研究团队目前拥有2名博士生导师(含1名青年博导)和4名硕士生导师;团队成员包括主任医师(教授)1名、副主任医师3名副研究员1名、主治医师3名以及医师2名。秦琪副主任医师先后入选“北京科技新星”(2021)与“北京市优秀青年人才”(2023)；王治斌主治医师于2022年入选北京市医管局青苗计划；陈欧阳副研究员毕业于杜克大学，于2024年加入团队，并入选北京市“海聚工程”青年人才项目。团队成员先后主持国家自然科学基金5项，以及科技部“国家重点研发计划”课题2项。目前有2名博士后、13名博士研究生、6名硕士研究生和4名本科生在读。多名团队成员及学生在第十四届“挑战杯”秦创原中国大学生创业计划竞赛中获得铜奖，并多次荣获国家奖学金、北京市优秀毕业生等荣誉称号。

唐毅教授课题组致力于阿尔茨海默病及相关认知障碍疾病的发病机制及早期诊断干预研究。团队先后承担国家重点研发计划、国家自然科学基金重点国际合作项目等国家和省部级课题16项。团队主要研究方向包括：

1. 基于动物和人源细胞模型的阿尔茨海默病发病机制研究；

2. 靶向神经免疫互作治疗阿尔茨海默病；

3. 以认知训练和经颅电刺激为代表的非药物干预的早期疗效和神经机制研究；

4. 基于神经电生理和感知觉的认知障碍疾病发病机制和早期诊断研究；

5. 全国多中心认知队列研究。

国家自然科学基金委员会，重点国际合作项目，82220108009，40Hz经颅交流电刺激对阿尔茨海默病早期干预疗效的神经机制研究，2023/01-2027/12

科学技术部，国家重点研发计划“主动健康和人口老龄化科技应对”重点专项，2022YFC3602600，老年人失能风险的预警与早期防控体系研究，2022/12-2025/11

国家自然科学基金委员会，面上项目，81970996，阿尔茨海默病听觉信息整合障碍的神经机制及其早期诊断作用研究，2020/01-2023/12

北京市自然科学基金委员会，北京杰出青年科学基金项目，JQ19024，胆碱能影像标志物在阿尔茨海默病早期诊断和认知干预评估中的作用研究，2019/11-2022/12

北京市科学技术委员会，首都临床诊疗技术研究及示范应用，Z191100006619046，计算机辅助认知训练早期干预血管性认知障碍技术的优化研究，2019/08-2022/08

科学技术部，国家重点研发计划“重大慢性非传染性疾病防控研究”，2017YFC1310102，阿尔茨海默病痴呆前阶段干预新方法的研究，2017/07-2021/06

国家自然科学基金委员会，面上项目，81671040，胆碱能神经通路在阿尔茨海默病痴呆前阶段及认知训练中的作用机制，2017/01-2020/12

北京市科学技术委员会，首都临床特色应用研究，Z151100004015078，计算机辅助认知训练早期干预阿尔茨海默病痴呆前阶段的随机对照研究，2015/03-2018/09

教育部，留学回国人员科研启动基金，应用家族性AD 患者原代成纤维细胞研究tau 蛋白磷酸化在PS1 Val97Leu突变致病机制中的作用，2010/01-2013/12

北京市自然科学基金委员会，面上项目，7102072，Tau蛋白和自噬在家族性AD发病机制中作用的研究，2010/01-2012/12

国家自然科学基金委员会，青年基金，30900478，应用家族性AD患者原代成纤维细胞研究PS1 Val97Leu突变的发病机制，2010/01-2012/12

1.      Wei T, Zhou J, Wang Z, Liu X, Mi Y, Zhao Y, Xing Y,Zhao B, Zhou S, Liu Y, Liu Y*, Tang Y*.Coupled sleep rhythm disruption predicts cognitive decline in Alzheimer’sdisease. Sci Bull. 2025. Available online 12 March 2025. doi.org/10.1016/j.scib.2025.03.023.

2.      Chen X, Hu G, Chang L, Li X, Tang Y,Wu Y, Zhang R, Zhang C, Wang J, Wang X, Wang S. Nitrate ameliorates myelin lossand cognitive impairment in Alzheimer's disease through upregulation ofneuronal sialin and subsequent inhibition of TPPP phosphorylation. Sci Bull. 2025 Mar 9:S2095-9273(25)00245-2.

3.      Que X, Zhang T, Liu X, Yin Y, Xia X, Gong P, Song W,Qin Q, Xu ZD, Tang Y*. The role of TREM2 in myelin sheathdynamics: A comprehensive perspective from physiology to pathology. ProgNeurobiol. 2025 Apr;247:102732.

4.      Guo R, Li D, Li F, Ji L, Liu H, Qiao H, Lv Z, TangY, Wang D. Effects of whole-head 810 nm near-infrared therapy oncognitive and neuropsychiatric symptoms in Alzheimer's disease: A pilot study.J Alzheimers Dis. 2025 Mar;104(1):52-60.

5.      Liu Y, Chang J, Zhao Y, Gao P, Tang Y*.Frailty and social contact with dementia risk: A prospective cohort study. JAffect Disord. 2025 Apr 15;375:129-136.

6.      Yu Y, Shen H, Qin Q, Wang J, Nie Y, Wen L, TangY*, Qu M. The investigation of peripheral inflammatory andoxidative stress biomarkers in dementia with Lewy Bodies, compared withAlzheimer's Disease, and mild cognitive impairment. Neuroscience. 2025 Mar5;568:209-218.

7.      Liu L, Geng C, Teipel SJ, Khachaturian Z, TangY*. Dawn of disease modifying interventions fordementia-Alzheimer syndrome: an assessment of safety and efficacy of promisingcandidates. Sci Bull (Beijing). 2025 Feb 26;70(4):444-447.

8.      Lu Q, Wang Y, Qu B, Wang C, Su X, Wang S, Xing Y,Qin W, Tang Y, Zhang N. Structural and Functional Projections ofthe Nucleus Basalis of Meynert and Their Changes After Cognitive Training inIndividuals With Mild Cognitive Impairment. CNS Neurosci Ther. 2024Dec;30(12):e70194.

9.      Wang Z, Wang C, Wei T, Mi Y, Zhou S, Liu X, Jia J,Li L, Zhao G, Tang Y*. Impaired temporal coding associatedwith central auditory dysfunction and cognitive impairment in Alzheimer'sdisease. Sci Bull. 2024 Oct 16:S2095-9273(24)00751-5. doi:10.1016/j.scib.2024.10.012.

10.   Shen H, Yu Y, Wang J, Nie Y, Tang Y*,Qu M*. Plasma lipidomic signatures of dementia with Lewy bodiesrevealed by machine learning, and compared to alzheimer's disease. AlzheimersRes Ther. 2024 Oct 15;16(1):226. doi: 10.1186/s13195-024-01585-7.

11.   Zhao K, Wang D, Wang D, Chen P, Wei Y, Tu L, Chen Y,Tang Y, Yao H, Zhou B, Lu J, Wang P, Liao Z, Chen Y, Han Y, ZhangX, Liu Y. Macroscale connectome topographical structure reveals thebiomechanisms of brain dysfunction in Alzheimer's disease. Sci Adv. 2024 Oct11;10(41):eado8837. doi: 10.1126/sciadv.ado8837.

12.   Yang K, Yang X, Yin P, Zhou M, Tang Y*.Temporal trend and attributable risk factors of Alzheimer's disease and otherdementias burden in China: Findings from the Global Burden of Disease Study2021. Alzheimers Dement. 2024 Sep 23. doi: 10.1002/alz.14254.

13.   Wang T, Yan S, Shan Y, Xing Y, Bi S, Chen Z, Xi H,Xue H, Qi Z, Tang Y*, Lu J*. AlteredNeuronal Activity Patterns of the Prefrontal Cortex in Alzheimer's DiseaseAfter Transcranial Alternating Current Stimulation: A Resting-State fMRI Study.J Alzheimers Dis. 2024 Sep 12. doi: 10.3233/JAD-240400.

14.   Tang Y*, Xing Y, Sun L, Wang Z, Wang C, Yang K, Zhu W, ShiX, Xie B, Yin Y, Mi Y, Wei T, Tong R, Qiao Y, Yan S, Wei P, Yang Y, Shan Y,Zhang X, Jia J, Teipel SJ, Howard R, Lu J, Li C, Zhao G. TRanscranialAlterNating current stimulation FOR patients with mild Alzheimer's Disease(TRANSFORM-AD): a randomized controlled clinical trial. Alzheimers Res Ther.2024 Sep 12;16(1):203. doi: 10.1186/s13195-024-01570-0.

15.   Zhou S, Xu J, Liu X, Li A, Zhao B, Geng C, Wei T,Liu Y, Wang Z, Tang Y*. Brain fog assessment inpatients recovered from COVID-19 in China: a development and validation study.Int J Neurosci. 2024 Sep 2:1-11. doi: 10.1080/00207454.2024.2398616.

16.   Liu L, Wang H, Xing Y, Zhang Z, Zhang Q, Dong M, MaZ, Cai L, Wang X, Tang Y*. Dose-response relationshipbetween computerized cognitive training and cognitive improvement. NPJ DigitMed. 2024 Aug 15;7(1):214. doi: 10.1038/s41746-024-01210-9.

17.   Wang X, Su L, Han J, Han Y, Yin Y, Huang J, TangY*, Zhao Y*, Qin Q*. Retinalvasculopathy with cerebral leukoencephalopathy and systemic manifestations inconjunction with systemic lupus erythematosus: Missed diagnosis ormisdiagnosis? Immun Inflamm Dis. 2024 Aug;12(8):e1367. doi: 10.1002/iid3.1367.

18.   Lu Y, Mao F, Yin P, Chang J, Zhao Z, Yang K, Qin Q,Zhou M, Tang Y*. A comprehensive index to evaluatecognitive health at the population scale. Chin Med J (Engl). Published onlineAugust 9, 2024. doi:10.1097/CM9.0000000000003241

19.   Geng C, Tang Y*.Association between levels of sex hormones and risk of multiple sclerosis: amendelian randomization study. Acta Neurol Belg. Published online July 29,2024. doi:10.1007/s13760-024-02613-x

20.   Chang J, Liu Y, Zhao Y, Gao P, Tang Y*.Association of sleep duration with excess risk of dementia among shift workersin the UK biobank: a population-based cohort study. J Neurol. Publishedonline July 20, 2024. doi:10.1007/s00415-024-12580-1

21.   Yin Y, Yang H, Li R, Wu G, Qin Q, Tang Y*.What do the conflicting findings in the trem2 transgenetic mouse model tell us?A systematic review of the role of TREM2 in Alzheimer's disease. Chin Med J(Engl). Published online June 24, 2024. doi:10.1097/CM9.0000000000003000

22.   Li QG, Xing Y, Zhu ZD, Fei XL*, TangY*, Lu J*. Effects of computerized cognitivetraining on functional brain networks in patients with vascular cognitiveimpairment and no dementia. CNS Neurosci Ther. 2024;30(6):e14779.doi:10.1111/cns.14779

23.   Liu Y, Chang J, Zhao Y, Tang Y*.Neuroticism personality, social contact, and dementia risk: A prospectivecohort study. J Affect Disord. 2024;358:391-398.doi:10.1016/j.jad.2024.05.055

24.   Geng C, Meng K, Tang Y*.Identifying the mediating role of inflammation on the relationship betweensocioeconomic status and Alzheimer's disease: a Mendelian randomizationanalysis and mediation analysis. J Neurol. 2024;271(5):2484-2493.doi:10.1007/s00415-023-12176-1

25.   Geng C, Meng K, Zhao B, Liu X, Tang Y*.Causal relationships between type 1 diabetes mellitus and Alzheimer's diseaseand Parkinson's disease: a bidirectional two-sample Mendelian randomizationstudy. Eur J Med Res. 2024;29(1):53. doi:10.1186/s40001-023-01628-z

26.   Geng C, Wang Z, Tang Y*.Machine learning in Alzheimer's disease drug discovery and targetidentification. Ageing Res Rev. 2023 Dec 15:102172. doi:10.1016/j.arr.2023.102172.

27.   Wang M, Wei T, Yu C, Li R, Yin Y, Yang H, Di R, XiaX, Qin Q, Tang Y*. Integrative Metabolomics and WholeTranscriptome Sequencing Reveal Role for TREM2 in Metabolism Homeostasis inAlzheimer's Disease. Mol Neurobiol. 2023 Dec 8. doi:10.1007/s12035-023-03840-8.

28.   Li J, Shan Y, Zhao X, Shan G, Wei PH, Liu L, Wang C,Wu H, Song W, Tang Y, Zhao GG, Lu J. Structural and functionalchanges in the brain after chronic complete thoracic spinal cord injury. BrainRes. 2024 Jan 15;1823:148680. doi: 10.1016/j.brainres.2023.148680.

29.   Zhao K, Chen P, Alexander-Bloch A, Wei Y, Dyrba M,Yang F, Kang X, Wang D, Fan D, Ye S, Tang Y, Yao H, Zhou B, Lu J,Yu C, Wang P, Liao Z, Chen Y, Huang L, Zhang X, Han Y, Li S, Liu Y. Aneuroimaging biomarker for Individual Brain-Related Abnormalities InNeurodegeneration (IBRAIN): a cross-sectional study. EClinicalMedicine.2023 Oct 26;65:102276. doi: 10.1016/j.eclinm.2023.102276.

30.   Liu Y, Wang Z, Wei T, Zhou S, Yin Y, Mi Y, Liu X, TangY*. Alterations of Audiovisual Integration in Alzheimer'sDisease. Neurosci Bull. 2023 Dec;39(12):1859-1872. doi: 10.1007/s12264-023-01125-7.

31.   Liu LY, Xing Y, Zhang ZH, Zhang QG, Dong M, Wang H,Cai L, Wang X, Tang Y*. Validation of a ComputerizedCognitive Training Tool to Assess Cognitive Impairment and EnableDifferentiation Between Mild Cognitive Impairment and Dementia. J AlzheimersDis. 2023;96(1):93-101. doi: 10.3233/JAD-230416.

32.   Wei T, Shi X, Sun W, Song W, Zhou S, Zhao Y, Wang Z*,Tang Y*. Identifying Suitable Targets for Alzheimer'sDisease and Other Eight Common Neurological Disorders Using the Human PlasmaProteome: A Mendelian Randomization Study. J Alzheimers Dis Rep. 2023Aug 4;7(1):811-822. doi: 10.3233/ADR-230058.

33.   Nie Y, Chu C, Qin Q, Shen H, Wen L, Tang Y*,Qu M*. Lipid metabolism and oxidative stress in patients withAlzheimer's disease and amnestic mild cognitive impairment. Brain Pathol.2024 Jan;34(1):e13202. doi: 10.1111/bpa.13202.

34.   Zhou S, Wei T, Liu X, Liu Y, Song W, Que X, Xing Y*,Wang Z*, Tang Y*. Causal effects ofCOVID-19 on structural changes in specific brain regions: a Mendelianrandomization study. BMC Med. 2023 Jul 19;21(1):261. doi:10.1186/s12916-023-02952-1.

35.   Yang H, Qin Q, Wang M, Yin Y, Li R, Tang Y*.Crosstalk between peripheral immunity and central nervous system in Alzheimer'sdisease. Cell Immunol. 2023 Sep-Oct;391-392:104743. doi:10.1016/j.cellimm.2023.104743.

36.   Teipel S, Tang Y, Boccardi M.Predicting cognitive decline in older people by structural and molecularimaging. Curr Opin Neurol. 2023 Aug 1;36(4):253-263. doi:10.1097/WCO.0000000000001172.

37.   Liu XD, Wei T, Shi L, Zhou SJ, Liu YF, Song WY, QueXW, Wang ZB*, Tang Y*. Causal relationshipbetween gastroesophageal reflux disease, Barrett's esophagus, and epilepsy: Abidirectional Mendelian randomization study. Brain Behav. 2023Sep;13(9):e3117. doi: 10.1002/brb3.3117.

38.   Qin Q, Qu J, Yin Y, Liang Y, Wang Y, Xie B, Liu Q,Wang X, Xia X, Wang M, Zhang X, Jia J, Xing Y*, Li C*, TangY*. Unsupervised machine learning model to predict cognitiveimpairment in subcortical ischemic vascular disease. Alzheimers Dement.2023 Feb 14. doi: 10.1002/alz.12971.

39.   Qin Q, Wang M, Li H*, Xu ZD*, TangY*. Editorial: The role of microglia in the pathogenesis ofneurodegenerative diseases. Front Aging Neurosci. 2023 Jan 6;14:1105896.doi: 10.3389/fnagi.2022.1105896.

40.   Liu PP, Dai SK, Mi TW, Tang GB, Wang Z, Wang H, DuHZ, Tang Y*, Teng Z*,Liu CM*. Acetate supplementation restores cognitive deficitscaused by ARID1A haploinsufficiency in excitatory neurons. EMBO Mol Med.2022;e15795. doi:10.15252/emmm.202215795.

41.   Yu CJ, Wang M, Li RY, Wei T, Yang HC, Yin YS, Mi YX,Qin Q*, Tang Y*. TREM2 and Microglia Contribute to the SynapticPlasticity: from Physiology to Pathology. Mol Neurobiol. 2023Feb;60(2):512-523. doi: 10.1007/s12035-022-03100-1.

42.   Xia X, Qin Q*, Peng Y, Wang M, Yin Y, Tang Y*.Retinal Examinations Provides Early Warning of Alzheimer's Disease. JAlzheimers Dis. 2022;10.3233/JAD-220596. doi: 10.3233/JAD-220596.

43.   Shi X, Wei T, Hu Y, Wang M, Tang Y*.The associations between plasma soluble Trem1 and neurological diseases: aMendelian randomization study. J Neuroinflammation. 2022 Sep6;19(1):218. doi:10.1186/s12974-022-02582-z.

44.   Lutz MW, Khachaturian AS, Zetterberg H, Blennow K,Willette AA, Mielke MM, Hayden KM, Dodge HH, Tang Y, GreenbergBD, Kukull WA, Khachaturian ZS. Biomarkers of Alzheimer syndrome and relateddementias: A&D author's guide. Alzheimers Dement. 2022Sep;18(9):1595-1601. doi: 10.1002/alz.12772.

45.   Zhang SF, Dai SK, Du HZ, Wang H, Li XG, Tang Y*,Liu CM*. The epigenetic state of EED-Gli3-Gli1 regulatory axis controlsembryonic cortical neurogenesis. Stem Cell Reports. 2022 Sep13;17(9):2064-2080. doi: 10.1016/j.stemcr.2022.07.004.

46.   Yu Y, Lu Y, Wang F, Lu Y, Xie B, Meng X, TangY*. Acanthocytes Identified in Huntington's Disease. Front Neurosci.2022 Jun 6; 16:913401. doi: 10.3389/fnins.2022.913401.

47.   Qin Q, Wang M, Yin Y, Tang Y*. TheSpecific Mechanism of TREM2 Regulation of Synaptic Clearance in Alzheimer'sDisease. Front Immunol. 2022 May 19; 13:845897. doi:10.3389/fimmu.2022.845897.

48.   Li RY, Qin Q, Yang HC, Wang YY, Mi YX, Yin YS, WangM, Yu CJ, Tang Y*. TREM2 in the pathogenesis of AD: a lipidmetabolism regulator and potential metabolic therapeutic target. MolNeurodegener. 2022 Jun 3;17(1):40. doi: 10.1186/s13024-022-00542-y.

49.   Wang YY, Deng YS, Dai SK, Mi TW, Li RY, Liu PP, LiuC, HeBD, He XC, Du HZ, Yang HC, Tang Y*, Liu CM*, Teng ZQ*. Lossof microglial EED impairs synapse density, learning and memory. MolPsychiatry. 2022 Jul; 27(7):2999-3009. doi: 10.1038/s41380-022-01576-w.

50.   Wei T, Guo Z, Wang Z, Li C, Zhu W, Zheng Y, Yin Y,Mi Y, Xia X, Hou H, Tang Y*. Five Major Psychiatric Disorders andAlzheimer's Disease: A Bidirectional Mendelian Randomization Study. JAlzheimers Dis. 2022 Mar 31. doi: 10.3233/JAD-220010.

51.   Mi Y, Qin Q, Xing Y, Tang Y*. CapgrasSyndrome as the Core Manifestation of Early-Onset Alzheimer's Disease. JAlzheimers Dis. 2022 Mar 2. doi: 10.3233/JAD-215565.

52.   Temp AGM, Ly A, van Doorn J, Wagenmakers EJ, TangY, Lutz MW, Teipel S. A Bayesian perspective on Biogen's aducanumabtrial. Alzheimers Dement. 2022 Mar 2. doi: 10.1002/alz.12615.

53.   Shenoy SA, Zheng S, Liu W, Dai Y, Liu Y, Hou Z, MoriS, Tang Y, Cheng J, Duan W, Li C. A novel and accuratefull-length HTT mouse model for Huntington's disease. Elife. 2022 Jan13;11:e70217. doi: 10.7554/eLife.70217.

54.   Teipel S, Gustafson D, Ossenkoppele R, Hansson O,Babiloni C, Wagner M, Riedel-Heller S, Kilimann I, Tang Y.Alzheimer's disease - standard of diagnosis, treatment, care, and prevention. JNucl Med. 2022 Feb 10:jnumed.121.262239. doi: 10.2967/jnumed.121.262239.

55.   Qin Q, Yin Y, Xing Y, Wang X, Wang Y, Wang F, TangY*. Lipid Metabolism in the Development andProgression of Vascular Cognitive Impairment: A Systematic Review. FrontNeurol. 2021 Nov 19;12:709134. doi: 10.3389/fneur.2021.709134.

56.   Xing Y, Yang J, Zhou A, Wang F, Tang Y*, Jia J*. Alteredbrain activity mediates the relationship between white matter hyperintensityseverity and cognition in older adults. Brain Imaging Behav. 2021 Oct20. doi: 10.1007/s11682-021-00564-y.

57.   Wang C#, Wang Z#, Xie B, Shi X, Yang P, Liu L, Qu T, Qin Q, Xing Y, Zhu W, Teipel SJ,Jia J, Zhao G*, Li L*, Tang Y*. Binaural processing deficit and cognitive impairment in Alzheimer’sdisease. Alzheimers Dement. 2022;18(6):1085-1099.doi:10.1002/alz.12464DOI: 10.1002/alz.12464.

58.     Wang Z, Zhu W, Xing Y, Jia J, TangY*. B vitamins and prevention of cognitivedecline and incident dementia: a systematic review and meta-analysis. NutrRev. 2022 Mar 10;80(4):931-949.

59.     Temp AGM, Lutz MW, Trepel D, TangY, Wagenmakers EJ, Khachaturian AS, Teipel S. How Bayesian statisticsmay help answer some of the controversial questions in clinical research onAlzheimer's disease. Alzheimers Dement. 2021 Jun;17(6):917-919.

60.    XingY, Yang J, Zhou A, Wang F, Wei C, Tang Y*, Jia J*. White MatterFractional Anisotropy Is a Superior Predictor for Cognitive Impairment ThanBrain Volumes in Older Adults With Confluent White Matter Hyperintensities. FrontPsychiatry. 2021, 5;12:633811. doi: 10.3389/fpsyt.2021.633811. eCollection2021.

61.     Wang F, Ma X, Shi Y, Jia L, Zuo X,Yu Y, Jin H, Tang Y, Guo D, Jia J. Cognitive profiles inadult-onset neuronal intranuclear inclusion disease: a case series from thememory clinic. Neurol Sci. 2020; doi: 10.1007/s10072-020-04864-x.

62.     Wang Z, Yang J, Zhu W, TangY*, Jia J. The synaptic marker neurogranin as a disease state biomarkerin Alzheimer's disease: a systematic review and meta-analysis. Int JNeurosci. 2021; 10:1-9. doi: 10.1080/00207454.2021.1881087.

63.     Qin Q, Teng Z, Liu C, Li Q, Yin Y,Tang Y*. TREM2, microglia, and Alzheimer's disease. MechAgeing Dev. 2021;195:111438.

64.     Jia L, Du Y, Chu L, Zhang Z, Li F,Lyu D, Li Y, Li Y, Zhu M, Jiao H, Song Y, Shi Y, Zhang H, Gong M, Wei C, TangY, Fang B, Guo D, Wang F, Zhou A, Chu C, Zuo X, Yu Y, Yuan Q, Wang W,Li F, Shi S, Yang H, Zhou C, Liao Z, Lv Y, Li Y, Kan M, Zhao H, Wang S, Yang S,Li H, Liu Z, Wang Q, Qin W, Jia J; COAST Group. Prevalence, risk factors, andmanagement of dementia and mild cognitive impairment in adults aged 60 years orolder in China: a cross-sectional study. Lancet Public Health.2020;5(12):e661-e671.

65.     Jia L, Li F, Wei C, Zhu M, Qu Q,Qin W, Tang Y, Shen L, Wang Y, Shen L, Li H, Peng D, Tan L, LuoB, Guo Q, Tang M, Du Y, Zhang J, Zhang J, Lyu J, Li Y, Zhou A, Wang F, Chu C,Song H, Wu L, Zuo X, Han Y, Liang J, Wang Q, Jin H, Wang W, Lü Y, Li F, Zhou Y,Zhang W, Liao Z, Qiu Q, Li Y, Kong C, Li Y, Jiao H, Lu J, Jia J. Prediction ofAlzheimer's disease using multi-variants from a Chinese genome-wide associationstudy. Brain. 2020. doi: 10.1093/brain/awaa364.

66.     Sikkes SAM, Tang Y,Jutten RJ, Wesselman LMP, Turkstra LS, Brodaty H, Clare L, Cassidy-Eagle E, CoxKL, Chételat G, Dautricourt S, Dhana K, Dodge H, Dröes RM, Hampstead BM,Holland T, Lampit A, Laver K, Lutz A, Lautenschlager NT, McCurry SM, MeilandFJM, Morris MC, Mueller KD, Peters R, Ridel G, Spector A, van der Steen JT,Tamplin J, Thompson Z; ISTAART Non-pharmacological Interventions ProfessionalInterest Area, Bahar-Fuchs A. Toward a theory-based specification ofnon-pharmacological treatments in aging and dementia: Focused reviews andmethodological recommendations. Alzheimers Dement. 2021;17(2):255-270.

67.     Jia L, Xu H, Chen S, Wang X, YangJ, Gong M, Wei C, Tang Y, Qu Q, Chu L, Shen L, Zhou C, Wang Q,Zhao T, Zhou A, Li Y, Li F, Li Y, Jin H, Qin Q, Jiao H, Li Y, Zhang H, Lyu D,Shi Y, Song Y, Jia J*. The APOE ε4 exerts differential effects on familial andother subtypes of Alzheimer's disease. Alzheimers Dement. 2020. doi:10.1002/alz.12153.

68.     Tang Y*, Xing Y, Cui L, Wu C, Wen X, SongH, Wu L, Chang H, Song J, Wang Y*, Zhao G*. Neurology practice during theCOVID-19 outbreak and post-pandemic era: experiences and challenges. Eur JNeurol. 2020;27(12):e81-e83. doi:10.1111/ene.14445

69.     Jia L, Zhu M, Kong C, Pang Y,Zhang H, Qiu Q, Wei C, Tang Y, Wang Q, Li Y, Li T, Li F, Wang Q,Li Y, Wei Y, Jia J. Blood neuro-exosomal synaptic proteins predict Alzheimer'sdisease at the asymptomatic stage. Alzheimers Dement. 2021;17(1):49-60.

70.     Qin Q, Yin Y, Wang Y, Lu Y, TangY*, Jia J*. Gene mutations associated with early onset familialAlzheimer's disease in China: An overview and current status. Mol GenetGenomic Med. 2020 Aug 6:e1443. doi: 10.1002/mgg3.1443.

71.     Xing Y, Zhu Z, Du Y, Zhang J, QuQ, Sun L, Li Y, Guo Y, Peng G, Liu Y, Yu Y, Qiao Y, Xie B, Shi X, Lu J, Jia J, TangY*. The Efficacy of COGnitive tRaining in patiEnts with Amnestic mildcoGnitive impairmENT (COG-REAGENT): Protocol for a Multi-Center RandomizedControlled Trial. J Alzheimers Dis. 2020;75(3):779-787.

72.     Xing Y, Wei P, Wang C, Shan Y, YuY, Qiao Y, Xie B, Shi X, Zhu Z, Lu J, Zhao G, Jia J, Tang Y*.TRanscranial AlterNating current Stimulation FOR patients with Mild Alzheimer'sDisease (TRANSFORM-AD study): Protocol for a randomized controlled clinicaltrial. Alzheimers Dement (N Y). 2020;6(1):e12005.

73.     Xie B, Shi X, Xing Y, TangY*. Association between atherosclerosis and Alzheimer's disease: Asystematic review and meta-analysis. Brain Behav. 2020;10(4):e01601.

74.    QinQ, Tang Y*, Dou X, Qu Y, Xing Y, Yang J, Chu T, Liu Y, Jia J.Default mode network integrity changes contribute to cognitive deficits insubcortical vascular cognitive impairment, no dementia. Brain Imaging Behav. 2021;15(1):255-265.

75.     Jia J*, Wei C, Chen W, Jia L, ZhouA, Wang F, Tang Y, Xu L. Safety and Efficacy of Donepezil10 mg/day in Patients with Mild to Moderate Alzheimer's Disease. JAlzheimers Dis. 2020. doi: 10.3233/JAD-190940.

76.     Jia L, Fu Y, Shen L, Zhang H, ZhuM, Qiu Q, Wang Q, Yan X, Kong C, Hao J, Wei C, Tang Y, Qin W, LiY, Wang F, Guo D, Zhou A, Zuo X, Yu Y, Li D, Zhao L, Jin H, Jia J*. PSEN1,PSEN2, and APP mutations in 404 Chinese pedigrees with familial Alzheimer'sdisease. Alzheimers Dement. 2020;16(1):178-191.

77.     Tang Y*, Liu Y, Li D, Guo D, Xing Y*. Anovel mutation in the CYP27A1 gene in a family with cerebrotendinousxanthomatosis. Int J Neurosci. 2020; 1-4.

78.     Quan M, Zhao T, Tang Y,Luo P, Wang W, Qin Q, Li T, Wang Q, Fang J, Jia J*. Effects of gene mutationand disease progression on representative neural circuits in familialAlzheimer's disease. Alzheimers Res Ther. 2020;12(1):14.

79.    WangH, Fan Z, Shi C, Xiong L, Zhang H, Li T, Sun Y, Guo Q, Tian Y, Qu Q, Zhang N,Cheng Z, Wu L, Wu D, Han Z, Tian J, Xie H, Tan S, Gao J, Luo B, Pan X, Peng G,Qin B, Tang Y, Wang K, Wang T, Zhang J, Zhao Q, Gauthier S, YuX*. Consensus statement on the neurocognitive outcomes for early detection ofmild cognitive impairment and Alzheimer dementia from the ChineseNeuropsychological Normative (CN-NORM) Project. Journal of global health.2019; 9(2): 020320

80.     Shi X, Xie B, Xing Y, Tang Y*.Plasma Clusterin as a Potential Biomarker for Alzheimer's Disease-A SystematicReview and Meta-analysis. Curr Alzheimer Res. 2019;16(11):1018-1027.

81.     Jia L, Quan M, Fu Y, Zhao T, Li Y,Wei C, Tang Y, Qin Q, Wang F, Qiao Y, Shi S, Wang YJ, Du Y, ZhangJ, Zhang J, Luo B, Qu Q, Zhou C, Gauthier S, Jia J*; Group for the Project ofDementia Situation in China. Dementia in China: epidemiology, clinicalmanagement, and research advances. Lancet Neurol. 2020 Jan;19(1):81-92.

82.    ShenL, Qin W, Wu L, Zhou A, Tang Y, Wang Q, Jia L, Jia J*. Two novelpresenilin-1 mutations (I249L and P433S) in early onset Chinese Alzheimer'spedigrees and their functional characterization. Biochem Biophys Res Commun.2019;516(1):264-269.

83.     Tang Y#*, Xing Y#, Zhu Z#, He Y, Li F, Yang J, Liu Q, Li F,Teipel SJ, Zhao G*, Jia J*. The effects of 7-week cognitive training inpatients with vascular cognitive impairment, no dementia (the Cog-VACCINEstudy): A randomized controlled trial. AlzheimersDement. 2019;15(5):605-614.

84.     Liu Z*, Jiao L, Qiu Z, Da Y, Tang Y, Lin Y, Li D, Huang J,Kang X, Dong H*. Clinical characteristics of patients with paraneoplasticmyelopathy.  J Neuroimmunol. 2019 ;330:136-142.

85.     Tang Y*, Qin Q*, Xing Y, Guo D, DiL, Jia J. AARS2 leukoencephalopathy: a new variant of mitochondrialencephalomyopathy. Mol Genet Genomic Med.2019; 7(4):e00582.

86.     Babulal GM, Quiroz YT, Albensi BC,Arenaza-Urquijo E, Astell AJ, Babiloni C, Bahar-Fuchs A, Bell J, Bowman GL,Brickman AM, Chételat G, Ciro C, Cohen AD, Dilworth-Anderson P, Dodge HH, DreuxS, Edland S, Esbensen A, Evered L, Ewers M, Fargo KN, Fortea J, Gonzalez H,Gustafson DR, Head E, Hendrix JA, Hofer SM, Johnson LA, Jutten R, Kilborn K,Lanctôt KL, Manly JJ, Martins RN, Mielke MM, Morris MC, Murray ME, Oh ES, ParraMA, Rissman RA, Roe CM, Santos OA, Scarmeas N, Schneider LS, Schupf N, SikkesS, Snyder HM, Sohrabi HR, Stern Y, Strydom A, Tang Y, Terrera GM, Teunissen C, Melo van Lent D, WeinbornM, Wesselman L, Wilcock DM, Zetterberg H, O'Bryant SE*; International Societyto Advance Alzheimer's Research and Treatment, Alzheimer's Association.Perspectives on ethnic and racial disparities in Alzheimer's disease andrelated dementias: Update and areas of immediate need. Alzheimers Dement. 2019;15(2):292-312.

87.     Du X#, Ji Y#, Chen T*, Tang Y, Han B. Can workingmemory capacity be expanded by boosting working memory updating efficiency inolder adults? Psychology and Aging.2018;33(8):1134-1151. (IF 2.608)

88.     Jia J*, Wei C, Chen S, Li F, Tang Y, Qin W, Shi L, Gong M, XuH, Li F, He J, Song H, Yang S, Zhou A, Wang F, Zuo X, Chu C, Liang J, Jia L,Gauthier S. Efficacy and safety of the compound Chinese medicine SaiLuoTong invascular dementia: A randomized clinical trial. Alzheimers Dement (N Y): TRCI. 2018; 4:108-117.

89.     Tang Y*,Lutz MW, Xing Y. A systems-based model of Alzheimer's disease. Alzheimers Dement. 2019;15(1):168-171.

90.     Hayden KM*, Inouye SK, CunninghamC, Jones RN, Avidan MS, Davis D, Kuchel GA, Tang Y, Khachaturian AS. Reduce the burden of dementia now. Alzheimers Dement. 2018;14(7):845-847.

91.     Khachaturian AS*, Hayden KM,Mielke MM, Tang Y, Lutz MW,Gold M, Kukull WA, Mohs R, Gauthier S, Molinuevo JL, Zetterberg H, KhachaturianZS. New thinking about thinking, part two. Theoretical articles for Alzheimer's& Dementia. Alzheimers Dement.2018;14(6):703-706.

92.    Li J, Wu L, TangY, Zhou A, Wang F, Xing Y, Jia J*. Differentiation ofneuropsychological features between posterior cortical atrophy and early onsetAlzheimer's disease. BMC Neurol.2018;18(1):65.

93.    Khachaturian AS#*, Hayden KM, Mielke MM, Tang Y, Lutz MW, Gustafson DR,Kukull WA, Mohs R, Khachaturian ZS. Future prospects and challenges forAlzheimer's disease drug development in the era of the NIA-AA ResearchFramework. Alzheimers Dement.2018;14(4):532-534.

94.    Wang Z, Qin W, Wei CB, Tang Y, Zhao LN, Jin HM, Li Y, Wang Q, Luan XQ, He JC, JiaJ*. The microRNA-1908 up-regulation in the peripheral blood cells impairsamyloid clearance by targeting ApoE. IntJ Geriatr Psychiatry. 2018;33(7):980-986.

95.    Jia J#*, Wei C*, Chen S, Li F, Tang Y, Qin W, Zhao L, Jin H, Xu H, Wang F, Zhou A, Zuo X,Wu L, Han Y, Han Y, Huang L, Wang Q, Li D, Chu C, Shi L, Gong M, Du Y, Zhang J,Zhang J, Zhou C, Lv J, Lv Y, Xie H, Ji Y, Li F, Yu E, Luo B, Wang Y, Yang S, QuQ, Guo Q, Liang F, Zhang J, Tan L, Shen L, Zhang K, Zhang J, Peng D, Tang M, LvP, Fang B, Chu L, Jia L, Gauthier S. The cost of Alzheimer's disease in Chinaand re-estimation of costs worldwide. AlzheimersDement. 2018;14(4):483-491

96.    Zhang Y, Guo D, Tang Y*. Autonomic dysfunction in a patient with X-linkedadrenoleukodystrophy. Int J Neurosci.  2017; 28:1-2

97.    Liu Q#, Zhu Z#, Teipel SJ, Yang J, Xing Y, Tang Y*, Jia J* White MatterDamage in the Cholinergic System Contributes to Cognitive Impairment inSubcortical Vascular Cognitive Impairment, No Dementia. Front. Aging Neurosci. 2017; 9: 47.

98.    Jia J#*, Gauthier S, Pallotta S, Ji Y, Wei W, XiaoS, Peng D, Guo Q, Wu L, Chen S, Kuang W, Zhang J, Wei C, Tang Y. Consensus-based recommendations for the managementof rapid cognitive decline due to Alzheimer's disease. Alzheimers Dement. 2017;13(5):592-597.

99.    Dong J, Qin W, Wei C, Tang Y, Wang Q, Jia J*. A Novel PSEN1 K311R MutationDiscovered in Chinese Families with Late-Onset Alzheimer's Disease AffectsAmyloid-β Production and Tau Phosphorylation. J Alzheimers Dis.2017;57(2):613-623.

100.  JiaJ#*, Wei C#, Jia L, Tang Y,Liang J, Zhou A, Li F, Shi L, Doody RS. Efficacy and Safety of Donepezil inChinese Patients with Severe Alzheimer's Disease: A Randomized ControlledTrial. J Alzheimers Dis.2017;56(4):1495-1504.

101.  XingY#, Tang Y#, Zhao L, Wang Q,Qin W, Ji X, Zhang J, Jia J*. Associations between plasma ceramides andcognitive and neuropsychiatric manifestations in Parkinson's disease dementia. J Neurol Sci. 2016;370:82-87.

102.  Tang Y#*, Zhu Z#, Liu Q, Li F, Yang J, Li F, Xing Y, Jia J*. The efficacy ofCognitive training in patients with VAsCular Cognitive Impairment, No dEmentia(the Cog-VACCINE study): study protocol for a randomized controlled trial. Trials. 2016;17(1):392.

103.  XingY#, Tang Y#, Zhao L, Wang Q,Qin W, Zhang J, Jia J*. Plasma ceramides and neuropsychiatric symptoms ofAlzheimer’s disease. J Alzheimers Dis.2016; 52(3):1029-35.

104.  Jia J*,Zuo X, Jia XF, Chu C, Wu L, Zhou A, Wei C, TangY, Li D, Qin W, Song H, Ma Q, Li J, Sun Y, Min B, Xue S, Xu E, Yuan Q,Wang M, Huang X, Fan C, Liu J, Ren Y, Jia Q, Wang Q, Jiao L, Xing Y, Wu X;China Cognition and Aging Study (COAST) Group. Diagnosis and treatment ofdementia in neurology outpatient departments of general hospitals in China. Alzheimers Dement. 2016; 12(4):446-53.

105.  Xing Y,Tang Y, Jia J*. SexDifferences in Neuropsychiatric Symptoms of Alzheimer's Disease: The ModifyingEffect of Apolipoprotein E ε4 Status. BehavNeurol. 2015;2015:275256. doi: 10.1155/2015/275256.

106.  Tang Y*#, Wang X#, Jia J#. Mercury poisoning presenting as sporadiccreutzfeldt-jakob disease: a case report. AnnIntern Med. 2015;162(6):462-3.

107.  Lu H,Wang XB, Tang Y*. Subduralhematoma associated with high altitude. ChinMed J (Engl). 2015;128(3):407-8.

108.  Qin W,Jia X, Wang F, Zuo X, Wu L, Zhou A, Li D, Min B, Wei C, Tang Y, Xing Y, Dong X, Wang Q, Gao Y, Li Y, Jia J*.Elevated plasma angiogenesis factors in Alzheimer's disease. J Alzheimers Dis. 2015;45(1):245-52.

109.  LiangJ, Li F, Wei C, Song H, Wu L, Tang Y,Jia J*. Rationale and Design of a Multicenter, Phase 2 Clinical Trial toInvestigate the Efficacy of Traditional Chinese Medicine SaiLuoTong in VascularDementia. J Stroke Cerebrovasc Dis. 2014; 23(10):2626-34.

110.  Jia J*,Zhou A, Wei C, Jia X, Wang F, Li F, Wu X, Mok V, Gauthier S, Tang M, Chu L,Zhou Y, Zhou C, Cui Y, Wang Q, Wang W, Yin P, Hu N, Zuo X, Song H, Qin W, Wu L,Li D, Jia L, Song J, Han Y, Xing Y, Yang P, Li Y, Qiao Y, Tang Y, Lv J, Dong X. The prevalence of mild cognitiveimpairment and its etiological subtypes in elderly Chinese. Alzheimers Dement. 2014;10(4):439-47.

111.  Jia J*,Wang F, Wei C, Zhou A, Jia X, Li F, Tang M, Chu L, Zhou Y, Zhou C, Cui Y, WangQ, Wang W, Yin P, Hu N, Zuo X, Song H, Qin W, Wu L, Li D, Jia L, Song J, Han Y,Xing Y, Yang P, Li Y, Qiao Y, Tang Y,Lv J, Dong X. The prevalence of dementia in urban and rural areas of China. Alzheimers Dement. 2014;10(1):1-9

112.  Jia J*,Wang F, Yuan Q, Qin W, Tang Y,Zuo XM, Han Y. Progresses on Genetics of Predementia Phase of Alzheimer'sDisease. Prog Biochem Biophys.2012;39(8), 698-702.

113.  Xing Y,Wei C, Chu C, Zhou A, Li F, Wu L, Song H, Zuo X, Wang F, Qin W, Li D, Tang Y, Jia XF, Jia J*.Stage-specific gender differences in cognitive and neuropsychiatricmanifestations of vascular dementia. Am JAlzheimers Dis Other Demen. 2012;27(6):433-8.

114.  Tang Y#, Xing Y#, Lin MT, Zhang J, Jia J*. Hashimoto's encephalopathy cases:Chinese experience. BMC Neurol. 2012;24;12:60.

115.  DongHQ#, Liu Z#, Tang Y, Lu Y,Wang Q, Jia J*. Recurrent Fisher-Bickerstaff syndrome: report of a Chinesecase. Chin Med J (Engl).2011;124(17):2786-8.

116.  Tang Y#, Chu C#, Lin MT, Wei G, Zhang X, Da Y, Huang H, Jia J*. Hashimoto'sencephalopathy mimicking spinocerebellar ataxia. J Neurol. 2011;258(9):1705-7.

117.  HuangH#*, Chen J, Lin T, Wang T, Tang Y,Dong Y, Wang J. Epoxyeicosatrienoic acids--novel mechanism and pharmacologicaltherapy of chronic renocardiac syndrome. MedHypotheses. 2011;76(4):550-2.

118.  Tang Y, Ding Y, Li CJ,Wang XB*, Jia J. longitudinal lesion of the spinal cord in a patient withVogt-Koyanagi-Harada disease. J NeurolNeurosurg Psychiatry 2010;81:941-942

119.  Xu EH#,Tang Y, Li D, Jia J*.Polymorphism of HD and UCHL-1 genes in Huntington's disease. J Clin Neurosci. 2009, 16(11):1473-7.

120.  Li Y#,Liu W#, Oo TF, Wang L, Tang Y,Jackson-Lewis V, Zhou C, Geghman K, Bogdanov M, Przedborski S, Beal MF, BurkeRE, Li C*. Mutant hR1441GLRRK2 BAC Transgenic Mice Recapitulate Cardinal Features of Parkinson’sDisease. Nature Neuroscience 2009,12(7):826-8.

121.  Tang Y#, HuangY#, Shen W, Liu DP*, Liu G, Wang Z, Tang XB, Liang CC. Cluster specificregulation pattern of upstream regulatory elements in human α- and β-globingene clusters. Exp. Cell Res. 2008,314(1):115-22

122.  WeiYJ#*, Tang Y#, Cui CJ#, ZhangH, Liu XN, Zhang H, Hu SS*. Expression pattern of dog stromal cell derivedfactor-1 (SDF-1) and implications in ischemic myocardium. Cytokine 2007, 40(1):52-9

123.  Tang Y, Wang Z,Huang Y, Liu G, Shen W, Tang XB, Feng DX, Liu DP*, Liang CC, Gene Order inHuman alpha-globin Locus is Required for Their Temporal Specific Expressions. GenesCells. 2006,11(2):123-31.

124.  Tang Y, LiuDP*, Liang CC. Further understanding of the beta-globin locus regulation at themolecular level: looping or linking models? Genes Cells. 2002, 7(9):889-900.

125.  Tang XB, Feng DX, Di LJ, Huang Y, Fu XH, Liu G, TangY, Liu DP*, Liang CC. HS-48 alone has no enhancement role on theexpression of human alpha-globin gene cluster. Blood Cells Mol Dis. 2007, 38(1):32-6

126.  Shen W, Huang Y, Tang Y, Liu DP*, Liang CC. AGeneral Method to Modify BACs to Generate Large Recombinant DNA Fragments Mol.Biotechnology.2005, 31: 181-186

127.  HuangY, Liu DP*, Feng DX, Wu M, Shen W, Tang Y, Tang XB, Liang CC. Noexistence of translocus balancer to coordinate the expression and regulation ofhuman hemoglobin genes in transgenic mice study. Int J Biochem Cell Biol.2004, 36(7): 1261-5.

128. Tang Y, Liu DP, Liang CC. Further understanding of the beta-globin locusregulation at the molecular level: looping or linking models? Genes Cells.2002, 7(9): 889-900.

129.首都医科大学宣武医院国家神经疾病医学中心,中国疾病预防控制中心慢性非传染性疾病预防控制中心,国家卫生健康委能力建设和继续教育中心,等. 唐毅 （通讯作者），中国阿尔茨海默病蓝皮书（精简版）[J].中华医学杂志,2024,104(29)：2701-2727.

130.国家卫生健康委能力建设和继续教育中心, 中国神经科学学会, 衰老标志物联合体, 等. 唐毅 （通讯作者），阿尔茨海默病体液标志物临床应用中国指南（2024版）. 中华医学杂志,2024, 104(35): 3292-3306.

131.脑认知健康管理中国专家共识制定委员会,《中华健康管理学杂志》编辑委员会. 唐毅（通讯作者），脑认知健康管理中国专家共识（2023）. 中华健康管理学杂志,2023,17(12)：881-892.

132.中华医学会神经病学分会痴呆与认知障碍学组, 认知数字疗法中国专家共识写作组. 唐毅（通讯作者），认知数字疗法中国专家共识（2023）. 中华医学杂志, 2023, 103(9) : 640-647.

133.中国医师协会神经内科医师分会, 认知训练中国指南写作组，唐毅（通讯作者），认知训练中国指南（2022年版）. 中华医学杂志, 2022, 102(37) : 2918-2925.

134.认知训练中国专家共识写作组, 中国医师协会神经内科医师分会认知障碍疾病专业委员会，唐毅朱祖德执笔. 认知训练中国专家共识[J].中华医学杂志,2019,99( 1 ): 4-8.

135.中国痴呆与认知障碍诊治指南写作组,中国医师协会神经内科医师分会认知障碍疾病专业委员会，贾建平，唐毅执笔.2018中国痴呆与认知障碍诊治指南(六):阿尔茨海默病痴呆前阶段[J].中华医学杂志,2018,98(19):1457-1460.

136.中国痴呆与认知障碍诊治指南写作组,中国医师协会神经内科医师分会认知障碍疾病专业委员会，唐毅，吕佩源执笔.2018中国痴呆与认知障碍诊治指南(七):阿尔茨海默病的危险因素及其干预[J].中华医学杂志,2018,98(19):1461-1466.