•与北京脑重大疾病研究院合作，应用无创静息态功能MRI数据精准定位个体化脑功能网络的新技术，解决了rTMS调控干预的关键难点。

•与中国科学院电工所建立了交叉合作研究平台，就rTMS临床应用中的电磁场生物效应相关基础问题开展了跨学科的交叉研究。

•与美国Vanderbilt大学影像中心合作，基于灰质-白质通讯的功能连接性，从全脑角度来研究脑网络变化的新的分析方法，研究AD、MSA等疾病

•1. 基于静息态fMRI研究AD、癫痫、MSA等脑白质和脑网络功能，解析重大脑疾病发病机制，全面认知大脑功能网络

•2. 应用TMS-EEG，ppTMS无创脑刺激技术发现，AD、癫痫、MSA等早期诊断和疾病跟踪的基于扰动的生物标志物、解决大脑振荡脑电网络活动方案

•3.无创电磁精准调控技术治疗AD、癫痫、MSA等个体化方案及调控神经环路机制研究

•4. 基于个体化fMRI定位新技术精准引导的rTMS治疗AD和MCI的研究

1、主持项目（在研）：北京市首都卫生发展科研专项自主创新项目，项目名称“基于个体化fMRI定位新技术精准引导的rTMS治疗轻度认知障碍的研究”，2022-01月至2024-12，52万元

2、主持项目（在研）：国家自然科学基金委员会与芬兰科学院合作交流项目(8211101524) ，项目名称“阿尔茨海默病临床前期患者β淀粉样蛋白PET定量分析和MRI影像组学特征的合作研究”，2022-03至2024-02,10万元

1.     Hua Lin#*（通讯作者）, Li Lin#, Lyuan Xu, Siran Li, Penghui Song, Muwei Li. Combinedfunctional and structural imaging of brain white matter reveals stage-dependentimpairment in multiple system atrophy of cerebellar type. npj ParkinsonsDisease. 2022 August, Accepted. IF:9.304  Q1区

2.    Jin G, Chen J, Du J, He L, QiL, Wu D, Wang Y, Lin H*（通讯作者）, Ren L*. Repetitivetranscranial magnetic stimulation to treat benign epilepsy with centrotemporalspikes. Brain Stimul. 2022,15: 601-604.  IF:9.611 Q1区

3.    Hua Lin#, Jiehui Jiang#, Zhuoyuan Li, Can Sheng,Wenying Du, Xiayu Li, Ying Han*. Identification of Subjective Cognitive Declinedue to Alzheimer’s disease Using Multimodal MRI combining with machinelearning. Cerebral Cortex, 2022 Mar 28. Online ahead of print.  IF:6.108  Q1区

4.     Hua Lin#, Yu Sun#, Muwei Li, Yang Zhan, Li Lin, ZhaohuaDing, Ying Han. Sex modulates the APOEε4 effect on white matter and corticalfunctional connectivity in individuals with amnestic mild cognitive impairment.European Journal of Neurology, 2020, Aug;27(8):1415-1421. IF:6.089 Q1区

5.     Gong M, Wang S, Lin H∗（通讯作者）. Postural instability and backward leaning in apatient of familial fatal insomnia with positive SOX1 antibodies. Sleep Med.2022 Feb 18;91:59-61.  IF: 4.609  Q2区

6.    Lianghui Ni, Mingyan Zhao, ZhishanHu, Kun Yang, Xing Zhao, Haijing Niu∗ and Hua Lin∗（通讯作者）. NeuralMechanism of Shentai Tea Polyphenols on Cognitive Improvements for Individualswith Subjective Cognitive Decline: A Functional Near-Infrared SpectroscopyStudy. Journal of Alzheimer’s Disease 2021,82:1137–1145. IF:4.850  Q2区

7.    Penghui Song, Siran Li, Suobin Wang, Hua Wei, Hua Lin＊（通讯作者）,Yuping Wang. Repetitive transcranial magnetic stimulation of the cerebellumimproves ataxia and cerebello-fronto plasticity in multiple system atrophy: arandomized, double-blind, sham-controlled and TMS- EEG study. Aging (AlbanyNY), 2020 Oct;12(20):20611-20622. IF:5.682  Q2区

8.     Hua Lin, Muwei Li, Yang Zhan, Li Lin, Kun Yang, Shimin Hu,Ying Han.Disrupted white matter functional connectivity in aMCI APOEε4 carriers: aresting-state study. Brain Imaging and Behavior, 2021 Aug;15(4): 1739-1747.  IF:3.978  Q2区

9.     Penghui Song#, Dan Cao#, Siran Li, Rong Wang,Yuping Wang, Hua Lin∗（通讯作者）. Effects of hyperventilationwith face mask on brain network in patients with epilepsy. Epilepsy Research,2021, 176: 106741. IF:3.143  Q3区

10.  Hua Lin, Ningning Hu, Yanfeng Zhang, Yuping Wang, Robert L.Macdonald. Whole exome sequencing reveals novel NOV and DCAF13 variants in aChinese pedigree with familial cortical myoclonic tremor with epilepsy.Neuroscience Letters, 2018,684:115-120.

11.  Hua Lin, Wenjuan Li, Jiaxiang Ni, Yuping Wang. Clinical study ofrepetitive transcranial magnetic stimulation of the motor cortex for thalamicpain. Medicine. 2018, 97(27):1-6.

12.  Lin H,Gong L,Zhan S,Wang Y,Liu A.Novel biallelic missense mutations in CTC1 gene identified in a Chinese familywith Coats plus syndrome. J Neurol Sci.2017,15;382:142-145.

13.  Jingyun Li#, Hua Lin#（共同第一作者）, Xinlin Zhua, Liping Lib, Xin Wanga,Aihua Liu, Xiaopan Wua, Fenghe Niua, Yuping Wangb*,Ying Liua** Association study of functional polymorphisms in serotonintransporter gene with temporal lobe epilepsy in Han Chinese population. European Journal of Neurology,2012,19(2):351-353. IF: 4.387  Q1区

14.  Hua Lin, Jingyun Li, Mengyang Wang, Zheng Wang, Yuping Wang,∗Liwen Wu,∗∗  Mutation screening of three Chinese familieswith genetic epilepsy with febrile seizures plus. Neuroscience Letters,2011,500:123-128.

15.  Hua Lin，Yuangui Huang，Yuping Wang，Jianping Jia. Spatiotemporal Profile of N-Cadherin Expression in the mossyfiber sprouting and synaptic plasticity following seizures. Mol Cell Biochem ,2011,358(1-2):201-205.