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主要从事治疗神经系统重大疾病新药的研究与开发,获得国家自然科学基金2项,北京自然科学基金2项,首都卫生发展专项基金1项,参与国家“重大新药创制”科技重大专项、北京市科委“十病十药”研究项目等;负责企业联合项目2项,含1项国际合作。发表SCI论文30余篇,发明专利授权3项。入选北京市医院管理中心青苗计划,北京市中医管理局第三批中药骨干人才,北京市医药卫生科技创新成果转化专家库2024年度第二批入库专家。按照国家中药新药审评审批标准,完成1.1类中药复方新药参芪醒脑颗粒治疗AD的临床前药效学研究。参与多个创新药的I期临床试验设计并责项目管理工作。目前担任中国民族医药协会医药现代化与临床专业委员会常务理事、中国医药教育协会老年药学专业委员会委员、中草药、中国药理学通报、中药药理与临床等杂志青年编委。
1. 绞股蓝总皂苷通过NPC1调控内质网-溶酶体膜接触改善胆固醇转运治疗AD的机制研究,北京市自然科学基金面上项目, 2025-2027
2. 椰子油抗氧化及改善记忆功能的作用及机制研究(HX-A-2024081),VX Essential Sdn.Bhd(企业合作), 2025-2026
3. 山茱萸环烯醚萜苷通过IRE1α/XBP1/FOXO1调控“内质网应激-自噬交互作用”减少tau蛋白聚集的研究, 国家自然科学基金面上项,2021-2024
4. 山茱萸环烯醚萜苷对tau蛋白寡聚体的影响及与JNK1/Beclin1/PI3KC3自噬调控通路相关的作用机制, 国家自然科学基金青年基金,2018-2020
5. 山茱萸环烯醚萜苷对tau蛋白寡聚体的影响及其对神经功能的作用机制,北京市自然科学基金青年项目,2016-2017
6. 创新药物山茱萸环烯醚萜苷对血管性痴呆认知功能及昼夜节律的影响, 首都卫生发展专项青年优才,2020-2022
(1) Cuicui Yang, Xinhai Jiang, Zizhao Cheng, Cengceng Zheng, Chaoying Hu*. Neuroprotective effects of Analgecine by modifying cholesterol metabolism in EAE mice model of multiple sclerosis[J]. Journal of Neuroimmunology, 2025, 407: 578704.
(2) Zheng CC, Zhao YJ, Hu CY, Zhang L, Li GK, Yang CC. Transcriptomic and network analysis identifies shared pathways across Alzheimer's disease and vascular dementia. Brain Research. 2025, 1854:149548.
(3)Yang CC*, Zheng CC, Zhuang YM, Xu SH, Li J, Hu CY*. Synaptic Vesicle-Related Proteins and Ubiquilin 2 in Cortical Synaptosomes Mediate Cognitive Impairment in Vascular Dementia Rats.Molecular Neurobiology. 2025, 62(2):1415-1432.
(4)Gao D, Zheng CC, Hao JP, Yang CC*, Hu CY*. Icariin ameliorates behavioral deficits and neuropathology in a mouse model of multiple sclerosis. Brain Research. 2023, 1804:148267.
(5)Zheng CC#, Yang CC#, Gao D, Zhang L, Li YL Li L, Zhang L*. Cornel iridoid glycoside alleviates microglia-mediated inflammatory response via the NLRP3/Calpain pathway. Journal of Agricultural and Food Chemistry, 2022, 70(38):11967-11980.
(6)Miao BB#, Gao D#, Hao JP, Li YL, Li L, Wang JB, Xiao XH, Yang CC*, Zhang L*. Tetrahydroxy stilbene glucoside alters neurogenesis and neuroinflammation to ameliorate radiation-associated cognitive disability via AMPK/Tet2. International Immunopharmacology, 2022, 110:108928.
(7) Yang CC*, Zheng CC, Luo Y, Guo KW, Gao D, Zhang L, Li L, Zhang L*. Cornel iridoid glycoside and its effective component regulate ATPase Vps4A/JNK to alleviate autophagy deficit with autophagosome accumulation[J]. American Journal of Chinese Medicine, 2022, 50 (6):1599-1615.
(8)Yang CC#(杨翠翠), Gong SL#, Chen XP, Wang MY, Zhang L, Zhang L*, Hu CY*. Analgecine regulates microglia polarization in ischemic stroke by inhibiting NF-κB through the TLR4 MyD88 pathway[J]. International Immunopharmacology, 2021, 99: 107930.
(9)Yang CC(杨翠翠), Bao XJ, Zhang L, Li YL, Li Lin*, Zhang L *. Cornel iridoid glycoside ameliorates cognitive deficits in APP/PS1/tau triple transgenic mice by attenuating amyloid-beta, tau hyperphosphorylation and neurotrophic dysfunction[J].Annals of Translational Medicine, 2020, 8(6):328.
(10)Yang CC(杨翠翠), Luo Y, Guo KW, Zheng CC, Li L, Zhang L*. Cornel iridoid glycoside regulates modification of Tau and alleviates synaptic abnormalities in aged P301S mice[J].Current Medical Science, 2020, 40(6):1040-1046.

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