andmural cells contribute to the pathogenesis of cavernous malformations. Exp Mol Med, 2023, online epub ahead. 【IF 12.153】

【3】       Jian Ren, Tao Hong,Hongqi Zhang. Cellular Origin of Sporadic CCMs. NEJM. 2022,386(13):1290-1291. 【IF 176.079】

【4】       Yu J#, Zhang S#, Bian L#,He C, Ye M, Li G, Hu P, Sun L, Ling F, Zhang H*, Hong T*. Clinicalfeatures and outcomes of perimedullary arteriovenous fistulas: comparisonbetween micro- and macro-type lesions. J Neurointerv Surg. 2022 Jun22;neurintsurg-2021-018412. 【IF 8.572】

【5】       Ren J#, Jiang N#, Bian L#,Dmytriw AA, Zeng G, He C, Sun L, Li X, Ma Y, Yu J, Li G, Ye M, Hu P, Li J, YangF, Li Q, Ling F, Zhang H*, Hong T*. Natural History of Spinal CordCavernous Malformations: A Multicenter Cohort Study. Neurosurgery. 2022 Apr1;90(4):390-398. 【IF 5.315】

【6】       Jia-Xing Yu# Chuan He#Ming Ye# Gui-Lin Li, Li-Song Bian, Fan Yang, Xiao-DongZhai, Feng Ling, Hong-QiZhang*, Tao Hong*. The efficacy and deficiency of contemporary treatmentfor spinal cord arteriovenous shunts. BRAIN.2021,144(11):3381-3391. 【IF15.255】

【7】       Tao Hong#, Xiao Xiao#, Jian Ren#, Bing Cui, Yuru Zong, Jian Zou, Zqi Kou, Nan Jiang,Guolu Meng, Gao Zeng, Yongzhi Shan, Hao Wu, Zan Chen, Jiantao Liang, Xinru Xiao,Jie Tang, Yukui Wei, Ming Ye, Liyong Sun, Guilin Li, Peng Hu, Rutai Hui, HongqiZhang*, Yibo Wang*. Somatic MAP3K3 and PIK3CA mutations insporadic cerebral and spinal cord cavernous malformations. BRAIN, 2021 Oct22;144(9):2648-2658. 【IF 15.255】

【8】       Feng Y#, Yu J#, Xu J#, HeC, Bian L, Li G, Ye M, Hu P, Sun L, Jiang N, Ling F, Hong T*, Zhang H*.Natural History and Clinical Outcomes of Paravertebral Arteriovenous Shunts.Stroke. 2021 Dec;52(12):3873-3882. 【IF 10.17】

【9】       Jian Ren, Yukui Wei, TaoHong*. Combined Cranial Intraosseous and Cerebral Cavernous MalformationsWith Pathogenic CCM1 Germline Sequence Variations. JAMA Neurology, 2021,78(2): 247-248.

【10】     He Y#, Hong T#, Wang M#, Jiao L#, Ge Y, Haacke EM, Li T*, Hongqi Z*.Prevention and control of COVID-19 in neurointerventional surgery: expertconsensus from the Chinese Federation of Interventional and TherapeuticNeuroradiology (CFITN) and the International Society for Neurovascular Disease(ISNVD). J Neurointerv Surg, 2020 Jul;12(7):658-663. 【IF 8.572】

【11】     Jia-Xing Yu#, Tao Hong#*, Timo Krings, Chuan He, Ming Ye, Li-YongSun, Xiao-Dong Zhai, Si-Shi Xiang, Yong-Jie Ma, Li-Song Bian, Jian Ren, Peng-YuTao, Jing-Wei Li, Fan Yang, Gui-Lin Li, Feng Ling, Hong-Qi Zhang*. Naturalhistory of spinal cord arteriovenous shunts: an observational study. BRAIN,2019, 142 (8): 2265-2275. 【IF 15.255】

【12】     J Ren#, T Hong#, G Zeng, C He, X Li, Y Ma, J Yu, HQ Zhang*. Characteristicsand Long-Term Outcome of 20 Children with Intramedullary Spinal Cord CavernousMalformations. Neurosurgery, 2020 Jun 1;86(6):817-824. 【IF 5.315】

【13】     Jian Ren#, Tao Hong#, Chuan He, Liyong Sun, Xiaoyu Li, Yongjie Ma,Jiaxing Yu, Feng Ling, Hongqi Zhang*. Coexistence of Intracranial and SpinalCord Cavernous Malformations Predict Aggressive Clinical Presentation. FrontNeurol, 2019 Jun 13;10:618【IF 4.086】

【14】     Jian Ren#, Tao Hong#, Chuan He, Xiaoyu Li, Yongjie Ma, Jiaxing Yu,Feng Ling, Hongqi Zhang*. Surgical Approaches and Long-Term Outcomes of IntramedullarySpinal Cord Cavernous Malformations: A Single-Center Consecutive Series of 219Patients. JNS Spine, 2019,4, 31 (1):123-132. 【IF 3.467】

【15】     Tao Hong#, Yupeng Yan#, Jingwei Li#, IvanRadovanovic, Xiangyuan Ma, Yang W. Shao, Jiaxing Yu, Yongjie Ma, Peng Zhang,Feng Ling, Shuchen Huang, Hongqi Zhang*, Yibo Wang*. High prevalence of KRAS/BRAFsomatic mutations in brain and spinal cord arteriovenous malformations. BRAIN,2018, 142(1): 23-34. 【IF 15.255】

【16】     T Hong#, JX Yu#, W Liu, LS Bian, F Yang, YJ Ma, FLing, HQ Zhang*. Filum Terminale Arteriovenous Fistulas with Multiple ShuntPoints: A Report of Two Exceptional Cases. World Neurosurgery.2018,10(118):235-239. 【IF 2.210】

【17】     JX Yu#, T Hong#, YJ Ma, F Ling, HQ Zhang*. A New Type of SpinalEpidural Arteriovenous Fistulas Causes Spinal Epidural Hemorrhage: An Analysisof Five Cases and Natural History Consideration. World Neurosurgery, 2017,7(103):371-379. 【IF 2.210】

【18】     Tao Hong, J.E. Park, Feng Ling, K.G. terBrugge, M.Tymianski, Hongqi Zhang*, Timo Krings*. Comparison of 3 Different Types ofSpinal Arteriovenous Shunts below the Conus in Clinical Presentation,Radiologic Findings, and Outcomes. AJNR Am J Neuroradiol, 2017, 38(2): 403-409. 【IF 4.966】