王玉记教授带领的团队目前由多位青年教师以及8名博士生和11名硕士生组成。其中青年教师均具有博士学位和国外留学及科研的经历。总体来说是一支年轻化、能力强，具有较高科研水平和可持续发展的优秀团队。

主持项目

1. 2018-2020年 北京长城学者项目，小分子PAD4抑制剂抗肿瘤药物研究，300万

2. 2015-2018年 科技部863青年科学家项目，小分子抗肿瘤药物纳米制备技术研究，117万

3. 2015年 北京市科技转化项目，鸟氨酸试剂盒的开发研究，50万

4. 2015-2018年 北京市高创计划项目，小分子纳米抗肿瘤药物研究，50万

5. 2014-2017年 国家自然科学基金面上项目可对接PAD4活性口袋扰乱肿瘤细胞自噬的精氨酸衍生物的构效关系研究，61万

6. 2013年 北京市科技新星项目，新型PAD4抑制剂的合成及抗肿瘤分子机理研究，35万

7. 2009-2011年 国家自然科学基金青年项目N-葡萄糖基-L-氨基酸络二氯铂的设计合成与抗肿瘤活性评价，19万

发表SCI论文80余篇，第一作者或责任作者论文31篇

1.Wen Pan#,Geng Hu#, Shaorong Li#,Guoqing Li, Xiaoyu Feng, Zhifang Wu,Dong Zhang, Lizheng Qin, Xue Wang, Liang Hu,Junji Xu, Lei Hu, Yijiang Jia, Xin Wen, Jinsong Wang, Chunmei Zhang, Jian Zhou,Wenbin Li, Xiaogang Wang*, YujiWang*, Songlin Wang*. Nanonitrator:novel enhancer of inorganic nitrate’s protective effects, predicated on swarmlearning approach. Science Bulletin, 2023, S2095-9273(23)00220-7.doi:10.1016/j.scib.2023.03.043, IF=20.577

2.Xinmiao Lan, Jie Zhong,Regina Huang, Yuhan Liu, Xiaowei Ma, Xuan Li, Dan Zhao, Guangchao Qing, YuxuanZhang, Lu Liu, Jinjin Wang, Xu Ma, Ting Luo, Weisheng Guo, Yuji Wang*,Li-Li Li*,Yu-Xiong Su*,Xing-Jie Liang*.Conformation Dependent Architectures of Assembled Antimicrobial Peptides withEnhanced Antimicrobial Ability. Adv Healthc Mater, 2023, 4:e2301688. doi:10.1002/adhm.202301688. Epub ahead of print. PMID: 37540835, IF=10.0

3.Pang Y, Shi R, Chan L, Lu Y,Zhu D, Liu T, Yan M*,Yuji Wang*, Wang Wang*.The combination of the HDC1 inhibitor SAHA and doxorubicin has synergicefficacy in triple negative breast cancer in vivo. Pharmacol Res. 2023, 106926.doi: 10.1016/j.phrs.2023.106926, IF=9.3

4.Di Zhu, Yu Lu, Bo Hu, Yuheng Pang, BingruLiu, Miao Zhang, Wenjing Wang*, YujiWang*. Highly-tumor-targetedPAD4 inhibitors with PBA modification inhibit tumors in vivo by specificallyinhibiting the PAD4-H3cit-NETs pathway in neutrophils. European Journal ofMedicinal Chemistry, 2023, 258:https://doi.org/10.1016/j.ejmech.2023.115619.  IF=7.088

5.Yu Lu,Di Zhu, Liujia Chan, Bu Hu, Marmar Tuohan, Li Li, Wei Wang*,Yuji Wang*. The ruthenium complexassists in nuclear targeting and selective killing of tumor cells. Nanoscale,2023, 15, 11529 doi: 10.1039/d3nr02707d  IF=8.307

6.Shuangling Chen, Meng Liang, Chengli Wu, Xiaoyi Zhang, YujiWang*, Ming Zhao*. Poly-ɑ, β-d, l-Aspartyl-Arg-Gly-Asp-Ser-Based Urokinase Nanoparticles forThrombolysis Therapy. Molecules, 2023, 28, 2578: 1-16. IF=4.927

7.Yan Shang Gu, Yu Lu, Yuji Wang*, Wensheng Lu, Wei Wang*. LowMolecular Weight Hydrogel for Wound Healing. Pharmaceutics, 2023, 15,  IF=6.5

8.Jie Zhong, Weiye Wen, Jinjin Wang, MengyuZhang, Yijiang Jia, Xiaowei Ma, Yu-xiong Su*, Yuji Wang*. Xinmiao Lan*. Bone-Targeted Dual Functional Lipid-coated Drug Delivery System forOsteosarcoma Therapy. Pharm Res, 2023, 40:231-243. IF=4.58

9.Bing Li, Yingxu Li, Shuangling Chen, Yuji Wang, Yuanyuan Zheng*. VEGF mimetic peptide-conjugated nanoparticles formagnetic resonance imaging and therapy of myocardial infarction. J ControlRelease, 2023 Jun 15:S0168-3659(23)00390-5. doi: 10.1016/j.jconrel.2023.06.017.IF=11.467

10.Di Zhu#, Yu Lu#, Lin Gui, Wenjing Wang, XiHu, Su Chen, Yanming Wang, Yuji Wang*. Self-assembling, pH-responsive nanoflowers forinhibiting PAD4 and neutrophil extracellular trap formation and improving thetumor immune microenvironment. ActaPharmaceutica Sinica B, 2022,12: 2552.  IF=14.9

11.Yu Lu, Di Zhu,Quynh Bao Truong Le, YujiWang*, Wei Wang*. Ruthenium-based antitumor drugsand delivery systems from monotherapy to combination therapy. Nanoscale, 2022,doi.org/10.1039/D2NR02994D  IF=8.307 outside front cover

12.Di Zhu, Yu Lu, Yanming Wang*, Yuji Wang*. PAD4and its inhibitors in cancer progression and prognosis. Pharmaceutics, 2022, Pharmaceutics,2022,14, 2414  IF=6.5

13. Yu Lu, Di Zhu, Quynh Le, Yuji Wang*, Wei Wang*. An NMRstudy on hydration and molecular interaction of phytantriol-based liquidcrystals. Pharmaceutics, 2022, 14, 2312  IF=6.5

14. Yu Lu, Di Zhu, Lin Gui, Yuanming Li, Wenjing Wang, Jiawang Liu YujiWang*. A dual-targeting ruthenium nanodrug that inhibits primarytumor growth and lung metastasis by the PARP/ATM pathway. Journal ofNanobiotechnology, 2021, 19:115.  IF=10.4

15. Yu Lu, ZidongPeng, Di Zhu, Yijiang Jia, Ayijiang Taladaohan, Yuanming Li, Jiawang Liu,Yanming Wang, Yuji Wang*, RGD Peptide and PAD4 Inhibitor-Loaded Gold Nanorods forChemo-Photothermal Combined Therapy to Inhibit Tumor Growth, Prevent LungMetastasis and Improve Biosafety. International Journal of Nanomedicine 2021, 16:5565.  IF=6.40

16. Ming Wei, Xia Wang, Yanting Song, Di Zhu, Dan Qi, Shiyu Jiao, Guomin Xie, Ye Liu, Baoqi Yu, Jie Du, Yuji Wang*, Aijuan Qu*. Inhibitionof peptidyl arginine deiminase 4-dependent neutrophil extracellular trapsformation reduces angiotensin II-induced abdominal aortic aneurysms rupture inmice. Front Cardiovasc Med. 2021,8:676612. IF=6.04

17.Peng Wang, Lin Gui, Yuji Wang,* Sheng Wang*. In vitro evaluation of a pectin-RGDS-OC8H17-paclitaxelnano-particle coated balloon. Applied Nanoscience, 2021, 11:1339.

18.Yu Zhao, Ran Lu, Xin Wang, Xiaochen Huai,Caiyun Wang, Yuji Wang*, Su Chen*. Visible light-induced antibacterial and osteogenic cell proliferationproperties of hydrogenated TiO2 nanotubes/Ti foil composite. Nanotechnology, 2021, 32:195101.

19.Songlin Song, Lin Gui, Qiqi Feng, Ayijiang Taledaohan,Yuanming Li, Wei Wang, Yanming Wang and Yuji Wang*. TAT-modifiedgold nanoparticles enhance the anti-tumor activity of PAD4 inhibitors.International Journal of Nanomedicine. 2020:15 6659.

20.Xueyuan Chen, YiZheng, Songlin Song,Ying Liu, Yi Wang,Yong Huang,Xiaoyi Zhang, Meng Zhang, MingZhao, Yuji Wang*, LiLi*.Design andSynthesis of Biotinylated Bivalent Carboline Derivatives as Potent AntitumorAgents. J. Org. Chem. 2020, 85, 18, 11618.

21.Yuji Wang, Xinyi Xu, Ce Song, Jianhui Wu, Xi Hu, Haimei Zhu,Xiaoyi Zhang, Yaonan Wang, Lin Gui, Ming Zhao, Shiqi Peng. ATIQCTPCtargeting MMP-9: A key step to slowing primary tumor growth and inhibiting metastasisof Lewis lung carcinoma in vivo. Oncotarget, 2017, 2017, 8: 63881.

22.Yuji Wang, Jingcheng Tang, Haimei Zhu, Xueyun Jiang, JiawangLiu, Wenyun Xu, Haiping Ma, Qiqi Feng, Jianhui Wu, Ming Zhao, Shiqi Peng.Aqueous extract of Rabdosia rubescens leaves: forming nanoparticles, targetingP-selectin, and inhibiting thrombosis. International Journal of Nanomedicine,2015, 10:6905.

23.GuifengKang, Yuji Wang (Co-first author),Jiawang Liu, Jianhui Wu, Ming Zhao, Guochun Li, Ning Li, Li Peng, Xiaoyi Zhang,Li Li, Nathan Mair, Shiqi Peng. Development of three-component conjugates: Toget nano-globes with porous surface, high in vivo anti-osteoporosis activityand minimal side effects. Journal of Materials Chemistry, 2012, 22:21740.

24.Yuji Wang, Jianhui Wu, Guifeng Kang, Ming Zhao, Lin Gui, NingLi, Li Peng, Xiaoyi Zhang, Li Li, Shiqi Peng. Novel nano-materials,RGD-tetrapeptide-modified 17b-amino-11a-hydroxyandrost-1,4- diene-3-one:synthesis, self-assembly based nano-images and in vivo anti-osteoporosisevaluation. Journal of Materials Chemistry, 2012, 22:4652.

25. Yuji Wang, Pingxin Li, Shu Wang, Jing Hu, Xiangyun Amy Chen,Jianhui Wu, Megan Fisher, Kira Oshaben, Na Zhao, Ying Gu, Dong Wang, Gong Chen,Yanming Wang. Anticancer PAD inhibitors regulate the autophagy flux and themammalian target of rapamycin complex activity. Journal of BiologicalChemistry, 2012, 287:25941.

26.HuiliangZhang, Yuji Wang (Co-first author),Ming Zhao, Jianhui Wu, Xiaoyi Zhang, Lin Gui, Meiqing Zheng, Li Li, JiawangLiu, Shiqi Peng. Synthesis and In Vivo Lead Detoxification Evaluation ofPoly-α,β-DL-aspartyl-L-methionine. Chemical Research in Toxicology, 2012,25:471.

27. Yuji Wang, Kang Guifeng, Liu Jiawang, Zhao Ming, Wu Jianhui,Zhang Xiaoyi, Li Ye, Zhong Xiaobo, Yang Yifan and Peng Shiqi. Novel potassiumN-[(2S,3R,4R,5R)-2,3,4,5,6-Pentahydroxylhex-1-yl]-L-amino acid dichloro-platinates (II) with high anti-tumor activity and low side reaction.Metallomics, 2012, 4:441.

28.Yuji Wang, Xueyun Jiang, Jiawang Liu, Ming Zhao, Guifeng Kang, JianhuiWu, Li Peng, Shiqi Peng. HPLC-MS aided PC12 cell systems: to quantitativelymonitor the conversion of nitronyl nitroxide in biological systems with andwithout NO. Molecular BioSystems, 2011, 7:1678.

29.YujiWang, Guifeng Kang, MingZhao, Jianhui Wu, Xiaoyi Zhang, Yifan Yang, Jiawang Liu, Shiqi Peng. A newplatinum-complex showing easy preparation, promising anti-tumor activity, andbetter efficacy and distribution properties than oxaliplatin. MolecularBioSystems, 2011, 7:3245.

30.Yuji Wang, Lei Wei, Ming Zhao, Shenghui Mei, Meiqing Zheng,Yifan Yang, Hong Wang, Gong Chen, Shiqi Peng. Development of highly effectivethree-component cytoprotective adjuncts for cisplatin cancer treatment:synthesis and in vivo evaluation in S180-bearing mice. Metallomics, 2011,3:1212.

31. Yuji Wang, Lanrong Bi, Baoguang Hou, Yu Chen, Ming Zhao, ChaoWang, Wei Wang, Jingfang Ju, Shiqi Peng. Design and synthesis ofpentahydroxylhexylamino acids and their effect on lead decorporation. ChemicalResearch in Toxicology, 2007, 20:609.

专利授权267项，代表如下：

1. 王玉记, 王伟, 卢玉, 阿依江. 一种PHTrp-Cu络合物及其制备方法、低分子量水凝胶制剂及其制备方法；202010716158.4（已授权）

2. 王玉记，刘佳望，高洁，阿依江，玛尔玛尔，周建，一种基于(S)-2-癸酰氨基-3-(1-萘基)丙酰基-亮氨酰-缬氨酸的紫杉醇胶束。202110060528.8（已授权）

3. 王玉记，冯琦琦，高洁，贾翌江，李元明，卢燃，氨基酸衍生物及其制备方法和应用、一种抗肿瘤胶束及其制备方法。202110011732.0（已授权）

4. 王玉记, 李元明, 王彦明, 宋松林, 贾翌江, 桂琳. 王玉记, 王彦明, 朱迪, 卢玉, 刘波涛, 曲爱娟. 可荧光示踪的氨基酸衍生物及其制备方法和应用；202010766644.7（已授权）

5. 王玉记，王彦明，朱迪，卢玉，阿依江，贾翌江，王炜，小分子PAD4抑制剂及其制备方法和应用。202110012190.9（已授权）

6.王玉记, 刘佳望, 桂琳, 卢玉, 朱迪, 阿依江. 咔啉钌类络合物及其制备方法和应用；202010750075.7已授权（已授权）

7.王玉记, 张启迪, 王彦明, 彭紫东, 阿依江, 冯琦琦. 含RGD序列肽的纳米载体及其制备方法、载药体系及其制备方法和应用。202010566900.8（已授权）

8.王松灵;王玉记;秦力峥;胡亮;胡磊;李国情.一种微囊及其制备方法和在预防和/或治疗放射治疗引起的唾液腺损伤中的应用;专利号：202110951722.5（已授权）

9.王松灵;王玉记;李文斌;冯晓宇;潘雯;吴志芳;周建。一种硝酸盐和维生素C微囊在治疗干燥综合征中的应用；专利号：202110951708.5（已授权）

10.王玉记, 王盛, 李元明, 姜钱晨, 贾翌江, 朱迪. 一种药物涂层球囊用药物涂覆液、药物涂层球囊；专利号202010581872.7（已授权）

11.王玉记, 李元明, 王彦明, 宋松林, 贾翌江, 桂琳. 一种纳米药物载体及其制备方法、载药体系及其制备方法和应用。20201056247.5（已授权）

12. 周建, 王松灵, 王玉记. 一种促进牙本质再生的纳米颗粒、凝胶及其制备方法和应用。2021102401177（已授权）

13. 赵明,王玉记,樊琦. 6-(乙酰-AA-巯基)嘌呤,其合成,与顺铂联用的活性和应用.CN112110925B（已授权）

14.赵明,王玉记,樊琦. 6-S,9-N-(二乙酰-Lys-OBzl-巯基)嘌呤、其合成、活性和应用. CN112125905B（已授权）

15.赵明,王玉记,樊琦. 6-S,9-N-(二乙酰-Lys-OBzl-巯基)嘌呤,其合成,活性和应用.CN112110924B.（已授权）

16. 卢燃，姚尧，王玉记，周建，陈溯。一种Ta离子掺杂二氧化钛纳米管及其制备方法和应用。CN116288595A（已授权）

17.卢燃，姚尧，王玉记等. 一种Ta离子掺杂二氧化钛纳米管及其制备方法和应用[P]. 北京市：CN116288595B,2023-09-01.（已授权）

18.赵明,王玉记,樊琦. 6-(乙酰-AA-巯基)嘌呤,其合成,与顺铂联用的活性和应用[P]. 北京市：CN112110925B,2023-06-27.（已授权）

19.赵明,王玉记,樊琦. 6-S,9-N-(二乙酰-Lys-OBzl-巯基)嘌呤、其合成、活性和应用[P]. 北京市：CN112125905B,2023-04-07.（已授权）

20.赵明,王玉记,樊琦. 6-S,9-N-(二乙酰-Lys-OBzl-巯基)嘌呤,其合成,活性和应用[P]. 北京市：CN112110924B,2023-01-13.（已授权）

1.        2023年北京市教书育人先锋

2.        2022年北京市优秀教师

3.        2021年北京市教育教学成果一等奖（排名2）

4.        2018年北京市青年教学名师

5.        2015年北京市高创计划“青年拔尖人才”

6.        2014年霍英东青年教师奖三等奖

7.        2013年北京市科技新星

8.        2011年北京市教育先锋号（排名2）