主持课题：

1.      高层次公共卫生技术人才建设项目（学科骨干-02-15），北京市卫生健康委员会

2.      法规差异性有害物高通量测定技术研究（2017YFC1601605），科技部重点研发计划

3.      环境因素对出生缺陷影响的前瞻性研究（2016YFC1000103）子课题，科技部重点研发计划

4.      虾过敏原蛋白存在水平及抗原表位场流分离快速识别技术研究（7162088），北京市自然科学基金

论文：

1.     Yi Yang, Jiachen Shi, Jie Yin, Yunjia Yang, Bing Shao，Jing Zhang*. Occurrence and Estimated Daily Intake ofCortisone and Cortisol in Aquatic Food from China TDS. Foods, 2022, 11, 3481.

2.     Yang Li, Yunjia Yang,Yue Zou, Lin Shu, Nan-yin Han, Yi Yang*. Characterization of themolecular properties and allergenicity (IgE-binding capacity) ofβ-lactoglobulin by heat treatment using asymmetric-flow field-flowfractionation and ultra-performance liquid chromatography quadrupole time offlight mass chromatography. Food Chemistry, 2022，374，131748.

3.     Yang Li, Yi Yang*,Yinghui Liu, Jinyuan Liu, Yunjia Yang, Jing Zhang, Yue Zou, Lin Shu, NanyinHan, Bing Shao. Combination of magnetic beads extraction and ultraperformanceliquid chromatography tandem mass spectrometry detection for the clinicaldiagnosis of allergies. Analytica Chimica Acta, 2022,1221,340157.

4.     Qihui Liang, Yang Li,Yue Zou, Lin Shu, Nanyin Han, Yi Yang*. Effect of parameters onretention behavior of ovalbumin and immunoglobulin E in asymmetrical flowfield-flow fractionation. Journal of Separation science plus, 2022, https://doi.org/10.1002/sscp.202200075

5.     Qiaozhen Guo, YiYang, Jing Zhang. Rapid screening for 315 drugs in food and biologicalmatrices by ultrahigh-performance liquid chromatography quadrupole time offlight mass spectrometry and its application to a specific incident. Journal ofSeparation Science Plus, 2022,https://doi.org/10.1002/sscp.202200037

6.     Guo, Q., Yang, Y.,Li, J., Shao, B. and Zhang, J. Screening for Plant Toxins in Honey and HerbalBeverage by Ultrahigh-Performance Liquid Chromatography-Ion Mobility-QuadrupoleTime of Flight Mass Spectrometry. American Journal of Analytical Chemistry,2022，13, 108-134.

7.     Yi Yang*, Huanhuan Yu, Yunjia Yang, Jing Zhang, Jie Yin, BingShao. Simultaneous Determination of 118 Pesticides in Vegetables by AtmosphericPressure Gas Chromatography−Tandem Mass Spectrometryand QuEChERs Based on Multiwalled Carbon Nanotubes. ACS Agric. Sci. Technol,2021, 1, 5, 460–468.

8.     Yang, Y.*, Liu, H., Zeng, W., Yang, Y., Zhang, J., Jie, Y., Wu,J., Lai, K. Characterization and epitope prediction of phosphopyruvatehydratase from Penaeus monodon (black tiger shrimp). J Food Sci, 2021,86(8),3457-3466.

9.     Ze Li, Jing Zhang,Yunjia Yang, Huilan Xu, Jianwu Wang, Yi Yang*. Determination ofSulfonamides in Milk by Cloud Point - Salting Out Extraction and Ultra HighPerformance Liquid Chromatography Tandem Mass Spectrometry. AnalyticalSciences, 2020, 36(12),1555-1559.

10.  Weichunbai Zhang,Jing Du, Hong Li, Yi Yang, Chang Cai, Qun Gao, Yang Xing, Bing Shao*,Gang Li*. Multiple-element exposure and metabolic syndrome in Chinese adults: Acase-control study based on the Beijing population health cohort. EnvironmentInternational, 2020, 143, 105959.

11.  Yunjia Yang, YiYang, Jing Zhang, Bing Shao, Jie Yin. Assessment of bisphenol Aalternatives in paper products from the Chinese market and their dermalexposure in the general population. Envitonmental Pollution, 2019, 244, 238-246

12.  Xin Zhang, YunjiaYang, Jing Zhang, Yi Yang, Fan Shen, Jianzhong Shen, Bing Shao.Determination of emerging chlorinated byproducts of diazepam in drinking water.Chemosphere, 2019, 218, 223-231

13.  Kailun Qi, Tong Liu,Yunjia Yang, Jing Zhang, Jie Yin, Xiaojing Ding, Weijie Qin, Yi Yang*. Arapid immobilized trypsin digestion combined with liquid chromatography –Tandem mass spectrometry for the detection of milk allergens in baked food.Food Control, 2019,102,179-187.

14.  Yunjia Yang, JingZhang, Jie Yin, Yi Yang*. Fast Simultaneous Determination of Eight SudanDyes in Chili Oil by Ultra-High-Performance Supercritical Fluid Chromatography.Journal of Analytical Methods in Chemistry, 2019, 1, 3731028.

15.  Yunjia Yang, JiachenShi, Yi Yang, Jing Zhang, Bing Shao. Transformation of sulfamethazineduring the chlorination disinfection process: Transformation, kinetics, andtoxicology assessment. Journal of Environmental Sciences, 2019, 76, 48-56

16.  Sai Zheng, JiachenShi, Jing Zhang, Yi Yang, Jianying Hu, Bing Shao. Identification of thedisinfection byproducts of bisphenol S and the disrupting effect on peroxisomeproliferator-activated receptor gamma (PPARγ) induced by chlorination. Water Research,2018, 132, 167-176

17.  Yi Yang, Yunjia Yang, Bing Shao, Jing Zhang*. A Simple and RapidMethod for Determination of Patulin in Juice by High Performance LiquidChromatography Tandem Mass Spectrometry. Food Anal. Methods, 2017, 10,2913-2918

18.  Yi Yang, Yin Zhang, Jing Zhang and Bing Shao. Identification ofmetabolites of AHTN in rat urine and feces by liquidchromatography/electrospray ionization quadrupole time-of-flight tandem massspectrometry. Analytical Methods, 2015, 7, 4443-4449.

19.  Jennifer Neumann, YiYang, Rebecca Kohler, Marco Giaisi, Mathias Witzens-Harig, Dong Liu, PeterH. Krammer, Wenhan Lin*, Min Li-Weber*. Mangrove dolabrane-type of diterpenestagalsins suppresses tumor growth via ROS-mediated apoptosis andATM/ATR–Chk1/Chk2-regulated cell cycle arrest. International Journal of Cancer,2015, 137, 2739-2748.

20.  Yi Yang, Yang Zhang, Dong Liu, Min Li-Weber, Bing Shao, WenhanLin. Dolabrane-type diterpenes from the mangrove plant Cerips tagal withantitumor activities. Fitoterapia, 2015, 103, 277-282.

21.  Yi Yang, Jing Zhang, Bing Shao. Quantitative analysis offourteen synthetic dyes in jelly and gummy candy by ultra performance liquidchromatography. Analytical Methods, 2014,6,5872-5878

22.  Jinwei Ren, YiYang, Dong Liu, Wei Chen, Peter Proksch, Bing Shao, Wenhan Lin. Sequentialdetermination of new peptaibols asperelines G-Z12 produced by marine-derivedfungus Trichoderma asperellum using ultrahigh pressure liquid chromatographycombined with electrospray-ionization tandem mass spectrometry. Journal of ChromatographyA, 1309 (2013) 90– 95

23.  Ming Li, Yunjia Yang,Yi Yang, Jie Yin, Jing Zhang, Bing Shao, Biotransformation of bisphenolAF to its major glucuronide metabolite reduces estrogenic activity. PLOS ONE,2013,8(12), e83170

24.  Yunjia Yang, Jie Yin,Yi Yang, Naiyuan Zhou, Jing Zhang, Bing Shao, Yongning Wu, Determinationof bisphenol AF (BPAF) in tissues, serum, urine and feces of orally dosed ratsby ultra-high-pressure liquid chromatography–electrospray tandem massspectrometry. Journal of Chromatography B, 901 (2012) 93– 97

25.  Yi Yang, Jie Yin, Yongning Wu, Bing Shao*, Simultaneousdetermination of five aluminum lake dyes in chewing gum by HPLC with photodiodearray detection. Food Additives and Contaminants, 2011, 28(9):1159-1167.

26.  Hao Wang, Jing Zhang,Fudie Gao, Yi Yang, Hejun Duana, Yongning Wu, Jean-Daniel Berset, BingShao*, Simultaneous analysis of synthetic musks and triclosan in human breastmilk by gas chromatography tandem mass spectrometry. Journal of ChromatographyB, 2011, 879:1861– 1869

27.  Jie Yin, Yi Yang,Keji Li, Jing Zhang, Bing Shao. Analysis of Anticancer Drugs in Sewage Water BySelective SPE and UPLC–ESI-MS–MS. Journal of Chromatography Science, 2010,48:781-789.

28.  Bing Shao*, XiaoliangCui, Yi Yang, Jing Zhang, Yongning Wu, Hejun Duan Validation of aSolid-phase Extraction and Ultra Performance Liquid Chromatography Tandem MassSpectrometric Method for the Detection of Sixteen Glucocorticoids in PigTissues. Journal of AOAC International, 2009, 92（2）, 604-611.

29.  Yi Yang, Bing Shao*, Jing Zhang, Yongning Wu, Hejun Duan.Determination of the residues of 50 anabolic hormones in muscle, milk and liverby very-high-pressure liquid chromatography–electrospray ionization tandem massspectrometry. Journal of Chromatography B, 2009, 877, 489-496.

30.  Ke Ma, Yi Yang,Zhiwei Deng, Nicole J. de Voogd, Peter Proksch, and Wenhan Lin. Two NewBromotyrosine Derivatives from the Marine Sponge Pseudoceratina sp. CHEMISTRY& BIODIVERSITY, 2008, 5,1313-1320

31.  Xiaofei Jia, BingShao*, Yongning Wu, Yi Yang, Jing Zhang, Simultaneous Determination ofTetracylines and Quinolones Antibiotics in Egg by Ultra-Performance LiquidChromatography–Electrospray Tandem Mass Spectrometry. Journal of AOACInternational, 2008, 91, 461-468.

32.  Yi Yang, Bing Shao*, Jing Zhang, Analysis of eight free progestogensin eggs by matrix solid-phase dispersion extroaction and very high pressureliquid chromatogphy with tandem mass spectrometry. Journal ofChromatography  B，2008，870，241-246.

33.  Bing Shao*, JingZhang, Yi Yang, Juan Meng, Yongning Wu and Hejun Duan, Simultaneousanalysis of thirteen diuretics residues in bovine milk by ultra-performanceliquid chromatography/tandem mass spectrometry. Rapid Communications in MassSpectrometry，2008，22，3427-3433.

34.  Bing Shao*, XiaojieSun, Jing Zhang, Jianying Hu, Huiru Dong,Yi Yang , Determination of ofloxacin enantiomers in sewage using two-step solid-phaseextraction and liquid chromatography with fluorescence detection. Journal of Chromatography A, 2008,1182，77-84.

35.  Xiaoliang Cui, BingShao*, Rong Zhao, Yi Yang, Jianying Hu, Xiaoming Tu. Simultaneousdetermination of seventeen glucocorticoids residues in milk and eggs byultraperformance liquid chromatography/electrospray tandem mass spectrometry.Rapid Commun. Mass Spectrom, 2006, 20: 2355-2364

36.  Yang Yi, Deng Zhiwei, Proksch P., Lin, Wenhan. Two new18-en-oleane derivatives from marine mangrove plant, barringtonia racemosa. DiePharmazie, 2006, 61,365-366

37.  杨奕，尹杰，杨蕴嘉，张晶.牛肉、牛奶中可的松和氢化可的松含量分析.食品科学，2021,42(16),261-266.

38.  段鹤君,郭巧珍,张昕,杨蕴嘉,杨奕*.75种农药的离子流淌度质谱多维数据库的建立.食品安全质量检测学报，2021,12(20),8026-8033

39.  杨奕,杨蕴嘉,尹杰,张晶. 液相色谱-串联质谱法测定动物肌肉和牛奶中的雌二醇. 食品安全质量检测学报，2021,12(9),3652.

40.  沈葹,杨奕,王晶波,陈曦,刘婷婷,卓勤. 基于超高效液相色谱-四极杆飞行时间质谱的非靶向代谢组学用于不同来源单花蜜的差异分析.色谱,2021,39(3),291-300.

41.  张维春柏，杜婧，尹杰，杨奕*。孕妇血清锌水平与新生儿神经管缺陷发生关联的Meta分析。现代预防医学，2020,47(19),3505.

42.  郁欢欢，杨奕，张晶，徐慧兰，王建武。大气压气相色谱法电离源-串联质谱法测定蔬菜中23种农药残留。中国食品卫生杂志，2020,32(1),31-38.

43.  李阳，杨奕，邵兵，邹悦，宋宇，舒琳，梁启慧，韩南银。非对称流场流分离⁃超高效液相色谱⁃串联四极杆飞行时间质谱用于过敏原蛋白表位筛选。色谱，2019,37,398-403.

44.  梁启慧，杨奕，邵兵，高也，宋宇，韩南银。载液组成对于卵白蛋白在非对称流场流分离通道中膜吸附和聚集行为的影响。色谱, 2018,36(5),480.

45.  齐开伦,杨奕,杨蕴嘉,邵兵,丁晓静.建立同位素稀释质谱法测定烘培食品中来源于鸡蛋的3种主要致敏蛋白。中国食品卫生杂志，2017,29(6),658.

46.  王硕,张向明,毛红霞,李书明,邵兵,杨奕.高效液相色谱法同时测定糖果中6种合成着色剂及其铝色淀. 现代预防医学,2016,22,4174-4178.

47.  张晶，卢丽彬，杨奕，孟娟，邵兵*，液相色谱-串联质谱法快速测定食品中的氟乙酸. 食品安全质量检测学报，2013,4(3),660-664.

48.  杨奕,张晶,赵珊,邵兵*. 超高效液相色谱法同时测定包衣糖果中5种铝色淀. 中国食品卫生杂志, 2013, 25(2),148-151.

49.  杨奕，邵兵*，超高压液相色谱-串联质谱法测定虾中硝基呋喃代谢物. 食品安全质量检测学报，2013,4(1),135-140.

50.  杨蕴嘉，牛宇敏，杨奕，张晶，邵兵*，在线固相萃取-液相色谱串联质谱法测定饮用水中的双酚A和壬基酚. 卫生研究，2013, 42(1),127-132.

51.  王 硕，张 晶，杨奕，张晓曦，邵 兵，高效液相色谱串联质谱同时测定城市污水处理厂污泥中20种磺胺类药物. 卫生研究，2012,41(2),240-246.

52.  杨佳佳，杨奕，张晶，邵兵，吴永宁。离子色谱-串联质谱同时测定蔬菜中的溴酸盐和高氯酸盐. 卫生研究，2012,41(2), 273-278.

53.  肖甚圣，杨奕，张晶，邵兵，吴永宁。超高效液相色谱串联质谱法测定鱼组织中6种抗雌激素药物. 色谱，2011, 29 (11), 1055-1061.

54.  赵珊，张晶，杨奕，邵兵*，超高效液相色谱-电喷雾串联四极杆质谱法检测果汁和葡萄酒中27种工业染料. 色谱，2010,28(4),357-362.

标准：

1.      GB/T21312-2007动物源性食品中14种喹诺酮药物残留检测方法液相色谱-质谱/质谱法。

2.     GB/T21313-2007动物源性食品中β-受体激动剂残留检测方法 液相色谱-质谱/质谱法。

3.     GB/T21981-2008动物源性食品中激素多残留检测方法 液相色谱-质谱/质谱法。

4.     丁晓静、王萍、杨奕，高运华等。消毒剂与抗菌剂中抗病毒药物检测方法与评价要求。WS/T 686-2020

专利：

1.      张洋,林文瀚,刘东,杨奕. 利用Tagalsin E和Tagalsin G制备抗肿瘤先导化合物TagalsinC的方法，201210122303.1

2.      邵兵,张晶,郭巧珍,杨奕,尹杰. 构建液相色谱-质谱数据库检测未知毒物的方法，201410093316.X