主持国家自然基金面上项目、国家重点研发计划“精准医学研究”重点专项分课题、首都卫生发展基金脑重大疾病研究专项、北京市教委课题、归国留学启动基金等课题。

代表作：

1. Han Y, Gao J, Zhou Y, Deng J, Yang H, Wang X, Wang J, Yang Y, Ren J, Chen L, Wang M, Deng Q, Wang H, Wang M, Li T.  rTMS Improves Cognition in Patients With Self-Limited Epilepsy With Centrotemporal Spikes With Electrical Status Epilepticus in Sleep via Increase of the Sleep Spindle. CNS Neurosci Ther, 2025 Jul;31(7):e70501

2. Xiong Z, Gao R, Wang R, Li T. Proteome-Wide Mendelian Randomization Reveals Novel Protein Targets for Epilepsy.Curr Neuropharmacol. 2025,Online ahead of print

3. Xiong Z, Deng J, Xie P, Tang C, Wang J, Deng Q, Yang Y, Zhang J, Guo M, Wang X, Guan Y, Luan G, Zhou J, Li T.

Deep Brain Stimulation Inhibits Epileptic Seizures via Increase of Adenosine Release and Inhibition of ENT1, CD39, and CD73 Expression. Mol Neurobiol 2025, 62(2):1800-1812

4. Xiong Z, Zhang J, Deng Q, Wang M, Li T. Vagus Nerve Stimulation Inhibits DNA and RNA Methylation in a Rat Model of Pilocarpine-Induced Temporal Lobe Epilepsy. CNS Neurosci Ther. 2025,31(6):e70484.

5. Guo M, Wang J, Xiong Z, Wang X, Yang Y, Zhang Y, Tang C, Zhang J, Guan Y, Chen F, Yao K, Teng P, Zhou J, Zhai F, Boison D, Luan G, Li T. Ectopic expression of neuronal adenosine kinase, a biomarker in mesial temporal lobe epilepsy without hippocampal sclerosis. Neuropathol Appl Neurobiol. 2023, 49(4):e12926.

6. Guo M, Zhang J, Wang J, Wang X, Gao Q, Tang C, Deng J, Xiong Z, Kong X, Guan Y, Zhou J, Boison D, Luan G, Li T. Aberrant adenosine signaling in patients with focal cortical dysplasia. Mol Neurobiol. 2023, 60(8):4396-4417.

7 Xie P, Liu S, Huang Q, Xiong Z, Deng J, Tang C, Xu K, Zhang B, He B, Wang X, Liu Z, Wang J, Zhou J, Guan Y, Luan G, Li T, Zhai F. Deep brain stimulation suppresses epileptic seizures in rats via inhibition of adenosine kinase and activation of adenosine A1 receptors. CNS Neurosci Ther. 2023, 29(9):2597-2607.

8. Guo M, Xie P, Liu S, Luan G, Li T. Epilepsy and Autism Spectrum Disorder (ASD): The Underlying Mechanisms and Therapy Targets Related to Adenosine. Curr Neuropharmacol, 2023. 21(1):54-66.

9. Liu S, Xiong Z, Wang J, Tang C, Deng J, Zhang J, Guo M, Guan Y, Zhou J, Zhai F, Luan G, Li T. Efficacy and potential predictors of vagus nerve stimulation therapy in refractory postencephalitic epilepsy. Ther Adv Chronic Dis, 2022. 13:20406223211066738.

10. Zhang Y, Wang X, Tang C, Guan Y, Chen F, Gao Q, Wang J, Zhou J, Zhai F, Boison D, Luan G, Li T. Genetic variations of adenosine kinase as predictable biomarkers of efficacy of vagus nerve stimulation in patients with pharmacoresistant epilepsy. Journal of Neurosurgery, 2021. 136(3):726-735.

11. Yang Y, Wang W, Wang J, Wang M, Li X, Yan Z, Deng Q, Feng X, Luan G, Yang X, Li T. Scalp-HFO indexes are biomarkers for the lateralization and localization of the epileptogenic zone in preoperative assessment. J Neurophysiol, 2021. 126(4):1148-1158.

12.He X, Chen F, Zhang Y, Gao Q, Guan Y, Wang J, Zhou J, Zhai F, Boison D, Luan G, Li T. Upregulation of adenosine A2A receptor and downregulation of GLT1 is associated with neuronal cell death in Rasmussen's encephalitis. Brain Pathology, 2020. 30(2):246-260.

13. Li T,Lytle N, Lan JQ, Sandau US, Boison D.Local disruption of glial adenosine homeostasis in mice associates with focal electrographic seizures: A first step in epileptogenesis?  Glia. 2012, 60(1):83-95.IF:4.82

14. Li T, Steinbeck JA, Lusardi T, Koch P, Lan JQ, Wilz A, Segschneider M, Simon RP, Brüstle O, Boison D. Suppression of kindling epileptogenesis by adenosine releasing stem cell-derived brain implants. Brain. 2007;130:1276-88.

15. Li T, Ren G, Lusardi T, Wilz A, Lan JQ, Iwasato T, Itohara S, Simon RP, Boison D. Adenosine kinase, a target for the prediction and prevention of epileptogenesis. J Clin Invest.2008,118（2）:571-582.IF:16.915

获奖：

1. 华夏医学科技奖 三等奖 2024

2. 山东省科技进步三等奖 2001

参编：

1.《神经科学》2022年10月第4版，编者，北京大学医学出版社。

2. 《神经系统疾病动物模型》