目前团队包括教授5名，副教授5名，高级职称10人，博士及以上学历14人，留学经历8人。

在临床工作和研究中，围绕垂体瘤、听神经瘤及脑转移瘤的三个核心病种，建立了三条医研协同主线。目前主要致力于如下研究：①难治性脑肿瘤临床与基础研究的深入和拓展；②脑转移瘤的多学科诊疗与基础转化研究；③以分子影像、柔性电极和LITT为核心新技术的临床转化与多中心评价。

已经在国际知名杂志Science，small，JNS, Genome Res, Oncoimmunology, Neuro Oncol, Cancer, Oncotarget, Cancer Lett 等发表相关研究论文100余篇，累积影响因子超过300。

团队已获批省部级以上课题15项，其中“863”子课题2项，国家自然科学基金6项。获得授权发明专利7项。主编及参编著作十余部。获中华医学科技奖等奖项十余项。

目前与美国哈佛大学、MD.Anderson癌症医学中心、匹兹堡大学医院、斯坦福大学核医学及分子显像学中心、南佛罗里达大学进行博士后交流及联合科学研究；

在研项目：

1.国家自然科学基金 面上项目 82071996  基于MRI影像基因组学预测垂体腺瘤侵袭的人工智能模型建立与临床评估  55万  2021-01-01～2024-12-31

2.北京市自然科学基金 7212008  基于3D培养研究ALDH1A3基因在生长激素型垂体腺瘤肿瘤干细胞分化中的作用   20万  20210101-20231231 

3.北京市医院管理中心“登峰”人才培养计划 160万  DFL20220502 20220101-20251231

结题项目：

1.科技部863课题：基于临床信息的垂体腺瘤蛋白质分子网络的研究，编号：2014AA020610，子课题负责人

2.国家卫计委行业专项：“脑肿瘤分子分类指导个体化诊疗体系的建立和应用推广”，编号：201402008，子课题负责人

3.年国家自然科学基金：Claudin-5通过调节血脑屏障通透性参与肿瘤脑转移过程的分子机制研究，编号:81471229，第一负责人

4.国家自然科学基金：下丘脑损伤后脑钠肽（BNP）变化与血钠紊乱的机理研究，编号：30371451，第一负责人

5.年北京市自然科学基金：HGF/cMet通道介导上皮向间质转化过程与垂体腺瘤侵袭性的分子机制研究 编号：7142054 ，第一负责人

6.北京市科技新星计划：颅颈交界区手术入路的显微外科解剖和生物力学研究，编号2003B25，第一负责人

7.北京市自然科学基金：颅颈交界区手术入路的显微解剖学研究和临床应用，编号7042013，第一负责人

8.2014年首都卫生发展科研专项：侵袭性垂体腺瘤的规范化治疗及预后评价系统的建立，编号:2009010032，第一负责人

9.北京市百千万人才项目：人垂体腺瘤侵袭性与甘丙肽的相关性研究

中国医师协会神经外科医师分会 候任会长

中国医师协会神经外科医师分会颅底外科学组 组长

北京医学会神经外科学分会 副主任委员

北京医学会神经外科学分会颅底外科学组 组长

世界华人神经外科协会  秘书长

以第一或通讯作者（含共同）在国际著名期刊发表SCI文章40余篇，累计影响因子超过200，被Nature Review Endocrinology、Trends Immunol等期刊正面评价。获奖10余次，出版著作5部。

近五年发表文章：

 1.     Zeng M, LiR, Xu X, Wang D, Dong J, Li S, et al. Ultrasound-guided superficial cervicalplexus block reduces opioid consumption in patients undergoing craniotomy viasuboccipital retrosigmoid approach: a randomized controlled trial. Reg AnesthPain Med. 2022.

2.     Jiang Y, Zhang Z, Wang YX, Li D, Coen CT,Hwaun E, et al. Topological supramolecular network enabled high-conductivity,stretchable organic bioelectronics. Science. 2022;375(6587):1411-7.

3.     Guan X, Wang Y, Zhang C, Ma S, Zhou W, JiaG, et al. Surgical Experience of Transcranial Approaches to Large-to-GiantPituitary Adenomas in Knosp Grade 4. Front Endocrinol (Lausanne).2022;13:857314.

4.     Zhou W, Wang Y, Ma S, Yuan L, Wang X, PengJ, et al. A Novel Imaging Grading Biomarker for Predicting Hearing Loss inAcoustic Neuromas. Clin Neuroradiol. 2021;31(3):599-610.

5.     Zhang D, Wang X, Wang X, Wang Z, Ma S,Zhang C, et al. CPNE3 regulates the cell proliferation and apoptosis in humanGlioblastoma via the activation of PI3K/AKT signaling pathway. J Cancer.2021;12(24):7277-86.

6.     Zhang D, Wang X, Ma S, Li P, Xue F, Mao B,et al. Targeted exome sequencing for the identification of common mutationalsignatures and potential driver mutations for brain metastases and prognosis.Oncol Lett. 2021;21(3):179.

7.     Zhang D, Ma S, Zhang C, Li P, Mao B, GuanX, et al. MicroRNA-935 Directly Targets FZD6 to Inhibit the Proliferation ofHuman Glioblastoma and Correlate to Glioma Malignancy and Prognosis. FrontOncol. 2021;11:566492.

8.     Xiao M, Du C, Zhang C, Zhang X, Li S, ZhangD, et al. Bioinformatics analysis of the prognostic value of NEK8 and itseffects on immune cell infiltration in glioma. J Cell Mol Med.2021;25(18):8748-63.

9.     Li P, Zhang D, Ma S, Kang P, Zhang C, MaoB, et al. Consistency of pituitary adenomas: Amounts of collagen types I andIII and the predictive value of T2WI MRI. Exp Ther Med. 2021;22(5):1255.

10.   Guan X, Wang Y, Sun Y, Zhang C, Ma S, ZhangD, et al. CTLA4-Mediated Immunosuppression in Glioblastoma is Associated withthe Infiltration of Macrophages in the Tumor Microenvironment. J Inflamm Res.2021;14:7315-29.

11.   Zhou W, Zhang C, Zhang D, Peng J, Ma S, WangX, et al. Comprehensive analysis of the immunological landscape of pituitaryadenomas: implications of immunotherapy for pituitary adenomas. J Neurooncol.2020;149(3):473-87.

12.   Zhou W, Liu X, van Wijnbergen JWM, Yuan L,Liu Y, Zhang C, et al. Identification of PIEZO1 as a potential prognosticmarker in gliomas. Sci Rep. 2020;10(1):16121.

13.   Wang Y, Zhou W, Ma S, Guan X, Zhang D, PengJ, et al. Identification of a Glycolysis-Related LncRNA Signature to PredictSurvival in Diffuse Glioma Patients. Front Oncol. 2020;10:597877.

14.   Niu F, Qian K, Qi H, Zhao Y, Jiang Y, Jia W,et al. CPCGI Reduces Gray and White Matter Injury by Upregulating Nrf2Signaling and Suppressing Calpain Overactivation in a Rat Model of ControlledCortical Impact. Neuropsychiatr Dis Treat. 2020;16:1929-41.

15.   Ma SC, Liu S, Agazzi S, Jia W. The JugularProcess: A Key Anatomical Landmark for Approaches to the Jugular Foramen. WorldNeurosurg. 2020;135:e686-e94.

16.   Ma J, Ma S, Yang J, Jia G, Jia W. Primaryspinal primitive neuroectodermal tumor: A single center series with literaturereview. J Spinal Cord Med. 2020;43(6):895-903.

17.   Li X, Liu B, Pei B, Chen J, Zhou D, Peng J,et al. Inkjet Bioprinting of Biomaterials. Chem Rev. 2020;120(19):10793-833.

18.   Li D, Liu Q, Qi Q, Shi H, Hsu EC, Chen W, etal. Gold Nanoclusters for NIR-II Fluorescence Imaging of Bones. Small.2020;16(43):e2003851.

19.   Kang P, Li PL, Peng JY, Ni M, Jia GJ, Jia W.Clinical Characteristics and Surgical Features of Intracranial Fibrosarcoma. JCraniofac Surg. 2020;31(3):825-8.

20.   Kang P, Han Z, Liao Z, Zhang H, Jia W, TianY. Knockdown of MCM10 Gene Impairs Glioblastoma Cell Proliferation, Migrationand Invasion and the Implications for the Regulation of Tumorigenesis. J MolNeurosci. 2020;70(5):759-68.

21.   Zhang D, Xiao M, Wang L, Jia W. Blood-BasedGlutamate Scavengers Reverse Traumatic Brain Injury-Induced Synaptic PlasticityDisruption by Decreasing Glutamate Level in Hippocampus Interstitial Fluid, butNot Cerebral Spinal Fluid, In Vivo. Neurotox Res. 2019;35(2):360-72.

22.   Wang X, Zhang D, Ma S, Li P, Zhou W, Zhang C,et al. Predicting the likelihood of early recurrence based on mRNA sequencingof pituitary adenomas. Gland Surg. 2019;8(6):648-56.

23.   Niu J, Zhang S, Ma S, Diao J, Zhou W, Tian J,et al. Preoperative prediction of cavernous sinus invasion by pituitary adenomasusing a radiomics method based on magnetic resonance images. Eur Radiol.2019;29(3):1625-34.

24.   Niu J, Wang J, Wang D, He X, Li Z, Li X, etal. Clinical, radiological features and surgical strategies for 23 NF1 patientswith intraorbital meningoencephalocele. Neurol Sci. 2019;40(6):1217-25.

25.   Ma SC, Yang J, Jia W. Application ofDextroscope in a Rare Type of Angiomatous Meningioma Characterized WithCoral-Like Vessels. J Craniofac Surg. 2019;30(4):e335-e7.

26.   Ma SC, Liu S, Agazzi S, Jia W. Rectus CapitisLateralis Muscle: A Cadaveric Study of a Key Surgical Landmark in the Posteriorand Lateral Approaches to the Jugular Foramen. World Neurosurg.2019;128:e859-e64.

27.   Ma SC, Li CD, Agazzi S, Jia W. ClinicalCharacteristics and Prognostic Factors of Treatment in Pediatric PosteriorCranial Fossa Ependymoma. Pediatr Neurosurg. 2019;54(2):98-107.

28.   Ma J, Jia G, Chen S, Jia W. ClinicalPerspective on Dysplastic Gangliocytoma of the Cerebellum (Lhermitte-DuclosDisease). World Neurosurg. 2019;122:16-23.

29.   Diao J, Zhang C, Zhang D, Wang X, Zhang J, MaC, et al. Role and mechanisms of a three-dimensional bioprinted microtissuemodel in promoting proliferation and invasion of growth-hormone-secretingpituitary adenoma cells. Biofabrication. 2019;11(2):025006.

30.   Zhou WJ, Wang X, Peng JY, Ma SC, Zhang DN,Guan XD, et al. Clinical Features and Prognostic Risk Factors of Choroid PlexusTumors in Children. Chin Med J (Engl). 2018;131(24):2938-46.

31.   Zhou WJ, Ma SC, Zhao M, Liu C, Guan XD, BaoZS, et al. Risk factors and the prognosis of sexual dysfunction in malepatients with pituitary adenomas: a multivariate analysis. Asian J Androl.2018;20(1):43-9.

32.   Ma SC, Li Q, Peng JY, Zhouwen JL, Zhang DN,Zhang CB, et al. CLDN5 affects lncRNAs acting as ceRNA dynamics contributing toregulating blood‑brain barrier permeability in tumor brain metastasis.Oncol Rep. 2018;39(3):1441-53.

33.  Li D, Weng JC, Zhang GJ, Hao SY, Tang J, ZhangLW, et al. Proposed Treatment Paradigm for Intracranial Chondrosarcomas Basedon Multidisciplinary Coordination. World Neurosurg. 2018;109:e517-e30.

34.   Li D, Hao SY, Wang L, Li GL, Wang JM, Wu Z,et al. Clinicoradiological features and surgical outcomes of primaryintracranial medulloepitheliomas: a single-center experience and pooledanalysis of individual patient data. J Neurosurg. 2018:1-15.

35.   Guan X, Zhang C, Zhao J, Sun G, Song Q, JiaW. CMTM6 overexpression is associated with molecular and clinicalcharacteristics of malignancy and predicts poor prognosis in gliomas.EBioMedicine. 2018;35:233-43.

36.   Guan X, Luo L, Begum G, Kohanbash G, Song Q,Rao A, et al. Elevated Na/H exchanger 1 (SLC9A1) emerges as a marker fortumorigenesis and prognosis in gliomas. J Exp Clin Cancer Res. 2018;37(1):255.

37.   Guan X, Hasan MN, Maniar S, Jia W, Sun D.Reactive Astrocytes in Glioblastoma Multiforme. Mol Neurobiol.2018;55(8):6927-38.

38.   Guan X, Hasan MN, Begum G, Kohanbash G,Carney KE, Pigott VM, et al. Blockade of Na/H exchanger stimulates glioma tumorimmunogenicity and enhances combinatorial TMZ and anti-PD-1 therapy. Cell DeathDis. 2018;9(10):1010.

首都五一劳动奖、北京市科技新星、北京市科学技术进步奖、中华医学科技奖、北京市百千万人才、北京市高层次创新创业人才支持计划领军人才；北京天坛医院优秀干部、优秀援外医疗队长、金柳叶刀奖、十佳住培带教老师、北京天坛医院优秀党务工作者。

2009.6-12，美国巴罗神经外科中心访问学者

2013.1-6，英国卡迪夫大学访问学者

2014.11-2015.6，北京市政府第二批援助特立尼达和多巴哥医疗队队长

2018.9，北京市政府第一批赴特立尼达和多巴哥专家组组长