课题组主要围绕冠心病外科治疗的临床与基础问题开展相关研究，重点关注低射血分数冠心病的相关治疗，以临床转化为重点，围绕冠状动脉旁路移植术及其并发症的诊治过程中尚未解决的问题设计课题，以期进一步明确CABG相关的手术指征，改进并规范手术流程，改善手术远期疗效。

国家自然科学基金面上项目,81070202、血流剪应力调节细胞间粘附分子-1表达在冠脉搭桥术后再狭窄中的作用及机制研究、2011/01-2013/12、32万元、已结题、主持

国家自然科学基金面上项目,81270300、机械瓣膜置换术后华法林抗凝治疗个体化差异的药物基因组学研究、2013/01-2016/12、55万元、已结题、主持

国家自然科学基金面上项目,81570373、机械牵张所致miR-551b-5p高表达对静脉桥血管再狭窄早期炎症反应的影响及作用机制的研究、2016/01-2019/12、74.4万元、已结题、主持

国家自然科学基金面上项目，81770412、活化转录因子3在静脉桥血管再狭窄早期内皮功能失调中的作用及调控机制的研究、2018/01-2021/12、55万元、在研、主持

北京市卫健委项目，首发2020-2Z-2067，机械瓣膜置换术后患者华法林个体化抗凝治疗方案对抗凝疗效和安全性影响的随机对照研究，2020/01-2022/12，在研，主持

北京市科委项目，Z151100003915084、冠心病合并中度功能性缺血性二尖瓣关闭不全患者不同手术方式的随机对照研究、2015/05-2018/08、15万元、已结题、主持

北京市科委项目，Z171100001017059、血流储备分数（FFR）指导冠状动脉旁路移植术血运重建策略的随机对照临床研究、2017/02－2020/08、15万元、在研、主持

1. 1.Xu S, Wu Z, Liu Y, Zhu J, Gong M, Sun L, Ran D, Zhang H. Influence of Preoperative Serum Albumin on Acute Kidney Injury after Aortic Surgery for Acute Type A Aortic Dissection: A Retrospective Cohort Study. Journal of clinical medicine 2023, 12(4).
2. 2.Li Y, Hou X, Xu X, Huang Z, Liu T, Xu S, Rui H, Zheng J, Dong R. Coronary artery bypass grafting vs. percutaneous coronary intervention in coronary artery disease patients with advanced chronic kidney disease: A Chinese single-center study. Frontiers in surgery 2022, 9: 1042186.
3. 3.Zhang K, Fu W, Dai Q, Zheng J, Biekan J, Wang Y, Yan P, Gu X, Mu J, Dong R. The number of myocardial infarction segments connected to papillary muscle is associated with the improvement in moderate ischemic mitral regurgitation. Cardiovascular diagnosis and therapy 2022, 12(6): 828-839.
4. 4.Fu W, Zhao Y, Zhang K, Dai Q, Biekan J, Zheng J, Dong R, Mu J. Retrospective, observational analysis of cardiac function associated with global preoperative myocardial scar in patients with ischemic cardiomyopathy after coronary artery bypass grafting. Journal of thoracic disease 2022, 14(11): 4319-4328.
5. 5.Chen C, Zhao Y, Li W, Zhang K, Dang H, Liu T, Song Y, Zheng J, Dong R. Relation of quantitative flow ratio with transit time coronary artery bypass graft flow measurement. Frontiers in cardiovascular medicine 2022, 9: 975759.
6. 6.Sun Y, Hu X, Zhang K, Rao M, Yin P, Dong R. A Single-Cell Survey of Cellular Heterogeneity in Human Great Saphenous Veins. Cells 2022, 11(17).
7. 7.Zhou N, Ji Z, Li F, Qiao B, Lin R, Jiang W, Zhu Y, Lin Y, Zhang K, Li S, You B, Gao P, Dong R, Wang Y, Du J. Machine Learning-Based Personalized Risk Prediction Model for Mortality of Patients Undergoing Mitral Valve Surgery: The PRIME Score. Frontiers in cardiovascular medicine 2022, 9: 866257.
8. 8.i Y, Hou X, Liu T, Xu S, Huang Z, Xu X, Dong R. Comparison of Coronary Artery Bypass Grafting and Drug-Eluting Stent Implantation in Patients With Chronic Kidney Disease: A Propensity Score Matching Study. Frontiers in cardiovascular medicine 2022, 9: 802181.
9. 9.Fu W, Wu L, Ma X, Zhao Y, Dong R, Mu J. Outcomes of surgical repair of anterior or posterior ventricular septal rupture after myocardial infarction. Cardiovascular diagnosis and therapy 2022, 12(2): 177-187.
10. 10.Hou X, Zhang K, Liu T, Li Y, Zhao Y, Song B, Huang Z, Zheng J, Dong R. No-Touch Sequential Saphenous Venous Harvesting Technique in Off-Pump Bypass Surgery: A Retrospective Study. Frontiers in cardiovascular medicine 2021, 8: 804739.
11. 11.Yan P, Zhang K, Cao J, Dong R. Left Ventricular Structure is Associated with Postoperative Death After Coronary Artery Bypass Grafting in Patients with Heart Failure with Reduced Ejection Fraction. International journal of general medicine 2022, 15: 53-62.
12. 12.Yan P, Liu T, Zhang K, Cao J, Dang H, Song Y, Zheng J, Zhao H, Wu L, Liu D, Huang Q, Dong R. Development and Validation of a Novel Nomogram for Preoperative Prediction of In-Hospital Mortality After Coronary Artery Bypass Grafting Surgery in Heart Failure With Reduced Ejection Fraction. Frontiers in cardiovascular medicine 2021, 8: 709190.
13. 13.Zheng JB, Hua K, Zhang K, Zhou SY, Xu SJ, Sheng JJ, DongR*. Prophylactic intra-aortic balloon pump in patients with leftmain disease undergoing off-pump coronary artery bypass grafting. BMCcardiovascular disorders 2020, 20(1): 266.
14. 14.Zhao Y, Meng S, Liu T, Dong R*. EconomicAnalysis of Surgical and Interventional Treatments for Patients with ComplexCoronary Artery Disease: Insights from a One-Year Single-Center Study. Med SciMonit 2020, 26: e919374.
15. 15.Song B, Yao B, Dang H, Dong R*. SolubleST2, Galectin-3 and clinical prognosis of patients with hypertrophiccardiomyopathy undergoing ventricular septal myectomy: a correlation analysis.Cardiovascular diagnosis and therapy 2020, 10(2): 145-152.
16. 16.Huang Z, Winata WA, Zhang K, Zhao Y, Li Y, Zhou N, Zhou S,Fu W, Qiao B, Li G, Shao Y, Zheng J*, Dong R*.Reconstruction of a lncRNA-Associated ceRNA Network in Endothelial Cells underCircumferential Stress. Cardiology research and practice 2020, 2020: e1481937.
17. 17.Cao J, Dong R*, Zhang K, Zhang H.Effects of myocardial viability and left ventricular remodeling on survival ofpatients with heart failure and reduced ejection fraction after coronary arterybypass grafting. Cardiovascular diagnosis and therapy 2020, 10(2): 183-192.
18. 18.R. Dong, K. Zhang, Y.L. Wang, F.Zhang, J. Cao, J.B. Zheng, H.J. Zhang, MiR-551b-5p Contributes to Pathogenesisof Vein Graft Failure via Upregulating Early Growth Response-1 Expression, ChinMed J (Engl), 2017, 130(13): 1578-1585.
19. 19.K. Hua, Y.Zhao, R. Dong*, T. Liu,Minimally Invasive Cardiac Surgery in China: Multi-Center Experience, Medicalscience monitor : international medical journal of experimental and clinicalresearch, 2018, 24: 421-426.
20. 20.R. Liu, J. Cao,Q. Zhang, X.M. Shi, X.D. Pan, R. Dong*,Clinical and genetic factors associated with warfarin maintenance dose innorthern Chinese patients with mechanical heart valve replacement, Medicine,2017, 96(2): e5658.
21. 21.D. Liu, R. Dong*, Clinicalmanifestation and surgical treatment analysis of five cases with biatrialmyxoma, Int J Cardiol, 2017, 228: 309-312.
22. 22.B. Song, R. Dong*, Comparison ofModified With Classic Morrow Septal Myectomy in Treating HypertrophicObstructive Cardiomyopathy, Medicine, 2016, 95(2): e2326.
23. 23.R. Liu, K.Zhang, Z.Z. Gong, X.M. Shi, Q. Zhang, X.D. Pan, R. Dong*, Association of apolipoprotein E (APOE)polymorphisms with warfarin maintenance dose in a northern Han Chinesepopulation, Lipids in health and disease, 2016, 15: 34.
24. 24.J. Zheng, K.Zhang, Y. Wang, J. Cao, F. Zhang, Q. Zhou, R.Dong*, Identification of a microRNA signature in endothelialcells with mechanical stretch stimulation, Mol Med Rep, 2015, 12(3): 3525-3530.
25. 25.J. Cao, K.Zhang, J. Zheng, R. Dong*,MicroRNA-146a and -21 cooperate to regulate vascular smooth muscle cellproliferation via modulation of the Notch signaling pathway, Mol Med Rep, 2015,11(4): 2889-2895.
26. 26.K. Zhang, J.Cao, R. Dong*, J. Du,Early growth response protein 1 promotes restenosis by upregulatingintercellular adhesion molecule-1 in vein graft, Oxid Med Cell Longev, 2013,2013: 432409.
27. 27.赵洋, 黄柱辉, 付威, 刘韬帅, 董然*. 右心系统子宫静脉平滑肌瘤临床分析. 中华医学杂志 2020, 100(22): 1741-1744.
28. 28.赵洋, 付威, 马小龙, 黄柱辉, 刘韬帅, 董然*. 心肌梗死合并前或后间隔穿孔的外科疗效分析. 中华胸心血管外科杂志 2020, 36(5): 291-295.
29. 29.吴立松, 董然*, 马小龙, 党海明, 宋跃, 曹剑, 刘冬, 黄琦. 冠状动脉旁路移植术后症状复发患者的旁路移植血管状态评估. 中华胸心血管外科杂志 2020, 36(8): 498-501.
30. 30.宋跃, 董然*, 党海明, 吴立松, 曹剑, 刘冬, 黄琦, 马小龙. 外科治疗冠心病合并中度缺血性二尖瓣反流围手术期疗效分析. 中华胸心血管外科杂志 2020, 36(10): 613-616.
31. 31.曹剑, 党海明, 宋跃, 吴立松, 刘冬, 黄琦, 董然*. 左室重塑对射血分数降低型心衰冠状动脉旁路移植围手术期风险及近期预后的影响. 中华医学杂志 2020, 100(18): 1380-1384.
32. 32.吴立松, 董然*, 党海明, 宋跃, 曹剑, 刘冬, 黄琦, 付威, 马小龙. 桡动脉序贯吻合的冠状动脉旁路移植术近期临床疗效分析. 中华医学杂志 2019, 99(42): 3308-3312.
33. 33.宋邦荣, 党海明, 徐晓宇, 董然*. 肥厚型梗阻性心肌病合并中重度二尖瓣反流的外科治疗 中华胸心血管外科杂志 2019,35(7): 406-409.
34. 34.李扬, 董然*, 刘韬帅, 华琨, 郑居兵, 周绍酉, 周宁, 黄柱辉. 冠状动脉旁路移植术治疗青年冠心病合并糖尿病患者疗效. 中华胸心血管外科杂志 2019, 35(8): 479-483.
35. 35.华琨,刘韬帅,李扬,赵洋,郑居兵,周宁,周绍酉,董然*.不接触大隐静脉获取技术在非体外循环冠状动脉旁路移植术中的短期效果[J].中华医学杂志,2018,98(20):1601-1604.
36. 36.华琨,盛娟娟,董然*.非体外循环下冠状动脉旁路移植术2546例短期临床疗效和院内死亡危险因素分析[J].中华医学杂志,2017,97(16):1218-1221.
37. 37.刘韬帅,陈宝田,董然*,李扬,赵洋,华琨.高龄患者非体外循环冠状动脉旁路移植术252例临床效果分析[J].中华医学杂志,2016,96(36):2903-2905.
38. 38.党海明,宋跃,曹剑,吴立松,董然*.心脏手术患者医院内感染致病菌分布与耐药性分析[J].中华流行病学杂志,2013,34(5):484-487.
39. 39.郑居兵,陈宝田,董然*,刘韬帅,李扬,曹剑.再次冠状动脉旁路移植术42例临床分析[J].中华外科杂志,2011,49(7):615-617.