李姝

首都医科大学, 首都医科大学附属北京天坛医院, 副主任医师 

 近五年主持或参加的其他科研项目/课题：

 (1) 白求恩公益基金会, 麻醉深度监测科研支持项目, SZCX-2024-B-003, 基于功能磁共振的烟雾病患者麻 醉镇静状态下脑网络改变的前瞻观察队列研究, 2024-10 至 2026-10, 10万元, 在研, 主持 

(2) 北京市医院管理中心, 青苗计划, QMS20220518, 基于围术期异构数据库和机器学习的神经外科患者围 术期脑出血及脑缺血事件风险预测模型 , 2023-01 至 2024-12, 7万元, 结题, 主持

(3) 北京市医院管理中心, 培育项目, PX2022018, 巨大脑膜瘤切除术患者应用氨甲环酸的有效性研究, 2022-01 至 2024-12, 15万元, 结题, 主持 

代表性论著：

 (1) Shu Li; Ruowen Li; Muhan Li; Qianyu Cui; Xingyue Zhang; Tingting Ma; Dexiang Wang; MinZeng; Hao Li; Zhaoshi Bao; Yuming Peng; Daniel I. Sessler ; Dexmedetomidine administration during brain tumour resection and postoperative delirium: a randomised controlled trial, Br J Anaesth, 2023.12, 130(2): e307-e316 

 (2) Shu Li; Minying Liu; Jingchao Yang; Xiang Yan; Yaru Wu; Liyong Zhang; Min Zeng; Dabiao Zhou; Yuming Peng; Daniel I. Sessler ; Intravenous tranexamic acid for intracerebral meningioma resections: A randomized, parallel-group, non-inferiority trial, Journal of Clinical Anesthesia, 2024, 92: 111285 

 (3) Shu Li; Xiang Yan; Ruowen Li; Xingyue Zhang; Tingting Ma; Min Zeng; Jia Dong; Juan Wang; Xiaoyuan Liu; Yuming Peng ; Safety of intravenous tranexamic acid in patients undergoing supratentorial meningiomas resection: protocol for a randomised, parallel-group, placebo control, non-inferiority trial., BMJ Open, 2022.2, 12(2): e052095 (4) Shu Li; Min Zeng; Jia Dong; Muhan Li; Xiang Yan; Ruowen Li; Yuewei Zhang; Xiaochuan Huo; Zhongrong Miao; Shuo Wang; Yuming Peng; Ruquan Han ; Management of Endovascular Treatment for Acute Ischemic Stroke During the COVID-19 Pandemic at a Single Institution in Beijing, China: A Brief Report, J Neurosurg Anesthesiol, 2021.10, 33(3): 268-272  (5) Haojie Yu; Minying Liu; Xingyue Zhang; Tingting Ma; Jingchao Yang; Yaru Wu; Jie Wang; Muhan Li; Juan Wang; Min Zeng; Liyong Zhang; Hailong Jin; Xiaoyuan Liu; Shu Li; Yuming Peng ; The effect of tranexamic acid on intraoperative blood loss in patients undergoing brain meningioma resections: Study protocol for a randomized controlled trial, PLOS ONE, 2023, 18(8) 

曾敏

首都医科大学, 首都医科大学附属北京天坛医院, 副主任医师

近五年主持或参加的其他科研项目/课题：

(1) 北京市医院管理局, 科研培育项目, PX2025013, 幕上肿瘤切除术患者多模式镇痛方案：一项 2×2 析

因随机临床试验, 2025-01 至 2027-12, 15万元, 在研, 主持

代表性论著：

(1) Min Zeng; Maoyao Zheng; Yue Ren; Xueke Yin; Shu Li; Yan Zhao; Dexiang Wang; Liyong Zhang; Xiudong Guan; Deling Li; Daniel I. Sessler; Yuming Peng ; Ultrasound-guided superficial cervical plexus blocks for persistent pain after suboccipital craniotomies: a randomized trial,Anesthesiology, 2025, 142(1): 166-175  

(2) Min Zeng; Xueke Yin; Maoyao Zheng; Yue Ren; Shu Li; Xiaolin Chen; Yuming Peng ; Intraoperative Hypotension and Postoperative Newly Developed Cerebral Infarction in Patients With Aneurysmal Subarachnoid Hemorrhage: A Retrospective Cohort Study, CNS NEUROSCIENCE & THERAPEUTICS, 2024, 30(12): 1-9

 (3) Min Zeng; Xin Xu; Ruowen Li; Xingyue Zhang; Tingting Ma; Qianyu Cui; Juan Wang; Shu Li; Yuming Peng ; Dexmedetomidine Prevents Chronic Incisional Pain After Brain Tumor Resection: A Secondary Analysis of the Randomized Control Trial, ANESTHESIA AND ANALGESIA, 2024, 138(4): 839847 

(4) Min Zeng; Maoyao Zheng; Jie Wang; Shu Li; Nan Ji; Yuming Peng ; Effect of perioperative dexmedetomidine on postoperative delirium in patients with brain tumours: a protocol of a randomised controlled trial, BMJ OPEN, 2024, 14(11): 1-7

 (5) Min Zeng; Ruowen Li; Xin Xu; Dexiang Wang; Jia Dong; Shu Li; Ira S Kass; Yuming Peng; Wang Jia ; Ultrasound-guided superficial cervical plexus block reduces opioid consumption in patients undergoing craniotomy via suboccipital retrosigmoid approach: a randomized controlled trial, Reg Anesth Pain Med, 2022, 47(7): 617-624 

王洁

首都医科大学,首都医科大学附属北京天坛医院,主治医师

代表性论著：

（1） Jie Wang; Runting Li; Shu Li; Tingting Ma; Xingyue Zhang; Yue Ren; Xiaolin Chen; Yuming Peng ; Intraoperative arterial pressure and Delayed Cerebral Ischemia in patients with aneurysmal subarachnoid hemorrhage after surgical clipping: A Retrospective cohort Study, Frontier in Neuroscience, 2023. 17(1064987): 01-09 

（2） Jie Wang; Yuming Peng ; Emergency treatment and anesthesia management of internal carotid artery injury during neurosurgery: Four case reports, World Journal of Clinical Cases, 2022. 10(27): 9865-9872  

（3） Lixiang Chen; Jie Wang; Jing Liu; Hua Wang; Christopher D. Hillyer; Lionel Blanc; Xiuli An; Narla Mohandas ; Dynamic changes in murine erythropoiesis from birth to adulthood: implications for the study of murine models of anemia, BLOOD ADVANCES, 2021. 5(1): 16-25   

（4） 王洁,马婷婷,崔倩宇,等. 帕金森病脑深部电刺激植入术患者术后谵妄的危险因素分析[J]. 国际麻醉学与复苏杂志,2024,45(1):26-30. DOI:10.3760/cma.j.cn321761-20221123-00962. 

李沐寒

首都医科大学,首都医科大学附属北京天坛医院,主治医师

代表性论著：

(1) Muhan Li; Tingting Ma; Xueke Yin; Xin Zhang; Tenghai Long; Min Zeng; Juan Wang; Qianyu Cui; Shu Li; Daniel I. Sessler; Rong Wang; Yuming Peng ; Cerebral oximetry index indicates delirium or stroke after carotid endarterectomy: An observational study, Journal of Clinical Anesthesia, 2025, 101: 111733 

(2) Muhan Li; Zhenzhen Xu; Siming Huang; Ting Li; Xueying Li; Dongxin Wang ; Effect of combined epidural anaesthesia on tumor-infiltrating lymphocytes in lung adenocarcinoma: a prospective exploratory sub-analysis, Acta Anaesthesiologica Scandinavica, 2018, 62(5): 687-

700 

(3) Muhan Li; Xuelian Pei; Guoliang Wang; Jun Zhan; Juan Du; Hao Jiang; Yan Tang; Hongquan Zhang; Huiying He ; Kindlin-2 promotes clear cell renal cell carcinoma progression through the Wnt signaling pathway, Oncology Reports, 2017, 38(3): 1551-1560 

(4) Muhan Li; Minying Liu; Qianyu Cui; Min Zeng; Shu Li; Liyong Zhang; Yuming Peng ; Effect of dexmedetomidine on postoperative delirium in patients undergoing awake craniotomies: studyprotocol of a randomized controlled trial, Trials, 2023, 24(607): 1-9 

王娟

 近五年主持或参加的其他科研项目/课题：

（1）2019年“氯胺酮抑制小鼠慢性疼痛抑郁样行为及其机制研究”，贝朗麻醉科学研究基金，主持，已结题

代表性论著：

（1）Wang, Juan et al. “Intraoperative blood pressure and cardiac complications after aneurysmal subarachnoid hemorrhage: a retrospective cohort study.” International journal of surgery (London, England) vol. 110,2 965-973. 

（2）Wang, Juan et al. “Subanesthetic Dose of Ketamine Improved CFA-induced Inflammatory Pain and Depression-like Behaviors Via Caveolin-1 in Mice.” Journal of neurosurgical anesthesiology vol. 32,4 (2020): 359-366. 

1.大语言模型驱动的急性出血性脑血管病围术期并发症多模态融合预警平台，2025.1-2027.12，在研，北京市医院管理局“扬帆”计划重点学科建设项目。

2.基于rSO2监测脑血流自主调节功能在颈动脉内膜剥脱术患者围术期应用研究，2024.01-2026.12，在研，首都卫生发展科研专项项目。

3.急性缺血性脑卒中血管内治疗麻醉管理规范研究，2019.08-2023.08，结题，北京市科委北京专项基金。

4. 围术期神经认知功能障碍脑网络连接和神经损伤相关性研究, 2020.1-2020.12, 结题，首都医科大学自然科学基金。

5. 科技部国家重点研发计划“老年患者术后中枢神经系统常见并发症预警及综合防治技术研究”(项目号：2018YFC2001901)。

6. 北京市医院管理局人才项目“青苗”基金（项目号：QML20150508）“BIS指导的麻醉方法对AIS血管内治疗患者临床转归影响的研究”。

7.国家留学人员回国创业启动支持计划，“AIS血管内治疗患者围术期管理与临床转归的研究”3万元。

8. 北京市医院管理局“科研培育计划”项目-老年非心脏手术患者术前合并隐匿性脑卒中队列研究（项目号：2018023）。

9.卫计委“首都发展卫生科技专项基金”自主创新项目“老年非心脏手术患者术后认知功能障碍和隐匿性脑卒中的前瞻队列研究”（项目号：2018-2-2044）。

1. Zeng M#, Zheng M#, Ren Y, Yin X, Li S, Zhao Y, Wang D, Zhang L, Guan X, Li D, Sessler DI, Peng Y*. Ultrasound-guided superficial cervical plexus blocks for persistent pain after suboccipital craniotomies: a randomized trial. Anesthesiology, 2025 Jan 1;142(1):166-175. doi:10.1097/ALN.0000000000005238

2. Liu X#, Zhang X#, Fan Y, Wang B, Wang J, Zeng M, Li S, Shen M, Zhang W, Sessler DI, Peng Y*. Intraoperative goal-directed fluid management and postoperative brain edema in patients having high-grade gliomas resections: a randomized trial. Int J Surg. 2024 Jul 22 doi:10.1097/JS9.0000000000001969 

3. Min Zeng, Xueke Yin, Maoyao Zheng, Yue Ren, Shu Li, Xiaolin Chen, Yuming Peng. Intraoperative Hypotension and Postoperative Newly Developed Cerebral Infarction in Patients With Aneurysmal Subarachnoid Hemorrhage: A Retrospective Cohort Study. CNS Neurosci Ther, 2024 Dec;30(12):e70156. doi: 10.1111/cns.70156.

4. Liu X#, Liu M#, Li S, Ren Y, Zheng M, Zeng M, Peng Y*. Efficacy and safety of tranexamic acid on blood loss and seizures in patients undergoing meningioma resection: A systematic review and meta-analysis. PLoS One, 19(9), e0308070. doi:10.1371/journal.pone.0308070 

5. Zeng M#, Zheng M#, Wang J, Li S, Ji N, Peng Y*. Effect of perioperative dexmedetomidine on postoperative delirium in patients with brain tumours: a protocol of a randomised controlled trial.   BMJ Open, 2024 Nov 7;14(11):e084380. doi: 10.1136/bmjopen-2024-084380. 

6. Wang J#, Lin F#, Zeng M, Liu M, Zheng M, Peng Y*, Li S, Yang X, Chen Y, Chen X, Sessler DI, Peng Y. Intraoperative blood pressure and cardiac complications after aneurysmal subarachnoid hemorrhage: a retrospective cohort study. Int J Surg. 2024 Feb 1;110(2):965-973. doi: 10.1097/JS9.0000000000000928. 

7. Li S#, Liu M#, Yang J, Yan X, Wu Y, Zhang L, Zeng M, Zhou D, Peng Y*, Sessler DI. Intravenous tranexamic acid for intracerebral meningioma resections: A randomized, parallel-group, non-inferiority trial. J Clin Anesth. 2024 Feb;92:111285. doi: 10.1016/j.jclinane.2023.111285. 

8. Yu H#, Liu M#, Zhang X, Ma T, Yang J, Wu Y, Wang J, Li M, Wang J, Zeng M, Zhang L, Jin H, Liu X, Li S*, Peng Y. The effect of tranexamic acid on intraoperative blood loss in patients undergoing brain meningioma resections: Study protocol for a randomized controlled trial. PLoS One. 2023 Aug 31;18(8):e0290725. doi: 10.1371/journal.pone.0290725. 

9. Li M#, Liu M#, Cui Q, Zeng M, Li S, Zhang L, Peng Y*. Effect of dexmedetomidine on postoperative delirium in patients undergoing awake craniotomies: study protocol of a randomized controlled trial. Trials. 2023 Sep 25;24(1):607. doi: 10.1186/s13063-023-07632-2. 

10. Yao J#, Li S#, Cui Q, Ren Y, Li M, Wang J, Zeng M, Ji N, Peng Y*, Sessler DI. Intraoperative Hypotension and Postoperative Stroke in Older Patients Who Had Brain Tumor Resections: A Retrospective Cohort Analysis. World Neurosurg. 2023 Jun;174:e72-e81. doi: 10.1016/j.wneu.2023.02.136. 

11. Yao J#, Shen Z#, Jin H, Ma T, Wang J, Li S, Zeng M, Liu X, Peng Y*. Dexmedetomidine after deep brain stimulation for prevention of delirium in elderly patients with Parkinson's disease: protocol for a single-centre, randomised, double-blind, placebo-controlled trial in China. BMJ Open. 2023 Jul 11;13(7):e070185. doi: 10.1136/bmjopen-2022-070185. 

12. Zeng M, Xu X, Li R, Zhang X, Ma T, Cui Q, Wang J, Li S, Peng Y*. Dexmedetomidine Prevents Chronic Incisional Pain After Brain Tumor Resection: A Secondary Analysis of the Randomized Control Trial. Anesth Analg. 2024 Apr 1;138(4):839-847. doi: 10.1213/ANE.0000000000006563. 

13. Liu X#, Zhang X#, Ma T, Li M, Zhang L, Li S, Zeng M, Kass IS and Peng Y*. Risk factors for postoperative thrombosis-related complications in patients undergoing malignant brain tumor resection: a retrospective cohort study. Front. Neurol. (2023)14:1108596. doi: 10.3389/fneur.2023.1108596. 

14. Cui Q, Ma T, Liu M, Shen Z, Li S, Zeng M, Liu X, Zhang L, Peng Y*. Intraoperative infusion of dexmedetomidine for prevention of postoperative delirium in elderly patients undergoing craniotomy: a protocol of randomised clinical trial. BMJ Open. 2023 Jan 23;13(1):e063976. doi: 10.1136/bmjopen-2022-063976. 

15. Zhao Y, Wang J, Li M, Ma T, Zhang X, Xu X, Zeng M, Peng Y*. The Influence of Trigeminocardiac Reflex on Postoperative Cardiac Adverse Events in Patients Undergoing Cerebellopontine Angle Tumor Resections: A Case-Control Study. World Neurosurg. 2023 Apr;172:e291-e298. doi: 10.1016/j.wneu.2023.01.010. 

16. Wang J, Li R, Li S, Ma T, Zhang X, Ren Y, Chen X, Peng Y*. Intraoperative arterial pressure and delayed cerebral ischemia in patients with aneurysmal subarachnoid hemorrhage after surgical clipping: A retrospective cohort study. Front Neurosci. 2023 Feb 17;17:1064987. doi: 10.3389/fnins.2023.1064987.

17. Li S#, Li R#, Li M, Cui Q, Zhang X, Ma T, Wang D, Zeng M, Li H, Bao Z, Peng Y*, Sessler DI. Dexmedetomidine administration during brain tumour resection for prevention of postoperative delirium: a randomised trial. Br J Anaesth. 2023 Feb;130(2):e307-e316. doi: 10.1016/j.bja.2022.10.041.  

18. Wang J, Peng Y*. Emergency treatment and anesthesia management of internal carotid artery injury during neurosurgery: Four case reports. World J Clin Cases. 2022 Sep 26;10(27):9865-9872. doi: 10.12998/wjcc.v10.i27.9865. 

19. Liu X, Zhang X, Fan Y, Li S, Peng Y*. Effect of intraoperative goal-directed fluid therapy on the postoperative brain edema in patients undergoing high-grade glioma resections: a study protocol of randomized control trial. Trials. 2022 Nov 19;23(1):950. doi: 10.1186/s13063-022-06859-9. 

20. Zeng M, Li R, Xu X, Wang D, Dong J, Li S, Kass IS, Peng Y*, Jia W. Ultrasound-guided superficial cervical plexus block reduces opioid consumption in patients undergoing craniotomy via suboccipital retrosigmoid approach: a randomized controlled trial. Reg Anesth Pain Med. 2022 Jun 29:rapm-2022-103534. doi: 10.1136/rapm-2022-103534.