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王然,医学博士,副研究员,从事儿童EB病毒感染相关疾病的致病机制研究;主持国家自然科学基金、北京市自然科学基金和首都卫生发展科研专项等,参与国家重点研发计划;任中国研究型医院学会病毒肿瘤学专委会委员等。
1. 国家自然科学基金青年科学基金项目, 82002130, 流行性乙型脑炎减毒活疫苗诱导的交叉反应性T细胞和IgG抗体在寨卡病毒垂直传播中的作用及其机制研究, 2021-01至2023-12
2. 北京市自然科学基金面上项目, 7222059, 乙脑疫苗诱导的CD4+ T细胞在寨卡病毒感染中的交叉保护机制及共同表位疫苗的研究, 2022-01至2024-12
3. 首都卫生发展科研专项, 2024-4-1142, 儿童EB病毒感染相关疾病中宿主及病毒基因甲基化检测系统的研发, 2024-01至2026-12
4. 北京市医院管理中心青年职工创新工作室一创新梦工场, 202328, 2024-01至2025-12
5. 北京市自然科学基金-海淀原始创新联合基金前沿项目, L242117, 基于EB病毒多功能T细胞表位的mRNA 疫苗设计及其免疫保护作用评价, 2024-10至2027-09
6. 国家重点研发计划(任务), 2024YFC2309801, 儿童EBV感染与重症EBV感染相关疾病的细胞免疫致病机制研究, 2024-12至2027-11
1. Feng Q#, Wang J#, Wang X#, Tian J, Zhang L, Dilmurat D, Liu M, Ai J, Feng G, Zeng Y, Wang R*, Xie Z*. Clinical Epidemiological Characteristics of Hospitalized Pediatric Viral Community-Acquired Pneumonia in Mainland China. J Infect. 2025, 90(3):106450.
2. Wang J, Wang R*, Xie Z*. Rethinking Paediatric Respiratory Infections: The Role of Mixed Pathogen Infections. Rev Med Virol. 2025, 35(2):e70021.
3. Ai J, Xiao H, Zhang L, Ma H, Wang D, Dilmurat D, Wang R*, Xie Z*. Dysfunction of γδ T cells in pediatric chronic active Epstein-Barr virus infection. Ital J Pediatr. 2024, 50(1):213.
4. Chen G#, Zhang L#, Wang R*, Xie Z*. Histone methylation in Epstein-Barr virus-associated diseases. Epigenomics. 2024, 16(11-12):865-877.
5. Dilmurat D#, Wang X#, Gao L, Tian J, Ai J, Zhang L, Liu M, Feng G, Zeng Y, Wang R*, Xie Z*. Clinical epidemiology of Epstein-Barr virus-associated Lymphoproliferative Disorders (EBV-LPDs) in hospitalized children: A six-year multi-institutional study in China. Ital J Pediatr. 2024, 50(1):125.
6. Duan Y, Zhu Y, Zhang L, Wang W, ZhangM, Tian J, Li Q, Ai J, Wang R*, Xie Z*. Activation of the NLRP3 inflammasome by human adenovirus type 7 L4 100-kilodalton protein. Front Immunol. 2024, 15:1294898.
7. Wang R, Xie Z*. The responsibility of thwarting and managing Japanese encephalitis cannot be understated - Outbreaks or resurgences may manifest, catching us off guard. PLoS Negl Trop Dis. 2023,17(11):e0011698.
8. Liu M, Wang R*, Xie Z*. T cell-mediated immunity during Epstein-Barr virus infections in children. Infect Genet Evol. 2023,112:105443.
9. Li Q#, Wang R#, Xu H, Zhang L, Fu Y, Tian J, Liu M, Feng G, Zeng Y, Chen X*, Xie Z*. Epidemiology and Disease Burden of Hospitalized Children with Viral Central Nervous System Infections in China, 2016 to 2020. Pediatr Neurol. 2023,138:38-44.
10. Zhen Z, Zhang L, Li Q, Zhu Y, Wang X, Fu X, Ai J, Wang R*, Xie Z, Ma S*. Cross-reactive antibodies against monkeypox virus exist in the population immunized with vaccinia TianTan strain in China. Infect Genet Evol. 2023,113:105477.
11. Wang R, Wang X, Zhang L, Feng G, Liu M, Zeng Y, Xie Z*. The epidemiology and disease burden of children hospitalized for viral infections within the family Flaviviridae in China: A national cross-sectional study. PLoS Negl Trop Dis. 2022,16(7):e0010562.
12. Liu M, Wang X, Zhang L, Feng G, Zeng Y, Wang R*, Xie Z*. Epidemiological characteristics and disease burden of infectious mononucleosis in hospitalized children in China: A nationwide retrospective study. Virol Sin. 2022, 37(5):637-645.
13. Wang R, Xie Z*. Non-hepatotropic viral hepatitis and its causative pathogens: The ongoing need for monitoring in children with severe acute hepatitis of unknown etiology. Pediatr Investig. 2022, 6(3):151-155.
14. Zhang L, Wang R*, Xie Z*. The roles of DNA methylation on the promotor of the Epstein-Barr virus (EBV) gene and the genome in patients with EBV-associated diseases. Appl Microbiol Biotechnol. 2022,106(12):4413-4426.
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