个人信息
Personal Information
联系方式
Contact Information
个人简介
Personal Profile
首都医科大学附属北京安贞医院,北京市心肺血管疾病研究所研究员,教授,博士研究生导师。国家自然科学基金项及目北京自然科学基金评审专家及国内外多家杂志特约审稿人。中国生物化学与分子生物学脂质与脂蛋白专业委员会委员,亚洲血管生物学专业委员会委员,中国研究型医院学会细胞外囊泡研究与应用专业委员会委员。先后主持国家级课题5项,省部级课题4项。在国际期刊中以第一作者和通讯作者发表SCI收录论文40余篇,包括PNAS,Circulation Research, Diabetes, Metabolism, Theranostics等。
项目名称 |
资助号 |
项目类别 |
项目经费 |
本人角色 |
起止时间 |
外泌体介导的心肌细胞-心肌成纤维细胞cross-talk在糖尿病心肌纤维化中的作用及机制研究 |
82270242 |
国家自然基金 面上项目 |
51万 |
负责人 |
2023.01- 2026.12 |
红细胞外泌体与内皮功能障碍:慢性间歇性缺氧诱导高血压的新机制 |
7192031 |
北京市市自然基金面上项目 |
20万 |
负责人 |
2019.01-2021.12 |
血清外泌体精氨酸酶1表达增加与血管内皮功能障碍:糖尿病小鼠血管功能损伤的新机制 |
31741064 |
国家自然基金 应急项目 |
15万 |
负责人 |
2018.01- 2018.12 |
心肌脂滴比较蛋白组学研究及心肌脂滴蛋白CGI-58 对心脏功能的影响 |
81471082 |
国家自然基金 面上项目 |
73万 |
负责人 |
2015.01- 2018.12 |
骨骼肌脂滴比较蛋白组学研究及骨骼肌脂滴蛋白OXPAT 对胰岛素抵抗的影响 |
81270932 |
国家自然基金 面上项目 |
70万 |
负责人 |
2013.01- 2016.12 |
SNAREs样蛋白SLPs对产油菌脂滴融合的影响 |
31100068 |
国家自然基金 青年基金项目 |
23万 |
负责人 |
2012.01- 2014.12 |
骨骼肌脂滴比较蛋白谱研究及apoA-I对骨骼肌脂滴的影响 |
5122028 |
北京自然基金 面上项目 |
11万 |
负责人 |
2012.01- 2014.12 |
项目名称 | 资助号 | 项目类别 |
外泌体介导的心肌细胞-心肌成纤维细胞cross-talk在糖尿病心肌纤维化中的作用及机制研究 | 82270242 | 国家自然基金 面上项目 |
红细胞外泌体与内皮功能障碍:慢性间歇性缺氧诱导高血压的新机制 | 7192031 | 北京市市自然基金面上项目 |
血清外泌体精氨酸酶1表达增加与血管内皮功能障碍:糖尿病小鼠血管功能损伤的新机制 | 31741064 | 国家自然基金 应急项目 |
1. Zhang, H. N., C. X. Yu,P. J. Zhang, W. W. Chen, A. L. Jiang, F. Kong, J. T. Deng, J. Y. Zhang, and C.Y. Young. Curcumin downregulates homeobox gene NKX3.1 in prostate cancer cellLNCaP. Acta Pharmacol Sin 2007.28:423-430.
2.Zhang, H. N.,L. Li, P. Gao, H. Z. Chen, R. Zhang, Y. S. Wei, D. P. Liu, and C. C. Liang.2010. Involvement of the p65/RelA subunit of NF-kappa B in TNF-alpha-inducedSIRT1 expression in vascular smooth muscle cells. Biochem Bioph Res Co 2010.397:569-575.
3.Li, L*., H. N. Zhang*, H. Z. Chen*, P. Gao, L. H. Zhu, H. L.Li, X. Lv, Q. J. Zhang, R. Zhang, Z. Wang, Z. G. She, R. Zhang, Y. S. Wei, G.H. Du, D. P. Liu, and C. C. Liang. SIRT1 Acts as a Modulator of NeointimaFormation Following Vascular Injury in Mice. Circ Res 2011.108:1180-U1195.
4.Zhang, H.*, Y. Wang*, J. Li*, J. Yu, J. Pu,L. Li, S. Zhang, G. Peng, F. Yang, and P. Liu. 2011. Proteome of skeletalmuscle lipid droplet reveals association with mitochondria and apolipoproteina-I. JProteome Res. 2011.10:4757-4768.
5. Zhang H*#, Li J#, Li L#, Liu P, Wei Y, Qian Z#. Ceramide enhancescox-2 expression and vsmc contractile hyperreactivity via er stress signalactivation. Vascular Pharmacology. 2017. 96–98: 26–32
6. Gao Z*,Zhang H*, Liu J, Lau CW, Liu P, Chen ZY, Lee HK, Tipoe GL, Ho HM, Yao X, Huang Y.Cyclooxygenase-2-dependentoxidative stress mediates palmitate-induced impairment of endothelium-dependentrelaxations in mouse arteries. Biochem Pharmacol. 2014. 91(4):474-82.
7. Zhang H, Liu J, Qu D,Wang L, Luo JY, Lau CW, Liu P, Gao Z, Tipoe GL, Lee HK, Ng CF, Wan Ma RC, YaoX, Huang Y. Inhibition of miR-200c restores endothelial function in diabeticmice through suppression of COX-2. Diabetes. 2016 May;65; 16. 1196-1207
8.Li L, Zhang H*, Wang W, HongY, Wang J, Zhang S, Xu S, Shu Q, Li J, Yang F, Zheng M, Qian Z, Liu P*. Comparative proteomics reveals abnormalbinding of ATGL and dysferlin on lipid droplets from pressure overload-induced dysfunctionalrat hearts. Sci Rep. 2016. Jan22;6:19782.
9. Huina Zhang#*, Jian Liu#, Dan Qu, Li Wang, Chi MingWong, Chi-Wai Lau, Yuhong Huang, Yi Fan Wang, Huihui Huang, Yin Xia, Li Xiang,Zongwei Cai, Pingsheng Liu, Yongxiang Wei, Xiaoqiang Yao, Ronald Ching Wan Mai,Yu Huang*. Serum exosomes mediate delivery of arginase 1 as a novel mechanismfor endothelial dysfunction in diabetes. PNAS, 2018 July; 115; 29. E6927-E6936,
10. Huina Zhang#, Fan Yang#, YichenGuo, Li Wang, Fang Fang, Hao Wu, Shaoping Nie, Yifan Wang, Man-Lung Fung, YuHuang, Haiteng Deng, Yanwen Qin, Xinliang Ma*, Yongxiang Wei*. The contributionof chronic intermittent hypoxia to OSAHS: from the perspective of serumextracellular microvesicle proteins. Metabolism-clinical and experimental, 2018,85,97–108.
11. LuPeng, Yu Li, Xinwei Li, Yunhui Du, Linyi Li, Chaowei Hu, Jing Zhang, Yanwen Qin, Yongxiang Wei*, Huina Zhang*. Extracellular Vesicles Derived from Intermittent Hypoxia–Treated RedBlood Cells Impair Endothelial Function Through Regulating eNOS Phosphorylationand ET-1 Expression. Cardiovascular Drugs and Therapy, 2021, 35, 901–913
12. Lu Peng#,Xinwei Li, Yu Li, Wen Zhao, Shaoping Nie, Huahui Yu, Yue Qi, Yanwen Qin*, Huina Zhang*. Increased concentrations ofmyeloperoxidase in serum and serum extracellular vesicles are associated withtype 2 diabetes mellitus. Clinica Chimica Acta,2021, 522:70-76.
13. Yu Li#, Huina Zhang#,Yunhui Du, Lu Peng, Yanwen Qin, Huirong Liu, Xinliang Ma*, YongxiangWei*. Extracellular vesiclemicroRNA cargoes from intermittent hypoxia-exposed cardiomyocytes and theireffect on endothelium. Biochem Bioph Res Co, 2021, 548,182e188
14. Huina Zhang1#*, JinghuiDong2#, Chi-Wai Lau3, Yu Huang3*. Berberine reverses nitroglycerintolerance through suppressing PKCa activity in vascular smooth muscle cells. CardiovascularDrugs and Therapy,2022 08;36 (4), 633-643.
15. Linghai Li#, Jinghui Wang, Ding Li, Huina Zhang*.Morphine increases myocardialtriacylglycerol through regulating adipose triglyceride lipase S406 phosphorylation.Life Sciences 2021 2021 Oct 15;283:119866.
16. Huina Zhang*#, Lu Peng,Yifan Wang, Wen Zhao, Wayne Bond Lau, Yajing Wang, Yu Li, Yunhui Du, Linyi Li,Yu Huang, Shaoping Nie, Yanwen Qin, Xinliang Ma, Yongxiang Wei. Extracellularvesicle-derived miR-144 as a novel mechanism for chronic intermittenthypoxia-induced endothelial dysfunction. Theranostics 2022;12(9):4237-4249.
17. XinweiLi1#, Wen Zhao1#, Lu Peng1, Yu Li1, Shaoping Nie2 , Huahui Yu1 , Yanwen Qin1and Huina Zhang*. Elevated serum extracellularvesicle arginase 1 in type 2 diabetes mellitus: a cross-sectionalstudy in middle-aged and elderly population. BMC EndocrineDisorders (2022) 22:62
18. Wen Zhao1#, Xinwei Li1#, Xinxin Li1, Lu Peng1, Yu Li1 , Yunhui Du1 , Jianxun He2 , Yanwen Qin1 and Huina Zhang1*. Signifcantincrease of serum extracellular vesicle-packaged growth diferentiationfactor 15 in type 2 diabetes mellitus: a cross-sectional study. EuropeanJournal of Medical Research (2023) 28:37
文件上传中...