导师风采
何江弘
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  • 主任医师
  • 导师类别:硕士,博士生导师
  • 性别: 男

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  • 所属院系:附属北京天坛医院
  • 所属专业: 外科学(神外)
  • 邮箱 : he_jianghong@sina.cn
  • 工作电话 : -

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何江弘,主任医师,教授,中国神经科学学会 意识与意识障碍分会主任委员、北京医师协会 神经调控与人机交互专家委员会主任委员、北京神经科学学会 意识障碍专业委员会主任委员、中国康复医学会 颅脑创伤康复分会候任主委、中国认知学会意识研究分会副主任委员、中国医师协会神经修复学专业委员会促醒治疗学组组长、中华医学会 神经外科学分会 神经生理监测学组副组长。近5年,主持国家重点研发计划、军委创新特区重点专项、国家自然基金等科研项目,在意识障碍领域以第一/通讯作者发表SCI论文50余篇。对意识检测、神经调控、意图识别与输出、康复机器人等进行了持续的临床研究,在eLIFE、BRAIN STIMULATION等高质量期刊发表论文20余篇,牵头制定《慢性意识障碍诊疗中国专家共识》和《慢性意识障碍神经调控中国专家共识》,并编辑撰写多本专业书籍。


  • 研究方向Research Directions
意识障碍
2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行整体布局设计。 整体布局设计。
项目情况

1. 国家重点研发计划,2023YFB4706100,可恢复性弱能老人高相容性照护康复机器人技术与系统研发,2023/12-2026/11,2500万,主持,在研;

2. 国家自然基金项目,82272118,慢性意识障碍的脑微状态特征与机制研究 ,2023/01-2026/12,75万,主持,在研;

3. 北京市自然科学基金, 23G10455,面向意识障碍患者的多模式神经调控效应及机制研究,2023/01-2025/12,20万,主持,在研;

4. 北京卫健委“登峰人才计划”,2024/01-2027/12,160万,主持,在研;

5. 北京医学奖励基金会, YXJL-2022-09000277,意识障碍患者疼痛的脊髓电刺激治疗研究,2023/01- 2024/12,40万元,主持,在研;


科研项目

1. 国家重点研发计划,2023YFB4706100,可恢复性弱能老人高相容性照护康复机器人技术与系统研发,2023/12-2026/11,2500万,主持,在研;

2. 国家自然基金项目,82272118,慢性意识障碍的脑微状态特征与机制研究 ,2023/01-2026/12,75万,主持,在研;

3. 北京市自然科学基金, 23G10455,面向意识障碍患者的多模式神经调控效应及机制研究,2023/01-2025/12,20万,主持,在研;

4. 北京卫健委“登峰人才计划”,2024/01-2027/12,160万,主持,在研;

5. 北京医学奖励基金会, YXJL-2022-09000277,意识障碍患者疼痛的脊髓电刺激治疗研究,2023/01- 2024/12,40万元,主持,在研;

6. 国家重点研发计划,18-H863-02-ZT-008-002-02,太赫兹对大脑醒觉及意识水平的表征和调控,2017/01-2021/12,200万,主持,结题;

7. 国家自然基金项目,81771128,中央丘脑电生理特征在意识障碍神经环路中的关键作用和机制研究 ,2018/01-2021/12,54万,主持,结题;

8. 广东省重点领域研发计划项目,脑机接口关键技术及软硬件产品研究,2019/1-2021/12,240万,子课题主持,结题;

9. 军队装备科研:战场颅内出血快速检测与动态监测一体化单兵卫勤装备可行性研究,2018/01-2020/12,80万,主持,结题;

10. 军队后勤科研,基于脑网络的战创伤后意识障碍神经调控治疗技术研究,2017/01-2019/12,80万,主持,结题;

11. 首都临床特色应用研究专项,Z14110700251411,多模态MR“丘脑-默认网络” 评定持续性植物状态患者意识的研究,2014/01-2017/12,25万,主持,结题;

12. 首都临床特色应用研究及成果推广,Z151100004015219,成果推广-品驰脑起搏器治疗帕金森病临床示范应用,2015/06-2017/05,22万,主持,结题;


研究成果

1. He J #, H Zhang# , Y Dang ,et al.(第一) Electrophysiological characteristics of CM-pf in diagnosis and outcome of patients with disorders of consciousness. Brain Stimul.2023;  29;16(5):1522-1532.  (Top期刊;IF= 7.7,一区)

2. He J #, Yi Yang#, Yi Zhang, et al.(第一)Hyperactive external awareness against hypoactive internal awareness in disorders of consciousness using resting state fMRI: highlighting the involvement of visuo-motor modulation. NMR Biomed, 2014, 27(8): 880-6. (IF= 2.9)

3. He J #, Yue Cui#, Ming Song, et al.(第一)Decreased functional connectivity between the mediodorsal thalamus and default mode network in disorders of consciousness. Acta Neurol Scand, 2015, 131:145-151. (IF= 3.5)

4. Wang H, Hu Y, Ge Q, Dang Y, Yang Y, Xu L, Xia X, Zhang P, He S, Laureys S, Yang Y,  He J(通讯作者),Thalamic burst and tonic firing selectively indicate patients’ consciousness level and recovery. The Innovation,  6(5),2025,(IF= 33.2,一区)

5. Li Y, Gao J, Yang Y, Zhuang Y, Kang Q, Li X, Tian M, Lv H,  He J(通讯作者). Temporal and spatial variability of dynamic microstate brain network in disorders of consciousness. CNS Neurosci Ther. 2024;30(2):e14641. (IF= 5.5,一区)

6. Zhuang Y, Ge Q, Li Q, Xu L, Geng X, Wang R, He J(通讯作者). Combined behavioral and EEG evidence for the 70 Hz frequency selection of short-term spinal cord stimulation in disorders of consciousness. CNS Neurosci Ther. 2023. doi: 10.1111/cns.14388.(IF= 5.5,一区)

7. Xu L, Ge Q, Lu H, Zhuang Y, Geng X, Chen X, Liu X, Sun H, Guo Z, Sun J, Qi F, Niu X, Wang A, Sun W, He J(通讯作者). Cerebrospinal fluid metabolite alterations in patients with different etiologies, diagnoses, and prognoses of disorders of consciousness. Brain Behav. 2023;13(8):e3070. doi: 10.1002/brb3.3070.(IF= 3.1)

8. Si J, Yang Y, Xu L, Xu T, Liu H, Zhang Y, Jing R, Li J, Wang D, Wu S, He J(通讯作者). Evaluation of residual cognition in patients with disorders of consciousness based on functional near-infrared spectroscopy. Neurophotonics. 2023 Apr;10(2):025003. (IF= 5.3,二区)

9. Zhuang Y, Ni G, Xu L, Chen X, Geng X, He J(通讯作者)Spinal cord stimulation improves motor function in disorders of consciousness: A case report. J Neurorestoratology 2023,11(3):100041.(IF= 3.3)

10. Liu Y, Zeng W, Pan N, Xia X, Huang Y, He J(通讯作者). EEG complexity correlates with residual consciousness level of disorders of consciousness. BMC Neurol. 2023 3;23(1):140. (IF= 2.6)

11. Zhang C, Yang Y, Han S, Xu L, Chen X, Geng X, Bie L, He J(通讯作者). The temporal dynamics of Large-Scale brain network changes in disorders of consciousness: A Microstate-Based study. CNS Neurosci Ther. 2023 29(1):296-305.(IF= 5.5,一区)

12. Yang Y, He Q, Dang Y, Xia X, Xu X, Chen X, Zhao J, He J(通讯作者). Long-term functional outcomes improved with deep brain stimulation in patients with disorders of consciousness. Stroke Vasc Neurol. 2023:svn-2022-001998.(IF= 5.9,一区)

13. Ge Qianqian, Wang Yanjun, Zhuang Yutong, Li Qinghua, Han Ruquan, Guo Wenzhi, He J(通讯作者). Opioid-induced short-term consciousness improvement in patients with disorders of consciousness. Frontiers in Neuroscience. 2023, 1662-453X.(IF=4.3)

14. Dang Y, Wang Y, Xia X, Yang Y, Bai Y, Zhang J, He J(通讯作者). Deep brain stimulation improves electroencephalogram functional connectivity of patients with minimally conscious state. CNS Neurosci Ther. 2023 Jan;29(1):344-353.(IF=5.5,一区)

15. Zhuang Y, Yang Y, Xu L, Chen X, Geng X, Zhao J, He J(通讯作者). Effects of short-term spinal cord stimulation on patients with prolonged disorder of consciousness: A pilot study. Front Neurol. 2022 14;13:1026221.(IF= 3.4)

16. Yang Y, He Q, Xia X, Dang Y, Chen X, He J(通讯作者), Zhao J. Long-term functional prognosis and related factors of spinal cord stimulation in patients with disorders of consciousness. CNS Neurosci Ther. 2022;28(8):1249-1258.(IF= 5.5,一区)

17. Dang Y, Ping J, Guo Y, Yang Y, Xia X, Huang R, Zhang J,He J(通讯作者). Cranioplasty for patients with disorders of consciousness. Annals of Palliative Medicine. 2021;10(8):8889-99.(IF= 1.925)

18. Liang Z, Shao S, Lv Z, Li D, Sleigh JW, Li X, Zhang C, He J(通讯作者). Constructing a Consciousness Meter Based on the Combination of Non-Linear Measurements and Genetic Algorithm-Based Support Vector Machine. IEEE Trans Neural Syst Rehabil Eng. 2020;28(2):399-408.(IF= 4.9,2区)

19. Xia X, Wang Y, Li C, Li X, He J, Bai Y(通讯作者). Transcranial magnetic stimulation-evoked connectivity reveals modulation effects of repetitive transcranial magnetic stimulation on patients with disorders of consciousness. Neuroreport. 2019 18;30(18):1307-1315.(IF= 1.7)

20. Cui Y, Song M, Lipnicki DM, Yang Y, Ye C, Fan L, Sui J, Jiang T, He J(通讯作者). Subdivisions of the posteromedial cortex in disorders of consciousness. Neuroimage Clin.2018;20:260-266.(IF= 4.2,二区)

21. Xia X, Yang Y, Guo Y, Bai Y, Dang Y, Xu R, He J. (通讯作者)Current Status of Neuromodulatory Therapies for Disorders of Consciousness. Neurosci Bull. 2018; 34:615–625 .(IF= 4.2,二区)

22. Xia X, Bai Y, Zhou Y, Yang Y, Xu R, Gao X, Li X, He J. (通讯作者)Effects of 10 Hz Repetitive Transcranial Magnetic Stimulation of the Left Dorsolateral Prefrontal Cortex in Disorders of Consciousness. Front Neurol.2017; 8:182.(IF= 3.4)

23. Xia X, Liu Y, Bai Y, Liu Z, Yang Y, Guo Y, Xu R, Gao X, Li X, He J. (通讯作者)Long-lasting repetitive transcranial magnetic stimulation modulates electroencephalography oscillation in patients with disorders of consciousness. Neuroreport.2017;28:1022-1029.(IF= 1.7)

24. Xia X, Zhang H, Gao H, Yang Y, Dai Y, Jiao Y, He J(通讯作者). Nearly asymptomatic intracranial capillary hemangiomas: A case report and literature review. Exp Ther Med.2017;14:2007-2014.(IF= 2.7)

25. Bai Y, Xia X, Li X, Wang Y, Yang Y, Liu Y, Liang Z, He J(通讯作者). Spinal cord stimulation modulates frontal delta and gamma in patients of minimally consciousness state. Neuroscience.2017;346:247-254.(IF= 3.3)

26. Wang X, Yang Y#, Laforge G, Chen X, Norton L, Owen AM, He J(共同通讯), Cong F. Global Field Time-Frequency Representation-Based Discriminative Similarity Analysis of Passive Auditory ERPs for Diagnosis of Disorders of Consciousness. IEEE Trans Biomed Eng. 2024 Jan 12;PP.  (IF=4.4,二区)

27. Xiao X, Xu L, Lu H, Liu X, Sun H, Guo Z, Sun J, Qi F, Niu X, Wang A, Ge Q, Zhuang Y, Geng X, Chen X, Lan Y, He J(共同通讯), Sun W. Untargeted Metabolomic Analyses of Body Fluids to Differentiate TBI DOC and NTBI DOC. Curr Mol Med. 2023 ,IF: 2.5 Q3.

28. Yang Y, Dai Y, He Q, Wang S, Chen X, Geng X,  He J(共同通讯), Duan F. Altered brain functional connectivity in vegetative state and minimally conscious state. Front Aging Neurosci. 2023 doi: 10.3389/fnagi.2023.1213904. (IF=4.8,二区)

29. Wang J, Xu L, Ge Q, Xue L, Liu Y, Wang C, Wu Y, Liu Y, Chen L, Zhuang Y, Geng X, Chen X, Wang B, Yu Q, He J(共同通讯), Zhao X. EEG microstate changes during hyperbaric oxygen therapy in patients with chronic disorders of consciousness. Front Neurosci. 2023 Apr 12;17:1145065. (IF=4.3,二区)

30. Dang Y, Xia X, Yang Y, Huang R, He J(共同通讯), Zhang J. Proposal of a Novel Procedure for C2-4 Cervical Spinal Cord Stimulator Implantation to Improve Complete Midline Coverage via Electrode Array in Patients with Disorders of Consciousness: A Retrospective Single-Center Study. J Integr Neurosci. 2023 Jan 4;22(1):6.(IF= 1.8)

31. Wang Y, Niu Z, Xia X, Bai Y, Liang Z, He J(共同通讯), Li X. Application of Fast Perturbational Complexity Index to the Diagnosis and Prognosis for Disorders of Consciousness. IEEE Trans Neural Syst Rehabil Eng. 2022;30:509-518.(IF= 4.9,二区)

32. Yifei W, Yi Y, Yu W, Jinling Z, Weihang Z, Shaoyuan LI, Mozheng WU, Jianghong He(共同通讯), Peijing R. Transcutaneous auricular vague nerve stimulation improved brain connection activity on patients of disorders of consciousness: a pilot study. J Tradit Chin Med. 2022;42(3):463-471. (IF=2.6)

33. He Q, Han B, Xia X, Dang Y, Chen X, He J(共同通讯), Yang Y. Related Factors and Outcome of Spinal Cord Stimulation Electrode Deviation in Disorders of Consciousness. Front Neurol. 2022; 13:947464. (IF=3.4)

34. Li M, Yang Y, Zhang Y, Gao Y, Jing R, Dang Y, Chen X, He J, Si J(共同通讯). Detecting Residual Awareness in Patients With Prolonged Disorders of Consciousness: An fNIRS Study. Front. Neurol. 2021, 12:618055. (IF= 3.4)

35. Song M, Yang Y, Yang Z, Cui Y, Yu S, He J, Jiang T(共同通讯). Prognostic models for prolonged disorders of consciousness: an integrative review.  Cell Mol Life Sci 2020, 77:3945-3961.(IF= 8,一区)

Wang Y, Bai Y, Xia X, Yang Y, He J, Li X(共同通讯). Spinal cord stimulation modulates complexity of neural activities in patients with disorders of consciousness. Int J Neurosci. 2020 130(7):662-670.(IF= 2.2)


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