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王群，医学博士，留美博士后。神经病学主任医师、教授、博士生导师。首都医科大学附属北京天坛医院神经病学中心癫痫科主任，脑功能疾病调控治疗北京市重点实验室副主任,北京脑重大疾病研究院兼任教授,北京市海外高层次引进人才(海聚工程)及北京市特聘专家。中华医 学会神经病学分会脑电图与癫痫学组委员，中华医学会心身医学分会神经反馈和调控协作组副组长，中国医师协会神经内科分会癫痫专委会委员，中国抗癫痫协会神经调控专委会副主任委员、脑电图与神经电生理分会常委,中国研究型医院学会脑功能研究与转化专委会常委。北京医学会神经病学分会癫痫学组副组长,北京抗癫痫协会神经内科专委会副主任委员，北京神经内科学会癫痫专委会主任委员。国家和北京市自然科学基评审专家,北京市科委项目评审专家。《临床神经病学杂志》、《中国现代神经病学杂志》、 《癫痫与神经电生理学杂志》、 《慢性病学杂志》 和《TranslationalNeuroscienceandClinics》 等杂志编級多种国内和国际SCI杂志审稿专家。要从事癫痫的神经电生理、 神经影像及神经药理学研究。主要社会任职为中华医学会神经病学分会脑电图与癫痫学组委员、中华医学会心身医学分会神经反馈和调控协作组副组长、中国医师协会神经内科分会癫痫专委会委员。北京市特聘专家等。
1:缺血性卒中后癫痫发病机制及修饰干预研究-国自然区域联合基金（202501-202812）
2:基于可穿戴设备及像电磁多模态信号构建人工智能辅助颞叶癫痫预警及诊疗决策体系研究-⾸都卫⽣发展科研专项（202401-202612）
3: 成⼈癫痫专病队列建设和诊治关键技术及服务体系研究-科技部(202210-202509)
4: 食欲素参与LGI1抗体脑炎相关癫痫合并睡眠障碍的神经内分泌机制研究-国自然面上项目（H0913）
5.Apocynin衍⽣物抑制NOX介导的铁死亡改善脑外伤后癫痫的机制研究-北京市⾃然科学基⾦(202301-202512)
6: 基于⼈⼯智能和电⽣理信号分析建模的颞叶癫痫的诊断、检测、⼲预和机制的研究-北京市⾃然科学基⾦(202010-202410)
7: 难治性癫痫致痫区多模态术前检查⼈⼯智能辅助诊断系统应⽤研究-⾸都卫⽣发展科研专项(202006-202306)
⽬前承担项⽬:
1:缺血性卒中后癫痫发病机制及修饰干预研究-国自然区域联合基金（202501-202812）
2:基于可穿戴设备及像电磁多模态信号构建人工智能辅助颞叶癫痫预警及诊疗决策体系研究-⾸都卫⽣发展科研专项（202401-202612）
3: 成⼈癫痫专病队列建设和诊治关键技术及服务体系研究-科技部(202210-202509)
4: 食欲素参与LGI1抗体脑炎相关癫痫合并睡眠障碍的神经内分泌机制研究-国自然面上项目（H0913）
5.Apocynin衍⽣物抑制NOX介导的铁死亡改善脑外伤后癫痫的机制研究-北京市⾃然科学基⾦(202301-202512)
6: 基于⼈⼯智能和电⽣理信号分析建模的颞叶癫痫的诊断、检测、⼲预和机制的研究-北京市⾃然科学基⾦(202010-202410)
6: 难治性癫痫致痫区多模态术前检查⼈⼯智能辅助诊断系统应⽤研究-⾸都卫⽣发展科研专项(202006-202306)
重要学术论文：
1.Jun-Min Chen, Guang Shi, Lu-Lu Yu, Wei Shan, Jing-Yu Sun, An-Chen Guo, Jian-Ping Wu, Tie-Shan Tang,* Xiang-Jian Zhang,* and Qun Wang* 3-HKA Promotes Vascular Remodeling After Stroke by Modulating the Activation of A1/A2 Reactive Astrocytes. Advanced Science. 2025;2412667:1-23
2. Sun T, Wu S, Liu X, Tao JX, Wang Q. Impact of intracranial subclinical seizures on seizure outcomes after SLAH in patients with mesial temporal lobe epilepsy. Clin Neurophysiol. 2024;160:121-129.
3. Shi X, Liu R, Wang Y, Yu T, Zhang K, Zhang C, Gu Y, Zhang L, Wu J, Wang Q, Zhu F. Cerebral glucose hypometabolism and hypoperfusion of cingulate gyrus: an imaging biomarker of autoimmune encephalitis with psychiatric symptoms. CNS Neurosci Ther. 2024;30(2):e14596.
4. Liu X, Zheng X, Shu Y, Qu X, Wang Q, Liu X, Hu FY, Liu J, Lian Y, He BM, Li C, Zhou D, Qiu W, Sun L, Hong Z. Genome-Wide Association Study Identifies IFIH1 and HLA-DQB1*05:02 Loci Associated With Anti-NMDAR Encephalitis. Neurol Neuroimmunol Neuroinflamm. 2024;11(3):e200221.
5. Sun Y, Li G, Liu X, Zhao X, Ren J, Ren G, Liu Y, Ai L, Wang Q. Cerebral glucose hypometabolism and hypoperfusion of cingulate gyrus: an imaging biomarker of autoimmune encephalitis with psychiatric symptoms. J Neurol. 2024;271(3):1247-1255.
6. Liu R, Sun L, Shi X, Li C, Guo X, Wang Y, Wang X, Zhang K, Wang Y, Wang Q, Wu J. Increased Expression of KNa1.2 Channel by MAPK Pathway Regulates Neuronal Activity Following Traumatic Brain Inju ry. Neurochem Res. 2024;49(2):427-440.
7. Liu R, Sun L, Du L, Guo X, Jia M, Wang Q and Wu J. Enhanced KNa1.1 Channel Underlies Cortical Hyperexcitability and Seizure Susceptibility after Traumatic Brain Injury. Elife 2023, 12:RP93304
8. Jia M, Guo X, Liu R, Sun L, Wang Q, Wu J. Overexpress miR-132 in the Brain Parenchyma by a Non-invasive Way Improves Tissue Repairment and Releases Memory Impairment After Traumatic Brain Injury. Cell Mol Neurobiol. 2023 Dec 17;44(1):5.
9. Xu L, Wang Q. The bidirectional relationship between Alzheimer's disease (AD) and epilepsy: A Mendelian randomization study. Brain Behav. 2023, 13(11):e3221.
10. Shi W, Sun H, Peng W, Chen Z, Wang Q, Lin W, Ding M, Sun H, Wang X, Wang T, Wang X, Liu Y, Chen Y, Zhu G, Zhou D, Li J.Prevalence and risk factors of anxiety and depression in adult patients with epilepsy: a multicenter survey-based study. Ther Adv Neurol Disord. 2023.16:17562864231187194.
11. Liu X, Wang Q, Ren L, Fang X, He Z, Ding J, Wang K, Xu H, Zhang H, Song Y, Lu Q, Sun M, Han X, Cao L, Lin W, Li X, Zhang Q, Ding Y, Wang F, Wang T, Wang J, Liu X, Wu Y, Chen Y, Feng Z, Wang S, Wang X, Guan Y, Xie X, Huang H, Zhang M, Wang X, Hong Z, Jiang W, Han Y, Deng Y, Zhao J, Liao J, Wang Y, Lian Y. COVID-19 vaccination for patients with epilepsy: A Chinese expert consensus. Epilepsy Behav. 2023:147:109387.
12. Pan J, Lv R, Wang Q, Zhao X, Liu J, Ai L. Discrimination between leucine-rich glioma-inactivated 1 antibody encephalitis and gamma-aminobutyric acid B receptor antibody encephalitis based on ResNet18. Vis Comput Ind Biomed Art. 2023, 18;6(1):17.
13. Xu N, Qin X, Zhou Z, Shan W, Ren J, Yang C, Lu L, Wang Q. Age differentially modulates the cortical tracking of the lower and higher level linguistic structures during speech comprehension. Cereb Cortex. 2023,33(19):10463-10474.
14. Sun Y, Zhou Z, Wang Q, Yan J, Zhang Z, Cui T. MRI characteristics due to gene mutations in a Chinese pedigree with Lafora disease. Mol Genet Genomic Med. 2023;11(10):e2228.
15. Guo X, Liu R, Jia M, Wang Q, Wu J. Ischemia Reperfusion Injury Induced Blood Brain Barrier Dysfunction and the Involved Molecular Mechanism. Neurochem Res. 2023;48(8):2320-2334.
16. Sun Y, Tao JX, Han X, Wang X, Zhu Y, Lian Y, Ren G, Wang Q. Clinical features and brain MRI volumetric changes in anti-mGluR5 encephalitis. Ann Clin Transl Neurol. 2023 Aug;10(8):1407-1416
17. Qiu D, Wang W, Mei Y, Tang H, Yuan Z, Zhang P, Zhang Y, Yu X, Yang C, Wang Q, Wang Y. Brain structure and cortical activity changes of new daily persistent headache: multimodal evidence from MEG/sMRI. J Headache Pain. 2023 Apr 26;24(1):45.
18. Sun Y, Qin X, Huang D, Zhou Z, Zhang Y, Wang Q. Anti-amphiphysin encephalitis: Expanding the clinical spectrum. Front Immunol. 2023;14:1084883.
19. Liu R, Sun L, Wang Y, Wang Q, Wu J. New use for an old drug: quinidine in KCNT1-related epilepsy therapy. Neurol Sci. 2023 Apr;44(4):1201-1206.
20. Yang H, Shi W, Fan J, Wang X, Song Y, Lian Y, Shan W, Wang Q. Transcutaneous Auricular Vagus Nerve Stimulation (ta-VNS) for Treatment of Drug-Resistant Epilepsy: A Randomized, Double-Blind Clinical Trial. Neurotherapeutics. 2023 Apr;20(3):870-880.
21. Li G, Wang M, Zheng M, Liu X, Yu T, Ren J, Wang Q. Causal effect of psychiatric disorders on epilepsy: A two-sample Mendelian randomization study. Brain Behav. 2023;13(4):e2939.
22. Wang K, Zhao X, Yuan L, Chen Q, Wang Q, Ai L. Cortical metabolic characteristics of anti-leucine-rich glioma-inactivated 1 antibody encephalitis based on 18F-FDG PET. Front Neurol. 2023;14:1100760.
23. Sun Y, Zhao X, Ai L, Wang Q. Metabolic phenotyping of pilomotor seizures in autoimmune encephalitis. CNS Neurosci Ther. CNS Neurosci Ther. 2023 Sep;29(9):2522-2529.
24. Xu N, Zhao B, Luo L, Zhang K, Shao X, Luan G, Wang Q, Hu W, Wang Q. Two stages of speech envelope tracking in human auditory cortex modulated by speech intelligibility. Cereb Cortex. 2023 Feb 20;33(5):2215-2228.
25. Zhang X, Zeng J, Gu X, Zhang F, Han Y, Zhang P, Wang Q, Gu R. Relapse After Drug Withdrawal in Patients with Epilepsy After Two Years of Seizure-Free: A Cohort Study. Neuropsychiatr Dis Treat. 2023;19:85-95.
26. Liu X, Li G, Yu T, Lv R, Cui T, Hogan RE, Wang Q. Prognostic significance and extra-hypothalamus dysfunction of hyponatremia in anti-leucine-rich glioma-inactivated protein 1 encephalitis. J Neuroimmunol. 2022;373:578000.
27. Sun L, Liu R, Yang H, Yu T, Wu J, Wang Q. Characteristics of Epileptiform Spike-wave Discharges and Chronic Histopathology in Controlled Cortical Impact Model of Sprague-Dawley Rats. Neurochem Res. 2022;47(12):3615-3626.
28. Yang H, Qi C, Su F, Shan W, Guo A, Wu J, Wang Y, You H, Wang Q. Cerebral Ischemia/Reperfusion Injury and Pharmacologic Preconditioning as a Means to Reduce Stroke-induced Inflammation and Damage. Neurochem Res. 2022;47(12):3598-3614.
29. Li G, Liu X, Yu T, Ren J, Wang Q. Positron emission tomography in autoimmune encephalitis: Clinical implications and future directions. Acta Neurol Scand. 2022;146(6):708-715.
30. Zhang Q, Jia M, Wang Y, Wang Q, Wu J. Cell Death Mechanisms in Cerebral Ischemia-Reperfusion Injury. Neurochem Res. 2022;47(12):3525-3542.
31. Zhao Y, Yang H, Shan W, Guo A, Wang Q. Moderate Ethanol-Preconditioning Offers Ischemic Tolerance Against Focal Cerebral Ischemic/Reperfusion: Role of Large Conductance Calcium-Activated Potassium Channel. Neurochem Res. 2022;47(12):3647-3658.
32. Yang H, Shan W, Fan J, Deng J, Luan G, Wang Q, Zhang Y, You H. Mapping the neural circuits responding to deep brain stimulation of the anterior nucleus of the thalamus in the rat brain. Epilepsy Res. 2022;187:107027.
33. Shan W, Yang H, Ren Q, Wang Q, An G. Generation of TSC1 knockout induced pluripotent stem cell (iPSC) line. Stem Cell Res. 2022;64:102888.
34. Sun J, Wu G, Qu B, Qi J, Deng J, Shao X, Du Y, Wang Q. Changes in heart rate during the peri-ictal period in focal epilepsy. Epileptic Disord. 2022;24(5):906-916.
35. Yu T, Liu X, Sun L, Lv R, Wu J, Wang Q. Risk factors for Drug-resistant Epilepsy (DRE) and a nomogram model to predict DRE development in post-traumatic epilepsy patients. CNS Neurosci Ther. 2022;28(10):1557-1567.
36. Li G, Liu X, Wang M, Yu T, Ren J, Wang Q. Predicting the functional outcomes of anti-LGI1 encephalitis using a random forest model. Acta Neurol Scand. 2022;146(2):137-143.
主编或副主编的著作/译
1.《癫痫持续状态》 主译 科学出版社，202401
2．《婴儿、儿童和青少年癫痫综合症》 主译 人民卫生出版社 202401
3．《ICU脑电图监测手册》主译 北京大学医学出版社 202301
4．《癫痫规范化诊断治疗和管理》 副主编 科学出版社 202201
5．《耐药性癫痫的诊治》 主译 AccScience Publishing 202201
6．《癫痫中心工作手册》 副主编 人民卫生出版社 202301
7．《神经系统单基因遗传病诊断》 副主编 人民卫生出版社 201601
8．《神经病学新进展》 副主编 人民卫生出版社 201801
9．《临床路径释义·神经内科分册》 副主编 中国协和医科大学出版社 201801
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