主任医师、教授：曹勇

博士研究生：李昊、焦玉明、霍然、王杰、许宏远

硕士研究生：赵绍智、张钧泽、孙瑛璠、余奇峰

项目情况

1.     人工智能脑心共患病高危预测模型及临床辅助决策系统的研究  中华人民共和国科学技术部-“十四五”重点研发计划  2021.12——2024.11

2.     MAP3K3基因突变通过调控血栓调节蛋白和细胞间紧密连接促进脑海绵状血管畸形发生的分子机制研究  国家自然科学基金-面上项目  2022.1——2025.12

3.     基于多组学研究的重大疾病精准医疗  北京市大数据精准医疗高精尖创新中心  2021.1——2022.12

4.     脑动脉瘤及脑动静脉畸形一站式复合手术术中抗凝方案的探索及风险获益评估  中华人民共和国科学技术部-“十三五”重点研发计划  2016.9——2021.6

5.     中国人重大脑疾病基因组学平台建设-AVM  北京市卫生和计划生育委员会  2019.1——2021.12

重要学术论文：

1.    Li H, Nam Y, Huo R, Fu W, Jiang B, Zhou Q, et al. De novo germline and somatic variants convergently promote endothelial-to-mesenchymal transition in simplex brain arteriovenous malformation. Circ Res. 2021;129:825-839

2.    Weng J, Yang Y, Song D, Huo R, Li H, Chen Y, et al. Somatic map3k3 mutation defines a subclass of cerebral cavernous malformation. Am J Hum Genet. 2021;108:942-950

3.    Weng JC, Wang J, Du X, Li H, Jiao YM, Fu WL, et al. Safety of aspirin use in patients with stroke and small unruptured aneurysms. Neurology. 2021;96:e19-e29

4.    Fu W, Huo R, Yan Z, Xu H, Li H, Jiao Y, et al. Mesenchymal behavior of the endothelium promoted by smad6 downregulation is associated with brain arteriovenous malformation microhemorrhage. Stroke. 2020;51:2197-2207

5.    Jiao Y, Li H, Fu W, Weng J, Huo R, Wang Y, et al. Classification of brain arteriovenous malformations located in motor-related areas based on location and anterior choroidal artery feeding. Stroke Vasc Neurol. 2021;6:441-448

6.    Jiao Y, Zhang JZ, Zhao Q, Liu JQ, Wu ZZ, Li Y, et al. Machine learning-enabled determination of diffuseness of brain arteriovenous malformations from magnetic resonance angiography. Transl Stroke Res. 2021; [Epub ahead of print]

7.    Wang J, Weng J, Li H, Jiao Y, Fu W, Huo R, et al. Atorvastatin and growth, rupture of small unruptured intracranial aneurysm: Results of a prospective cohort study. Ther Adv Neurol Disord. 2021;14:1756286420987939

8.    Fu W, Wang W, Li H, Jiao Y, Huo R, Yan Z, et al. Single-cell atlas reveals complexity of the immunosuppressive microenvironment of initial and recurrent glioblastoma. Front Immunol. 2020;11:835

9.    Jiao Y, Lin F, Wu J, Li H, Fu W, Huo R, et al. Plasticity in language cortex and white matter tracts after resection of dominant inferior parietal lobule arteriovenous malformations: A combined fmri and dti study. J Neurosurg. 2020;134:953-960

10.   Li D, Jiao YM, Wang L, Lin FX, Wu J, Tong XZ, et al. Surgical outcome of motor deficits and neurological status in brainstem cavernous malformations based on preoperative diffusion tensor imaging: A prospective randomized clinical trial. J Neurosurg. 2018;130:286-301

11.   Jiao Y, Lin F, Wu J, Li H, Wang L, Jin Z, et al. A supplementary grading scale combining lesion-to-eloquence distance for predicting surgical outcomes of patients with brain arteriovenous malformations. J Neurosurg. 2018;128:530-540

12.   Fu W, Wang W, Li H, Jiao Y, Weng J, Huo R, et al. Cytof analysis reveals a distinct immunosuppressive microenvironment in idh mutant anaplastic gliomas. Front Oncol. 2020;10:560211

13.   Wang LJ, Xue Y, Li H, Huo R, Yan Z, Wang J, et al. Wilms' tumour 1-associating protein inhibits endothelial cell angiogenesis by m6a-dependent epigenetic silencing of desmoplakin in brain arteriovenous malformation. J Cell Mol Med. 2020;24:4981-4991

14.   Fu W, Wang W, Li H, Jiao Y, Weng J, Huo R, et al. High dimensional mass cytometry analysis reveals characteristics of the immunosuppressive microenvironment in diffuse astrocytomas. Front Oncol. 2020;10:78

15.   Huo R, Fu W, Li H, Jiao Y, Yan Z, Wang L, et al. Rna sequencing reveals the activation of wnt signaling in low flow rate brain arteriovenous malformations. J Am Heart Assoc. 2019;8:e012746

重要奖项：

1.     大脑占位性疾病外科治疗与功能保护技术创新与推广  华夏医学科技奖  一等奖  2020

2.     脑血管畸形外科治疗脑功能保护创新技术的建立及推广应用  中华医学科技奖  二等奖  2020

3.     脑血管畸形外科治疗脑功能保护创新技术的建立及推广应用  北京市科学技术奖  二等奖  2019