胃肠肝胆肿瘤外科（普通外科一病区）简介

科室前身是北京铁路总院普外专业组，上世纪八十年代初成为独立建制科室，现任主任是彭吉润教授。科室在肝胆胰疾病和胃肠道肿瘤诊疗、肿瘤消融及微创治疗方面具有较强实力，是北京大学、首都医科大学外科学博士学位授予点，同时也是北京市普通外科专科医师培训基地。近年来，在Cell、Cancer Cell、Cell Research等国际著名期刊发表多篇科研论文，并荣获北京市自然科学一等奖一项。科室在2021年度中国医学院校/中国医院科技量值（STEM）排名中名列普通外科专业第39位，在北京市名列第6位。

近期论著

1.        Yedan Liu, Qiming Zhang, Baocai Xing, Nan Luo, Ranran Gao, Kezhuo Yu, XuedaHu, Zhaode Bu, Jirun Peng (共同通讯作者), Xianwen Ren (共同通讯作者), and Zemin Zhang (共同通讯作者). Immune phenotypic linkage between colorectal cancer and liver metastasis.Cancer Cell, 2022, 40:1-14, accepted. https://doi.org/10.1016/j.ccell.2022.02.013

2.        Zenghua Deng, Kanghua Huang, Dongfang Liu, Nan Luo, Tingting Liu, LongHan, Dexiao Du, Dongbo Lian, Zhaohui Zhong, Jirun Peng (共同通讯作者).Key Candidate Prognostic BiomarkersCorrelated with Immune Infiltration in Hepatocellular Carcinoma. Journal ofHepatocellular Carcinoma, 2021, 8:1607–1622.

3.        徐奇奇，朱卫华，甘丽云，张大方，郑晟旻，李澍，冷希圣，彭吉润（通讯作者）。微波消融与手术切除治疗小肝癌的综合疗效比较。中华普通外科杂志，2021，36（9）：649-652

4.        Zenghua Deng#, Mengmeng Xiao#, Dexiao Du, Nan Luo, Dongfang Liu, Tingting Liu, Dongbo Lian, Jirun Peng*（通讯作者）. DNASE1L3 as a Prognostic BiomarkerAssociated with Immune Cell Infiltration in Cancer. OncoTargets and Therapy, 2021,14: 2003-2017.

5.        Hui Guo, Jili Hu, Zhenquan Shen, Dexiao Du, Yufeng Zheng（共同通讯作者）, Jirun Peng（共同通讯作者）. In vitro and in vivo studies ofbiodegradable Zn-Li-Mn alloy staples designed for gastrointestinal anastomosis.Acta Biomaterialia, 2021,121: 713-723.

6.        Rui Yang, Sijin Cheng, Nan Luo, Ranran Gao, Kezhuo Yu, Boxi Kang, LiWang, Qiming Zhang, Qiao Fang, Lei Zhang, Chen Li, Aibin He, Xueda Hu, JirunPeng（共同通讯作者）, Xianwen Ren（共同通讯作者） and Zemin Zhang（共同通讯作者）. Distinct epigenetic features of tumorreactive CD8+ T cells incolorectal cancer patients revealed by genome-wide DNA methylation analysis.Genome Biol, 2020, 21:2. https://doi.org/10.1186/s13059-019-1921-y

7.        Xiaomeng Liu, Jie Ren, Nan Luo, Huahu Guo, Yuxuan Zheng, Jingyi Li, Fuchou Tang, Lu Wen（共同通讯作者）, Jirun Peng（共同通讯作者）. Comprehensive DNA methylation analysisof tissue-of-origin of plasma cell-free DNA by methylated CpG tandemamplification and sequencing (MCTA-Seq). Clinical Epigenetics, 2019, 11:93.https://doi.org/10.1186/s13148-019-0689-y

8.        Qiming Zhang, Yao He, Nan Luo, Shashank J. Patel, Yanjie Han, Ranran Gao,Madhura Modak, Sebastian Carotta, Christian Haslinger, David Kind, Gregory W.Peet, Guojie Zhong, Shuangjia Lu, Weihua Zhu, Yilei Mao, Mengmeng Xiao, MichaelBergmann, Xueda Hu, Sid P. Kerkar, Anne B. Vogt, Stefan Pflanz, Kang Liu（共同通讯作者）, Jirun Peng（共同通讯作者）, Xianwen Ren（共同通讯作者）, Zemin Zhang（共同通讯作者）. Landscape and Dynamics of Single Immune Cells in HepatocellularCarcinoma.Cell. 2019, 179, 829–845. https://doi.org/10.1016/j.cell.2019.10.003

9.        Kanghua Huang, Bowen Sun, Nan Luo, Huahu Guo, Jili Hu, Jirun Peng（通讯作者）. ProgrammedDeath Receptor 1 (PD1) Knockout and Human Telomerase Reverse Transcriptase(hTERT) Transduction Can Enhance Persistence and Antitumor Efficacy ofCytokine-Induced Killer Cells Against Hepatocellular Carcinoma. Med Sci Monit 2018; 24:4573-4582.

10.     Zhipeng Sun, Yubing Zhu, Aminbuhe, QingFan, Jirun Peng*, Nengwei Zhang*. Differential expression of APE1 in hepatocellular carcinoma and theeffects on proliferation and apoptosis of cancer cells.BioScience Trends,2018,12(5): 456-462.

11.     Zheng C, Zheng L, Yoo JK, Guo H, Zhang Y,Guo X, Kang B, Hu R, Huang JY, Zhang Q, Liu Z, Dong M, Hu X, Ouyang W（共同通讯作者）, Peng J（共同通讯作者）, Zhang Z（共同通讯作者）. Landscape of infiltrating T cells inliver cancer revealed by single-cell sequencing. Cell, 2017, 169 (7):1342-1356.e16.

12.     Yang Liu, Shengmin Zheng, Nan Li, HuahuGuo, Yufeng Zheng（共同通讯作者）,Jirun Peng（共同通讯作者）. In vivo response of AZ31 alloy asbiliary stents: a 6 months evaluation in rabbits. Scientific Reports, 2017,7:40184.

13.    Zhong Z, Gu H, Peng J（共同通讯作者）, Wang W, Johnstone BH, March KL, Farlow MR, Du Y. GDNF secreted fromadipose-derived stem cells stimulates VEGF-independent angiogenesis.Oncotarget. 2016 , 7(24):36829-36841.

14.    Hou Yu, Guo Huahu, Cao Chen, Li Xianlong, Hu Boqiang, Zhu Ping, WuXinglong, Wen Lu, Tang Fuchou, Huang Yanyi, Peng Jirun（共同通讯作者）. Single-cell triple omics sequencing revealsgenetic, epigenetic, and transcriptomic heterogeneity in hepatocellularcarcinomas. Cell Research, 2016, 26(3):304-319.

15.    Yang Liu, Shengmin Zheng, Nan Li, Huahu Guo, Yu fengZheng, Jirun Peng（共同通讯作者）. Study on the in vitro degradation behavior of pureMg and WE43 in human bile for 60 days for future usage in biliary. MaterialsLetters, 2016，179：100-103. doi:10.1016/j.matlet.2016.05.042

16.    Wen Lu, Li Jingyi, Guo Huahu, Liu Xiaomeng, Zheng Shengmin, Zhang Dafang,Zhu Weihua, Qu Jianhui, Guo Limin, Du Dexiao, Jin Xiao, Zhang Yuhao, Gao Yun,Shen Jie, Ge Hao, Tang Fuchou, Huang Yanyi, Peng Jirun（共同通讯作者）. Genome-scale detection of hypermethylated CpGislands in circulating cell-free DNA of hepatocellular carcinoma patients. CellResearch, 2015, 25(11):1250-1264.

17.   Li Xiaofeng, Peng Jirun（共同第一作者）, Pang Yanli, Yu Sen, Yu Xin, Chen Pengcheng, WangWenzhen, Han Wenling, Zhang Jun, Yin Yanhui, Zhang Yu. Identification of aFOXP3(+)CD3(+)CD56(+) population with immunosuppressive function in cancertissues of human hepatocellular carcinoma. Scientific Reports, 2015, 5:14757.

18.    Gong Lei, Wei Yuhua, Yu Xin, Peng Jirun（通讯作者）, Leng Xisheng. 3-Bromopyruvic acid, ahexokinase II inhibitor, is an effective antitumor agent on the hepatoma cells:in vitro and in vivo findings. Anti-Cancer Agents in Medicinal Chemistry, 2014,14(5):771-776.

19.    朱卫华，张大方，郑晟旻，金仲田，甘丽云，李澍，冷希圣，彭吉润（通讯作者）。微波消融治疗24例结直肠癌肝转移的临床疗效分析。腹部外科，2013；26（2）：19-22。

20.    Lei Gong, Zhuqingqing Cui, Pengcheng Chen, Hui Han, Jirun Peng (通讯作者), Xisheng Leng. Reduced survival of patients withhepatocellular carcinoma expressing hexokinase II. Med Oncol; 2012; 29(2): 909-914.

21.    Cui Zhuqingqing, Yu Xin, Guo Limin, Wei Yuhua, Zheng Shengmin, Li Wenxia,Chen Pengcheng, Zhu Jiye, Peng Jirun（共同通讯作者）. Combined analysis of serum alpha-fetoprotein andMAGE-A3-specific cytotoxic T lymphocytes in peripheral blood for diagnosis ofhepatocellular carcinoma. Disease Markers, 2013, 35(6):915-923.

22.    丁磊，高宏，陈奕至，黄静，朱煜冰，孔璐，昌红，彭吉润（通讯作者）。Claudin-7基因敲除诱导小鼠肠道炎症及其致癌机制的研究，中华普通外科杂志，2013，28（2），120-124。

23.    Peng Jirun（共同第一作者）, Guoxin Zhang, Seon-AhHa, Hyun Kee Kim, Jinah Yoo, Sanghee Kim, Jin Zhongtian, Cui Zhuqingqing, YounSoo Lee,Gi Hwan Gong, Joo Hee Yoon, Hae Nam Lee,Sa Jin Kim, Tae Eung Kim, EunYoung Song, Yun Kyung Lee, Yong Gyu Park, Jin Woo Kim*，HCCR-1 for detecting small hepatocellularcarcinoma latent in a cirrhotic liver: a prospective cohort study. Gut, 2012,61(10), 1514-1515.

24.     PengJirun, Guoxin Zhang, Hyun Kee Kim,Seon-Ah Ha, Jin Zhongtian, Qiao Shishi, Cui Zhuqingqing, Gong Lei, Jinah Yoo,Sanghee Kim, Yong Gyu Park, Jing Wang, Yang Yang, Zekuan Xu, Zuhu Huang, YunKyung Lee, Eun Young Song, Jin Woo Kim.Clinical utility of alpha fetoproteinand HCCR-1, alone or in combination, in patients with chronic hepatitis, livercirrhosis and hepatocellular carcinoma. Disease Markers, 2011; 30: 307–315.

25.     Shi-ShiQiao, Zhu-Qing-Qing Cui, Lei Gong, Hui Han, Peng-Cheng Chen, Li-Min Guo, XinYu, Yu-Hua Wei, Seon-Ah Ha, Jin Woo Kim, Zhong-Tian Jin, Shu Li, Ji-RunPeng, Xi-Sheng Leng. Simultaneous Measurements of Serum AFP, GPC-3 and HCCRfor Diagnosing Hepatocellular Carcinoma. Hepato-Gastroenterology, 2011: 58:1-6（通讯作者）.

26.     HuiHan, Ji-Run Peng, Peng-Cheng Chen, Lei Gong, Shi-Shi Qiao, Wen-ZhenWang, Zhu-Qingqing Cui, Xin Yu, Yu-Hua Wei, Xi-Sheng Leng.A novel system ofartificial antigen-presenting cells efficiently stimulates Flu peptide-specificcytotoxic T cells in vitro. Biochem Biophys Res Commun, 2011; 411(3): 530-535.（通讯作者）