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2005年毕业于第四军医大学，获博士学位。后于解放军307医院历任任主治医师及副主任医师。2013年调入首都医科大学附属北京世纪坛医院肿瘤内科工作，2015年晋升为主任医师。现任首都医科大学附属北京世纪坛医院肿瘤内科主任。工作期间由于业绩突出先后于2012、2016年被医院选送经国家公派赴美国斯隆-凯特琳癌症中心、约翰霍普金斯大学医学院等国际权威肿瘤诊疗研究机构进修学习各1年。2015年入选北京市卫生系统高层次卫生技术人才。
临床工作聚焦肿瘤诊疗中的难点与热点，遵循以循证医学为基础的规范化与基于精准治疗的个体化相结合的原则，践行多学科诊疗的模式，给予患者最佳治疗。擅长乳腺肿瘤、肺部肿瘤、消化道肿瘤、妇科肿瘤等常见体部实体肿瘤及中枢神经系统肿瘤的综合诊治，作为学科带头人积极开展实体肿瘤免疫和靶向治疗，作为主要研究者开展参与多项新药临床研究。现任乳腺病防治学会姑息与康复专业委员会常务委员、北京健康促进会肺癌诊疗专家委员会常务委员、中国医药生物技术协会生物诊断技术分会免疫评估与免疫治疗学组委员、北京癌症防治学会胃癌防治专业委员会委员。科研聚焦肿瘤免疫微环境领域，在肿瘤细胞与免疫细胞形成的cell-in-cell结构的生物学作用及调控机制方向取得了系列原创性成果，建立了用于肿瘤组织中cell-in-cell结构分型定量的“EML”方法，首次提出了功能性病理指标的概念；鉴定了cell-in-cell结构调控的关键分子元件，为进一步发展靶向抗肿瘤治疗策略提供靶点；原创性发现cell-in-cell结构促进免疫细胞在细胞内对于肿瘤细胞的杀伤，提出胞内杀伤的概念，探索了肿瘤免疫治疗杀伤增强新的策略。近5年以第一或通讯作者在Advanced Science, Cell Discovery, CellDeath Differentiation等国际期刊发表SCI论文26篇，其中IF>10分8篇，合计IF266.3分。作为课题负责人承担国家自然科学基金面上项目2项、青年项目1项，承担北京市自然科学基金面上项目1项及北京市自然科学基金-北京市教委联合重点科技项目1项，承担北京市科委项目1项。作为项目负责人参与国家重点研发计划2项。近5年获批经费403万元，授权国家发明专利2项。
作为肿瘤学博士研究生导师，重视本科生及研究生的教学培养。目前在读博士生3名、硕士生3名，在站博士后1名。
本课题组致力于解析新型细胞死亡方式（cell-in-cell mediated cell death；entosis）的执行机制、肿瘤免疫调节机制及其在重大疾病中的生物学功能；积极推动合成生物学技术在相关研究成果中的转化应用。课题组目前在肿瘤以及传染性疾病（新冠等）等方向有成熟研究基础及积累。相关研究工作发表在Cell Discovery、Advanced Science、Cell Research、Cell Death and Differentiation、Signal Transduction and Targeted Therapy、Cell Reports、Nucleic Acids Research等杂志。课题组一直与包括北京生物工程研究所孙强课题组在内的多个课题组保持深度合作，拥有成熟的教学管理体系、先进的实验设备、丰富的基础实验和临床试验经验及充足的科研经费，同时团队气氛融洽，成果产出丰厚，已成功培养硕博研究生数名。
1. 2023.1-2026.12 国家自然科学基金面上项目 FLRT3抑制异质性cell-in-cell结构形成机制及细胞免疫调节作用研究（项目编号82273184）第一申请人
2. 2022.11-2027.10国家重点研发计划“合成生物学”重点专项 实体瘤响应工程免疫细胞的设计合成与应用（2022YFA0912403）项目骨干
3. 2022.4-2024.04 国家重点研发计划“主动健康和人口老龄化科技应对”重点专项 衰老相关免疫调控机制与甲基化时钟建立（2022YFC3600100）项目骨干
4. 2021.1-2023.12 北京市自然科学基金-北京市教育委员会科技计划重点项目 异质性cell-in-cell结构介导肿瘤细胞杀伤增强的机制研究（项目编号KZ202110025029）第一申请人
5. 2021.10-2024.10 北京市科学技术委员会 首都临床诊疗技术研究与转化应用项目 新型功能病理指标cell-in-cell结构预测乳腺癌新辅助化疗疗效的探索性研究（项目编号Z211100002921033）第一申请人
6. 2021.1-2023.12 医管中心-科研培育计划 新型功能病理指标cell-in-cell结构预测乳腺癌新辅助化疗疗效的探索性研究（项目编号pX2021033）第一申请人
7. 2016.1-2019.12 国家自然科学基金面上项目 肿瘤细胞/靶细胞在与免疫细胞形成cell-in-cell结构中的作用及机制研究（项目编号81572799）第一申请人
8. 2016.1-2018.12 北京市自然科学基金面上项目 异质性cell in cell结构形成机制的初步研究（项目编号7162091） 第一申请人
9. 2010.1-2012.12 国家自然科学基金青年项目 肿瘤组织来源的间质干细胞影响乳癌骨转移的初步研究（项目编号30901455） 第一申请人
10. 2020.1-2023.12 国家自然科学基金面上项目 Entosis作为一种新的上皮细胞分裂监测机制的概念性验证（项目编号31970685）第二申请人
11. 2015.1-2018.12 国家自然科学基金面上项目 Entosis介导的细胞竞争及其在肿瘤细胞克隆选择中的作用研究（项目编号30871364）第二申请人
1. 黄红艳，孙强，牛祖彪. 胰腺肿瘤组织中CICs在制备预测胰腺癌预后生存产品中的应用（专利号ZL201910226915.7）
2. 黄红艳，孙强，张鑫. 乳腺肿瘤组织中CICs在制备预测胰腺癌预后生存产品中的应用（专利号ZL201910226907.2）
1. SuYan§,Huang Hongyan§, Luo Tianzhi§, Zheng You,Fan Jie, Ren He, Tang Meng, Niu Zubiao, Wang Chenxi, Wang Yuqi, ZhangZhengrong, Liang Jianqing, Ruan Banzhan, Gao Lihua, Chen Zhaolie, Melino Gerry,Wang Xiaoning, and Sun Qiang*. Cell-in-CellStructure Mediates In-Cell Killing Suppressed by CD44. Cell Discov, 2022. 8(1): 35. DOI:10.1038/s41421-022-00387-1 (IF=38.079)
2. TangMeng§, Hui Xu§, HuangHongyan§, Hao Kuang, Chenxi Wang, Qinqin Li, Xin Zhang,Yizhong Ge, Mengmeng Song, Xi Zhang, Ziwen Wang, Chaobing Ma, Jinlin Kang,Wanfang Zhang, You Wang, Bo Zhang, Xiaowei Zhang, Yongbing Chen, Minghua Cong, GerryMelino, Xiaobin Wang, Fuxiang Zhou*, Sun Qiang*, Hanping Shi*. Metabolism-basedmolecular subtyping endows effective ketogenic therapies in colon cancer withmutant p53. Advanced Science, 2022Oct;9(29):e2201992. Epub 2022 Aug 28. DOI: 10.1002/advs.202201992. (IF=17.521)
3. YuexianWei§, Zubiao Niu§, Xinyu Hou§, MengzheLiu§, Yuqi Wang§, Yongan Zhou§, ChenxiWang , Qunfeng Ma , Yichao Zhu , XinyueGao , Peiyun Li , Shuo Gao , SiboZhan , Zi Yang , Yanhong Tai , QiujuShao , Jianlin Ge , Jilei Hua , LihuaGao , Qiang Sun *, Hong Jiang*, Hongyan Huang*.Subtype-based analysis of cell-in-cell structures innon-small cell lung cancer. Am JCancer Res, 2023 Mar 15;13(3):1091-1102. eCollection 2023. (IF=5.942)
4. TangMeng§, Su Yan§, Zhao Wei§, Niu Zubiao§,Ruan Banzhan, Li Qinqin, Zheng You, Wang Chenxi, Zhou Yong, Zhang Bo, ZhouFuxiang, Huang Hongyan*, Shi Hanping*, and Qiang Sun*. AIM-CICs:Automatic Identification Method for Cell-in-cell Structures based onConvolutional Neural Network. J Mol Cell Biol,2022, DOI: 10.1093/jmcb/mjac044 (IF=8.185)
5. ZhouLulin, Niu Zubiao, Wang Yuqi, Zheng You, Zhu Yichao, Wang Chenxi, Gao Xiaoyan,Gao Lihua, Zhang Wen, Zhang Kaitai, Melino Gerry, HuangHongyan*,Wang Xiaoning*, and Sun Qiang*. Senescence as a dictator ofpatient outcomes and therapeutic efficacies in human gastric cancer. Cell Death Discov, 2022. 8(1): 13.DOI: 10.1038/s41420-021-00769-6.(IF=7.109)
6. ShuoWang§, QiShi§, YuzeZhao§ , YuguangSong, Guoliang Qiao*, Guangjie Liu , Qian Zhu, LefuHuang, Chang Xu, Bing Liu , Zheng Chen , Hongyan Huang*. Expansionof CD3+CD8+PD1+ T lymphocytes and TCR repertoire diversity predictclinical responses to adoptive cell therapy in advanced gastric cancer. Am J Cancer Res, 2022 May 15;12(5):2203-2215.(IF=5.942)
7. ShuoWang§, Yuze Zhao§, Yuguang Song§, Guoliang Qiao, Yan Di, JingZhao, Pingping Sun, Huixia Zheng, He Huang, Hongyan Huang*. ERBB2D16 Expression inHER2 Positive Gastric Cancer Is Associated With Resistance to Trastuzumab. Front Oncol, 2022. 12: 855308.DOI: 10.3389/fonc.2022.855308. (IF=5.738)
8. ZhangZhengrong§, Zheng You§, Niu Zubiao§, Zhang Bo§,Wang Chenxi§, Yao Xiaohong§, Peng Haoran, Franca DelNonno, Wang Yunyun, ZhuYichao, Su Yan, Tang Meng, Jiang Xiaoyi, Ren He, He Meifang, Wang Yuqi, GaoLihua, Zhao Ping, Shi Hanping, Chen Zhaolie, Wang Xiaoning, Piacentini Mauro,Bian Xiuwu, Melino Gerry, Liu Liang*,Huang Hongyan*,Sun Qiang*.SARS-CoV-2 spike protein dictates syncytium-mediated lymphocyte elimination. Cell Death Differ,2021 DOI: 10.1038/s41418-021-00782-3. (IF=12.067)
9. LiangJianqing§, Niu Zubiao§, Zhang Bo§, Yu Xiaochen§,ZhengYou, Wang Chenxi, Ren He, Wang Manna, Ruan Banzhan, Qin Hongquan, Zhang Xin,Zheng You, Gu Songzhi, Sai Xiaoyong, Tai Yanhong, Gao Lihua, Ma Li, ChenZhaolie, Huang Hongyan*, Wang Xiaoning*, and Sun Qiang*. p53-dependentElimination of Aneuploid Mitotic Offspring by Entosis. Cell Death Differ,2021 DOI: 10.1038/s41418-020-00645-3. (IF=12.067)
10. ChenJianxin§, Yang Fan§, Shi Qi, Zhao Yuze, and HuangHongyan*.A Retrospective Study on Spinal Dissemination of Supratentorial Glioma. Front Oncol, 2021. 11: 765399.DOI: 10.3389/fonc.2021.765399. (IF=6.244)
11. HongyanHuang§;Yichao Zhu§; Niu Zubiao; Lulin Zhou and Sun Qiang*.SARS-CoV-2 N501Y variants of concern and their potential transmission by mouse. Cell Death Differ, 2021DOI: 10.1038/s41418-02100846-4 (IF=12.067)
12. RenHe, Ma Chaobing, Peng Haoran, Zhang Bo, Zhou Lulin, Su Yan, Gao Xiaoyan, and Huang Hongyan*. Micronucleus production, activation of DNA damageresponse and cGAS-STING signaling in syncytia induced by SARS-CoV-2infection. Biology Direct, 2021. 16(1): 20.DOI:10.1186/s13062-021-00305-7. (IF=7.137)
13. ChenJianxin§, Zhao Yuze§, Hou Xinyu§, Gao Xiaoyan, Shi Qi, LiShan, and Huang Hongyan*. Combined carboplatin andetoposide chemotherapy for patients with recurrent glioma. AnnPalliat Med, 2021. 10(12):12650-12656.DOI: 10.21037/apm-21-3382. (IF=2.595)
14. ChenJianxin§, Shi Qi§, Li Shan, Zhao Yuze, HuangHongyan*. Clinical characteristics ofglioblastoma with metastatic spinal dissemination. AnnPalliat Med, 2022. 11(2):506-512.DOI: 10.21037/apm-21-3387. (IF=2.595)
15. ZubiaoNiu§, Zhengrong Zhang§, Xiaoyan Gao§, Peng Du§, JingjingLu, Bohua Yan, Chenxi Wang, You Zheng, Hongyan Huang*,Qiang Sun*. N501Y mutation imparts cross-species transmission of SARS-CoV-2 tomice by enhancing receptorbinding. Signal Transduct Target Ther, 2021.DOI: 10.1038/s41392-021-00704-2 (IF=38.104)
16. ChenJianxin§, Shi Qi§, Li Shan, Zhao Yuze, and HuangHongyan*. Characteristics of spinaldissemination in adult low-grade glioma: a retrospective cohort study at asingle institute. Ann Palliat Med, 2021. 10(12): 12643-12649.DOI:10.21037/apm-21-3390. (IF=2.595)
17. WangYuqi§, Niu Zubiao§, Zhou Lulin§, Zhou Yongan§,Ma Qunfeng§, Zhu Yichao, Liu Mengzhe, Shi Yinan, Tai Yanhong, ShaoQiuju, Ge Jianlin, Hua Jilei, Gao Lihua, Huang Hongyan*, Jiang Hong*, and Sun Qiang*. Subtype-BasedAnalysis of Cell-in-cell Structures in Esophageal Squamous Cell Carcinoma. Front Oncol, 2021. 11(2163) DOI:10.3389/fonc.2021.670051. (IF=6.244)
18. Jiang Xiaoyi§,Zhang Zhengrong§, Wang Chenxi§, Ren Hongguang§,Gao Lihua§, Peng Haoran, Niu Zubiao, Ren He, HuangHongyan*, Sun Qiang*. Bimodular effects of D614G mutationon the spike glycoprotein of SARS-CoV-2 enhance protein processing, membranefusion and viral infectivity. Signal Transduct Target Ther, 2020. 5(1): 268-271. DOI: 10.1038/s41392-020-00392-4(IF=18.187)
19. HuangHongyan§*,He Meifang§, Zhang Yanbin§, Zhang Bo§, NiuZubiao, Zheng You, Li Wen, Cui Peilin*,Wang Xiaoning*,Sun Qiang*.Identification and validation of heterotypic cell-in-cell structure as anadverse prognostic predictor for young patients of resectable pancreatic ductaladenocarcinoma. Signal Transduct Target Ther, 2020. 5(1): 246-248. DOI:10.1038/s41392-020-00346-w. (IF=18.187)
20. WangManna§, Niu Zubiao§, Qin Hongquan§, RuanBanzhan, Zheng You, Ning Xiangkai, Gu Songzhi, Gao Lihua, Chen Zhaolie, WangXiaoning, Huang Hongyan*,Ma Li*,Sun Qiang*.Mechanical Ring Interfaces between Adherens Junction and Contractile Actomyosinto Coordinate Entotic Cell-in-Cell Formation. CellRep, 2020. 32(8):1-12. DOI: 10.1016/j.celrep.2020.108071 (IF=9.423)
21. Wang Chenxi§, Chen Ang§, Ruan Banzhan§, Niu Zubiao, Su Yan, Qin Hongquan, Zheng You, Zhang Bo,Gao Lihua, Huang Hongyan*, Wang Xiaoning*, Sun Qiang*. PCDH7 Inhibits the Formation of Homotypic Cell-in-CellStructure. Front CellDev Biol, 2020. 8(329):1-12. DOI. 10.3389/fcell.2020.00329 (IF=6.684)
22. Zhou Lulin§, NiuZubiao§, Jiang Xiaoyi§, Zhang Zhengrong§,Zheng You, Wang Zhongyi, Zhu Yichao, Gao Lihua, Huang Hongyan*,Wang Xiaoning*, Sun Qiang*. The SARS-CoV-2 targets by the pscRNAprofiling of ACE2, TMPRSS2 andFurin proteases. iScience, 2020.23(11): 1-15. DOI: 10.1101/2020.04.06.028522. (IF=5.458)
23. Ruan,B§., Niu, Z§., Jiang, X§., Li, Z., Tai, Y., Huang Hongyan*,Sun Qiang *.High Frequency of Cell-in-Cell Formation in Heterogeneous Human Breast CancerTissue in a Patient With Poor Prognosis: A Case Report and Literature Review. Front Oncol, 2019. 9: 1-6. DOI. 10.3389/fonc.2019.01444 (IF=4.848)
24. ZhangXin§, Niu Zubiao§, Qin Hongquan, Fan Jie, Wang Manna,Zhang Bo, Zheng You, Gao Lihua, Chen Zhaolie, Tai Yanhong*,Yang Mo*,Huang Hongyan*,and Sun Qiang*.Subtype-based Prognostic Analysis of Cell-in-Cell Structures in Early BreastCancer. Front Oncol, 2019. 9: 1-12. DOI.10.3389/fonc.2019.00895 (IF=4.848)
25. LiangJianqing§, Fan Jie§, Wang Manna, Niu Zubiao, ZhangZhengrong, Yuan Long, Tai Yanhong, Chen Zhaolie, Song Santai, Wang Xiaoning,Liu Xiaoqing*,Huang Hongyan*,and Sun Qiang*.CDKN2A inhibits formation of homotypic cell-in-cell structures. Oncogenesis, 2018. 7(6): 1-8. DOI.10.1038/s41389-018-0056-4 (IF=5.995)
26. RuanBanzhan, Zhang Bo, Chen Ang, Yuan Long, Liang Jianqing, Wang Manna, Zhang Zhengrong,Fan Jie, Yu Xiaochen, Zhang Xin, Niu Zubiao, Zheng You, Gu Songzhi, LiuXiaoqing, Du Hongli, Wang Jufang, Hu Xianwen, Gao Lihua, Chen Zhaolie*, Huang Hongyan*, Wang Xiaoning*,and Sun Qiang*. Cholesterol inhibits entotic cell-in-cell formation andactomyosin contraction. Biochem BiophysRes Commun, 2018.495(1): 1440-1446. (IF=2.466)
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