导师风采
陈楠
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  • 教授
  • 导师类别:硕士,博士生导师
  • 性别: 男
  • 学历:博士研究生
  • 学位:博士

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  • 所属院系:宣武医院
  • 所属专业: 影像医学与核医学
  • 邮箱 :
  • 工作电话 : -

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医学博士,博士后,主任医师,教授,博士研究生导师,科副主任。国家健康委员会人才交流服务中心高级人才评价项目专家。中华放射学会头颈学组、腹部专业委员会委员,中国放射医师协会头颈学组、泌尿生殖专委会委员,北京市放射学会腹部学组委员、中国医药质量管理协会医学影像质量研究委员会常务委员、中国微循环学会神经变性病专业委员会磁共振学组常务委员、中国医药教育㔹会神经肿瘤专委会常务委员。长期从事医学影像诊断工作,尤其擅长神经系统和腹腔、腹膜后疾病的诊断,目前已诊断患者数十万人。在中华放射学杂志、AJR、J neurological science等国内、外核心期刊发表学术论文190余篇;多次参加国际学术交流,在国际学术大会上发言20多次,参与论著撰写4部,作为负责人、主要完成人获国家科技部863计划、国家自然科学基金、北京市自然科学基金、北京市优秀人才项目课题等8项科研资助;曾获得省部级奖励3项。为<European Journal of Neurology>、《中国医学影像技术》杂志编委,《中国组织工程研究与临床康复》杂志执行编委、《中华现代临床医学杂志》常务编委。《European Journal of Neurology》、《European Radiology》、《ACATA RADIO》等十余种杂志审稿专家。


  • 研究方向Research Directions
神经影像
2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行整体布局设计。 整体布局设计。
科研项目

1. 中央军委科学技术委员会国防科技创新特区项目:基于多模态神经影像技术的创伤应激后障碍早期预警评估与训练干预系统(项目负责人,90万,合同编号:21-163-00-TS-018-007-01,起止时间: 20121.9—2024.8)

2. 国家自然科学基金面上项目:运动想象神经网络调控机制及对脊髓损伤患者运动康复的影响 (项目负责人,53万,项目编号:81871339.  起止时间: 2019.1—2022.12)

3. 国家自然科学基金面上项目:脊髓损伤后大脑初级感觉皮层重塑及神经网络连接变化机制的磁共振研究 (项目负责人,60万,项目编号:81271556.  起止时间: 2013.1—2016.12) 

4. 国家自然科学基金主任基金:《脊髓损伤后神经纤维再生和感觉功能重塑的DTI和fMRI研究》(项目负责人,30940022 10万.起止时间:2010.1-2011.12)

5.. 北京市教委面上项目: 《脊髓损伤后运动中枢结构和功能重塑的磁共振研究》(项目负责人,15万. 起止时间: 2012.1—2014.6)

6. 北京市自然科学基金:《MRI动态评价脊髓损伤后轴突病理变化及感觉功能重塑的研究》(7113155,项目负责人,4万. 起止时间:2011.1--2012.6)

7. 北京市优秀人才培养资助项目:《活体评价脊髓损伤后神经纤维再生和感觉功能重塑的研究》(项目负责人,3万. 起止时间:2008.1-2010.12)

8. 国家科学技术部863计划:《建立活体中国成人数字标准脑》(项目副组长及子课题负责人,50万,起止时间:2006.1-2009.12)。



研究成果

(1) Wang Y, Yang B, Wang L, Xin H, Qi Q, Jia Y, Guo X, Zheng W, Chen X, Li F, Chen Q, Du J, Lu J, Chen N*. Effective Connectivity Alterations of Directed Brain Network in Pediatric Patients With Spinal Cord Injury. CNS Neurosci Ther. 2025;31(12):e70720.  

(2) Yang B, Wang Y, Xin H, Wang L, Qi Q, Jia Y, Guo X, Zheng W, Sun C, Chen X, Du J, Hu Y, Lu J, Chen N*. Differential gray and white matter alterations in children with complete and incomplete spinal cord injuries: a preliminary MRI study using voxel-based morphometry and tract-based spatial statistics. Brain Struct Funct. 2025;230(8):164. d

(3) Qi Q, Wang L, Yang B, Jia Y, Wang Y, Xin H, Zheng W, Chen X, Chen Q, Li F, Du J, Lu J, Chen N*. Structure Changes in the Cervical Spinal Cord and Brain in Children With Complete Thoracolumbar Spinal Cord Injury. Neurorehabil Neural Repair. 2025 ;39(12):1008-1018.  

(4) Wang L, Yang B, Qi Q, Xin H, Wang Y, Jia Y, Chen Q, Zheng W, Chen X, Liang T, Sun C, Du J, Li B, Lu J, Chen N*.Brain functional reorganization in pediatric patients with spinal cord injury and the impact of motor imagery training on it: a preliminary study. IBRO Neurosci Rep. 2025;19:391-399.

(5) Xin H, Yang B, Wang Y, Wang L, Qi Q, Guo X, Jia Y, Zheng W, Chen X, Li F, Sun C, Lu J, Chen N*.Differential Alterations of Supraspinal Somatosensory Pathways in Complete and Incomplete Spinal Cord Injury Patients: A Task-Based fMRI Study. Acad Radiol. 2025 ;32(9):5516-5525.

(6) Qi Q, Wang L, Yang B, Jia Y, Wang Y, Xin H, Guo X, Zheng W, Chen X, Chen Q, Li F, Du J, Lu J, Chen N*.Using diffusion tensor imaging to assess children with spinal cord injury without fracture or dislocation. Spinal Cord. 2025l;63(7):342-347.

(7) Wang Y, Wang L, Yang B, Xin H, Qi Q, Jia Y, Guo X, Zheng W, Chen X, Li F, Sun C, Chen Q, Du J, Lu J, Chen N*. Alterations in Topological Structure and Modular Interactions in Pediatric Patients with Complete Spinal Cord Injury: A Functional Brain Network Study. J Neurotrauma. 2025;42(23-24):2217-2227.

(8) Xin H, Yang B, Wang Y, Qi Q, Wang L, Jia Y, Zheng W, Chen X, Li F, Sun C, Chen Q, Du J, Lu J, Chen N*. Altered Dynamic Brain Functional Network Connectivity Related to Visual Network in Spinal Cord Injury. J Neurotrauma. 2025;42(3-4):250-261.

(9) Xin H, Yang B, Jia Y, Qi Q, Wang Y, Wang L,Chen X, Li F, Lu J, Lu J, Chen N*.Graph Metrics Reveal Brain Network Topological Property in Neuropathic Pain Patients: A Systematic Review.Journal of Pain Research 2024:17 3277–3286

(10) Jia Y, Yang B, Xin H, Qi Q, Wang Y, Lin L, Xie Y, Huang C, Lu J, Qin W, Chen N*.Volumetric Integrated Classification Index: An Integrated Voxel-Based Morphometry and Machine Learning Interpretable Biomarker for Post-Traumatic Stress Disorder. Journal of imaging informatics in medicine, 38(4):1924–1934.

(11) Yang B, Xin H, Wang L, Qi Q, Wang Y, Jia Y, Zheng W, Sun C, Chen X, Du J, Hu Y, Lu J, Chen N*. Distinct brain network patterns in complete and incomplete spinal cord injury patients based on graph theory analysis. CNS Neurosci Ther. 2024;30(8):e14910.

(12) Wang L, Yang B, Zheng W, Liang T, Chen X, Chen Q, Du J, Lu J, Li B*, Chen N*.Alterations in cortical thickness and volumes of subcortical structures in pediatric patients with complete spinal cord injury. CNS Neurosci Ther. 2024;30(6):e14810.

(13) Qi Q, Wang L, Yang B, Jia Y, Wang Y, Xin H, Zheng W, Chen X, Chen Q, Li F, Du J, Lu J, Chen N*. The relationship between the structural changes in the cervical spinal cord and sensorimotor function of children with thoracolumbar spinal cord injury (TLSCI). Spinal Cord. 2024;62(7):414-420.

(14) Jia YL, Yang BN, Yang YH, Zheng WM, Wang L, Huang CY, Lu J, Chen N*. Application of machine learning techniques in the diagnostic approach of PTSD using MRI neuroimaging data: A systematic review. Heliyon. 2024;24;10(7):e28559.

(15) Yang B, Zheng W, Wang L, Jia Y, Qi Q, Xin H, Wang Y, Liang T, Chen X, Chen Q, Li B, Du J, Hu Y, Lu J, Chen N*. Specific Alterations in Brain White Matter Networks and Their Impact on Clinical Function in Pediatric Patients With Thoracolumbar Spinal Cord Injury. J Magn Reson Imaging. 2024 ;60(5):1842-1852.

(16) Ling Wang, Xin Chen, Weimin Zheng, Yanhui Yang, Beining Yang, Qian Chen, Xuejing Li, Tengfei Liang, Baowei Li, Yongsheng Hu, Jubao Du, Jie Lu, Nan Chen*.The possible neural mechanism of neuropathic pain evoked by motor imagery in pediatric patients with complete spinal cord injury: A preliminary brain structure study based on VBM. Heliyon, 2024;10(2),e24569

(17) Wang L, Wang S, Zheng W, Yang B, Yang Y, Chen X, Chen Q, Li X, Hu Y, Du J, Qin W, Lu J, Chen N*. Altered Brain Function in Pediatric Patients With Complete Spinal Cord Injury: A Resting-State Functional MRI Study. J Magn Reson Imaging. 2024;60(1):304-313.

(18) Chen X, Wang L, Zheng W, Yang Y, Yang B, Hu Y, Du J, Li X, Lu J, Chen N*. The gray matter atrophy and related network changes occur in the higher cognitive region rather than the primary sensorimotor cortex after spinal cord injury. PeerJ 2023.11:e16172

(19) Yang B, Jia Y, Zheng W, Wang L, Qi Q, Qin W, Li X, Chen X, Lu J, Li H*, Zhang Q*, Chen N*. Structural changes in the thalamus and its subregions in regulating different symptoms of posttraumatic stress disorder. Psychiatry Res Neuroimaging.2023;22;335:111706.

(20) Zhang C, Xu K*, Zhang H, Sha J, Yang H, Zhao H, Chen N*, Li K*. Recovery of glymphatic system function in patients with temporal lobe epilepsy after surgery. Eur Radiol. 2023;33(9):6116-6123.

(21) Wang L, Zheng WM, Liang TF, Yang YH, Yang BN, Chen X, Chen Q, Li XJ, Lu J, Li BW, Chen N*. Brain Activation Evoked by Motor Imagery in Pediatric Patients with Complete Spinal Cord Injury. AJNR Am J Neuroradiol. 2023;44(5):611-617.

(22) Wang L, Zheng W, Yang B, Chen Q,Li X, Chen X, Hu Y, Cao L, Ren J,Qin W, Yang Y, Lu J and Chen N*.Altered functional connectivity between primary motor cortex subregions and the whole brain in patients with incomplete cervical spinal cord injury.Front. Neurosci. 2022 ;16:996325.

(23) Wang L, Li X, Zheng W, Chen X, Chen Q, Hu Y, Cao L, Ren J, Qin W, Lu J, Chen N*. Motor imagery evokes strengthened activation in sensorimotor areas and its effective connectivity related to cognitive regions in patients with complete spinal cord injury. Brain Imaging Behav. 2022;16(5):2049-2060.

(24) Zheng W, Wang L, Yang B, Chen Q, Hu Y, Du J, Li X, Chen X, Qin W, Li B, Liang T, Li K, Lu J, Chen N*. Specific Brain Gray Matter Volume Changes in Pediatric Complete Spinal Cord Injury without Fracture or Dislocation Using Voxel-Based Morphometry Analysis: Preliminary Results. J Neurotrauma. 2023;40(9-10):931-938.

(25) Zheng W, Wang L, Yang B, Hu Y, Du J, Li X, Chen X, Qin W, Li K,Lu J, Chen N*.Cerebellum regulating cerebral functional cortex through multiple pathways in complete thoracolumbar spinal cord injury. Front. Neurosci. 2022;16:914549.

(26) Zhao Y, Zhang C, Yang H, Liu C, Yu T, Lu J, Chen N*, Li K*. Recovery of cortical atrophy in patients with temporal lobe epilepsy after successful anterior temporal lobectomy. Epilepsy Behav. 2021;123:108272.

(27) Zheng W, Wang L, Chen Q, Li X, Chen X, Qin W, Li K, Lu J, Chen N*. Functional Reorganizations Outside the Sensorimotor Regions Following Complete Thoracolumbar Spinal Cord Injury. J Magn Reson Imaging. 2021;54(5):1551-1559.

(28) Li X, Wang L, Chen Q, Hu Y, Du J, Chen X,2, Zheng W, Lu J, Chen N*.The Reorganization of Insular Subregions in Individuals with Below-Level Neuropathic Pain following Incomplete Spinal Cord Injury.Neural Plast. 2020 Mar 10;2020:2796571.

(29) Li X, Chen Q, Zheng W, Chen X, Wang L, Qin W, Li K, Lu J, Chen N*.Inconsistency between cortical reorganization and functional connectivity alteration in the sensorimotor cortex following incomplete cervical spinal cord injury. Brain Imaging Behav. 2020;14(6):2367-2377

(30) .Zhang C, Zhang H, Xu K, Yang H, Liu C, Yu T, Chen N*, Li K. Impaired prefrontal cortex-thalamus pathway in intractable temporal lobe epilepsy with aberrant executive control function: MRI evidence. Clin Neurophysiol. 2019;130(4):484-490.

(31) Chen Q, Zheng W, Chen X, Li X, Wang L, Qin W, Li K, Chen N*. Reorganization of the somatosensory pathway after subacute incomplete cervical cord injury. Neuroimage Clin . 2019;21:101674.

(32) Chen Q, Zheng W, Chen X, Li X, Wang L, Qin W, Li K, Chen N*.Whether Visual-related Structural and Functional Changes Occur in Brain of Patients with Acute Incomplete Cervical Cord Injury: A Multimodal Based MRI Study. Neuroscience.2018;14;393:284-294.

(33) Chen X, Qian T, Maréchal B, Zhang G, Yu T, Ren Z, Ni D, Liu C, Fu Y, Chen N*, Li K. Quantitative volume-based morphometry in focal cortical dysplasia: A pilot study for lesion localization at the individual level. Eur J Radiol. 2018;105:240-245.

(34) Chen X, Qian T, Kober T, Zhang G, Ren Z, Yu T, Piao Y, Chen N*, Li K1. Gray-matter-specific MR imaging improves the detection of epileptogenic zones in focal cortical dysplasia: A new sequence called fluid and white matter suppression (FLAWS). Neuroimage Clin.  2018;11;20:388-397.

(35) Zhang C, Yang H, Liu C, Zhang G, Chen N*, Li K. Brain network alterations of mesial temporal lobe epilepsy with cognitive dysfunction following anterior temporal lobectomy.Epilepsy Behav. 2018  13. pii: S1525-5050(18)30507-9.

(36) Yang H, Zhang C, Liu C, Yu T, Zhang G, Chen N*, Li K. Brain network alteration in patients with temporal lobe epilepsy with cognitive impairment . Epilepsy & Behavior. 2018;81:41-48

(37) Chen Q, Zheng W, Chen X, Wan L, Qin W, Qi Z, Chen N*, Li K. Brain Gray Matter Atrophy after Spinal Cord Injury: A Voxel-Based Morphometry Study. Front Hum Neurosci. 2017;11:211

(38) Zheng W, Chen Q, Chen X, Wan L, Qin W, Qi Z, Chen N*, Li K. Brain White Matter Impairment in Patients with Spinal Cord Injury. Neural Plast. 2017;2017:4671607. 

(39) Zhang C, Yang H, Qin W, Liu C, Qi Z, Chen N*, Li K .Characteristics of Resting-state Functional Connectivity in Intractable Unilateral Temporal Lobe Epilepsy Patients with Impaired Executive Control Function.Front Hum Neurosci. 2017 13;11:609.

(40)  Chen X, Wan L, Qin W, Zheng W, Qi Z, Chen N*, Li K. Functional Preservation and Reorganization of Brain during Motor Imagery in Patients with Incomplete Spinal Cord Injury: A Pilot fMRI Study. Front Hum Neurosci. 2016;15;10:46.

(41) Xing W, Nan C#, ZhenTao Z, Rong X, Luo J, Zhuo Y, DingGang S, KunCheng L. Probabilistic MRI brain anatomical atlases based on 1,000 Chinese subjects. PLoS One. 2013;8(1):e50939.

(42) Chen N*, Min PQ, Liu ZY, et al. Radiologic and Anatomic Study of the Extraperitoneal Space Associated With the Rectum. AJR Am J Roentgenol. 2010, 194(3):642-652.

(43) Chen N, Qin W, Li KC, et al. Time course of Hashimoto's Encephalopathy revealed by MRI: Report of Two Cases. Journal of the Neurological Sciences.2011, 300(1-2):169-172

 


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