我校神经生物系是国家和北京市重点学科，教育部神经变性病重点实验室、北京市神经再生修复研究重点实验室和北京市脑重大疾病省部共建国家重点实验室培育基地。首都医科大学拥有SPF级别动物实验中心，可为小鼠提供饲养、手术及取材等条件。本团队所在实验室配备完善的转基因小鼠繁育体系及显微手术操作平台，为神经退行性疾病研究提供强力支撑。

本团队构建了从分子机制到整体动物研究的完整技术链条：特色模型包括T1DM糖尿病模型/斑马鱼疾病模型等；细胞研究平台包括原代神经元培养、原代小胶质细胞培养和多种传代细胞培养；常见技术包括行为学实验、常见的分子生物学和生物化学实验、单细胞测序等生物信息学分析和机器学习等。

本团队与附属医院临床研究中心、军事医学科学院等建立深度合作，打造"临床问题-基础研究-转化应用"的创新闭环。现开展神经变性病分子靶点筛选和疾病预测模型构建等。

我们实行"科研全流程导师制"培养模式，从文献精读到Science/Nature系列论文剖析，课题设计→技术攻关→数据可视化→论文撰写的完整科研周期。现有教副教授2人、在读硕士研究生5人，近几年在高水平学术期刊发表论文数篇。我们期待具有科研热忱、勇于探索生命奥秘的优秀学子加入，共同破解神经疾病的密码！

1. 国家自然科学基金面上项目, 82071539, 2021.01-2024.12.

2. 北京市自然科学基金面上项目, 7232003, 2023.01-2025.12.

3. 北京市自然科学基金面上项目, 7192016, 2019.01-2021.12.

4. 北京市教育委员会科技计划一般项目, KM201910025029, 2019.01-2021.12.

5. 北京高等学校高水平人才交叉培养计划——实培计划, 2020.10-2021.12.

6. 国家自然科学基金青年项目, 81400948, 2015.01—2017.12.

7. 北京市自然科学基金青年项目, 7144188, 2014.01-2015.12.

8. 北京市教育委员会科技发展计划面上项目, KM201410025004, 2014.01-2016.12.

9. 教育部留学回国人员科研启动基金, 0117-514025, 2011.01-2014.01

[1] Yi Yan, Zhaohui Wang, Xiao Liu, Song Han, Junfa Li, YingZhang*, Li Zhao *. Identification ofbrain endothelial cell‑specific genes and pathways in ischemic stroke byintegrated bioinformatical analysis. Brain Circ., 2023, 9(4) :228-239.

[2] Yue Liu, Yuan Yuan, Yi Yan, Ruyue Wang, Zhaohui Wang,Xiao Liu, Ying Zhang, Jianyu Hua, Yue Wang, Li Zhao*. Mitochondrial pyruvatecarrier 1 alleviates hypoxic-ischemic brain injury in rats. Life Sci., 2023, 325:121686. 

[3] Ying Zhang, Longhui Ma, Yi Yan, Li Zhao, Song Han, Di Wu, Cesar V Borlongan, Junfa Li*, Xunming Ji*.cPKCγ-Modulated Autophagy Contributes to Ischemic Preconditioning-InducedNeuroprotection in Mice with Ischemic Stroke via mTOR-ULK1 Pathway. TranslStroke Res., 2023,14(5):790-801.

[4] Jiayin Zheng, Yue Wang, Yue Liu, Song Han, Ying Zhang,Yanlin Luo, Yi Yan, Junfa Li*, Li Zhao*. cPKCγ deficiency exacerbatesautophagy impairment and hyperphosphorylated Tau buildup through AMPK/mTORpathway in mice with type 1 diabetes mellitus. Neurosci Bull., 2022,38(10):1153-1169.

[5] Yue Wang, Yue Liu, Yuan Yuan, Ying Zhang, Yanlin Luo,Song Han, Yi Yan, Zhaohui Wang, Xiao Liu, LiZhao*. Downregulation of mitochondrial pyruvate carrier 2 aggravatesneuronal injury in the cortex following cerebral ischemia in rat. Brain ResBull., 2022 185:193-202.

[6]Yan-LinLuo , Yuan-Ying Wang , Su-Fang Zhu, Li Zhao, Yan-Ling Yin, Meng-Wen Geng , Chu-QiLei, Yan-Hui Yang, Jun-Fa Li, Guo-Xin Ni. An EZ-diffusion model analysis ofattentional ability n patients with retinal pigmentosa. Front Neurosci., 2021,1(14): 583493.

[7] YueWang , Qian Dong , Yu-Dan Chen , Wen-Li Hu , LiZhao*. IntracranialEpstein-Barr virus infection appearing as an unusual case of meningitis in animmunocompetent woman: a case report. J Int Med Res., 2020,48(2):300060520903215.  1-6

[8] YanlinLuo, Jingwei Bian, Zhijun Zheng, Li Zhao, Song Han, Xiaohong Sun, Junfa Li, GuoxinNi. Effects of methamphetamine abuse on spatial cognitive function. Sci Rep.,2018, 8(1): 5502.

[9] ZhiZhang, Frederico Machad, Li Zhao, Charlotte A Heinen, Ewout Foppen,Mariette T Ackermans, Jiangning Zhou, Peter H Bisschop , Anita Boelen, EricFliers, Andries Kalsbeek. Administration of Thyrotropin-Releasing Hormone inthe Hypothalamic Paraventricular Nucleus of Male Rats Mimics the Metabolic ColdDefense Response. Neuroendocrinology, 2018, 107(3):267-279.

[10] JiayinZheng, Yue Wang, Song Han, Yanlin Luo, Xiuli Sun, Ning Zhu, Li Zhao*, Junfa Li*. Identification of ProteinKinase C Isoforms Involved in Type 1Diabetic Encephalopathy in Mice. J DiabetesRes., 2018, 2018:8431249.

[11] DanZhang, Song Han, Shizun Wang, Yanlin Luo, Li Zhao*, Junfa Li*. cPKCγ-mediateddown-regulation of UCHL1 alleviates ischaemic neuronal injuries by decreasingautophagy via ERK-mTOR pathway. J Cell Mol Med., 2017, 21(12): 3641-3657.