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首都医科大学公共卫生学院教授，博士生导师，获批北京市“长城学者”、“青年拔尖人才”、“中青年骨干教师”、“优秀人才”等人才项目。主持国家自然科学基金5项。主要从事常见环境有害因素的健康损害效应、机制与干预策略研究，着重从表观遗传学、菌群、代谢和炎症免疫等角度研究环境化学物的致病机理、标志物及防控措施。在EBioMedicine, J Hazard Mater，Environ Int, Nano Res, Sci Total Environ，JCI Insight，Cell Death Dis, Environ Pollut, Free Radic Biol Med等发表SCI论文60余篇，获批软著1项、获得教学科研奖4项，参编学术著作6部。建设慕课和虚拟仿真项目各1项。担任中华医学科技奖评审委员会委员，教育部科技库专家，国家和省部级自然科学基金项目的评审专家，教育部学位论文评审专家，中国毒理学会第八届工业毒理学专业委员会委员，中华预防医学会职业心理健康学组委员、北京环境诱变剂学会理事和青年委员会副主任委员等。
近年主持的科研项目情况
1、国家自然科学基金面上项目，YTHDF3通过识别m6A修饰调控泛素结合酶表达在苯造血毒性中的作用和机制（82073520，2021.01-2024.12）；
2、国家自然科学基金面上项目，TET2介导STAT3低甲基化在苯造血毒性中的作用和机制（81773397， 2018.01-2021.12）；
3、国家自然科学基金面上项目，长链非编码RNA-VNN3和OBFC2A在苯血液毒性中的功能及机制研究（81472957，2015/01-2018/12）；
4、国家自然科学基金面上项目，差异甲基化基因作为低剂量苯毒效应敏感标志物的研究（81172639，2012.01-2015.12）；
5、“十三五”时期北京市属高校高水平教师队伍建设支持计划，长城学者培养计划，基于造血前体细胞的苯造血毒性表遗传标志分子研究(CIT&TCD20170323，2018.01-2020.12)。
近年主持的科研项目情况
1、国家自然科学基金面上项目，YTHDF3通过识别m6A修饰调控泛素结合酶表达在苯造血毒性中的作用和机制（82073520，2021.01-2024.12）；
2、国家自然科学基金面上项目，TET2介导STAT3低甲基化在苯造血毒性中的作用和机制（81773397， 2018.01-2021.12）；
3、国家自然科学基金面上项目，长链非编码RNA-VNN3和OBFC2A在苯血液毒性中的功能及机制研究（81472957，2015/01-2018/12）；
4、国家自然科学基金面上项目，差异甲基化基因作为低剂量苯毒效应敏感标志物的研究（81172639，2012.01-2015.12）；
5、“十三五”时期北京市属高校高水平教师队伍建设支持计划，长城学者(CIT&TCD20170323，2018.01-2020.12)。
1. Kang H, Zhang W, Jing J, Huang D, Zhang L, Wang J, Han L, Liu Z, Wang Z, Gao A*. The gut-brain axis involved in polystyrene nanoplastics-induced neurotoxicity via reprogramming the circadian rhythm-related pathways. J Hazard Mater. 2023 Sep 15;458:131949.
2. Zhang L, Kang H, Zhang W, Wang J, Liu Z, Jing J, Han L, Gao A*. Probiotics ameliorate benzene-induced systemic inflammation and hematopoietic toxicity by inhibiting Bacteroidaceae-mediated ferroptosis. Sci Total Environ. 2023 Nov 15;899:165678.
3. Zhang L, Liang J, Gao A*. Contact to perfluoroalkyl substances and thyroid health effects: A meta-analysis directing on pregnancy. Chemosphere. 2023 Feb;315:137748.
4. Liu Z, Guo X, Zhang W, Wang J, Zhang L, Jing J, Han L, Gao A*. Oxidative stress-affected ACSL1 hydroxymethylation triggered benzene hematopoietic toxicity by inflammation and senescence. Food Chem Toxicol. 2023 Oct;180:114030.
5. Han L, Wang J, Zhang L, Jing J, Zhang W, Liu Z, Gao A*. The role of N6-methyladenosine modification in benzene-induced testicular damage and the protective effect of melatonin. Chemosphere. 2023 Apr;319:138035.
6. Wang J, Han L, Liu Z, Zhang W, Zhang L, Jing J, Gao A*. Genus unclassified_Muribaculaceae and microbiota-derived butyrate and indole-3-propionic acid are involved in benzene-induced hematopoietic injury in mice. Chemosphere. 2023 Feb;313:137499.
7. Jing J, Zhang L, Han L, Wang J, Zhang W, Liu Z, Gao A*. Polystyrene micro-/nanoplastics induced hematopoietic damages via the crosstalk of gut microbiota, metabolites, and cytokines. Environ Int. 2022 Mar;161:107131.
8. Zhang L, Jing J, Han L, Liu Z, Wang J, Zhang W, Gao A*. Melatonin and probiotics ameliorate nanoplastics-induced hematopoietic injury by modulating the gut microbiota-metabolism. Nano Res. 2022 Nov 15;16(2):2885-2894.
9. Zhang W, Guo X, Ren J, Chen Y, Wang J, Gao A*. GCN5-mediated PKM2 acetylation participates in benzene-induced hematotoxicity through regulating glycolysis and inflammation via p-Stat3/IL17A axis. Environ Pollut. 2022 Feb 15;295:118708.
10. Zhang W, Wang J, Liu Z, Zhang L, Jing J, Han L, Gao A*. Iron-dependent ferroptosis participated in benzene-induced anemia of inflammation through IRP1-DHODH-ALOX12 axis. Free Radic Biol Med. 2022 Nov 20;193(Pt 1):122-133.
11. Guo X, Zhang L, Wang J, Zhang W, Ren J, Chen Y, Zhang Y, Gao A*. Plasma metabolomics study reveals the critical metabolic signatures for benzene-induced hematotoxicity. JCI Insight. 2022 Jan 25;7(2):e154999.
12. Yang QY, Guo X, Chen Y, Zhang W, Ren J,Wang J, Tang N*, Gao A*. Blood Levels of Perfluoroalkyl Substances (PFASs), Trace Elements, Heavy Metals and Their Associations with Metabolic Syndrome (MetS) in Chinese Male Adults Mediated by Metabolic-related Risk Factors. Sci Total Environ. 2020;740:142595.
13. Guo X, Zhong W, Chen Y, Zhang W, Ren J, Gao A*. Benzene metabolites trigger pyroptosis and contribute to haematotoxicity via TET2 directly regulating the Aim2/Casp1 pathway. EBioMedicine. 2019; 47: 578-589.
14. Chen Y, Zhang W, Guo X, Ren J, Gao A*. The crosstalk between autophagy and apoptosis was mediated by phosphorylation of Bcl-2 and beclin1 in benzene-induced hematotoxicity. Cell Death Dis. 2019; 10(10): 772.
15. Yang QY, Guo X, Sun P, Chen Y, Zhang W, Duan HW, Gao A*. Association of serum levels of perfluoroalkyl substances (PFASs) with the metabolic syndrome (MetS) in Chinese male adults: A cross–sectional study. Sci Total Environ. 2018;621:1542-1549.
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