研究方向：代谢性疾病药理。通过研究内源性代谢酶在炎症、糖脂代谢和能量代谢中的调控作用，阐明代谢紊乱机制，发现代谢疾病治疗新靶标；同时开展代谢疾病新药临床前评价研究。

技术专长：1. 代谢性疾病动物及细胞模型构建与功能评估; 2. 肝脏、脂肪、肌肉等代谢器官的原代细胞及3D类器官培养及行为功能鉴定 3. 分子生物学技术 （分子克隆，基因编辑，分子检测等）。

1. 国家自然基金 82000807  

2. 国家自然基金 82270898  

3. 北京市自然基金 7212148  

1. 国家自然科学基金 82000807 

2. 国家自然科学基金 82270898 

3. 北京市自然科学基金 7212148 

4. 北京市教委基金 KM202110025023 

5. 美国心脏协会AHA博士后基金 17POST33660460 

6. 首都医科大学优秀青年人才项目 B2404

1. Yang T, Wang Y, Li H, Shi F, Xu S, Wu Y, Xin J, Liu Y, Jiang M. Homeobox C4 transcription factor promotes adipose tissue thermogenesis. Diabetes 2025, 10.2337/db24-0675, doi:10.2337/db24-0675.

2. Yingting Wu, Xinyu Li, Jiaqi Xin, Ting Yang, Yi Liu, Yongsheng Zhao, Wen Xie#& Mengxi Jiang# ., Repurposing lansoprazole to alleviate metabolic syndrome via PHOSPHO-1 inhibition. Acta Pharm Sin B. 2024 Apr; 14(4): 1711–1725.

3. M. Jiang, Y. Gao, Z. Hu, Pharmacological innovation and clinical value of VV116, Lancet Infect Dis 24(4) (2024) e212.

4. Jiaqi Xin, Ting Yang, Xiaoyi Wu, Yingting Wu, Yi Liu, Xuan Liu, Mengxi Jiang# & Wei Gao#., Spatial transcriptomics analysis of zone-dependent hepatic ischemia-reperfusion injury murine model. Commun Biol. 2023 Feb 18;6(1):194.

5. Mengxi Jiang, Tony E Chavarria, Bingbing Yuan, Harvey F Lodish, Nai-Jia Huang., Phosphocholine accumulation and PHOSPHO1 depletion promote adipose tissue thermogenesis. Proceedings of the National Academy of Sciences of the United States of America. 2020 Jun 30;117(26):15055-15065. 

6. Bi Y, Jiang M, Guo W, Guan X, Xu M, Ren S, Yang D, Gaikwad NW, Selcer KW, Xie W., Sex-Dimorphic and Sex Hormone-Dependent Role of Steroid Sulfatase in Adipose Inflammation and Energy Homeostasis. Endocrinology. 2018 Sep 1;159(9):3365-3377.

7. Knoll M, Winther S, Natarajan A, Yang H, Jiang M, Thiru P, Shahsafaei A, Chavarria TE, Lamming DW, Sun L, Hansen JB, Lodish HF. (2017) SYK kinase mediates brown fat differentiation and activation. Nat Commun. 2017 Dec 13;8(1):2115.

8. Jiang, M., Xu, M., Ren, S., Selcer, K. W., and Xie, W. (2017) Transgenic overexpression of steroid sulfatase alleviates cholestasis. Liver Res. 2017 Jun;1(1):63-69.

9. Zheng Z, Zhao Z, Li S, Lu X, Jiang M, Lin J, An Y, Xie Y, Xu M, Shen W, Guo GL, Huang Y, Li S, Zhang X, Xie W. Altenusin, a Nonsteroidal Microbial Metabolite, Attenuates Nonalcoholic Fatty Liver Disease by Activating the Farnesoid X Receptor. Mol Pharmacol. 2017 Oct;92(4):425-436.

10. Garbacz WG, Jiang M, Xu M, Yamauchi J, Dong HH, Xie W, Sex- and Tissue-specific role of estrogen sulfotranferase in energy homeostasis and insulin sensitivity. Endocrinology. 2017 Nov 1;158(11):4093-4104. Adv Exp Med Biol. 2017; 1043:455-469.

11. Wojciech G Garbacz, Mengxi Jiang, Wen Xie, Sex-Dependent Role of Estrogen Sulfotransferase and Steroid Sulfatase in Metabolic Homeostasis. Advances in experimental medicine and biology. 2017:1043:455-469.

12. Jiang, M., Klein, M., Zanger, U. M., Mohammad, M. K., Cave, M. C., Gaikwad, N. W., Dias, N. J., Selcer, K. W., Guo, Y., He, J., Zhang, X., Shen, Q., Qin, W., Li, J., Li, S., and Xie, W. (2016) Inflammatory regulation of steroid sulfatase: A novel mechanism to control estrogen homeostasis and inflammation in chronic liver disease, Journal of Hepatology 64, 44-52. 

13. Chai, X. *, Guo, Y. *, Jiang, M. *, Hu, B., Li, Z., Fan, J., Deng, M., Billiar, T. R., Kucera, H. R., Gaikwad, N. W., Xu, M., Lu, P., Yan, J., Fu, H., Liu, Y., Yu, L., Huang, M., Zeng, S., and Xie, W. (2015) Oestrogen sulfotransferase ablation sensitizes mice to sepsis (* equal contribution), Nature Communications 6, 7979. 

14. Jiang, M., He, J., Kucera, H., Gaikwad, N. W., Zhang, B., Xu, M., O'Doherty, R. M., Selcer, K. W., and Xie, W. (2014) Hepatic overexpression of steroid sulfatase ameliorates mouse models of obesity and type 2 diabetes through sex-specific mechanisms, The Journal of Biological Chemistry 289, 8086-8097. 

15. Jiang, M., and Xie, W. (2013) Role of the constitutive androstane receptor in obesity and type 2 diabetes: a case study of the endobiotic function of a xenobiotic receptor, Drug Metabolism Reviews 45, 156-163. 

16. Hu, B., Guo, Y., Garbacz, W. G., Jiang, M., Xu, M., Huang, H., Tsung, A., Billiar, T. R., Ramakrishnan, S. K., Shah, Y. M., Lam, K. S., Huang, M., and Xie, W. (2015) Fatty acid binding protein-4 (FABP4) is a hypoxia inducible gene that sensitizes mice to liver ischemia/reperfusion injury, Journal of Hepatology 63, 855-862.

17. Guo, Y., Hu, B., Huang, H., Tsung, A., Gaikwad, N. W., Xu, M., Jiang, M., Ren, S., Fan, J., Billiar, T. R., Huang, M., and Xie, W. (2015) Estrogen Sulfotransferase Is an Oxidative Stress-responsive Gene That Gender-specifically Affects Liver Ischemia/Reperfusion Injury, The Journal of Biological Chemistry 290, 14754-14764.

18. Shi, X., Cheng, Q., Xu, L., Yan, J., Jiang, M., He, J., Xu, M., Stefanovic-Racic, M., Sipula, I., O'Doherty, R. M., Ren, S., and Xie, W. (2014) Cholesterol sulfate and cholesterol sulfotransferase inhibit gluconeogenesis by targeting hepatocyte nuclear factor 4alpha, Molecular and Cellular Biology 34, 485-497.

19. Ou, Z., Jiang, M., Hu, B., Huang, Y., Xu, M., Ren, S., Li, S., Liu, S., Xie, W., and Huang, M. (2014) Transcriptional regulation of human hydroxysteroid sulfotransferase SULT2A1 by LXRalpha, Drug Metabolism and Disposition: the Biological Fate of Chemicals 42, 1684-1689.

20. Xiao, L., Wang, J., Jiang, M., Xie, W., and Zhai, Y. (2013) The emerging role of constitutive androstane receptor and its cross talk with liver X receptors and peroxisome proliferator-activated receptor A in lipid metabolism, Vitamins and Hormones 91, 243-258.

21. Ou, Z., Shi, X., Gilroy, R. K., Kirisci, L., Romkes, M., Lynch, C., Wang, H., Xu, M., Jiang, M., Ren, S., Gramignoli, R., Strom, S. C., Huang, M., and Xie, W. (2013) Regulation of the human hydroxysteroid sulfotransferase (SULT2A1) by RORalpha and RORgamma and its potential relevance to human liver diseases, Molecular Endocrinology (Baltimore, Md.) 27, 106-115.

22. Saini, S. P., Zhang, B., Niu, Y., Jiang, M., Gao, J., Zhai, Y., Hoon Lee, J., Uppal, H., Tian, H., Tortorici, M. A., Poloyac, S. M., Qin, W., Venkataramanan, R., and Xie, W. (2011) Activation of liver X receptor increases acetaminophen clearance and prevents its toxicity in mice, Hepatology (Baltimore, Md.) 54, 2208-2217.

23. Ihunnah, C. A., Jiang, M., and Xie, W. (2011) Nuclear receptor PXR, transcriptional circuits and metabolic relevance, Biochimica et Biophysica Acta 1812, 956-963.

1. 2023.08，CN 114149371 A

2. 2024.12，ZL 2024 2 0905668.X