附属北京天坛医院-张星虎导师介绍
张星虎
主任医师
硕，博士生导师
男
附属北京天坛医院
神经病学
神经免疫及神经感染疾病诊疗
xhzhtiantan@hotmail.com
科研项目
研究成果
1. Liu J, Zhou R, Gong Y, Ding X, Huang Q,Zhang Y, Feng Y, Wang D, Zhou H, Ma Y, Zhang X, Zhou Y. A prospective study ontryptophan immunoadsorption in AQP4 antibody-positive neuromyelitis opticaspectrum disorders. J Clin Apher. 2022 Feb 1.Onlineahead of print.
2. Ma J, Yu H, Wang H, Zhang X, Feng K.Evaluation of effect of empirical attack-preventive immunotherapies inneuromyelitis optica spectrum disorders: An update systematic review and meta-analysis. J Neuroimmunol. 2022 Feb 15;363:577790.
3. Wang Y, Ma J, Chang H, Zhang X, Yin L.Efficacy of mycophenolate mofetil in the treatment of neuromyelitis opticaspectrum disorders: An update systematic review and meta -analysis. MultScler Relat Disord. 2021 Oct;55:103181.
4. Cong H, Liang M, Wang Y, Chang H, Du L,Zhang X, Yin L. Icariin ameliorates the cuprizone-induced acute brain demyelinationand modulates the number of oligodendrocytes, microglia and astrocytes in thebrain of C57BL/6J mice. Brain Res Bull. 2021 Oct;175:37-47.
5. Zhuo Z, Duan Y, Tian D, Wang X, Gao C,Ding J, Zheng F, Zhang T, Zhang X, Barkhof F, Shi FD, Liu Y. Brain structuraland functional alterations in MOG antibody disease. Mult Scler. 2021Aug;27(9):1350-1363.
6. Zheng F, Li Y, Zhuo Z, Duan Y, Cao G,Tian D, Zhang X, Li K, Zhou F, Huang M, Li H, Li Y, Zeng C, Zhang N, Sun J, YuC, Han X, Hallar S, Barkhof F, Liu Y. Structural and functional hippocampalalterations in Multiple sclerosis and neuromyelitis optica spectrum disorder. MultScler. 2021 Aug 11:13524585211032800.
7. Du L, Chang H, Xu W, Zhang X, Yin L.Elevated chemokines and cytokines for eosinophils in neuromyelitis opticaspectrum disorders. Mult Scler Relat Disord. 2021 Jul;52:102940.
8. Duan Y, Zhuo Z, Li H, Tian DC, Li Y,Yang L, Gao C, Zhang T, Zhang X, Shi FD, Barkhof F, Liu Y. Brain structuralalterations in MOG antibody diseases: a comparative study with AQP4seropositive NMOSD and MS. J Neurol Neurosurg Psychiatry. 2021Jul;92(7):709-716.
9. Chang H, Cong H, Wang H, Du L, Tian DC,Ma Y, Xu Y, Wang Y, Yin L, Zhang X. Thymic Involution and Altered Naive CD4 TCell Homeostasis in Neuromyelitis Optica Spectrum Disorder. Front Immunol.2021 Jul 16;12:645277.
10. Gao C, Zhuo Z, Duan Y, Yao Y, Su L,Zhang X, Song T. Structural and Functional Alterations in Visual Pathway AfterOptic Neuritis in MOG Antibody Disease: A Comparative Study With AQP4Seropositive NMOSD. Front Neurol. 2021 Jun 9;12:673472.
11. Wang Y, Chang H, Zhang X, Yin L.Efficacy of rituximab in the treatment of neuromyelitis optica spectrumdisorders: An update systematic review and meta-analysis. Mult Scler RelatDisord. 2021 May;50:102843.
12. Zhuo Z, Li Y, Duan Y, Cao G, Zheng F,Ding J, Tian D, Wang X, Wang J, Zhang X, Li K, Zhou F, Huang M, Li Y, Li H,Zeng C, Zhang N, Sun J, Yu C, Han X, Haller S, Barkhof F, Shi F, Liu Y.Subtyping relapsing-remitting multiple sclerosis using structural MRI. JNeurol. 2021 May;268(5):1808-1817.
13. Xu Y, Ren Y, Li X, Xu W, Wang X, Duan Y, Liu Y, Zhang X, Tian DC. PersistentlyGadolinium-Enhancing Lesion Is a Predictor of Poor Prognosis in NMOSD Attack: aClinical Trial. Neurotherapeutics. 2021 Apr;18(2):868-877.
14. Zhou R, Zeng Q, Yang H, Xu Y, Tan G,Liu H, Wang L, Zhou H, Zhang M, Feng J, Jin T, Zhang X, Wang J, Zhang X, Gao F,Yang C, Bu B, Li C, Zhang M, Dong H, Lin A, Liu W, Wu L, Wang M, Tang Y, WangH, Long Y, Wang Z, Zheng W. Status of Immunotherapy Acceptance in ChinesePatients With Multiple Sclerosis: Analysis of Multiple Sclerosis PatientSurvival Report 2018. Front Neurol. 2021 Apr 8;12:651511.
15. Cong H, Zhang M, Chang H, Du L, ZhangX, Yin L. Icariin ameliorates the progression of experimental autoimmuneencephalomyelitis by down-regulating the major inflammatory signal pathways ina mouse relapse-remission model of multiple sclerosis. Eur J Pharmacol.2020 Oct 15;885:173523.
16. Li W, Wu W, Chang H, Jiang M, Gao J, XuY, Xu D, Yin L, Zhang X. Cerebrospinal Fluid Cytokines in Patients withNeurosyphilis: The Significance of Interleukin-10 for the Disease. BiomedRes Int. 2020 Oct 1;2020:3812671.
17. Du L, Chang H, Xu W, Wei Y, Wang Y, YinL, Zhang X. Effect of NMO-IgG on the interleukin-6 cascade in astrocytes viaactivation of the JAK/STAT3 signaling pathway. Life Sci. 2020 Oct1;258:118217.
18. Song T, Chang H, Du L, Yin L, Shi F,Zhang X. Glucocorticoid receptor mutations and clinical sensitivity toglucocorticoid in Chinese multiple sclerosis patients. Neurol Sci. 2020Oct;41(10):2767-2771.
19. Li X, Tian DC, Fan M, Xiu Y, Wang X, LiT, Jia D, Xu W, Song T, Shi FD, Zhang X. Intravenous immunoglobulin for acuteattacks in neuromyelitis optica spectrum disorders (NMOSD). Mult Scler RelatDisord. 2020 Sep;44:102325.
20. Tian DC, Xiu Y, Wang X, Shi K, Fan M,Li T, Li H, Su L, Ma Y, Xu W, Song T, Liu Y, Shi FD, Zhang X. Cortical Thinningand Ventricle Enlargement in Neuromyelitis Optica Spectrum Disorders. FrontNeurol. 2020 Aug 27;11:872.
21. Peng Y, Dai F, Liu L, Chen W, Yan H,Liu A, Zhang X, Wang X, He J, Li Y, Li C, Chen L, Zhao Y, Li L, Ma Q, Wang J.Validation of the NEOS score in Chinese patients with anti-NMDAR encephalitis. NeurolNeuroimmunol Neuroinflamm. 2020 Aug 5;7(5):e860.
22. Du L, Wang H, Zhou H, Chang H, Wei Y,Cong H, Xu W, Ma Y, Song T, Zhang X, Yin L. Anti-NMDA receptor encephalitisconcomitant with myelin oligodendrocyte glycoprotein antibody diseases: Aretrospective observational study. Medicine (Baltimore). 2020 Jul31;99(31):e21238.
23. Fan M, Qiu W, Bu B, Xu Y, Yang H, HuangD, Lau AY, Guo J, Zhang MN, Zhang X, Yang CS, Chen J, Zheng P, Liu Q, Zhang C, Shi FD. Riskof COVID-19 infection in MS and neuromyelitis optica spectrum disorders. NeurolNeuroimmunol Neuroinflamm. 2020 Jun 4;7(5):e787.
24. Zhang C, Zhang M, Qiu W, Ma H, Zhang X,Zhu Z, Yang CS, Jia D, Zhang TX, Yuan M, Feng Y, Yang L, Lu W, Yu C, BennettJL, Shi FD; TANGO Study Investigators.Safety and efficacy of tocilizumab versusazathioprine in highly relapsing neuromyelitis optica spectrum disorder(TANGO): an open-label, multicentre,randomised, phase 2 trial. Lancet Neurol.2020 May;19(5):391-401.
25. Du L, Chang H, Wei Y, Zhang X, Yin L.Different roles of soluble CD40 ligand in central nervous system damage. NeurolRes. 2020 May;42(5):372-378.
26. Li W, Chang H, Wu W, Xu D, Jiang M, GaoJ, Huang Y, Xu Y, Yin L, Zhang X.Increased CSF Soluble TREM2 Concentration inPatients With Neurosyphilis. Front Neurol. 2020 Feb 5;11:62.
27. Wei Y, Chang H, Feng H, Li X, Zhang X,Yin L. Low Serum Interleukin-10 Is an Independent Predictive Factor for theRisk of Second Event in Clinically Isolated Syndromes. Front Neurol.2019 Jun 11;10:604.
28. Xu W, Zhou H, Li X, Wang L, Guo X, YinL, Chang H, Wei Y, Li Q, Deng J, Zhou X, Yang H, Zhang X, Yi F, Ma W.C1Q/TNF-related protein 4 expression correlates with herpes simplexencephalitis progression. Ann Transl Med. 2019 Jun;7(11):235.
29. Chang H, Wei Y, Chen Y, Du L, Cong H,Zhang X, Geng X, Yin L. The antipsychotic-like effects of clozapine in C57BL/6mice exposed to cuprizone:Decreased glial activation. Behav Brain Res.2019 May 17;364:157-161.
30. Li W, Jiang M, Xu D, Kou C, Zhang L,Gao J, Qin K, Wu W, Zhang X. Clinical and Laboratory Characteristics ofSymptomatic and Asymptomatic Neurosyphilis in HIV-Negative Patients: ARetrospective Study of 264 Cases. Biomed Res Int. 2019 May6;2019:2426313.
31. Song T, Li X, Liu Y, Zhang X.Prevalence and risk factors of deep venous thrombosis in patients withlongitudinally extensive transverse myelitis: one center data from China. BMCNeurol. 2018 Oct 30;18(1):179.
32. Wei Y, Chang H, Li X, Du L, Xu W, CongH, Yao Y, Zhang X, Yin L. CSF-S100B Is a Potential Candidate Biomarker forNeuromyelitis Optica Spectrum Disorders.Biomed Res Int. 2018 Oct 22;2018:5381239.
33. Gong X, Mei S, Li X, Li X, Zhou H, LiuY, Zhou A, Yang L, Zhao Z, Zhang X. Association between TPMT*3C and decreasedthiopurine S-methyltransferase activity in patients with neuromyelitis opticaspectrum disorders in China. Int J Neurosci. 2018 Jun;128(6):549-553.
34. Wei Y, Chang H, Li X, Wang H, Du L,Zhou H, Xu W, Ma Y, Yin L, Zhang X. Cytokines and Tissue Damage Biomarkers inFirst-Onset Neuromyelitis Optica Spectrum Disorders: Significance ofInterleukin-6. Neuroimmunomodulation. 2018;25(4):215-224.
35. Mei S, Li X, Gong X, Zhang X, Li X,Yang L, Zhu L, Zhou H, Liu Y, Zhou A, Zhang X, Zhao Z. Comparison of6-mercaptopurine with 6-thioguanine for the analysis of thiopurineS-methyltransferase activity in human erythrocyte by LC-MS/MS. BiomedChromatogr. 2017 Sep;31(9).
36. Li X, Mei S, Gong X, Zhou H, Yang L,Zhou A, Liu Y, Li X, Zhao Z, Zhang X. Relationship between Azathioprinemetabolites and therapeutic efficacy in Chinese patients with neuromyelitisoptica spectrum disorders. BMC Neurol. 2017 Jul 5;17(1):130.
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学校介绍
首都医科大学建校于1960年，是北京市重点高等院校，著名泌尿外科专家、中国科学院院士、中国工程院院士、原全国人大常委会副委员长吴阶平教授为首任院长。学校由校本部和附属医院(即临床医学院)组成。校本部设有基础医学院、生物医学工程学院、公共卫生与家庭医学学院、高等职业教育学院、中医药学院、顺义校区、继续教育学院、护理学院、卫生事业管理与发展学院及首都医科大学国际教学部；附属医院包括宣武医院(第一临床医学院)、附属北京友谊医院(第二临床医学院)、附属北京朝阳医院(第三临床医学院)、附属北京同仁医院(第四临床医学院)、附属北京天坛医院(第五临床医学院)、附属北京安贞医院(第六临床医学院)、附属北京口腔医院(口腔医学院)、附属北京儿童医院(儿科医学院)、附属北京妇产医院(妇产医学院)、附属北京安定医院(精神卫生学院)、附属复兴医院(第八临床医学院)、附属北京中医医院(中医药临床医学院)和康复医学院。
学校和附属医院现有教职员工和医护人员22575人。有院士4人，正高职称700余人，副高职称1800余人。学校学科专业齐全，学科力量雄厚，在基础和临床各专业拥有一大批具有很高造诣的专家学者，现有3个国家级重点学科，有38个博士学位授予权学科，58个硕士学位授予权学科和2个博士后科研流动站。
校本部和附属医院总占地面积97.3万平方米，总建筑面积134万平方米 ，固定资产总值近46.5亿元，图书馆藏书108.3万册 ，住院病床10039张。学校开办的七年制专业中设有临床医学和口腔医学；五年制专业中设有临床医学、口腔医学、预防医学、护理学、中医学等；四年制专业中设有生物医学工程、中药学和康复治疗学。在临床医学专业中设有儿科医学、康复医学、医学影像、精神卫生与精神病学和医学检验5个专业方向；在生物医学工程专业中设有医学影像设备与技术和听力学专业方向。高等职业教育设有护理、医学检验、药学、医学影像技术、康复技术、口腔修复工艺、眼科验光、实验动物技术、中医学、中药制剂、医学信息、临床医学、预防医学、中药经营贸易和中医学美容专业方向15个专业。首都医科大学现已成为以培养高层次本科生与研究生为核心、以临床应用型人才为主和培养预防、康复、生物医学工程和医学基础各学科、各层次人才，位于全国先进医学院校行列的高等学府。
学校具有较强的学术发展与科研实力，在校本部和附属医院建有一批国家级和市级重点学科和重点实验室，建有高水平的国家级或市级研究和培训机构，如卫生部全科医学培训中心、临床医学研究所、基础医学研究所、神经科学研究所、眼科研究所、老年病医疗研究中心、泌尿外科研究所、心肺血管医疗研究中心、生命科学院、卫生毒理检测中心、生物工程技术研究中心、祖国医学研究所、临床疾病研究中心、中医肝病临床研究中心、生殖医学研究所、心血管疾病临床试验及社区干预中心和北京市卫生政策与卫生经济研究中心等。神经生物学、细胞生物学、电生理学、基础免疫学、实验寄生虫学、医学图像处理、生物医学、信息检测与处理、神经内科、神经外科、心脏内外科、肾移植、呼吸和消化内科、口腔颌面外科、眼科、耳鼻咽喉科、小儿血液病等领域在国内外享有较高声誉，很多学科的研究和医疗水平已经达到或接近国际先进水平。
学校十分重视对外交流与合作，改革开放以来，先后与世界20多个国家和地区签定了友好交流协议， 近十年中,先后接待美国、加拿大、英国、澳大利亚、法国、瑞典、日本、荷兰、意大利、德国、丹麦及台湾、香港和澳门等50多个国家和地区的专家学者8000余人次来校进行学术交流和参观访问。同时，学校积极选送教师、科研人员和管理干部出国进修、参加学术会议和考察访问。
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