1. 新型溶瘤病毒恶性肿瘤治疗及增效策略的研发（国家重点研发计划，重点专项），子课题，已结题；

1. 多病共患老年人生活质量维护及危险因素控制优化策略研究（国家重点研发计划），已结题；

1.  miR-224 靶向介导ADAM17调控儿童脑干胶质瘤细胞侵袭能力的机制研究（北京市教委科技计划重点项目），已结题；

1. 显微手术切除听神经瘤面听神经功能保留的临床研究（首都临床特色应用研究），已结题；

1. 脑血管病和中枢神经系统肿瘤综合防治技术的研发、转化与应用（卫生行业科研专项），子课题，已结题；

1. 致敏树突状细胞联合过继T细胞对鼠脑恶性胶质瘤的治疗作用及其机制研究（国家自然科学基金），第二参与人，已结题；

近5年发表文章：

1. 1、       LiuD#, Song D#, Ning W, Zhang X, Chen S, Zhang H*. Efficacy and safety ofprophylaxis for venous thromboembolism in brain neoplasm patients undergoingneurosurgery: a systematic review and Bayesian network meta-analysis. JThromb Thrombolysis. 2023 Feb 10. doi: 10.1007/s11239-023-02780-3. Epubahead of print. PMID: 36763224.

   2、       ChenY#, Zhao C, Li S, Wang J, Zhang H*. Immune Microenvironment andImmunotherapies for Diffuse Intrinsic Pontine Glioma. Cancers (Basel).2023 Jan 18;15(3):602. doi: 10.3390/cancers15030602. PMID: 36765560; PMCID:PMC9913210.
   

   3、       ChenY#, Guo Y#, Li S, Xu J, Ning W, Zhao C, Wang J, Qu Y, Zhang M, Zhou W, Cui Q*, ZhangH*. Remdesivir inhibits the progression of glioblastoma by enhancingendoplasmic reticulum stress. Biomed Pharmacother. 2023 Jan;157:114037.doi: 10.1016/j.biopha.2022.114037. Epub 2022 Nov 22. PMID: 36427388.

   4、       ChenY#, Guo Y#, Li S, Xu J, Wang X, Ning W, Ma L, Qu Y,Zhang M, Zhang H*. Identification of N6-Methyladenosine-RelatedlncRNAs as a Prognostic Signature in Glioma. Front Oncol. 2022 Mar 3;12:789283. doi: 10.3389/fonc.2022.789283.PMID: 35311131; PMCID: PMC8927984.

   5、       XuJ#, Guo Y#, Ning W, Wang X, Li S, Chen Y, Ma L, Qu Y,Song Y*, Zhang H*. Comprehensive Analyses of GlucoseMetabolism in Glioma Reveal the Glioma-Promoting Effect of GALM. Front CellDev Biol. 2022 Jan 20;9:717182.

   6、       GuoY, Li S, Huang P, Zhang H*, YuC*. Development of a prognosticmodel based on an immunogenomic landscape analysis of medulloblastoma. BiosciRep. 2021 Jan 29;41(1):BSR20202907.

   7、       XiangWang, Weihai Ning, Zhiqiang Qiu, Shenglun Li, Hongwei Zhang*, Chunjiang Yu*, Tumor-associated macrophages basedsignaling pathway analysis and hub genes identification in glioma, Medicine (Baltimore).99 (2020) e23840.

   8、       X.Wang#, Z. Qiu#, X. Ji, W. Ning, Y. An, S. Wang, HongweiZhang*, A novel workflow for cancer blood biomarker identification, Ann.Transl. Med. 8 (2020) 1430–1430

   9、       Y.Guo, X. Wang, W. Ning, Hongwei Zhang*, C. Yu*, Identification of two core genes inglioblastomas with different isocitrate dehydrogenase mutation status, Mol.Biol. Rep. 47 (2020) 7477–7488.

   10、   P.Huang#, Y. Guo#, Z. Zhao, W. Ning, H. Wang, C. Gu, M. Zhang,Y. Qu, Hongwei Zhang*,Y. Song*, UBE2T promotes glioblastoma invasion and migration via stabilizingGRP78 and regulating EMT, Aging (Albany. NY). 12 (2020) 10275–10289.

   11、   Y.Guo#, P. Huang#, W. Ning, Hongwei Zhang*, C. Yu*, Identification of CoreGenes and Pathways in Medulloblastoma by Integrated Bioinformatics Analysis, J.Mol. Neurosci. 70 (2020) 1702–1712.

   12、   P.Wang#, W. Ning#, Y. Qu, Hongwei Zhang*, Cavernous Hemangioma of the Trochlear Nervein Asian Population: Case Report and Review of the Literature, Neurol.India. (2020).

   13、   Y.Guo, R. Liu, L. Zhou, H. Zhao, F. Lv, L. Liu, Y. Huang*, Hongwei Zhang*, C. Yu*, S. Wang*,Blood-brain-barrier penetrable thiolated paclitaxel-oligo (p-phenylenevinylene) nanomedicine with increased drug efficiency for glioblastomatreatment, Nano Today. 35 (2020) 100969.

   14、   L.Ma, Y. Huang*, Hongwei Zhang*, W. Ning, R. Qi, H. Yuan, F. Lv,L. Liu, C. Yu*, S. Wang*, Sensitive Detection and Conjoint Analysisof Promoter Methylation by Conjugated Polymers for Differential Diagnosis andPrognosis of Glioma, ACS Appl. Mater. Interfaces. (2020)

   15、   Y.Guo, X. He, M. Zhang, Y. Qu, C. Gu, M. Ren, H. Wang, W. Ning, J. Li, C. Yu, HongweiZhang, Reciprocal control of ADAM17/EGFR/Akt signaling and miR-145 drivesGBM invasiveness, J. Neurooncol. 147 (2020) 327–337.

   16、   Peng Huang#; YuDuo Guo#; HongWei Zhang*，Identificationof Hub Genes in Pediatric Medulloblastoma by Multiple-Microarray Analysis, J Mol Neurosci，2019, 70(4):522-531.

2. 出版专著（含参编）
   

 《鞍区病变影像诊断与治疗策略》 人民卫生出版社  编著：于春江，张宏伟

 《神经内镜手术技术》 北京大学医学出版社  主编：张亚卓

 《颅底外科训练教程》 清华大学出版社  主编：于春江

承担课题

1. 新型溶瘤病毒恶性肿瘤治疗及增效策略的研发（国家重点研发计划，重点专项），子课题，已结题；
2. 多病共患老年人生活质量维护及危险因素控制优化策略研究（国家重点研发计划），已结题；
3.  miR-224 靶向介导ADAM17调控儿童脑干胶质瘤细胞侵袭能力的机制研究（北京市教委科技计划重点项目），已结题；
4. 显微手术切除听神经瘤面听神经功能保留的临床研究（首都临床特色应用研究），已结题；
5. 脑血管病和中枢神经系统肿瘤综合防治技术的研发、转化与应用（卫生行业科研专项），子课题，已结题；
6. 致敏树突状细胞联合过继T细胞对鼠脑恶性胶质瘤的治疗作用及其机制研究（国家自然科学基金），第二参与人，已结题；