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主任医师、教授、博士生导师。北京同仁医院角膜病专科主任、北京市眼科研究所副所长。2005年于首都医科大学获眼科学博士学位。2017/4-2017/12美国哈佛大学和加州大学圣迭戈分校访问学者。担任亚洲干眼协会委员，中华变态反应学会鼻眼过敏学组副组长，中国医师协会眼科分会角膜病学组委员，北京医学会眼科专业委员会委员，中华眼科学会青年委员，眼科杂志编委，中华眼科医学杂志编委，中华眼科杂志，中华实验眼科杂志通讯编委。
从事角膜及眼表疾病基础和临床研究，是国内角膜移植手术量最多的中青年专家之一。开展猪来源异种角膜材料系列研究，为角膜盲患者拓展角膜来源；开展调节性T细胞及多种免疫抑制剂防治角膜移植免疫排斥反应综合策略研究，明显延长植片存活时间；在国际上首次报道改良角膜缘干细胞种植术，节省角膜材料，取得良好效果；创新岛状眶下血管神经唇腺移植术，明显改善重症干眼患者症状，提高角膜透明度；医工交叉构建在体角膜生物力学特征模型，提高圆锥角膜早期诊断率；自主创研高频热电场治疗仪，治疗干眼取得良好效果。
承担国家自然科学基金项目4项，北京市重点攻关项目1项。以第1完成人获中国中西医结合学会科技奖一等奖（2021）。以第一作者及通讯发表SCI论文40余篇，作为核心专家制定国际共识1部，国内共识8部。入选中央保健专家，青年北京学者、北京市科技新星、北京市卫生系统高层次人才。
已经建立了一支具有较强科研能力、包括免疫学、材料学、分子生物学、生物信息学等多学科多层次多维度的中青年人才队伍，实现了多种产品的创新研发及转化并已应用于临床。作为院级优秀导师与国家精品资源共享课骨干成员，指导学生夯实基础、开拓创新，现已指导博士生毕业4人，在读4人，硕士生毕业6人，在读6人，并指导学生在读期间发表SCI、中文核心期刊论文，取得大量科研成果。
1. 眼表疾病发病机制及精准诊疗策略研究，省部级项目，青年北京学者计划（NO.022），400万元，2021-01-01至2025-12-31，主持；
2. 基于大样本队列观察及多中心随机对照试验探索环境因素、红光调控和体质干预对近视防控效果的临床研究，省部级项目，北京市卫生健康委员会-首都卫生发展科研专项项目（首发重点专项2022-1-1081），90万元，2022-01-01至2024-12-31，主持；
3. SP/JAK/STAT通路在过敏性结膜炎相关眼表损伤中的免疫调控机制研究，国家自然科学基金，面上项目（82171018），57万元，2022-01-01至2025-12-31，主持；
4. ROCK2-STAT 通路对 CD4+CD25+ LAP+调节性 T 细胞介导的角膜移植免疫耐受调控机制的研究，国家自然科学基金，面上项目（81970764），55万元，2020-01-01至2023-12-31，主持；
5. RhoA/ROCK/PI3K 通路在调节性 T 细胞介导角膜移植免疫耐受中调控机制研究，省部级项目，北京市自然科学基金面上项目（7182037），20万元，2018-01-01至2020-12-31，主持。
一、 重要学术论文
1. Li, S., Zhang, P., Li, A., Bao, J., Pan,Z., Jie, Y, (2022). TIGIT-Fc Prolongs Corneal Allograft Survival in Mice byUpregulating TIGIT/CD226 Expression and the Proportion of Helios+Foxp3+ TregCells. TRANSPLANTATION, https://doi.org/10.1097/TP.0000000000004257
2. Zhang, P., Tian, L., Bao, J., Li, S.,Li, A., Wen, Y., Wang, J., Jie, Y, (2022). Isotretinoin Impairs the SecretoryFunction of Meibomian Gland Via the PPARγ Signaling Pathway. INVEST OPHTH VISSCI, 63 (3), 29. https://doi.org/10.1167/iovs.63.3.29
3. Bao, J., Tian, L., Meng, Y., Wu, B.,Wang, J., He, J., Shao, Q., Wang, C., Jie, Y., Zhang, L, (2022). Total IgE intears accurately reflects the severity and predicts the prognosis of seasonalallergic conjunctivitis. Clin Transl Allergy, 12 (3), e12139. https://doi.org/10.1002/clt2.12139
4. Li, S., Yang, K., Wang, J., Li, S., Zhu,L., Feng, J., Tian, L., Jie, Y, (2021). Effect of a Novel Thermostatic Deviceon Meibomian Gland Dysfunction: A Randomized Controlled Trial in ChinesePatients. OPHTHALMOL THER, 11 (1), 261-270. https://doi.org/10.1007/s40123-021-00431-5
5. Zhang, D., Tian, L., Zhang, H., Zheng,Y., Fu, C., Zhai, C., Jie, Y., Li, L, (2022). Differences of CornealBiomechanics Among Thin Normal Cornea, Forme-Fruste Keratoconus, and CorneaAfter SMILE. Front Bioeng Biotechnol, 10 861924. https://doi.org/10.3389/fbioe.2022.861924
6. Qin, X., Tian, L., Zhang, H., Zhang, D.,Jie, Y., Zhang, HX., Li, L, (2022). Determine Corneal Biomechanical Parametersby Finite Element Simulation and Parametric Analysis Based on ORA Measurements.Front Bioeng Biotechnol, 10 862947. https://doi.org/10.3389/fbioe.2022.862947
7. Li, Y., Tian, L., Guo, LL., Hao, Y.,Jie, Y, (2022). In Vivo Corneal Biomechanical Properties in a Selected ChinesePopulation, Measured Using the Corneal Visualization Scheimpflug Technology.Front Bioeng Biotechnol, 10 863240. https://doi.org/10.3389/fbioe.2022.863240
8. Guo, LL., Tian, L., Cao, K., Li, YX.,Li, N., Yang, WQ., Jie, Y, (2021). Comparison of the morphological andbiomechanical characteristics of keratoconus, forme fruste keratoconus, andnormal corneas. SEMIN OPHTHALMOL, 36 (8), 671-678. https://doi.org/10.1080/08820538.2021.1896752
9. Tian, L., Zhang, D., Guo, L., Qin, X.,Zhang, H., Zhang, H., Jie, Y., Li, L, (2021). Comparisons of cornealbiomechanical and tomographic parameters among thin normal cornea,forme fruste keratoconus, and mild keratoconus. Eye Vis (Lond), 8 (1), 44.https://doi.org/10.1186/s40662-021-00266-y
10. Deng, X., Tian, L., Liu, Z., Zhou, Y.,Jie, Y, (2021). A deep learning approach for the quantification of lower tearmeniscus height BIOMED SIGNAL PROCES, 68 102655. https://doi.org/10.1016/j.bspc.2021.102655
11. Meng, Y, Lu, H, Wang, C, Wang, Y, Meng,N, Yang, K, Jie, Y, Zhang, L, (2021). Naso-ocular neuropeptide interactions inallergic rhinoconjunctivitis, rhinitis, and conjunctivitis. World Allergy OrganJ, 14 World Allergy Organ J. https://doi.org/10.1016/j.waojou.2021.100540
12. Yu, J., Feng, J., Jin, T., Tian, L.,Zhu, L., Cao, K., Li, S., Jie, Y, (2021). The Effect of a Novel Strategy inTreating Primary Pterygium: A Prospective Randomized Clinical Study. AM JOPHTHALMOL, 225 108-116. https://doi.org/10.1016/j.ajo.2021.01.001
13. Wang, Y., Hu, X., Yang, K., Zhang, Y.,Deng, S., Wang, Z., Li, S., Tian, L., Jie, Y, (2021). Clinical outcomes ofmodified simple limbal epithelial transplantation for limbal stem celldeficiency in Chinese population: a retrospective case series. Stem Cell ResTher, 12 (1), 259. https://doi.org/10.1186/s13287-021-02345-2
14. Zhang, H, Tian, L, Guo, L, Qin, X,Zhang, D, Li, L, Jie, Y, Zhang, H, (2021). Comprehensive evaluation of corneasfrom normal, forme fruste keratoconus and clinical keratoconus patients usingmorphological and biomechanical properties. INT OPHTHALMOL, 41 INT OPHTHALMOL. https://doi.org/10.1007/s10792-020-01679-9
15. Tian, L, Zhang, H, Guo, LL, Qin, X,Zhang, D, Li, L, Wu, Y, Jie, Y, Zhang, H, (2021). Distribution of CornealGeometric Landmarks and Relationship Between Their Distances and BiomechanicalParameters in the Development of Keratoconus. Front Bioeng Biotechnol, 9 FrontBioeng Biotechnol. https://doi.org/10.3389/fbioe.2021.766163
16. Tian, L, Qin, X, Zhang, H, Zhang, D,Guo, LL, Zhang, HX, Wu, Y, Jie, Y, Li, L, (2021). A Potential Screening Indexof Corneal Biomechanics in Healthy Subjects, Forme Fruste Keratoconus Patientsand Clinical Keratoconus Patients. Front Bioeng Biotechnol, 9 Front BioengBiotechnol. https://doi.org/10.3389/fbioe.2021.766605
17. Hao, Y., Tian, L., Cao, K., Jie, Y,(2021). Repeatability and Reproducibility of SMTube Measurement in Dry EyeDisease Patients. J OPHTHALMOL, 2021 1589378. https://doi.org/10.1155/2021/1589378
18. Tian, L., Wen, Y., Li, S., Zhang, P.,Wang, Y., Wang, J., Cao, K., Du, L., Wang, N., Jie, Y, (2022). Benefits andSafety of Astaxanthin in the Treatment of Mild-To-Moderate Dry Eye Disease.Front Nutr, 8 796951. https://doi.org/10.3389/fnut.2021.796951
19. Zang, Y., Li, S., Ruan, F., Liu, Z.,Jie, Y, (2020). Tacrolimus dye drop treatment for the management of earlypost-operative intraocular inflammation after therapeutic keratoplasty forsevere infectious keratitis. EXP THER MED, 20 (4), 3260-3268. https://doi.org/10.3892/etm.2020.9057
20. Yang, K., Zhao, Y., Lu, H., Zang, Y.,Mao, Y., Hong, J., Jie, Y, (2020). Graft survival and endothelial outcomesafter penetrating keratoplasty and Descemet stripping automated endothelialkeratoplasty: A systematic review and meta-analysis. EXP THER MED, 20 (3),2794-2804. https://doi.org/10.3892/etm.2020.9010
21. Lin, D, Tian, L, Zhang, S, Wang, L,Jie, Y, Zhou, Y, (2020). Keratoconus Diagnosis: Validation of a Novel ParameterSet Derived from IOP-Matched Scenario. J OPHTHALMOL, 2020 J OPHTHALMOL. https://doi.org/10.1155/2020/6530279
22. Jie, Y., Sella, R., Feng, J., Gomez,ML., Afshari, NA, (2019). Evaluation of incomplete blinking as a measurement ofdry eye disease. OCUL SURF, 17 (3), 440-446. https://doi.org/10.1016/j.jtos.2019.05.007
23. Ruan, F., Zang, Y., Sella, R., Lu, H.,Li, S., Yang, K., Jin, T., Afshari, NA., Pan, Z., Jie, Y, (2019). IntensePulsed Light Therapy with Optimal Pulse Technology as an Adjunct Therapy forModerate to Severe Blepharitis-Associated Keratoconjunctivitis. J OPHTHALMOL,2019 3143469. https://doi.org/10.1155/2019/3143469
24. Li, S., Jie, Y, (2019). Cataractsurgery and lens implantation. CURR OPIN OPHTHALMOL, 30 (1), 39-43. https://doi.org/10.1097/ICU.0000000000000547
25. Guo, X., Li, A., Fan, Y., Yu, Y., Guo,W., Jie, Y, (2019). Combined use of 0.1% fluorometholone and meibomian glandexpression improves symptoms of moderate and severe dry eye disease, even inpatients with systemic immune disease BIOTECHNOL BIOTEC EQ, 33 (1), 1237-1243. https://doi.org/10.1080/13102818.2019.1656107
26. Li, S., Lu, H., Sella, R., Zhang, W.,Dong, H., Guo, C., Afshari, NA., Pan, Z., Jie, Y, (2018). The Effects ofAnti-LAP Monoclonal Antibody Down-regulation of CD4+LAP+ T Cells on AllogeneicCorneal Transplantation in Mice. Sci Rep, 8 (1), 8021. https://doi.org/10.1038/s41598-018-26235-5
27. Li, A., Li, S., Ruan, F., Jie, Y,(2018). Atopic keratoconjunctivitis: A diagnostic dilemma-a case report.MEDICINE, 97 (16), e0372. https://doi.org/10.1097/MD.0000000000010372
28. Li, S, Yu, J, Guo, C, Jie, Y, Pan, Z,(2018). The Balance of Th1/Th2 and LAP+Tregs/Th17 Cells Is Crucial for GraftSurvival in Allogeneic Corneal Transplantation. J OPHTHALMOL, 2018 JOPHTHALMOL. https://doi.org/10.1155/2018/5404989
二、 重要奖项
1. 2021年度北京市科技进步一等奖，复杂角膜盲复明关键技术创研及人工角膜规范化推广应用
2. 眼表疾病中西医结合理论基础及创新诊疗策，省部级奖励，中国中西医结合学会
3. 青年北京学者，北京市人才工作领导小组
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