本团队以生理学与病理生理学系为平台，依托于代谢紊乱相关心血管疾病北京市重点实验室和代谢紊乱相关心血管疾病国际合作实验室，致力于阐明代谢紊乱相关心血管疾病的免疫学机制及其与增龄的关系。团队具有病理生理学与免疫学学科交叉的研究优势，重视基础与临床合作，与安贞医院、宣武医院、天津医科大学宝坻临床学院等多家医院共同开展课题，同时与美国托马斯杰斐逊大学医院、德克萨斯农商大学进行科研合作。目前团队成员包括教授1人，副教授1人，副主任技师1人，讲师3人，博士3人，硕士3人，本科生4人。

名称：调节性T细胞衰老在β1肾上腺素受体自身抗体致心衰中的作用及机制研究

来源：国家自然科学基金（面上项目）

课题编号：81970334

起止日期：2020.1-2023.12

项目负责人：刘慧荣

重要学术论文：

1. Hao Chen, SuliZhang, Xi Zhang and Huirong Liu*. QR code model: a new possibility for GPCRphosphorylation recognition. Cell Communication and Signaling. 2022;20(1):23.

2. Meili Wang,Xiaochen Yin, Shuanglei Li, Xi Zhang, Ming Yi, Chunyu He, Xiaoyue Li, Wei Wang,Suli Zhang*, Huirong Liu*. Large-Conductance Calcium-Activated PotassiumChannel Opener, NS1619, Protects Against Mesenteric Artery Remodeling Inducedby Agonistic Autoantibodies Against the Angiotensin II Type 1 Receptor. Journalof the American Heart Association. 2022;11: e024046.

3. Hao Chen#, NingCao#, Li Wang, Ye Wu , Haojie Wei, Yuming Li, Youyi Zhang, Suli Zhang* andHuirong Liu*. Biased activation of β2-AR/Gi/GRK2 signal pathway attenuatedβ1-AR sustained activation induced by β1-adrenergic receptor autoantibody. Cell Death Discovery. 2021;7(1):340.

4. Xin Wei, Y e Wu,Wen Wang, Suli Zhang, Dan Liu*, Huirong Liu*.  Decreased dynamin-relatedprotein 1-related mitophagy induces myocardial apoptosis in the aging heart.Acta Biochimica et Biophysica Sinica. 2021;53(10):1354-1366.

5. Chunyu He ,Xiaoyue Li , Meili Wang , Suli Zhang *, Huirong Liu*. Deletion of BK channelsdecreased skeletal and cardiac muscle function but increased smooth musclecontraction in rats. Biochemical and Biophysical Research Communications. 2021;570:8-14.

6. Yuhui Zhao#; YanBai#, Yang Li, Yu Dong, Yuhao Guo, Wen Wang*, Huirong Liu*.  Disturbanceof myocardial metabolism participates in autoantibodies against β 1-adrenoceptor-induced cardiac dysfunction. Clinical and ExperimentalPharmacology and Physiology. 2021;48(6):846-854.

7. Yihui Shao, GuoqiLi, Shan Huang, Zhenfeng Li, Bokang Qiao, Duanduan Chen, Yulin Li, HuirongLiu*, Jie Du*, Ping Li*. Effects of Extracellular Matrix Softening on VascularSmooth Muscle Cell Dysfunction. Cardiovascular Toxicology. 2020;20(6):548-556.

8. Pengli Wang,Chunyu He, Mingming Yue, Tongtong Wang, Lina Bai, Ye Wu, Dan Liu, Meili Wang,Yan Sun, Yan Li, Suli Zhang*, Huirong Liu*. The AT1 receptor autoantibodycauses hypoglycemia in fetal rats via promoting the STT3A-GLUT1-glucose uptakeaxis in liver.  Molecular and Cellular Endocrinology. 2020;518:111022.

9. Lina Bai, MeiliWang, Suli Zhang, Mingming Yue, Yuhao Guo, Pengli Wang, Huirong Liu*.AT1-receptor autoantibody exposure in utero contributes to cardiac dysfunctionand increased glycolysis in fetal mice. Acta Biochimica et Biophysica Sinica.2020;52(12):1373-1381.

10. Yan Sun, Yang Li,Meili Wang, Mingming Yue, Lina Bai, Jingwei Bian, Weiwei Hao, Jing Sun, SuliZhang*, Huirong Liu*. Increased AT 2 R Expression Is Induced by AT1RAutoantibody via Two Axes, Klf-5/IRF-1 and circErbB4/miR-29a-5p, to PromoteVSMC Migration. Cell Death & Disease. 2020;11(6):432.

11. Li Wang, Na Ning,Changtu Wang, Xiaohong Hou, Yuan Yuan, Yanan Ren, Cong Sun, Zi Yan, XiaohuiWang, and Huirong Liu*. Endoplasmic reticulum stress contributed to β1-adrenoceptor autoantibody-induced reduction of autophagy in cardiomyocytes.Acta Biochimica et Biophysica Sinica.  2019, 51(10):1016-1025.

12. Dan Liu, LinguoWu, Ye Wu, Xin Wei, Wen Wang, Suli Zhang, Ming Yi, Jing Li*, Huirong Liu*,Xinliang Ma. Heat shock factor 1-mediated transcription activation of Omi/HtrA2induces myocardial mitochondrial apoptosis in the aging heart. Aging (AlbanyNY). 2019;11(20):8982-8997.

13. Linguo Wu#, DanLiu#, Ye Wu, Xin Wei, Zhaojia Wang, Wen Wang, Suli Zhang, Hong Yang, Ming Yi,Huirong Liu*. p53 mediated transcription of Omi/HtrA2 in aging myocardium.Biochemical and Biophysical Research Communications. 2019;519(4):734-739.

14. Ming Yi#, Ye Wu#,Jun Long#, Fei Liu, Zhi Liu , Ying-Hua Zhang, Xi-Peng Sun, Zhen-Xing Fan , JingGao, Jin Si, Xue-Bing Zuo, Lei-Min Zhang, Ning Shi,  Zu-Pei Miao, Zhao-RunBai, Bin-Yu Liu, Hui-Rong Liu*, Jing Li*. Exosomes secreted fromosteocalcin-overexpressed endothelial progenitor cells promoted endothelialcell angiogenesis. American Journal of Physiology-Cell Physiology. 2019;317(5):C932-C941.

15. Sun Y, Zhang S,Yue M, Li Y, Bi J, Hui-Rong Liu*. Angiotensin II inhibits apoptosis of mouseaortic smooth muscle cells through regulating the circNRG-1/miR-193b-5p/NRG-1axis. Cell Death & Disease. 2019;10(5):362.

16. Zhiyuan Wang#, YeWu#, Suli Zhang, Yuhui Zhao, Xiaochen Yin, Wen Wang, Xinliang Ma*, HuirongLiu*. The role of NO-cGMP pathway inhibition in vascular endothelial-dependentsmooth muscle relaxation disorder of AT1-AA positive rats: Protective effectsof adiponectin. Nitric Oxide-Biology and Chemistry. 2019;87:10-22.

17. Yunhui Du, XiaoLi, Haicun Yu, Li Yan, Wayne Bond Lau, Shihan Zhang, Yanwen Qin, Wen Wang,Xinliang Ma, Huirong Liu*, Michael Fu. Activation of T Lymphocytes as a NovelMechanism in Beta1-Adrenergic Receptor Autoantibody-Induced Cardiac Remodeling.Cardiovascular Drugs and Therapy. 2019;33(2):149-161.

18. Jingwei Bian#,Jinghui Lei#， Xiaochen Yin, Pengli Wang, Ye Wu, XiaoliYang, Li Wang, Suli Zhang*, Huirong Liu*, Michael L. X. Fu. Limited AT1Receptor Internalization Is a Novel Mechanism Underlying SustainedVasoconstriction Induced by AT1 Receptor Autoantibody from Preeclampsia.Journal of the American Heart Association. Journal of the American HeartAssociation. 2019;8(6):e011179.

19. Xu Wenli, Wu Ye,Wang Li, Bai Yan, Du Yunhui, Li Yang, Cao Ning, Zhao Yuhui, Zhang Youyi,Huirong Liu*. Autoantibody against beta1-adrenoceptor promotes thedifferentiation of natural regulatory T cells from activated CD4+ T cells byup-regulating AMPK-mediated fatty acid oxidation. Cell death & disease.2019;10(3):158.

20. Chunyu He, MeiliWang, Zi Yan, Suli Zhang*, Huirong Liu*. Isolation and Culture of VascularSmooth Muscle Cells from Rat Placenta. Journal of Cellular Physiology. 2019;234(6):7675-7682.

21. Wang Meili, YinXiaochen, Zhang Suli, Mao Chenfeng, Cao Ning, Yang Xiaochun, Bian Jingwei, HaoWeiwei, Fan Qian, Huirong Liu*. Autoantibodies against AT1 Receptor Contributeto Vascular Aging and Endothelial Cell Senescence. Aging and Disease. 2019;10(5):1012-1025.

22. Xiaochen Yin#,Suli Zhang#, Zhen Zhou, Jingwei Bian, Ye Wu, Pengli Wang, Yulin Gong, Lina Bai,Weiwei Hao, Xinliang Ma*, Huirong Liu*. Active immunization using hand-pushemulsification method increases the operator's risk of transcutaneousimmunization. Biochemical and Biophysical Research Communications. 2018;506(4):970-975.  

23. Zhang S, Wei M,Yue M, Wang P, Yin X, Wang L, Yang X, Liu H*. Hyperinsulinemia precedes insulinresistance in offspring rats exposed to angiotensin II type 1 autoantibody inutero. Endocrine. 2018;62(3):588-601.

24. Peng Wang, SuliZhang, Jie Ren, Li Yan, Lina Bai, Li Wang, Pengli Wang, Jingwei Bian, XiaochenYin, Huirong Liu*. The inhibitory effect of BK Ca channels induced byautoantibodies against angiotensin II type 1 receptor is independent of AT1R.Acta Biochimica et Biophysica Sinica. 2018;50(6):560-566.

25. Jiahui Xu#, KunJiao#, Xin Liu, Qi Sun, Ke Wang, Haibo Xu, Shangyue Zhang, Ye Wu, Linguo Wu,Dan Liu, Wen Wang*, Huirong Liu*. Omi/HtrA2 Participates in Age-RelatedAutophagic Deficiency in Rat Liver. Aging and Disease. 2018;9(6):1031-1042. 

26. Li Wang, Yang Li,Na Ning, Jin Wang, Zi Yan, Suli Zhang, Xiangying Jiao, Xiaohui Wang, HuirongLiu*. Decreased autophagy induced by β1-adrenoceptor autoantibodies contributesto cardiomyocyte apoptosis. Cell Death & Disease.  2018;9(3):406.

27. Jingwei Bian,Suli Zhang, Ming Yi, Mingming Yue, Huirong Liu*. The mechanisms behinddecreased internalization of angiotensin II type 1 receptor. VascularPharmacology.  2018;103-105:1-7.

28. Jinghui Lei, SuliZhang, Pengli Wang, Yang Liao, Jingwei Bian, Xiaochen Yin, Ye Wu, Lina Bai,Feng Wang, Xiaoli Yang*, Huirong Liu*. Long-term presence of angiotensin IItype 1 receptor autoantibody reduces aldosterone production by triggering Ca2+overload in H295R cells. Immunologic Research. 2018;66(1):44-51.

主编或副主编的著作/译著：

《心血管生理学基础与临床》（第3版）主编  高等教育出版社  202002

重要奖项：

抗G蛋白偶联受体自身抗体在心血管疾病中的作用及相关机制探究华夏医学科技奖  二等奖  201912

首都医科大学优秀教育教学奖  个人  201901

全国高校黄大年式教师团队  团队负责人  201801