1、 北京市“青年北京学者”计划，2025/01-2029/12，主持。

2、 国家自然科学基金面上项目32370573，2024/01-2027/12，主持。

3、 科技部国家重点研发计划“合成生物学专项”2022YFA0912401，2022.11-2027.10，课题骨干。

代表性学术论文：

1. D. Ji*, X. Xiao*, A. Luo*, X. Fan, J. Ma, D. Wang, M. Xia, L. Ma, P. Wang, W. Li#, P. Chen#. FACT mediates the depletion of macroH2A1.2 to expedite gene transcription. Molecular Cell (2024) 84, 3011-3025

2. D. Ji*, C. Shao*, J. Yu*, Y. Hou, X. Gao., Y. Wu., L. Wang#, P. Chen#. FOXA1 Forms Biomolecular Condensates that Unpack Condensed Chromatin to Function as a Pioneer Factor. Molecular Cell (2024) 84, 244-260

3. J. Zhao*, J. Lan*, M. Wang*, C. Liu*, A. Song, T. Zhang, L. Wang, B. Zhu, P. Chen#, J. Yu#, G. Li#. H2AK119ub1 differentially fine-tunes gene expression by modulating canonical PRC1- and H1-dependent chromatin compaction. Molecular Cell (2024) 84, 1191-1205

4. P. Chen#, G. Li#, W. Li#. Nucleosome dynamics derived at the single-molecule level bridges its structures and functions. JACS Au (2024) 4, 866−876 

5. A. Luo*, J. Kong*, J. Chen*, X. Xiao*, J. Lan, X. Li, C. Liu, P. Wang, G. Li, W. Li#，P. Chen#. H2B ubiquitination recruits FACT to maintain a stable altered nucleosome state for transcriptional activation. Nature Communications (2023) 14, 741

6. Y. Wang*, C. Liu*, J. Zhao*, J. Yu, A.Luo, X. Xiao, S. Dou, L. Ma, P. Wang, M. Li, G. Li, J. Yan#, P. Chen#, W. Li#.H2A mono-ubiquitination differentiates nucleosomeassembly and disassembly functions of FACT. Nucleic Acids Research (2022) 50, 833-846

7. X. Xiao*, C. Liu*, Y. Pei*, Y. Wang, J.Kong, K. Lu, L. Ma, S. Dou, P. Wang, G. Li, P. Chen# and W. Li#. Histone H2A Ubiquitination Reinforces MechanicalStability and Asymmetry at the Single-nucleosome Level. J. Am. Chem. Soc.(2020) 142,3340-3345

8. H. Long*, L. Zhang*, M. Lv*, Z. Wen*, W.Zhang, X. Chen, P. Zhang, T. Li, L. Chang, C. Jin, G. Wu, X. Wang, F. Yang, J.Pei, P. Chen, R. Margueron, H. Deng, M. Zhu# and G. Li#. H2A.Z facilitates licensing and activation of earlyreplication origins. Nature (2020) 577, 576-581