National Ministry ofScience and Tech foundation

·       2017.7-2020.12National Key R&D Program I.D. 2017YFC0909601 (RMB16,000,000 PI)

 Discovery and application of individual targets for diabetes mellitus

National Science Foundationof China (NSFC) Grants

·       2020.01-2024.12NSFC Project Grant I.D. 8193000241 (RMB3,000,000 PI)

Effects of KCNH6 Channel on theRegulation of Incretin Secretion

·       2016.01-2020.12NSFC Project Grant I.D. 81561128015 (RMB3,528,000 PI)

Biomarkers for the treatment andprognosis of sight-threatening diabetic retinopathy

·       2015.01-2018.12NSFC Project Grant I.D. 81471014 (RMB1,500,000 PI)

Modelling of diabetic animals withhumanized gene mutation and knockout of hERG gene

·       2013.01-2016.12NSFC Project Grant I.D. 81270918 (RMB 800,000 PI)

Coregulating factors ofATP-sensitive potassium channel and insulin secretion

·       2011.01-2013.12NSFC Project Grant I.D. 81070644 (RMB 320,000 PI)

Mechanism of Ang (1-7) on promotingislet β cell insulin secretion

·       2009.01-2011.12NSFC Project Grant I.D. 30871187 (RMB 300,000 PI)

Impact of pancreatic exocrinefunction on endocrine islet function

·       2007.01-2009.12NSFC Project Grant I.D. 30671001 (RMB 290,000 PI)

Impact of pancreaticangiotensin-converting enzyme 2 on islet function

Other Grants

·       2012.01-2015.12Beijing Municipal Science and Technology Project I.D. D171100002817005 (RMB3,600,000 PI)

      Diagnostic value of new microvascularbiomarkers in predicting diabetic nephropathy

·       2012.01-2015.12National 863 Project Grant I.D.2012AA02A201 (RMB 20,000,000)

Genomics and bioinformatics studyon major diseases / diabetes (RMB 1,000,000 Sub-PI)

·       2013.01-2016.12Beijing Natural Science Foundation Grant I.D. 7131005 (RMB 650,000 PI)

The mechanisms of islet local ACE2regulation of insulin secretion through mitochondrial

·       2012.01-2015.12Beijing Municipal Science and Technology Project

Pre-diabetes screening study I.D.D12110000412001 (RMB 1,500,000 PI)

·       2006.01-2008.12Beijing Capital Medical Res. Foundation I.D. 2005-2008 (RMB 100,000 PI)

Microangiopathy in pre-diabetespopulation

·       2011.01-2012.12Beijing Capital Medical Res. Foundation I.D. 2009-Z-SQ03 (RMB 300,000 PI)

Researchon the management and predicting model for prediabetes in community population

Selected Publications: 

1.    Zhao MM, Zhu Y, Zhang L, Zhong G, Tai L, Liu S, Yin G, Lu J, He Q, Li MJ, Zhao RX,Wang H, Huang W, Fan C, Shuai L, Wen Z, Wang C, He X, Chen Q, Liu B, Xiong X,Bu Z, Wang Y, Sun F, Yang JK. Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies. Cell Discovery 2022, 8(1):53.

2.    CaoX, Shi TT, Zhang CH, Jin WZ, Song LN, Zhang YC, Liu JY, Yang FY, Rotimi CN, XuA, Yang JK. ACE2 pathway regulates thermogenesis and energy metabolism. eLife 2022 11:e72266.

3.    LiuC, Yuan YC, Guo MN, Xin Z, Chen GJ, Bentley AR, Hua L, Zheng JP, Ekoru K, Yang JK. Incidence of Type 1 Diabetes May Be Underestimated in the Chinese Population: Evidence From 21.7 Million People Between 2007 and 2017. Diabetes Care 2021, 44(11):2503-2509

4.    ZhaoMM, Lu J, Li S, Wang H, Cao X, Li Q, Shi TT, Matsunaga K, Chen C, Huang H,Izumi T, Yang JK. Berberine is an insulin secretagogue targeting the KCNH6 potassium channel. Nature Communications 2021, 12(1):5616.

5.    Yang JK, Lu J, Yuan SS, Asan, Cao X, Qiu HY, Shi TT, Yang FY, Li Q, Liu CP et al: From Hyper- to Hypoinsulinemia and Diabetes: Effect of KCNH6 on Insulin Secretion. Cell Reports 2018, 25(13):3800-3810

6.    Yang JK, Wang YY, Liu C, ShiTT, Lu J: Urine Proteome Specific for Eye Damage Can Predict Kidney Damage in Patients With Type 2 Diabetes: A Case-Control and a 5.3-Year Prospective Cohort Study. Diabetes Care 2017, 40(2): 253-260.

7.    Yang JK, Zhou JB, Xin Z, ZhaoL, Yu M, Feng JP, Yang H, Ma YH: Interactions among related genes of renin-angiotensin system associated with type 2 diabetes. Diabetes Care 2010,33(10):2271-2273.

8.    Yang JK, Liu W, Shi J, Li YB:An association between subclinical hypothyroidism and sight-threatening diabetic retinopathy in type 2 diabetic patients. Diabetes Care 2010, 33(5):1018-1020.