在研课题 （9项，经费1532万）：

1. 国家自然科学委员会重点国际合作项目，题目：近红外光调控脑类淋巴系统减少额颞叶痴呆病理性tau蛋白沉积的机制研究. 项目编号：W2511084;经费：230万，起止时间：2026.01-2030.12

2. 北京市卫生健康委员会扬帆3.0项目，题目：朊蛋白病的精准诊断和治疗研究，项目编号：ZLRK202515，经费：600万. 起止时间：2025.01-2027.12.

4. 国家自然科学委员会面上项目，题目：额颞叶痴呆脱抑制行为的眶额叶-伏隔核神经环路机制研究，项目编号：82271464；经费：52万. 起止时间：2023.01-2026.12.

5. 北京市医院管理中心“登峰”计划专项经费资助，编号：DFL20240805，项目经费：160万，起止时间：2024.1-2027.12.  Beijing Hospitals Authority’s Ascent Plan, Code:DFL20240805

6.  北京市高层次公共卫生技术人才建设项目培养计划-领军人才，项目编号：领军人才-03-03  项目经费：210万，起止时间：2024.01-2026.12.

7. 北京市卫建委首发项目，皮肤实时诱导转化技术（RT-QUIC）在朊蛋白病中诊断价值的应用研究，项目编号：2024-2-2018 项目经费：40万，起止时间：2024.01-2026.12.

8. 北京自然科学基金面上项目，类淋巴功能在额颞叶痴呆Tau蛋白沉积中的作用及机制研究. 项目编号：7242067 项目经费：20万，起止时间：2024.01-2026.12.

9. 北京神经变性病学会，中国额颞叶痴呆基因组学多中心研究，项目经费：120万，起止时间：2024.06-2026.06

近3年来，代表作如下：

1. Chu M, Yue A, Yan S, Yu B, He Q, Chen Y, Hou J, Nan H, Ye H, Nie B, Rosa-Neto P, Qu M*, Lu J*, Wu L*. Glymphatic Dysfunction in Frontotemporal Dementia: Link with Vascular Dysfunction and Inflammation. Alzheimers Dement. 2025 Aug;21(8):e70561. doi: 10.1002/alz.70561.

2. Chen Z, Wang Y, Liu R, Wu L. Clinical Reasoning: A 10-Year-Old Boy With Progressive Tremor, Insomnia, and Autonomic Dysfunction. Neurology. 2025 Nov 11;105(9):e214297. doi: 10.1212/WNL.0000000000214297. Epub 2025 Oct 17.PMID: 41105905

3. Nan H#, Chu M#, Yue A, He Q, Li J, Liu Y, Chi L, Liu X, Peng G, Wu L. Analyses of NOTCH3 variants in Chinese patients with clinically diagnosed Alzheimer's disease and frontotemporal dementia. Alzheimers Res Ther. 2025 Aug 9;17(1):186. doi: 10.1186/s13195-025-01836-1.

4. Nan H#, Chu M#, Jiang D, Liang W, Li Y, Wu Y, Wang Z*, Wu L*. Identification and characterization of Mutations in PSEN1, PSEN2, and APP Genes in Chinese Patients with Alzheimer's Disease. Identification and characterization of variants in PSEN1, PSEN2, and APP genes in Chinese patients with early-onset Alzheimer's disease. Alzheimers Res Ther. 2025 Feb 27;17(1):54. doi: 10.1186/s13195-025-01702-0.PMID: 40016812 

5.  Wang Z#, Wang C#, Yuan B#, Liu L#, Zhang H, Zhu M, Chai H, Peng J, Huang Y, Zhou S, Liu J*, Wu L*, Wang W*. Akkermansia muciniphila and its metabolite propionic acid maintains neuronal mitochondrial division and autophagy homeostasis during Alzheimer’s disease pathologic process via GPR41 and GPR43. Microbiome. 2025 Jan 20;13(1):16. doi: 10.1186/s40168-024-02001-w.PMID: 39833898 (中科院1区IF=13.8)

6. Chen Z, Jiang D, Kong Y, Zhang J, Min C, Bi S, Yan S, Ye H, Li J, Wang L, Lu J, Wu L. Association of Glymphatic Function With Clinical Characteristics in Patients With Clinical and Asymptomatic Creutzfeldt-Jakob Disease. Neurology. 2025 Jan 14;104(1):e210055. doi: 10.1212/WNL.0000000000210055. Epub 2024 Dec 13.PMID: 39671544(中科院1区，IF=7.7)

7. Chen ZY#, Shi Q#, Xiao K#, Kong Y, Liang DL, Wang YH, Min R, Zhang J, Wang Z, Ye H, Gao R, Chu M, Nan HT, Jiang DM, Li JJ, Wang L, Zou WQ, Wu LY*, Dong XP*. Multi-Site Skin Biopsies for Prion Seeding Activity Outperform Cerebrospinal Fluid in Prion Disease Diagnosis. JAMA Neurol. 2024 Oct 14. doi: 10.1001/jamaneurol.2024.3458. Online ahead of print. （IF=22.2）

8. Chen Z, Wang Z, Wu L. Isolated Diffuse Precentral Gyrus Signals in Creutzfeldt-Jakob Disease. JAMA Neurol. 2024 May 28. doi: 10.1001/jamaneurol.2024.1466. Online ahead of print. (中科院1区，IF=22.2)

9. Chu M, Jiang D, Nan H, Wen L, Liu L, Qu M*, Wu L* Vascular dysfunction in sporadic bvFTD: white matter hyperintensity and peripheral vascular biomarkers. Alzheimers Res Ther. 2024 Apr 5;16(1):72. doi: 10.1186/s13195-024-01422-x.PMID: 38581060 (IF=9.2, 中科院1区)

10. Chu M#, Jiang D#, Li D#, Yan S, Liu L, Nan H, Wang Y, Wang Y, Yue A, Ren L, Chen K, Rosa-Neto P*, Lu J*, Wu L*. Frontotemporal Lobar Degeneration Neuroimaging Initiative† Atrophy network mapping of clinical subtypes and main symptoms in frontotemporal dementia. Brain. 2024 Mar 1:awae067. doi: 10.1093/brain/awae067. Online ahead of print.(中科院1区，IF=14.6)

11. Jiang D, Liu L, Kong Y, Chen Z, Rosa-Neto P, Chen K, Ren L, Chu M*, Wu L*. Glymphatic failure and its regional distribution feature in behavioral variant frontotemporal dementia. Ann Neurol. 2023 Sep;94(3):442-456. doi: 10.1002/ana.26710.  (中科院1区，IF=11.27)

12. Chu M#, Wen L#, Jiang D, Liu L, Nan H, Yue A, Wang Y, Wang Y, Qu M, Wang N*, Wu L*. Peripheral inflammation in behavior-variant frontotemporal dementia: Relationships to central degeneration and clinical measures. J Neuroinflammation. 2023 Mar 8;20(1):65. doi: 10.1186/s12974-023-02746-5. (IF=9.587, Q1区)

13. Liu L#, Chu M#, Nie B, Jiang D, Xie K, Cui Y, Liu L, Kong Y, Chen Z, Nan H, Rosa-Neto P, Wu L*. Altered Metabolic Connectivity within the Limbic Cortico-Striato-Thalamo-Cortical Circuit in Presymptomatic and Symptomatic Behavioral Variant Frontotemporal Dementia. Alzheimers Res Ther. 2023 Jan 5;15(1):3. doi: 10.1186/s13195-022-01157-7. (IF=8.823, Q1区)

14.  Cui Y#, Huang Z#*, Chu M, Xie K, Zhan S, Ghorayeb I, Garay A, Chen Z, Jing D, Wang Y, Wu L.*. Autonomic dysfunction assessed by nocturnal heart rate variability in fatal familial insomnia. Sleep. 2022 Dec 6:zsac294. doi: 10.1093/sleep/zsac294. Online ahead of print. (IF=6.313, Q1区) 

15.  Liu L^†, Liu S^†, Chu M, Wang J, Xie K, Cui Y, Ma J, Nan H, Cui C, Qiao H, Rosa-Neto P, Chan P*, Wu L*. Involvement of Striatal Motoric Part in Frontotemporal Dementia with Parkinsonism Due to C9orf72 Repeat Expansions. NPJ Parkinsons Dis. 2022 Oct 6;8(1):128. doi: 10.1038/s41531-022-00398-5. (IF=9.304, Q1区) 

16.  Zhang J#, Chu M#, Tian Z#, Xie K, Cui Y, Liu L, Meng J, Yan H, Ji YM, Jiang Z, Xia TX, Wang D, Wang X, Zhao Y, Ye H, Li J, Wang L, Wu L*. Clinical profile of fatal familial insomnia: phenotypic variation in 129 polymorphisms and geographic regions. J Neurol Neurosurg Psychiatry 2022, 93(3): 291-297. (IF=13.654, Q1区)