
长期致力于儿童血液病临床与科研工作,主要研究方向为儿童噬血细胞综合征、朗格罕细胞组织细胞增生症等组织细胞疾病的发病机制以及难治复发病例的诊疗。目前担任全国儿童EBV感染协作组副组长,中华医学会儿科学分会血液学组秘书,国家卫生健康委儿童血液病专病委员会秘书,中国医师协会血液科医师分会组织细胞疾病专业委员会委员等。《中华儿科学杂志》第16届通迅编委,《中华医学杂志》英文版第9届通迅编委。
近5年主持国自然面上项目、北京市科技新星计划、北京市科技计划首都特色项目、首都卫生发展科研专项、北京市医院管理中心儿科协同重点项目子课题、北京航空航天大学北京高精尖创新中心任务等国家及省部级课题8项,近5年以第一或通迅作者在国际血液学权威杂志BLOOD(2篇)、Haematologica(2篇)、Journal of Hematology & Oncology(1篇)等发表SCI及核心期刊论文40余篇,作为骨干成员获批国家发明专利1项。
发表文章(第一作者或通信作者):
1. Xiaoman Bi, Qing Zhang, Lei Chen, Dan Liu, Yueying Li,Xiaoxi Zhao, Ya Zhang, Liping Zhang, Jingkun Liu, Chaoyi Wu, Zhigang Li, YunzeZhao, Honghao Ma, Gang Huang, Xin Liu, Qian-Fei Wang, Rui Zhang.NBAS,a gene involved in cytotoxic degranulation, is recurrently mutated in pediatrichemophagocytic lymphohistiocytosis. Journal of hematology & oncology. 2022 Jul 28; 15 (1) :101.
2. Qing Zhang , * Yun-Ze Zhao,,* Hong-Hao Ma, Dong Wang, LeiCui, Wei-Jing Li, Ang Wei, Chan-Juan Wang, Tian-You Wang, Zhi-Gang Li, and RuiZhang. A study of ruxolitinib response–basedstratifiedtreatment for pediatric hemophagocyticlymphohistiocytosis. BLOOD. 2022;16(139):3493-504.
3. Ang Wei, Xia Lu, HonghaoMa, Hongyun Lian, Xu Yang, Liping Zhang, Dong Wang, Sitong Chen, Qing Zhang,Zhigang Li, Rui Zhang, Jigang Yang, Tianyou Wang. 18F-FDG PET/CT for Identifying thePotential Primary Diseases and Predicting Prognosis of Secondary HemophagocyticLymphohistiocytosis in Children. Contrast media & molecularimaging. 2022; 2022 :4849081.
4. Zhuo Li, Ning Sun, QingZhang, Hong-Hao Ma, Dong Wang, Yun-Ze Zhao, Chang-Qing Yang, Rui Zhang, Li-BoZhao. Development and application of an LC-MS/MS method for pharmacokineticstudy of ruxolitinib in children with hemophagocytic lymphohistiocytosis. Analyticalmethods : advancing methods and applications 2022 Jun 16;14(23):2293-2303
5. Wenxin Ou, Honghao Ma, AngWei, Yunze Zhao, Liping Zhang, Hongyun Lian, Qing Zhang, Sitong Chen, DongWang, Zhigang Li, Rui Zhang, Tianyou Wang. Clinical significance of cerebrospinal fluid soluble CD25in pediatric hemophagocytic lymphohistiocytosis with central nervous systeminvolvement. Pediatric blood & cancer. 2022 Apr20; e29712.
6. Dong Wang, Xi-Hua Chen,Ang Wei, Chun-Ju Zhou, Xue Zhang, Hong-Hao Ma, Hong-Yun Lian, Li Zhang, QingZhang, Xiao-Tong Huang, Chan-Juan Wang, Ying Yang, Wei Liu, Tian-You Wang*,Zhi-Gang Li*, Lei Cui*, Rui Zhang*. Clinical features and treatment outcomes ofpediatric Langerhans cell histiocytosis with macrophage activationsyndrome-hemophagocytic lymphohistiocytosis. Orphanet journal of rarediseases 2022 Apr 04;17(1):151
7. Jia-Feng Yao, Dong Wang,Hong-Hao Ma, Hong-Yun Lian, Li Zhang, Tian-You Wang, Zhi-Gang Li, Jin Jiang*,Lei Cui*, Rui Zhang*. Characteristics and Treatment Outcomes of PediatricLangerhans Cell Histiocytosis with Thymic Involvement. The Journal ofpediatrics 2022 05;244:194-202
8. Hongyun Lian, Lei Cui,Ying Yang, Ang Wei, Hua Cheng, Na Li, Li Zhang, Honghao Ma, Xiaoxi Zhao, TianyouWang*, Zhigang Li*, Rui Zhang*. Second-line regimen for CNS-involved pediatricLangerhans cell histiocytosis. Pituitary 2022Feb;25(1):108-115
9. Xia Lu#, Ang Wei#, XuYang, Jun Liu, Siqi Li, Ying Kan, Wei Wang, Tianyou Wang, Rui Zhang*, JigangYang* . The Role of Pre-therapeutic 18F-FDG PET/CT in PediatricHemophagocytic Lymphohistiocytosis With Epstein-Barr Virus Infection. Frontiersin medicine 2021;8:836438
10. Hongyun Lian, Ang Wei,Lejian He, Ying Yang, Honghao Ma, Liping Zhang, Yitong Guan, Qing Zhang, DongWang, Zhigang Li*, Rui Zhang*, Tianyou Wang*. Clinical Analysis of Pediatric Systemic JuvenileXanthogranulomas: A Retrospective Single-Center Study. Frontiers inpediatrics. 2021; 9 :672547.
11. Chan-Juan Wang, Lei Cui,Hong-Hao Ma, Dong Wang, Li Zhang, Hong-Yun Lian, Wei-Jing Li, Qing Zhang,Tian-You Wang*, Zhi-Gang Li*, Rui Zhang*. BRAF V600E Mutation in Cell-Free DNA,Rather than in Lesion Tissues, at Diagnosis Is An Independent Prognostic Factorin Children with Langerhans Cell Histiocytosis. Molecular cancertherapeutics 2021 07;20(7):1316-1323
12. Honghao Ma#, LipingZhang#, Ang Wei, Jun Yang, Dong Wang, Qing Zhang, Yunze Zhao, Sitong Chen,Hongyun Lian, Li Zhang, Chunju Zhou, Maoquan Qin, Zhigang Li*, Tianyou Wang*,Rui Zhang*. Outcome of L-DEP regimen for treatment of pediatricchronic active Epstein-Barr virus infection. Orphanet journal of rare diseases2021 06 10;16(1):269
13. Ang Wei#, Honghao Ma#, LipingZhang, Zhigang Li, Yitong Guan, Qing Zhang, Dong Wang, Hongyun Lian, RuiZhang*, Tianyou Wang*. Clinical analysis of chronic active EBV infection with coronary artery dilatation anda matched case-control study. Orphanet journal of rarediseases. 2021 0128; 16 (1) :50.
14. Yang Y#, Wang C#, Wang D#, Cui L, Li N, Lian H, MaH, Zhao Y, Zhang L, Liu W, Wang Y, Wu W, Zhang R*, Li Z*, Wang T*. Clinical study ofMAP2K1-mutated Langerhans cell histiocytosis in children. J Cancer Res ClinOncol 2021;148:2517–2527
15. Zhao XX, Lian HY, Zhang L,Ma HH, Wang D, Zhao YZ, Liu W, Chen XH, Wang TY, Li ZG, Zhang R.Significance of serum Th1/Th2 cytokine levels in underlying diseaseclassification of childhood HLH. Cytokine. 2021; 149 :155729.
16. Shi H, He H, Cui L,Kvedaraite E, Bian Z, Huang T, Lee C, Li ZG, He J, Gong Y, Li Z, Zhou J, ZengY, Li X, Ni Y, Bai Z, Liu C, Li N, Ma H, Wang D, Lan Y, Ginhoux F, ZhangR, Liu B. Transcriptomic Landscape of Circulating Mononuclear Phagocytes inLangerhans Cell Histiocytosis at Single-cell Level. Blood. 2021 Blood. 202110 07; 138 (14) :1237-1248.
17. Qing Zhang, Yun-Ze Zhao,Hong-Hao Ma, Dong Wang, Nan Zhang, Zhi-Gang Li, Rui Zhang. Successful rescue ofa lethal Griscelli syndrome type 2 presenting with neurological involvement andhemophagocytic lymphohistiocytosis: a case report. BMC pediatrics 2021 0531;21(1):253
18. Qing Zhang, Ang Wei,Hong-Hao Ma, Li Zhang, Hong-Yun Lian, Dong Wang, Yun-Ze Zhao, Lei Cui, Wei-JingLi, Ying Yang, Tian-You Wang, Zhi-Gang Li, and Rui Zhang. A pilot study ofruxolitinib as a front-line therapy for 12 children with secondaryhemophagocytic lymphohistiocytosis. Haematologica 2021,106(7):1892-1901
19. Ying Yang, Dong Wang, LeiCui, Hong-Hao Ma, Li Zhang, Hong-Yun Lian, Qing Zhang, Xiao-Xi Zhao, Li-PingZhang, Yun-Ze Zhao, Na Li, Tian-You Wang, Zhi-Gang Li, Rui Zhang. Effectivenessand Safety of Dabrafenib in the Treatment of 20 Chinese Children withBRAFV600E-Mutated LCH. Cancer research and treatment. 2021 Jan;53(1):261-269;IF(2020):4.679
20. Ying Yang, Dong Wang, NaLi, Honghao Ma, Hongyun Lian, Lei Cui, Qing Zhang, Xiaoxi Zhao, Liping Zhang,Yunze Zhao, Chanjuan Wang, Li Zhang, Tianyou Wang, Zhigang Li, Rui Zhang.Improvement in Pituitary Imaging After Targeted Therapy in Three Children withBRAF-Mutated Langerhans Cell Histiocytosis with Pituitary Involvement. OncoTargets Ther 2020;13:12357-63 IF(2020):4.147
21. Lei Cui, Li Zhang,Hong-Hao Ma, Chan-Juan Wang, Dong Wang, Hong-Yun Lian, Wei-Jing Li, Qing Zhang,Na Li, Tian-You Wang*, Zhi-Gang Li*, Rui Zhang*. Circulating cell-freeBRAFV600E during chemotherapy is associated with prognosis of children withLangerhans cell histiocytosis. Haematologica. 2020 Sep 1;105(9):e444-447.
22. Yun-Ze Zhao, Zhi-Gang Li,Li Zhang, Hong-Yun Lian, Hong-Hao Ma, Dong Wang, Xiao-Xi Zhao, Qing Zhang,Tian-You Wang, Rui Zhang. L‐DEP regimen salvagetherapy for paediatric patients with refractory Epstein‐Barr virus‐associated haemophagocyticlymphohistiocytosis. British Journal of Haematology 2020 11; 191 (3) :453-459.
23. Guang Hua Zhu#, Li PingZhang#, Zhi Gang Li, Ang Wei, Ying Yang, Yu Tian, Hong Hao Ma, Dong Wang, Xiao XiZhao, Yun Ze Zhao, Na Li, Wei Liu, Tian You Wang*, Rui Zhang*. Associationsbetween PRF1 Ala91Val polymorphism and risk of hemophagocytic lymphohistiocytosis:a meta-analysis based on 1366 subjects. World J Pediatr WJP 2020Dec;16(6):598-606
24. Ang Wei#, Honghao Ma#,Zhigang Li, Liping Zhang, Qing Zhang, Dong Wang, Hongyun Lian, Rui Zhang*, TianyouWang*. Short-term effectiveness of ruxolitinib in the treatment of recurrent orrefractory hemophagocytic lymphohistiocytosis in children. InternationalJournal of Hematology 2020 Oct; 112 (4) :568-576.
25. Na Li, Lei Cui, HonghaoMa, Zhihua Gong, Hongyun Lian, Chanjuan Wang, Qing Zhang, Xiaoxi Zhao, XihuaChen, Yu Tian, Ying Yang, Ang Wei, Rui Zhang*, Zhigang Li*, Tianyou Wang* Osteopontin is highly secreted in the cerebrospinal fluid ofpatient with posterior pituitary involvement in Langerhans cellhistiocytosis.International journal of laboratory hematology 2020Dec;42(6):788-795
26. Honghao Ma#, Rui Zhang#,Liping Zhang, Ang Wei, Xiaoxi Zhao, Ying Yang, Wei Liu, Zhigang L*i, MaoquanQin*, Tianyou Wang* Treatment of pediatric primary hemophagocyticlymphohistiocytosis with the HLH-94/2004 regimens and hematopoietic stem celltransplantation in China. Annals of hematology 2020Oct;99(10):2255-2263
27. Zhao Y, Li Z, Zhang L, LianH, Ma H, Wang D, Zhao X, Zhang Q, Wang T, ZhangR*. Clinical Features and Outcomes of Patients with HemophagocyticLymphohistiocytosis at Onset of Systemic Autoinflammatory Disorder and Comparewith Epstein-Barr virus (EBV)-related Hemophagocytic Lymphohistiocytosis. Medicine. 2020, 99(1):e18503
28. Wei A, Ma H, LiZ, Zhang L, Zhang R*, Wang T*. Type-IV Glycogen Storage DiseaseAssociated with Hemophagocytic lymphositiocytosis: a case report. Journal ofPediatric Hematology and Oncology 2020;42(5):368-369
29. Wei A, Ma H, Zhang L, LiZ, Zhang Q, Wang D, Zhang L, Lian H, Zhang R, Wang T. Hemophagocyticlymphohistiocytosis resulting from a cytokine storm triggered by septicemia ina child with chronic granuloma disease: a case report and literature review.BMC Pediatr. 2020 Mar 3;20(1):100.
30. Wei A, Ma H, LiZ, Zhang L, Zhang R*, Wang T*. Successful treatment of a childwith idiopathic multicentric Castleman disease associated with hemophagocyticlymphohistiocytosis using tocilizumab. Pediatr Blood Cancer. 2019Jul;66(7):e27759.
31. Zhang L, LiZ, Liu W, Ma H, Wang T*, Zhang R*. Genetic characterizationof pediatric primary hemophagocytic lymphohistiocytosis in China: asingle-center study. Ann Hematol. 2019 Oct;98(10):2303-2310
32. Zhao XX, Lian HY, Zhang L,Ma HH, Wang D, Zhao YZ, Liu ZW, Wang TY, Zhang R, Li ZG. Significance of serumferritin level in hemophagocytic lymphohistiocytosis diagnosis. Int J LabHematol. 2019, 41(4):503-508
33. Zhang Q, Ma H, Ma J, WangD, Zhao Y, Wang T, Li Z, Wu R, Zhang R. Clinical and genetic analysis ofimmunodeficiency-related diseases associated with PIK3CD mutations.Pediatr Investig. 2019 Jan 8;2(4):257-262.
34. Yun‐Ze Zhao, Hua Cheng, Chang‐Hong Ding, Hong‐Hao Ma, Tong‐Li Han, Jiu‐Wei Li, Dong Wang, Zhi‐Gang Li, Tian‐You Wang, Rui Zhang. Neurological Abnormality Could be the First andOnly Symptom of Familial Hemophagocytic Lymphohistiocytosis, Report of TwoFamilies. Chinese Medical Journal. 2018,131(24): 3004-3006
35. Dong Wang, Lei Cui,Zhi-Gang Li, Li Zhang, Hong-Yun Lian, Hong-Hao Ma, Yun-Ze Zhao, Xiao-Xi Zhao,Tian-You Wang, Rui Zhang. Clinical Research of Pulmonary Langerhans CellHistiocytosis in Children. ChineseMedical Journal. 2018,131(15):1794-1798
36. Yun-Ze Zhao, Lei Cui,Zhi-Gang Li, Li Zhang, Hong-Yun Lian, Hong-Hao Ma, Dong Wang, Xiao-Xi Zhao,Tian-You Wang, Rui Zhang. Central Nervous System Involvement in 179 ChineseChildren with Hemophagocytic Lymphohistiocytosis. Chinese Medical Journal. 2018,131(15):1786-1792
37. 田宇#、张蕊#、张利平、杨颖、魏昂、彭晓霞、李志刚、王天有*.常用一线单药治疗儿童新诊断ITP Meta分析. 中国小儿血液与肿瘤杂志,2021,26(2):21-28
38. 廉红云#、李志刚、崔蕾、魏昂、杨颖、程华、何乐健、张莉、赵晓曦、王天有、张蕊*.系统性幼年黄色肉芽肿4例临床分析. 中国小儿血液与肿瘤杂志, 2021,26 (2):84-88.
39. 廉红云#、赵晓曦、张莉、崔蕾、马宏浩、王冬、赵云泽、李志刚、王天有、张蕊*.儿童皮肤单器官受累的朗格罕细胞组织细胞增生症的临床分析. 中华实用儿科临床杂志,2021,36(07):520-524
40. 张晴 崔蕾, 马宏浩, 王冬, 赵云泽, 王天有, 李志刚*, 张蕊*. 血浆及全血EB病毒DNA对EB病毒相关噬血细胞性淋巴组织细胞增生症患儿预后的影响. 中华实用儿科临床杂志 2020;35:1139-43.
41. 魏昂、马宏浩、张利平、吴润晖、张蕊*,王天有. 以噬血细胞综合症为首发表现的肝炎相关再生障碍性贫血5例临床分析. 中华儿科杂志2020,58(3):213-217
42. 张蕊,王天有*. 噬血细胞性淋巴组织细胞增生症——罕见病,大问题. 中华儿科杂志2019,57(10):740-742
43. 廉红云,张莉,李志刚,马宏浩,王冬,赵云泽,赵晓曦,王天有,张蕊*. 儿童颅面骨受累的朗格罕细胞组织细胞增生症临床分析. 中华实用儿科临床杂志2019, 34(15):1151-1155
44. 马宏浩, 王天有, 张莉, 廉红云, 王冬, 赵云泽, 赵晓曦, 张蕊*. 儿童EB病毒相关噬血细胞性淋巴组织细胞增生症的预后相关危险因素分析. 北京医学, 2018, 40(7):622-628
首都医科大学建校于1960年,是北京市重点高等院校,著名泌尿外科专家、中国科学院院士、中国工程院院士、原全国人大常委会副委员长吴阶平教授为首任院长。学校由校本部和附属医院(即临床医学院)组成。校本部设有基础医学院、生物医学工程学院、公共卫生与家庭医学学院、高等职业教育学院、中医药学院、顺义校区、继续教育学院、护理学院、卫生事业管理与发展学院及首都医科大学国际教学部;附属医院包括宣武医院(第一临床医学院)、附属北京友谊医院(第二临床医学院)、附属北京朝阳医院(第三临床医学院)、附属北京同仁医院(第四临床医学院)、附属北京天坛医院(第五临床医学院)、附属北京安贞医院(第六临床医学院)、附属北京口腔医院(口腔医学院)、附属北京儿童医院(儿科医学院)、附属北京妇产医院(妇产医学院)、附属北京安定医院(精神卫生学院)、附属复兴医院(第八临床医学院)、附属北京中医医院(中医药临床医学院)和康复医学院。
学校和附属医院现有教职员工和医护人员22575人。有院士4人,正高职称700余人,副高职称1800余人。学校学科专业齐全,学科力量雄厚,在基础和临床各专业拥有一大批具有很高造诣的专家学者,现有3个国家级重点学科,有38个博士学位授予权学科,58个硕士学位授予权学科和2个博士后科研流动站。
校本部和附属医院总占地面积97.3万平方米,总建筑面积134万平方米 ,固定资产总值近46.5亿元,图书馆藏书108.3万册 ,住院病床10039张。学校开办的七年制专业中设有临床医学和口腔医学;五年制专业中设有临床医学、口腔医学、预防医学、护理学、中医学等;四年制专业中设有生物医学工程、中药学和康复治疗学。在临床医学专业中设有儿科医学、康复医学、医学影像、精神卫生与精神病学和医学检验5个专业方向;在生物医学工程专业中设有医学影像设备与技术和听力学专业方向。高等职业教育设有护理、医学检验、药学、医学影像技术、康复技术、口腔修复工艺、眼科验光、实验动物技术、中医学、中药制剂、医学信息、临床医学、预防医学、中药经营贸易和中医学美容专业方向15个专业。首都医科大学现已成为以培养高层次本科生与研究生为核心、以临床应用型人才为主和培养预防、康复、生物医学工程和医学基础各学科、各层次人才,位于全国先进医学院校行列的高等学府。
学校具有较强的学术发展与科研实力,在校本部和附属医院建有一批国家级和市级重点学科和重点实验室,建有高水平的国家级或市级研究和培训机构,如卫生部全科医学培训中心、临床医学研究所、基础医学研究所、神经科学研究所、眼科研究所、老年病医疗研究中心、泌尿外科研究所、心肺血管医疗研究中心、生命科学院、卫生毒理检测中心、生物工程技术研究中心、祖国医学研究所、临床疾病研究中心、中医肝病临床研究中心、生殖医学研究所、心血管疾病临床试验及社区干预中心和北京市卫生政策与卫生经济研究中心等。神经生物学、细胞生物学、电生理学、基础免疫学、实验寄生虫学、医学图像处理、生物医学、信息检测与处理、神经内科、神经外科、心脏内外科、肾移植、呼吸和消化内科、口腔颌面外科、眼科、耳鼻咽喉科、小儿血液病等领域在国内外享有较高声誉,很多学科的研究和医疗水平已经达到或接近国际先进水平。
学校十分重视对外交流与合作,改革开放以来,先后与世界20多个国家和地区签定了友好交流协议, 近十年中,先后接待美国、加拿大、英国、澳大利亚、法国、瑞典、日本、荷兰、意大利、德国、丹麦及台湾、香港和澳门等50多个国家和地区的专家学者8000余人次来校进行学术交流和参观访问。同时,学校积极选送教师、科研人员和管理干部出国进修、参加学术会议和考察访问。