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首都医科大学附属北京友谊医院普外中心 主任医师,副教授,硕士研究生导师,医学博士,博士后。长期从事普通外科的临床及科研工作,尤其是消化系统肿瘤,主要包括胃、肠、肝、胆、胰腺恶性肿瘤的化学治疗、靶向治疗、免疫治疗及临床基础研究。任 中国医师协会外科学分会MDT专业委员会委员,中国研究型医院学会分子诊断医学专业委员会委员,北京医学会肿瘤学分会委员,北京医师协会肿瘤专业专家委员会委员,北京癌症防治协会消化道肿瘤精准治疗专业委员会常务委员,北京乳腺病防治学会国际医疗与合作专业委员会委员等。
北京市自然科学基金委员会, 北京市自然科学基金面上项目, 7212024, 基于CRISPRa 技术激活突变基因转化胃癌免疫冷肿瘤的作用机制研究, 2021-01 至 2023-12, 主持
国家自然科学基金委员会,国家自然科学基金面上项目,81172317,新耐药基因Txr1在进展期胃癌奥沙利铂化疗中的耐药机制研究,2012.01至2015.12,主持
北京市自然科学基金委员会, 北京市自然科学基金面上项目, 7212024, 基于CRISPRa 技术激活突变基因转化胃癌免疫冷肿瘤的作用机制研究, 2021-01 至 2023-12, 主持
国家自然科学基金委员会,国家自然科学基金面上项目,81172317,新耐药基因Txr1在进展期胃癌奥沙利铂化疗中的耐药机制研究,2012.01至2015.12,主持
Huo X, Feng D, Zhang S, Li Z, Li X, Li C, Guo M, Wang J, Zhang Z, Lu Q, Du X, Bai Z, Chen Z. Characterization and clinical evaluation of microsatellite instability and loss of heterozygosity within tumor-related genes in colorectal cancer. BMC Med Genomics. 2021 Sep 25;14(1):235. doi: 10.1186/s12920-021-01051-5. PubMed PMID: 34563193; PubMed Central PMCID: PMC8466986.
Cen S, Liu K, Zheng Y, Shan J, Jing C, Gao J, Pan H, Bai Z, Liu Z. BRAF Mutation as a Potential Therapeutic Target for Checkpoint Inhibitors: A Comprehensive Analysis of Immune Microenvironment in BRAF Mutated Colon Cancer. Front Cell Dev Biol. 2021;9:705060. doi: 10.3389/fcell.2021.705060. eCollection 2021. PubMed PMID: 34381786; PubMed Central PMCID: PMC8350390.
Huo X, Xiao X, Zhang S, Du X, Li C, Bai Z, Chen Z. Characterization and clinical evaluation of microsatellite instability and loss of heterozygosity in tumor-related genes in gastric cancer. Oncol Lett. 2021 Jun;21(6):430. doi: 10.3892/ol.2021.12691. Epub 2021 Mar 30. PubMed PMID: 33868468; PubMed Central PMCID: PMC8045158.
Wang G, Chow RD, Zhu L, Bai Z, Ye L, Zhang F, Renauer PA, Dong MB, Dai X, Zhang X, Du Y, Cheng Y, Niu L, Chu Z, Kim K, Liao C, Clark P, Errami Y, Chen S. CRISPR-GEMM Pooled Mutagenic Screening Identifies KMT2D as a Major Modulator of Immune Checkpoint Blockade. Cancer Discov. 2020 Dec;10(12):1912-1933. doi: 10.1158/2159-8290.CD-19-1448. Epub 2020 Sep 4. PubMed PMID: 32887696; PubMed Central PMCID: PMC7710536.
Wang, Guangchuan; Chow, Ryan D.; Bai, Zhigang; Zhu, Lvyun; Errami, Youssef; Dai, Xiaoyun;Dong, Matthew B.; Ye, Lupeng; Zhang, Xiaoya; Renauer, Paul A.; Park, Jonathan J.; Shen, Li; Ye, Hanghui; Fuchs, Charles S.; Chen, Sidi; Multiplexed activation of endogenous genes by CRISPRa elicits potent antitumor immunity, Nature Immunology, 2019, 20(11): 1494-1505
Bai ZG, Zhang ZT. A systematic review and meta-analysis on the effect of angiogenesis blockade for the treatment of gastric cancer. Onco Targets Ther. 2018;11:7077-7087. doi: 10.2147/OTT.S169484. eCollection 2018. PubMed PMID: 30410364; PubMed Central PMCID: PMC6200090.
Bai Z, Wang J, Wang T, Li Y, Zhao X, Wu G, Yang Y, Deng W, Zhang Z. Clinicopathologic parameters associated with postoperative complications and risk factors for tumor recurrence and mortality after tumor resection of patients with colorectal cancer. Clin Transl Oncol. 2018 Feb;20(2):176-192. doi: 10.1007/s12094-017-1708-0. Epub 2017 Jul 14. PubMed PMID: 28710725.
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