
长期致力于食品安全检测技术研究,污染物健康效应及风险评估研究。主持和参与多项国家级、省部级科研项目,在Food chemisty,Analytica Chimica Acta,Food Control 等国内外学术期刊发表文章五十余篇,出版著作1 部,获得专利授权2 项,制定国家标准3 项,获得华夏医学科技奖一等奖1 项,北京市科技奖三等奖1 项,入选北京市高层次公共卫生技术人才。
主持课题:
1. 高层次公共卫生技术人才建设项目(学科骨干-02-15),北京市卫生健康委员会
2. 法规差异性有害物高通量测定技术研究(2017YFC1601605),科技部重点研发计划
3. 环境因素对出生缺陷影响的前瞻性研究(2016YFC1000103)子课题,科技部重点研发计划
4. 虾过敏原蛋白存在水平及抗原表位场流分离快速识别技术研究(7162088),北京市自然科学基金
论文:
1. Yi Yang, Jiachen Shi, Jie Yin, Yunjia Yang, Bing Shao,Jing Zhang*. Occurrence and Estimated Daily Intake of Cortisone and Cortisol in Aquatic Food from China TDS. Foods, 2022, 11, 3481.
2. Yang Li, Yunjia Yang, Yue Zou, Lin Shu, Nan-yin Han, Yi Yang*. Characterization of the molecular properties and allergenicity (IgE-binding capacity) of β-lactoglobulin by heat treatment using asymmetric-flow field-flow fractionation and ultra-performance liquid chromatography quadrupole time of flight mass chromatography. Food Chemistry, 2022,374,131748.
3. Yang Li, Yi Yang*, Yinghui Liu, Jinyuan Liu, Yunjia Yang, Jing Zhang, Yue Zou, Lin Shu, Nanyin Han, Bing Shao. Combination of magnetic beads extraction and ultraperformance liquid chromatography tandem mass spectrometry detection for the clinical diagnosis of allergies. Analytica Chimica Acta, 2022,1221,340157.
4. Qihui Liang, Yang Li, Yue Zou, Lin Shu, Nanyin Han, Yi Yang*. Effect of parameters on retention behavior of ovalbumin and immunoglobulin E in asymmetrical flow field-flow fractionation. Journal of Separation science plus, 2022, https://doi.org/10.1002/sscp.202200075
5. Qiaozhen Guo, Yi Yang, Jing Zhang. Rapid screening for 315 drugs in food and biological matrices by ultrahigh-performance liquid chromatography quadrupole time of flight mass spectrometry and its application to a specific incident. Journal of Separation Science Plus, 2022, https://doi.org/10.1002/sscp.202200037
6. Guo, Q., Yang, Y., Li, J., Shao, B. and Zhang, J. Screening for Plant Toxins in Honey and Herbal Beverage by Ultrahigh-Performance Liquid Chromatography-Ion Mobility-Quadrupole Time of Flight Mass Spectrometry. American Journal of Analytical Chemistry, 2022,13, 108-134.
7. Yi Yang*, Huanhuan Yu, Yunjia Yang, Jing Zhang, Jie Yin, Bing Shao. Simultaneous Determination of 118 Pesticides in Vegetables by Atmospheric Pressure Gas Chromatography−Tandem Mass Spectrometry and QuEChERs Based on Multiwalled Carbon Nanotubes. ACS Agric. Sci. Technol, 2021, 1, 5, 460–468.
8. Yang, Y.*, Liu, H., Zeng, W., Yang, Y., Zhang, J., Jie, Y., Wu, J., Lai, K. Characterization and epitope prediction of phosphopyruvate hydratase from Penaeus monodon (black tiger shrimp). J Food Sci, 2021,86(8), 3457-3466.
9. Ze Li, Jing Zhang, Yunjia Yang, Huilan Xu, Jianwu Wang, Yi Yang*. Determination of Sulfonamides in Milk by Cloud Point - Salting Out Extraction and Ultra High Performance Liquid Chromatography Tandem Mass Spectrometry. Analytical Sciences, 2020, 36(12),1555-1559.
10. Weichunbai Zhang, Jing Du, Hong Li, Yi Yang, Chang Cai, Qun Gao, Yang Xing, Bing Shao*, Gang Li*. Multiple-element exposure and metabolic syndrome in Chinese adults: A case-control study based on the Beijing population health cohort. Environment International, 2020, 143, 105959.
11. Yunjia Yang, Yi Yang, Jing Zhang, Bing Shao, Jie Yin. Assessment of bisphenol A alternatives in paper products from the Chinese market and their dermal exposure in the general population. Envitonmental Pollution, 2019, 244, 238-246
12. Xin Zhang, Yunjia Yang, Jing Zhang, Yi Yang, Fan Shen, Jianzhong Shen, Bing Shao. Determination of emerging chlorinated byproducts of diazepam in drinking water. Chemosphere, 2019, 218, 223-231
13. Kailun Qi, Tong Liu, Yunjia Yang, Jing Zhang, Jie Yin, Xiaojing Ding, Weijie Qin, Yi Yang*. A rapid immobilized trypsin digestion combined with liquid chromatography – Tandem mass spectrometry for the detection of milk allergens in baked food. Food Control, 2019,102,179-187.
14. Yunjia Yang, Jing Zhang, Jie Yin, Yi Yang*. Fast Simultaneous Determination of Eight Sudan Dyes in Chili Oil by Ultra-High-Performance Supercritical Fluid Chromatography. Journal of Analytical Methods in Chemistry, 2019, 1, 3731028.
15. Yunjia Yang, Jiachen Shi, Yi Yang, Jing Zhang, Bing Shao. Transformation of sulfamethazine during the chlorination disinfection process: Transformation, kinetics, and toxicology assessment. Journal of Environmental Sciences, 2019, 76, 48-56
16. Sai Zheng, Jiachen Shi, Jing Zhang, Yi Yang, Jianying Hu, Bing Shao. Identification of the disinfection byproducts of bisphenol S and the disrupting effect on peroxisome proliferator-activated receptor gamma (PPARγ) induced by chlorination. Water Research, 2018, 132, 167-176
17. Yi Yang, Yunjia Yang, Bing Shao, Jing Zhang*. A Simple and Rapid Method for Determination of Patulin in Juice by High Performance Liquid Chromatography Tandem Mass Spectrometry. Food Anal. Methods, 2017, 10, 2913-2918
18. Yi Yang, Yin Zhang, Jing Zhang and Bing Shao. Identification of metabolites of AHTN in rat urine and feces by liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Analytical Methods, 2015, 7, 4443-4449.
19. Jennifer Neumann, Yi Yang, Rebecca Kohler, Marco Giaisi, Mathias Witzens-Harig, Dong Liu, Peter H. Krammer, Wenhan Lin*, Min Li-Weber*. Mangrove dolabrane-type of diterpenes tagalsins suppresses tumor growth via ROS-mediated apoptosis and ATM/ATR–Chk1/Chk2-regulated cell cycle arrest. International Journal of Cancer, 2015, 137, 2739-2748.
20. Yi Yang, Yang Zhang, Dong Liu, Min Li-Weber, Bing Shao, Wenhan Lin. Dolabrane-type diterpenes from the mangrove plant Cerips tagal with antitumor activities. Fitoterapia, 2015, 103, 277-282.
21. Yi Yang, Jing Zhang, Bing Shao. Quantitative analysis of fourteen synthetic dyes in jelly and gummy candy by ultra performance liquid chromatography. Analytical Methods, 2014,6,5872-5878
22. Jinwei Ren, Yi Yang, Dong Liu, Wei Chen, Peter Proksch, Bing Shao, Wenhan Lin. Sequential determination of new peptaibols asperelines G-Z12 produced by marine-derived fungus Trichoderma asperellum using ultrahigh pressure liquid chromatography combined with electrospray-ionization tandem mass spectrometry. Journal of Chromatography A, 1309 (2013) 90– 95
23. Ming Li, Yunjia Yang, Yi Yang, Jie Yin, Jing Zhang, Bing Shao, Biotransformation of bisphenol AF to its major glucuronide metabolite reduces estrogenic activity. PLOS ONE,2013,8(12), e83170
24. Yunjia Yang, Jie Yin, Yi Yang, Naiyuan Zhou, Jing Zhang, Bing Shao, Yongning Wu, Determination of bisphenol AF (BPAF) in tissues, serum, urine and feces of orally dosed rats by ultra-high-pressure liquid chromatography–electrospray tandem mass spectrometry. Journal of Chromatography B, 901 (2012) 93– 97
25. Yi Yang, Jie Yin, Yongning Wu, Bing Shao*, Simultaneous determination of five aluminum lake dyes in chewing gum by HPLC with photodiode array detection. Food Additives and Contaminants, 2011, 28(9):1159-1167.
26. Hao Wang, Jing Zhang, Fudie Gao, Yi Yang, Hejun Duana, Yongning Wu, Jean-Daniel Berset, Bing Shao*, Simultaneous analysis of synthetic musks and triclosan in human breast milk by gas chromatography tandem mass spectrometry. Journal of Chromatography B, 2011, 879:1861– 1869
27. Jie Yin, Yi Yang, Keji Li, Jing Zhang, Bing Shao. Analysis of Anticancer Drugs in Sewage Water By Selective SPE and UPLC–ESI-MS–MS. Journal of Chromatography Science, 2010, 48:781-789.
28. Bing Shao*, Xiaoliang Cui, Yi Yang, Jing Zhang, Yongning Wu, Hejun Duan Validation of a Solid-phase Extraction and Ultra Performance Liquid Chromatography Tandem Mass Spectrometric Method for the Detection of Sixteen Glucocorticoids in Pig Tissues. Journal of AOAC International, 2009, 92(2), 604-611.
29. Yi Yang, Bing Shao*, Jing Zhang, Yongning Wu, Hejun Duan. Determination of the residues of 50 anabolic hormones in muscle, milk and liver by very-high-pressure liquid chromatography–electrospray ionization tandem mass spectrometry. Journal of Chromatography B, 2009, 877, 489-496.
30. Ke Ma, Yi Yang, Zhiwei Deng, Nicole J. de Voogd, Peter Proksch, and Wenhan Lin. Two New Bromotyrosine Derivatives from the Marine Sponge Pseudoceratina sp. CHEMISTRY & BIODIVERSITY, 2008, 5,1313-1320
31. Xiaofei Jia, Bing Shao*, Yongning Wu, Yi Yang, Jing Zhang, Simultaneous Determination of Tetracylines and Quinolones Antibiotics in Egg by Ultra-Performance Liquid Chromatography–Electrospray Tandem Mass Spectrometry. Journal of AOAC International, 2008, 91, 461-468.
32. Yi Yang, Bing Shao*, Jing Zhang, Analysis of eight free progestogens in eggs by matrix solid-phase dispersion extroaction and very high pressure liquid chromatogphy with tandem mass spectrometry. Journal of Chromatography B,2008,870,241-246.
33. Bing Shao*, Jing Zhang, Yi Yang, Juan Meng, Yongning Wu and Hejun Duan, Simultaneous analysis of thirteen diuretics residues in bovine milk by ultra-performance liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry,2008,22,3427-3433.
34. Bing Shao*, Xiaojie Sun, Jing Zhang, Jianying Hu, Huiru Dong,Yi Yang , Determination of ofloxacin enantiomers in sewage using two-step solid-phase extraction and liquid chromatography with fluorescence detection. Journal of Chromatography A, 2008,1182,77-84.
35. Xiaoliang Cui, Bing Shao*, Rong Zhao, Yi Yang, Jianying Hu, Xiaoming Tu. Simultaneous determination of seventeen glucocorticoids residues in milk and eggs by ultraperformance liquid chromatography/electrospray tandem mass spectrometry. Rapid Commun. Mass Spectrom, 2006, 20: 2355-2364
36. Yang Yi, Deng Zhiwei, Proksch P., Lin, Wenhan. Two new 18-en-oleane derivatives from marine mangrove plant, barringtonia racemosa. Die Pharmazie, 2006, 61,365-366
37. 杨奕,尹杰,杨蕴嘉,张晶.牛肉、牛奶中可的松和氢化可的松含量分析.食品科学,2021,42(16),261-266.
38. 段鹤君,郭巧珍,张昕,杨蕴嘉,杨奕*.75种农药的离子流淌度质谱多维数据库的建立.食品安全质量检测学报,2021,12(20),8026-8033
39. 杨奕,杨蕴嘉,尹杰,张晶. 液相色谱-串联质谱法测定动物肌肉和牛奶中的雌二醇. 食品安全质量检测学报,2021,12(9),3652.
40. 沈葹,杨奕,王晶波,陈曦,刘婷婷,卓勤. 基于超高效液相色谱-四极杆飞行时间质谱的非靶向代谢组学用于不同来源单花蜜的差异分析.色谱,2021,39(3),291-300.
41. 张维春柏,杜婧,尹杰,杨奕*。孕妇血清锌水平与新生儿神经管缺陷发生关联的Meta分析。现代预防医学,2020,47(19),3505.
42. 郁欢欢,杨奕,张晶,徐慧兰,王建武。大气压气相色谱法电离源-串联质谱法测定蔬菜中23种农药残留。中国食品卫生杂志,2020,32(1),31-38.
43. 李阳,杨奕,邵兵,邹悦,宋宇,舒琳,梁启慧,韩南银。非对称流场流分离⁃超高效液相色谱⁃串联四极杆飞行时间质谱用于过敏原蛋白表位筛选。色谱,2019,37,398-403.
44. 梁启慧,杨奕,邵兵,高也,宋宇,韩南银。载液组成对于卵白蛋白在非对称流场流分离通道中膜吸附和聚集行为的影响。色谱, 2018,36(5),480.
45. 齐开伦,杨奕,杨蕴嘉,邵兵,丁晓静.建立同位素稀释质谱法测定烘培食品中来源于鸡蛋的3种主要致敏蛋白。中国食品卫生杂志,2017,29(6),658.
46. 王硕,张向明,毛红霞,李书明,邵兵,杨奕.高效液相色谱法同时测定糖果中6种合成着色剂及其铝色淀. 现代预防医学,2016,22,4174-4178.
47. 张晶,卢丽彬,杨奕,孟娟,邵兵*,液相色谱-串联质谱法快速测定食品中的氟乙酸. 食品安全质量检测学报,2013,4(3),660-664.
48. 杨奕,张晶,赵珊,邵兵*. 超高效液相色谱法同时测定包衣糖果中5种铝色淀. 中国食品卫生杂志, 2013, 25(2),148-151.
49. 杨奕,邵兵*,超高压液相色谱-串联质谱法测定虾中硝基呋喃代谢物. 食品安全质量检测学报,2013,4(1),135-140.
50. 杨蕴嘉,牛宇敏,杨奕,张晶,邵兵*,在线固相萃取-液相色谱串联质谱法测定饮用水中的双酚A和壬基酚. 卫生研究,2013, 42(1),127-132.
51. 王 硕,张 晶,杨奕,张晓曦,邵 兵,高效液相色谱串联质谱同时测定城市污水处理厂污泥中20种磺胺类药物. 卫生研究,2012,41(2),240-246.
52. 杨佳佳,杨奕,张晶,邵兵,吴永宁。离子色谱-串联质谱同时测定蔬菜中的溴酸盐和高氯酸盐. 卫生研究,2012,41(2), 273-278.
53. 肖甚圣,杨奕,张晶,邵兵,吴永宁。超高效液相色谱串联质谱法测定鱼组织中6种抗雌激素药物. 色谱,2011, 29 (11), 1055-1061.
54. 赵珊,张晶,杨奕,邵兵*,超高效液相色谱-电喷雾串联四极杆质谱法检测果汁和葡萄酒中27种工业染料. 色谱,2010,28(4),357-362.
标准:
1. GB/T 21312-2007动物源性食品中14种喹诺酮药物残留检测方法液相色谱-质谱/质谱法。
2. GB/T 21313-2007动物源性食品中β-受体激动剂残留检测方法 液相色谱-质谱/质谱法。
3. GB/T 21981-2008动物源性食品中激素多残留检测方法 液相色谱-质谱/质谱法。
4. 丁晓静、王萍、杨奕,高运华等。消毒剂与抗菌剂中抗病毒药物检测方法与评价要求。WS/T 686-2020
专利:
1. 张洋,林文瀚,刘东,杨奕. 利用Tagalsin E和Tagalsin G制备抗肿瘤先导化合物Tagalsin C的方法,201210122303.1
2. 邵兵,张晶,郭巧珍,杨奕,尹杰. 构建液相色谱-质谱数据库检测未知毒物的方法,201410093316.X
首都医科大学建校于1960年,是北京市重点高等院校,著名泌尿外科专家、中国科学院院士、中国工程院院士、原全国人大常委会副委员长吴阶平教授为首任院长。学校由校本部和附属医院(即临床医学院)组成。校本部设有基础医学院、生物医学工程学院、公共卫生与家庭医学学院、高等职业教育学院、中医药学院、顺义校区、继续教育学院、护理学院、卫生事业管理与发展学院及首都医科大学国际教学部;附属医院包括宣武医院(第一临床医学院)、附属北京友谊医院(第二临床医学院)、附属北京朝阳医院(第三临床医学院)、附属北京同仁医院(第四临床医学院)、附属北京天坛医院(第五临床医学院)、附属北京安贞医院(第六临床医学院)、附属北京口腔医院(口腔医学院)、附属北京儿童医院(儿科医学院)、附属北京妇产医院(妇产医学院)、附属北京安定医院(精神卫生学院)、附属复兴医院(第八临床医学院)、附属北京中医医院(中医药临床医学院)和康复医学院。
学校和附属医院现有教职员工和医护人员22575人。有院士4人,正高职称700余人,副高职称1800余人。学校学科专业齐全,学科力量雄厚,在基础和临床各专业拥有一大批具有很高造诣的专家学者,现有3个国家级重点学科,有38个博士学位授予权学科,58个硕士学位授予权学科和2个博士后科研流动站。
校本部和附属医院总占地面积97.3万平方米,总建筑面积134万平方米 ,固定资产总值近46.5亿元,图书馆藏书108.3万册 ,住院病床10039张。学校开办的七年制专业中设有临床医学和口腔医学;五年制专业中设有临床医学、口腔医学、预防医学、护理学、中医学等;四年制专业中设有生物医学工程、中药学和康复治疗学。在临床医学专业中设有儿科医学、康复医学、医学影像、精神卫生与精神病学和医学检验5个专业方向;在生物医学工程专业中设有医学影像设备与技术和听力学专业方向。高等职业教育设有护理、医学检验、药学、医学影像技术、康复技术、口腔修复工艺、眼科验光、实验动物技术、中医学、中药制剂、医学信息、临床医学、预防医学、中药经营贸易和中医学美容专业方向15个专业。首都医科大学现已成为以培养高层次本科生与研究生为核心、以临床应用型人才为主和培养预防、康复、生物医学工程和医学基础各学科、各层次人才,位于全国先进医学院校行列的高等学府。
学校具有较强的学术发展与科研实力,在校本部和附属医院建有一批国家级和市级重点学科和重点实验室,建有高水平的国家级或市级研究和培训机构,如卫生部全科医学培训中心、临床医学研究所、基础医学研究所、神经科学研究所、眼科研究所、老年病医疗研究中心、泌尿外科研究所、心肺血管医疗研究中心、生命科学院、卫生毒理检测中心、生物工程技术研究中心、祖国医学研究所、临床疾病研究中心、中医肝病临床研究中心、生殖医学研究所、心血管疾病临床试验及社区干预中心和北京市卫生政策与卫生经济研究中心等。神经生物学、细胞生物学、电生理学、基础免疫学、实验寄生虫学、医学图像处理、生物医学、信息检测与处理、神经内科、神经外科、心脏内外科、肾移植、呼吸和消化内科、口腔颌面外科、眼科、耳鼻咽喉科、小儿血液病等领域在国内外享有较高声誉,很多学科的研究和医疗水平已经达到或接近国际先进水平。
学校十分重视对外交流与合作,改革开放以来,先后与世界20多个国家和地区签定了友好交流协议, 近十年中,先后接待美国、加拿大、英国、澳大利亚、法国、瑞典、日本、荷兰、意大利、德国、丹麦及台湾、香港和澳门等50多个国家和地区的专家学者8000余人次来校进行学术交流和参观访问。同时,学校积极选送教师、科研人员和管理干部出国进修、参加学术会议和考察访问。