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黄越教授对脑库的建设（脑组织病理和分子病理）具有长期的工作基础。她在澳大利亚悉尼脑库工作 12 年，从事志愿者队列的基因检测和入库脑组织的病理分类工作，已给出近 100 例志愿捐献者的脑组织大体和显微镜报告，熟知国际上脑库运行的整体流程。在回国四年的时间里，了解了国内脑库建设所必须的政策和相关的条件基础，掌握人体脑与组织的病理诊断，开拓了尸检所涉及的人体组织样本库建设，及捐献志愿者长期随访队列的建设。
其研究领域主要涉及到神经变性病的研究，包括：1）神经变性病肠脑途径的研究，2）神经罕见病的基因和病理诊断及iPSC的培养，3) 病理性包涵体形成模型的构建，4) 导致病理包涵体形成的组织微环境变化， 5） 神经系统疾病的脑健康关爱
在教学方面：为首都医科大学的博士生导师，指导了1个博后，4个博士生，2个硕士生。曾连续三年为北京协和医科大学辅导博士生及研究生课程（2017-2020），为清华大学本科生讲授“神奇的大脑”课程（2020），承办了三届国家级继续教育项目：脑库的建设（2019-今）
其它：入选北京海聚人才计划（2020），中国教育部的春晖计划（2017）, 澳大利亚科技部的国际科技交流计划（2008）。在社会服务方面：为Frontiers in Neurology - Neurogenetics的副主编，为Current Alzheimer Research杂志的编委，曾为20余个国际杂志审稿（如：Annalsof Neurology, etc），为国自然青年项目的评审专家，为工业和信息化部人才、宁波甬江引才工程，和学术桥人才评审专家。澳大利亚华人生物医学科学家协会（AACBS）的首任会长;中国红十字会天坛脑健康志愿服务队的创始人。
1. 心脑共病的组织分子病理学检测 – 心血管重大疾病防治省部共建协同创新中心， 首都医科大学，2022.04-2023.04
2. 临床评价用RT-QuIC诊断共核蛋白病的准确性，ID: 2022SKLID306，传染病预防控制国家重点实验室，2022.06-2023.06
3. 捐献志愿者的脑健康管理，中国人体器官捐献管理中心，2021.08-2021.12
4. 探讨p25alpha介导的细胞外泌囊泡对共核蛋白病进展的影响机制及临床应用。国自然面上项目，ID：82071417，2021.01-2024.12
近 5 年所发表的文章（2017-）
1. Qiu WY, Ma C, Bao AM,Zhu KQ, Huang Y, YanXX,Zhang J, Zhong CJ,Zhou JJ, Shen Y, ZhengXY,Zhang LW, Shu YS, Tang BS, Zhang ZX, Duan SM. Standardized operationalprotocol for human brain banking in China [J]. Jie Pou Xue Bao, 2017, 48(03):334-341. [仇文颖, 马超, 包爱民, 竺可青, 黄越, 严小新, 章京, 钟春玖, 周江宁, 申勇, 郑晓瑛, 张力伟, 舒友生, 唐北沙, 张振馨, 段树民. 中国人脑组织库标准化操作方案 [J]. 解剖学报, 2017,48(03): 334-341.]
2. Li ZB, He SW, Xiong T, Shen DG, Huang Y (2017) Novel Compound Heterozygous DYSF Mutations Lead toDysferlinopathy. EC Paediatrics 3.4: 400-403.
3. Che XQ, Zhao QH, Huang Y,Li X, Ren RJ, Chen SD, Wang G, Guo QH. Clinicaland Genetic Features of MAPT, GRN, C9orf72 and CHCHD10 Genes Mutations in Chinese Patients with Frontotemporal Dementia. Current Alzheimer Research. 2017;14(10):1102-1108.
4. Langenhove TV, Piguet O, BurrellJR, Leyton C, Foxe D, Abela M, Bartley L, Kim WS, Jary E, Huang Y, Dobson-Stone C, Kwok JB,Halliday GM, Hodges JR. Predicting development of amyotrophic lateral sclerosis in frontotemporal dementia.Journal of Alzheimer’s Disease. 2017;58(1):163-170. doi: 10.3233/JAD-161272.
5. Sheng C, Xia MR, Yu HK, Huang Y, Lu Y, Liu F, He Y, Han Y. MedialTemporal Atrophy and Abnormal Global Functional NetworkConnectivity in Patients with Amnestic Mild Cognitive Impairment. PlosOne. 2017;12(6):e0179823.
6. Huang Y. Book Review: Landmark Papersin Neurology. CurrentAlzheimer Research. CurrAlzheimer Res.2017;14(12):1348-1349
7. Qiu W-Y, Yang Q, Zhang W, Wang N, Zhang D, Huang Y, Ma C. The Correlations Between Postmortem Brain Pathologies and Cognitive Dysfunction in Aging and Alzheimer's DiseaseCurr Alzheimer Res.2018;15(5):462-473.
8. Forrest SL, Kril JJ, Stevens CH, KwokJB, Hallupp M, Kim WS, Huang Y,McGinley CV, Werka H, Kiernan MC. et al. Retiring the term FTDP-17as MAPT mutations are geneticforms of sporadicfrontotemporal tauopathies. Brain. 2018; 141(2):521-534.
9. Sheng C, Huang Y, Han Y. Dissection of prodromal Alzheimer’s disease. Front Biosci(Landmark Ed) 23: 1272-1291.2018.01.01.
10. Che XQ*, Zhao QH*, Huang Y*, Li X, Ren RJ, Chen SD, Guo QH, Wang G. Mutation Screeningof the CHCHD2 Gene for Alzheimer’s Disease and Frontotemporal Dementiain Chinese MainlandPopulation. Journal of Alzheimer’s Disease.2018; 61(4): 1283-1288.
11. Wang G, Cui HL, Huang Y. Reader response: Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium. Neurology, 2018;90(6):38.
12. Qiu W, Zhang HL, Bao AM, Zhu KQ, Huang Y, Yan XX, Zhang J, Zhong C, Zhou JN, Shen Y, Zheng XY, Zhang LW, Shu YS, Tang BS, Zhang ZX, Wang G, Zhou R, Sun B, Gong C, Duan S, Ma C. Standardised operational protocolfor human brain banking in China. NeuroscienceBulletin. 2019,35(2):270-276.
13. Hu YB, Ren RJ, Zhang YF, Huang Y, Cui HL, Ma C, Qiu WY, Wang H,Cui PJ, Chen HZ, Wang G (2019) Rho‐associated coiled‐coil kinase 1 activation mediates amyloid precursor protein site‐specific Ser655 phosphorylation andtriggers amyloid pathology.Aging cell. 2019. July 9, https://doi.org/10.1111/acel.13001.
14. Qian E, HuangY*. Subtyping of Parkinson’s Disease - where are we up to? Aging &Disease. 2019. 10(5):1130-1139. 5.402
15. Kong WL, Huang Y*, Qian E, Morris M*.Constipation and Probable Rapid Eye MovementSleep Behavior Disorder Associate with Cognitive Processing Speed andAttention over Five Years FollowingClinical Diagnosis in Males with Parkinson’s Disease.Scientific Report. 2020.11.04; 10, Articlenumber: 19014 (2020) IF=4.576
16. Forrest SL, Halliday GM, Sizemova A, Roijen M, McGinley CV, Bright F, Kapur M, McGeachieAB, McCann H, Shepherd CE, Tan RH, Affleck AJ, Huang Y, Kril J. A Practical Approachto Differentiate the Frontotemporal Tauopathy Subtypes. Journal ofNeuropathology and Experimental Neurology. 2020;79(10):1122–1126. IF=3.685
17. Cao LX, Huang Y*, Cai ZY, Chen B, Chen SD, Fan DS,Fang BY, Guo YJ, Han Y, Huang HP, Ji WJ, Li HY, Liu K,Pei Z, Peng DT, Shi FD, Sui Y,Tang BS, Wang F, Wang W, Wang ZX, Wu AH, Xu Y, YangDD, Zhang GF, Zhang LW, Zhang ZT, Zhao W, Zhao XQ, Wang YJ*. Brain bank in neurologyhistory and development [J]. Zhongguo Xian Dai Shen Jing Bing Za Zhi, 2020, 20 (10): 914-923.[曹凌晓, 黄越, 蔡志友, 陈彪, 陈生弟, 樊东升, 方伯言, 郭燕军, 韩璎, 黄华品, 纪文军, 李红燕, 刘坤, 裴中, 彭丹涛, 施福东, 隋轶, 唐北沙, 王枫, 王雯, 王朝霞, 吴安华, 徐运, 杨东东, 张国富, 张力伟, 张振涛, 赵伟, 赵性泉, 王拥军。脑库与神经病学建设[J]. 中国现代神经疾病杂志, 2020, 20 (10): 914-923.] IF=0.97
18. Huang Y, Morris M. Rapid Response:Decoding the brain – the value of human brain tissue banking for research. BMJ,2021.01.29
19. Pan FF, Wang Y, Huang L, Huang Y, Guo QH. Validation of the Chineseversion of Addenbrooke’s cognitive examination IIIfor detectingmild cognitive impairment. Aging and mental health. 1-8, 03 Feb 2021. PMID: 33533261
20. Yin JH, Huang Y*,Bian XW, Chen B, Chen SD, Cui HX, et al. Consensus on biosafety protectionof human brain tissue bank[J].A Er Ci Hai Mo Bing JiXiang Guan Bing Za Zhi. 2021,4:1-15.[尹金辉, 黄越, 卞修武, 陈彪, 陈生弟，崔慧先, 董格红，郭慧君，何跃颂，朴月善，唐北沙，王德田，吴安华，张玉琪，周韧，张力伟*. 人脑组织库生物安全防护共识[J]. 阿尔茨海默病及相关病杂志 2021 年, 2021.05.08，DOI:10.3969/j.issn.2096-5516.2021.01.002.
21. Cao LX, Dong W, Li Y, Li SX, Chen B, Huang Y.Brain pathological analysis of Parkinson's diseasecombined with cerebral small vessel disease: one case report and literaturereview. 曹凌晓 董威 李渊 李少祥 陈彪 黄越. 帕金森病合并脑小血管病人脑组织病理学分析：附一例报告并文献复习.中国现代神经疾病杂志 2021 年 4 月第 21 卷第 4 期 Chin JContemp Neurol Neurosurg, April 2021, Vol. 21, No. 4. 255-261. IF=0.97
22. Huang Y. Clinical pathological conference is acompulsory element of human brain banking. 黄越. 临床病例病理讨论是人脑组织库建设 不可或缺的一部分. 中国现代神经疾病杂志 2021 年 4 月第 21 卷第 4 期 Chin J Contemp Neurol Neurosurg, April 2021, Vol. 21, No. 4.233-235, IF=0.97
23. Du J, Yang Q, Mi SX, Fan P, CuiHX, Huang Y. The significance of human brain banking construction forAlzheimer's disease research. 杜鹃 杨倩 米世雄 樊平 崔慧先 黄越,人脑组织库建设对阿尔茨海默病研究的意义, 中国现代神经疾病杂志 2021 年 4 月第 21 卷第 4 期 Chin J Contemp Neurol Neurosurg, April 2021, Vol. 21, No. 4.245-249. IF=0.97
24. Hu WZ, Yang ZH, Huang Y,Shi GZ, Zhang Z, Liu LP, Zhou JX. Interpretation of ‘Determination of BrainDeath/Death by Neurological Criteria (Version 2020)’。胡文政，杨中华，黄越，石广志，张哲，刘丽萍，周建新。2020版《脑死亡/符合神经病学标准的死亡判定》解读，中国现代神经疾病杂志 2021 年 4 月第 21 卷第 4 期 Chin J Contemp Neurol Neurosurg, April 2021, Vol. 21, No. 4. 241-244. IF=0.97
25. Du G, Dong W, Yang Q, Yu XY, Ma JH, Gu WH, Huang Y. Altered GutMicrobiota Related to Inflammatory Responses in Patients with Huntington’sDisease. Front. Immunol., 19 February 2021 | doi：10.3389 / fimmu.2020.603594; IF=7.561
26. You HJ, Wu TT, Du G, Huang Y,Zeng YX, Lin LS, Chen DB, Wu C, Li XH, Burgunder JM, Pei Z. Evaluation of BloodGlial Fibrillary Acidic Protein as a Potential Marker in Huntington’s Disease.Frontiers in Neurology, 2021. Nov.19, doi:10.3389/fneur.2021.779890, IF=4.003
27. Cao LX, Jiang Y, Piao YS, Huang Y.Rapid Motor Progression of Parkinson’s disease associateswith clinical and genetic variants. Frontiers in Bioscience - Landmark. 2021;26(12) DOI:10.52586/5044; IF=4.009
28. Huang Y, Wei J, Cooper A, Morris M. Parkinson'sDisease: From Genetics to Molecular Dysfunction and Targeted TherapeuticApproaches. Genes and Diseases. In press 2022.02.05; IF=8.4
29. DongW, Cui MC, Hu WZ, Zeng Q, Wang YL, Zhang W, Huang Y. Genetic andmolecular evaluation of SQSTM1/p62 on the neuropathologies of Alzheimer’sDisease. Frontiers in Aging Neuroscience 2022.02.28, DOI: 10.3389/fnagi.2022.829232;IF=5.750
30. Yang X, Dai ZF, Gao CX , Yin YQ, ShiCB, Liu RJ, Zhuang QC, Huang Y, Zhou B , Han ZM, Zheng XJ. Cerebralcavernous malformation development in chronic mouse models driven by dualrecombinases induced gene deletion in brain endothelial cells. Journal ofCerebral Blood Flow and Metabolism. In press.
31. ChenDD, Jiao L, Huang Y, Xiao K, Gao LP, ChenC, Shi Q* and Dong XP* Application of α-Syn RT-QuIC for Brain and SkinSpecimens of the Chinses Patients with Parkinson Disease. Front. Aging Neurosci. Accepted on May 16.
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