基础研究：

1 北京市科委，Z191100007619018，基于多组学的胶质母细胞瘤的新抗原免疫治疗方法优化研究，临床研究部分负责人

2 国家科技支撑计划，2014BAI04B02，基于分子病理学的脑胶质瘤个性化及综合治疗研究，参加。

3 国家自然科学基金面上项目，81372693，胶质母细胞瘤干性起源的分子生物学研究，参加

4 北京市自然科学基金，7132079，全基因组突变筛选脑胶质瘤抵抗替莫唑胺化疗相关基因的研究，主持。

5 国家自然科学基金，81101664，激活星形细胞在肿瘤脑转移抵抗化疗的左右与分子机制研究，主持。

临床试验（主要负责人或分中心PI）：

1 个体化疫苗治疗复发脑胶质瘤临床研究

2 CART免疫细胞治疗复发脑胶质瘤临床研究

3 尼妥珠单抗联合同步放化疗治疗新诊断儿童弥漫内生型桥脑胶质瘤（DIPG）的多中心、前瞻性、开放、单臂临床研究

4 注射用聚乙二醇伊利替康联合替莫唑胺用于脑胶质瘤II期临床研究

5 一项在携带IDH1 或 IDH2 突变的残留或复发性 2 级胶质瘤亚洲受试者中开展的 Vorasidenib（S095032/AG881）的 III 期、多中心、随机、双盲、安慰剂对照研究

代表性论文：

1. Lin Q#, WeiY, Xu G, Wang L, Ling F, Chen X, Cheng Y, Zhou Y. Integrative multi-omic profiling ofthe neoantigen landscape of glioblastoma for the development of therapeuticvaccines reveals vast heterogeneity in immunogenic signatures. FrontOncol. 2025 Mar 21;15:1507632.

2. Cheng Y, Zhang L, Wu X, Wakimoto H, GengH, Wei Y, Xu G, Xiao X, Bai J, Wang Y, Hu Z, Wang L, Lin Q#. Distinct clinical profiles and mutationlandscapes of gliomas originating from the neocortex, mesocortex, andcerebellum. Genes Dis. 2023 Apr 5;11(1):53-56.

3. Lin Q#, BaT, Ho J, Chen D, Cheng Y, Wang L, Xu G, Xu L, Zhou Y, Wei Y, Li J, Ling F. First-in-HumanTrial of EphA2-Redirected CAR T-Cells in Patients With Recurrent Glioblastoma:A Preliminary Report of Three Cases at the Starting Dose. Front Oncol. 2021 Jun21;11:694941.

4. Cheng Y, Song S, Wei Y, Xu G, An Y, MaJ, Yang H, Qi Z, Xiao X, Bai J, Xu L, Hu Z, Sun T, Wang L, Lu J, Lin Q#. Glioma Imaging byO-(2-18F-Fluoroethyl)-L-Tyrosine PET and Diffusion-Weighted MRI and CorrelationWith Molecular Phenotypes, Validated by PET/MR-Guided Biopsies. Front Oncol.2021 Nov 29;11:743655.

5. Song S, Cheng Y, Ma J, Wang L, Dong C,Wei Y, Xu G, An Y, Qi Z, Lin Q#,Lu J#. SimultaneousFET-PET and contrast-enhanced MRI based on hybrid PET/MR improves delineationof tumor spatial biodistribution in gliomas: a biopsy validation study. Eur JNucl Med Mol Imaging. 2020 Jun;47(6):1458-1467.

6. LinQ,Balasubramanian K, Fan D, Kim SJ, Guo L, Wang H, Bar-Eli M, Aldape KD, FidlerIJ. Reactive astrocytes protect melanoma cells from chemotherapy bysequestering intracellular calcium through gap junction communication channels.Neoplasia. 2010 Sep;12(9):748-54.

7. Lin Q#, LiuZ, Ling F, Xu G. Astrocytes protect glioma cells from chemotherapy andupregulate survival genes via gap junctional communication. Mol Med Rep. 2016Feb;13(2):1329-35.